{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:48:51Z","timestamp":1792158531630,"version":"4.4.0"},"reference-count":63,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2012,12,21]],"date-time":"2012-12-21T00:00:00Z","timestamp":1356048000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0052309","type":"journal-article","created":{"date-parts":[[2012,12,21]],"date-time":"2012-12-21T20:48:22Z","timestamp":1356122902000},"page":"e52309","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Regional Differences in Susceptibiity of Bronchial Epithelium to Mesenchymal Transition and Inhibition by the Macrolide Antibiotic Azithromycin"],"prefix":"10.1371","volume":"7","author":[{"given":"Balarka","family":"Banerjee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Musk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika N.","family":"Sutanto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie T.","family":"Yerkovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Hopkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darryl A.","family":"Knight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanna","family":"Lindsey-Temple","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M.","family":"Stick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Kicic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel C.","family":"Chambers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,12,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.healun.2009.08.004","article-title":"The registry of the International Society for Heart and Lung Transplantation: Twenty-sixth official adult lung and heart-lung transplantation report-2009","volume":"28","author":"JD Christie","year":"2009","journal-title":"J Heart Lung Transpl"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S1053-2498(02)00398-4","article-title":"Bronchiolitis obliterans syndrome 2001: an update of the diagnostic criteria","volume":"21","author":"M Estenne","year":"2002","journal-title":"J Heart Lung Transpl"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1164\/rccm.200706-951OC","article-title":"Severity of lymphocytic bronchiolitis predicts long-term outcome after lung transplantation","volume":"177","author":"AR Glanville","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1097\/TP.0b013e31816651de","article-title":"<italic>Pseudomonas aeruginosa<\/italic> colonization of the allograft after lung transplantation and the risk of bronchiolitis obliterans syndrome","volume":"85","author":"P Botha","year":"2008","journal-title":"Transplantation"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.healun.2011.06.007","article-title":"The airway epithelium is a direct source of matrix degrading enzymes in bronchiolitis obliterans syndrome","volume":"30","author":"B Banerjee","year":"2011","journal-title":"J Heart Lung Transpl"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1016\/j.healun.2004.11.040","article-title":"Epithelial to mesenchymal transition in clinically stable lung transplant recipients","volume":"24","author":"IA Forrest","year":"2005","journal-title":"J Heart Lung Transpl"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/j.1600-6143.2009.02558.x","article-title":"Post-transplant bronchiolitis obliterans syndrome is associated with bronchial epithelial to mesenchymal transition","volume":"9","author":"S Hodge","year":"2008","journal-title":"Am J Transplant"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/S0002-9440(10)62533-3","article-title":"Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis","volume":"159","author":"J Yang","year":"2001","journal-title":"Am J Pathol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/rr175","article-title":"Idiopathic pulmonary fibrosis: an epithelial\/fibroblastic cross-talk disorder","volume":"3","author":"M Selman","year":"2002","journal-title":"Respir Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1164\/rccm.200811-1730OC","article-title":"Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-beta1","volume":"180","author":"TL Hackett","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"ref11","first-page":"2727","article-title":"Subepithelial corneal fibrosis partially due to epithelial-mesenchymal transition of ocular surface epithelium","volume":"16","author":"M Kawashima","year":"2010","journal-title":"Mol Vis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1159\/000101322","article-title":"Liver fibrosis: possible involvement of EMT","volume":"185","author":"T Ikegami","year":"2007","journal-title":"Cells Tissues Organs"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/j.1600-6143.2009.02953.x","article-title":"Inflammation and epithelial to mesenchymal transition in lung transplant recipients: role in dysregulated epithelial wound repair","volume":"10","author":"LA Borthwick","year":"2010","journal-title":"Am J Transplant"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.healun.2009.12.003","article-title":"Azithromycin is associated with increased survival in lung transplant recipients with bronchiolitis obliterans syndrome","volume":"29","author":"R Jain","year":"2010","journal-title":"J Heart Lung Transpl"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.healun.2004.04.020","article-title":"Integrity of airway epithelium is essential against obliterative airway disease in transplanted rat tracheas","volume":"24","author":"N Qu","year":"2005","journal-title":"J Heart Lung Transpl"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1164\/rccm.200601-071OC","article-title":"Azithromycin reduces airway neutrophilia and interleukin-8 in patients with bronchiolitis obliterans syndrome","volume":"174","author":"GM Verleden","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1128\/AAC.50.5.1805-1812.2006","article-title":"Novel effects of azithromycin on tight junction proteins in human airway epithelia","volume":"50","author":"V Asgrimsson","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"ref18","unstructured":"Halldorsson S, Gudjonsson T, Gottfredsson M, Singh PK, Gudmundsson GH, <etal>et al<\/etal>.. (2010) Azithromycin maintains airway epithelial integrity during <italic>Pseudomonas aeruginosa<\/italic> infection. Am J Respir Cell Mol Biol 42."},{"key":"ref19","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/1465-9921-10-99","article-title":"Successful establishment of primary small airway cell cultures in human lung transplantation","volume":"10","author":"B Banerjee","year":"2009","journal-title":"Respir Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1016\/j.rmed.2008.03.009","article-title":"Once-weekly azithromycin in cystic fibrosis with chronic <italic>Pseudomonas aeruginosa<\/italic> infection","volume":"102","author":"G Steinkamp","year":"2008","journal-title":"Respir Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u0394\u0394CT Method","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1373\/49.4.552","article-title":"Matrix-assisted laser desorption\/ionization time-of-flight mass spectrometry-based detection of microsatellite instabilities in coding DNA sequences: a novel approach to identify DNA-mismatch repair-deficient cancer cells","volume":"49","author":"T Bonk","year":"2003","journal-title":"Clin Chem"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1183\/09031936.00129107","article-title":"Selection of housekeeping genes for real-time PCR in atopic human bronchial epithelial cells","volume":"32","author":"JQ He","year":"2008","journal-title":"Eur Respir J"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/S1053-2498(99)00047-9","article-title":"Transforming growth factor beta (TGF-\u03b21) and obliterative bronchiolitis following pulmonary transplantation","volume":"18","author":"A El-Gamel","year":"1999","journal-title":"J Heart Lung Transpl"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"E1475","DOI":"10.1073\/pnas.1117988108","article-title":"Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition","volume":"108","author":"JR Rock","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1002\/hep.23368","article-title":"Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice","volume":"51","author":"K Taura","year":"2010","journal-title":"Hepatology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/ki.2011.77","article-title":"Scar wars: mapping the fate of epithelial-mesenchymal-myofibroblast transition","volume":"80","author":"SE Quaggin","year":"2011","journal-title":"Kidney Int"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00441-010-1029-x","article-title":"Differential susceptibility to epithelial-mesenchymal transition (EMT) of alveolar, bronchial and intestinal epithelial cells <italic>in vitro<\/italic> and the effect of angiotensin II receptor inhibition","volume":"342","author":"S Buckley","year":"2010","journal-title":"Cell and Tissue Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1465-9921-6-56","article-title":"TGF-\u03b21 induces human alveolar epithelial to mesenchymal cell transition (EMT)","volume":"6","author":"H Kasai","year":"2005","journal-title":"Respir Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1465-9921-8-1","article-title":"Detection of epithelial to mesenchymal transition in airways of a bleomycin induced pulmonary fibrosis model derived from an alpha-smooth muscle actin-Cre transgenic mouse","volume":"8","author":"Z Wu","year":"2007","journal-title":"Respir Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/00000658-199801000-00014","article-title":"Enhanced expression of TGF-\u03b2s and their receptors in human acute pancreatitis","volume":"227","author":"H Friess","year":"1998","journal-title":"Ann Surg"},{"key":"ref32","first-page":"1059","article-title":"Analysis of transforming growth factor (TGF)-\u03b1\/epidermal growth factor receptor, hepatocyte growth Factor\/c-met,TGF-\u03b2 receptor type II, and p53 expression in human hepatocellular carcinomas","volume":"3","author":"A Kiss","year":"1997","journal-title":"Clin Cancer Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1164\/rccm.200411-1537OC","article-title":"Azithromycin reverses airflow obstruction in established bronchiolitis obliterans syndrome","volume":"172","author":"B Yates","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1164\/ajrccm.173.4.465","article-title":"Azithromycin in bronchiolitis obliterans: Is the evidence strong enough?","volume":"173","author":"LF Angel","year":"2006","journal-title":"Am J Resp Crit Care"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1164\/rccm.200212-1424BC","article-title":"Maintenance azithromycin therapy for bronchiolitis obliterans syndrome: results of a pilot study","volume":"168","author":"SG Gerhardt","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1097\/01.TP.0000122412.80864.43","article-title":"Azithromycin therapy for patients with bronchiolitis obliterans syndrome after lung transplantation","volume":"77","author":"GM Verleden","year":"2004","journal-title":"Transplantation"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1097\/00007890-199708150-00027","article-title":"Salvage therapy with mycophenolate mofetil for lung transplant bronchiolitis obliterans: importance of dosage","volume":"64","author":"R Speich","year":"1997","journal-title":"Transplantation"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/01.tp.0000195781.02268.5e","article-title":"Conversion to sirolimus and mycophenolate can attenuate the progression of bronchiolitis obliterans syndrome and improves renal function after lung transplantation","volume":"81","author":"J Groetzner","year":"2006","journal-title":"Transplantation"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"761","DOI":"10.2165\/00003495-200565060-00004","article-title":"Bronchiolitis obliterans syndrome: risk factors and therapeutic strategies","volume":"65","author":"AI Scott","year":"2005","journal-title":"Drugs"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1183\/09031936.00134307","article-title":"A dichotomy in bronchiolitis obliterans syndrome after lung transplantation revealed by azithromycin therapy","volume":"32","author":"BM Vanaudenaerde","year":"2008","journal-title":"Eur Respir J"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1080\/01902140802093238","article-title":"EM703, a new derivative of erythromycin, inhibits transforming growth factor-\u03b2 signaling in human lung fibroblasts","volume":"34","author":"C Yu","year":"2008","journal-title":"Exp Lung Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.1128\/AAC.48.9.3457-3461.2004","article-title":"Azithromycin inhibits MUC5AC production induced by the Pseudomonas aeruginosa autoinducer N-(3-Oxododecanoyl) homoserine lactone in NCI-H292 Cells","volume":"48","author":"Y Imamura","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1128\/AAC.45.6.1930-1933.2001","article-title":"Azithromycin inhibits quorum sensing in Pseudomonas aeruginosa","volume":"45","author":"K Tateda","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1183\/09031936.00088410","article-title":"Pseudomonas aeruginosa accentuates epithelial-to-mesenchymal transition in the airway","volume":"37","author":"LA Borthwick","year":"2011","journal-title":"Eur Respir J"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/00007890-199701150-00008","article-title":"Mycophenolate mofetil in renal allograft recipients: a pooled efficacy analysis of three randomized, double-blind, clinical studies in prevention of rejection. The International Mycophenolate Mofetil Renal Transplant Study Groups","volume":"63","author":"P Halloran","year":"1997","journal-title":"Transplantation"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1097\/00007890-200006150-00033","article-title":"Mycophenolate mofetil reduces late renal allograft loss independent of acute rejection","volume":"69","author":"AO Ojo","year":"2000","journal-title":"Transplantation"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0140-6736(04)16808-6","article-title":"Mycophenolate mofetil versus azathioprine for prevention of acute rejection in renal transplantation (MYSS): a randomised trial","volume":"364","author":"G Remuzzi","year":"2004","journal-title":"Lancet"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/00007890-200107150-00016","article-title":"Control of antidonor antibody production with tacrolimus and mycophenolate mofetil in renal allograft recipients with chronic rejection","volume":"72","author":"TP Theruvath","year":"2001","journal-title":"Transplantation"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0003-4975(97)00845-X","article-title":"Mycophenolate mofetil for obliterative bronchiolitis syndrome after lung transplantation","volume":"64","author":"RI Whyte","year":"1997","journal-title":"Ann Thorac Surg"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/01.TP.0000101822.50960.AB","article-title":"Everolimus and mycophenolate mofetil are potent inhibitors of fibroblast proliferation after lung transplantation","volume":"77","author":"A Azzola","year":"2004","journal-title":"Transplantation"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.bbmt.2003.11.005","article-title":"A pilot study of tacrolimus and mycophenolate mofetil graft-versus-host disease prophylaxis in childhood and adolescent allogeneic stem cell transplant recipients","volume":"10","author":"O Ifeyinwa","year":"2004","journal-title":"Biol Blood Marrow Tr"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1124\/jpet.106.117051","article-title":"<italic>In vitro<\/italic> evidence for a direct antifibrotic role of the immunosuppressive drug mycophenolate mofetil","volume":"321","author":"N Roos","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1097\/FTD.0b013e3181e44260","article-title":"Mycophenolic acid displays IMPDH-dependent and IMPDH-independent effects on renal fibroblast proliferation and function","volume":"32","author":"DT Petrova","year":"2010","journal-title":"Ther Drug Monit"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S0014-4827(02)00015-0","article-title":"TGF-\u03b21-mediated fibroblast-myofibroblast terminal differentiation-the role of Smad proteins","volume":"282","author":"RA Evans","year":"2003","journal-title":"Exp Cell Res"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1016\/j.transproceed.2006.06.006","article-title":"The effects of different immunosuppressants on chronic allograft nephropathy by affecting the transforming growth factor-\u03b2 and Smads signal pathways","volume":"38","author":"R Gao","year":"2006","journal-title":"Transplantation P"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1600-6143.2005.01134.x","article-title":"Everolimus versus azathioprine in maintenance lung transplant recipients: an international, randomized, double-blind clinical trial","volume":"6","author":"GI Snell","year":"2006","journal-title":"Am J Transplant"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"33045","DOI":"10.1074\/jbc.M606366200","article-title":"Modulation of collagen and MMP-1 gene expression in fibroblasts by the immunosuppressive drug rapamycin. A direct role as an antifibrotic agent?","volume":"281","author":"N Poulalhon","year":"2006","journal-title":"J Biol Chem"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.1158\/0008-5472.CAN-10-4058","article-title":"mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways","volume":"71","author":"P Gulhati","year":"2011","journal-title":"Cancer Res"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1097\/JTO.0b013e31822adfb0","article-title":"Identifying inhibitors of epithelial-mesenchymal transition by connectivity map-based systems approach","volume":"6","author":"AK Reka","year":"2011","journal-title":"J Thorac Oncol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1177\/039139880502800213","article-title":"Effects of rapamycin on the epithelial-to-mesenchymal transition of human peritoneal mesothelial cells","volume":"28","author":"A Aguilera","year":"2005","journal-title":"Int J Artif Organs"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1111\/j.1600-6143.2009.02770.x","article-title":"Translational Research: Animal Models of Obliterative Bronchiolitis after Lung Transplantation","volume":"9","author":"M Sato","year":"2009","journal-title":"American Journal of Transplantation"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1513\/pats.200605-107JG","article-title":"Human and Murine Obliterative Bronchiolitis in Transplant","volume":"4","author":"JF McDyer","year":"2007","journal-title":"Proceedings of the American Thoracic Society"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"602","DOI":"10.3109\/01902148.2010.492895","article-title":"Azithromycin reduces pulmonary fibrosis in a bleomycin mouse model","volume":"36","author":"WA Wuyts","year":"2010","journal-title":"Exp Lung Res"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0052309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,7]],"date-time":"2019-07-07T09:58:48Z","timestamp":1562493528000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0052309"}},"subtitle":[],"editor":[{"given":"Rajasingh","family":"Johnson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,12,21]]},"references-count":63,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2012,12,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0052309","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,21]]}}}