{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:48:43Z","timestamp":1792082923364,"version":"4.4.0"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2012,12,31]],"date-time":"2012-12-31T00:00:00Z","timestamp":1356912000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0052332","type":"journal-article","created":{"date-parts":[[2012,12,31]],"date-time":"2012-12-31T17:22:13Z","timestamp":1356974533000},"page":"e52332","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":108,"title":["IL-13 Promotes Collagen Accumulation in Crohn\u2019s Disease Fibrosis by Down-Regulation of Fibroblast MMP Synthesis: A Role for Innate Lymphoid Cells?"],"prefix":"10.1371","volume":"7","author":[{"given":"Jennifer R.","family":"Bailey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W.","family":"Bland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Tarlton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moganaden","family":"Moorghen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Sylvester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher S. J.","family":"Probert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine V.","family":"Whiting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,12,31]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1572-0241.2006.01010.x","article-title":"Fibrogenesis in Crohn\u2019s disease","volume":"102","author":"JP Burke","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0016-5085(98)70535-9","article-title":"Stimulation of transforming growth factor beta1 by enteric bacteria in the pathogenesis of rat intestinal fibrosis","volume":"114","author":"M Mourelle","year":"1998","journal-title":"Gastroenterology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev.immunol.21.120601.141142","article-title":"IL-13 effector functions","volume":"21","author":"TA Wynn","year":"2003","journal-title":"Annu Rev Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/S0022-3565(24)35380-7","article-title":"Interleukin-13 modulates collagen homeostasis in human skin and keloid fibroblasts","volume":"292","author":"A Oriente","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.5858\/2001-125-1331-OMOTSB","article-title":"Obliterative muscularization of the small bowel submucosa in Crohn disease: a possible mechanism of small bowel obstruction","volume":"125","author":"G Koukoulis","year":"2001","journal-title":"Arch Pathol Lab Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1159\/000113517","article-title":"Interleukin-4 and interleukin-13 enhance human bronchial smooth muscle cell proliferation","volume":"146","author":"Y Bosse","year":"2008","journal-title":"Int Arch Allergy Immunol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"G226","DOI":"10.1152\/ajpgi.2002.282.2.G226","article-title":"Role of IL-4, IL-13, and STAT6 in inflammation-induced hypercontractility of murine smooth muscle cells","volume":"282","author":"H Akiho","year":"2002","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Hershey GK (2003) IL-13 receptors and signaling pathways: an evolving web. J Allergy Clin Immunol 111: 677\u2013690; quiz 691.","DOI":"10.1067\/mai.2003.1333"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nm1332","article-title":"IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis","volume":"12","author":"S Fichtner-Feigl","year":"2006","journal-title":"Nat Med"},{"key":"ref10","unstructured":"Fichtner-Feigl S, Young CA, Kitani A, Geissler EK, Schlitt HJ, <etal>et al<\/etal>.. (2008) IL-13 signaling via IL-13R alpha2 induces major downstream fibrogenic factors mediating fibrosis in chronic TNBS colitis. Gastroenterology 135: 2003\u20132013, 2013 e2001\u20132007."},{"key":"ref11","first-page":"163","article-title":"ERK1\/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo","volume":"116","author":"PJ Lee","year":"2006","journal-title":"J Clin Invest"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1167\/iovs.02-0420","article-title":"Effects of Th2 cytokines on expression of collagen, MMP-1, and TIMP-1 in conjunctival fibroblasts","volume":"44","author":"A Leonardi","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"C435","DOI":"10.1152\/ajpcell.00035.2004","article-title":"Interleukin-13 augments transforming growth factor-beta1-induced tissue inhibitor of metalloproteinase-1 expression in primary human airway fibroblasts","volume":"288","author":"X Zhou","year":"2005","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Scharl M, Frei S, Pesch T, Kellermeier S, Arikkat J, <etal>et al<\/etal>.. (2012) Interleukin-13 and transforming growth factor beta synergise in the pathogenesis of human intestinal fistulae. Gut.","DOI":"10.1136\/gutjnl-2011-300498"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1161\/01.RES.0000070112.80711.3D","article-title":"Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry","volume":"92","author":"R Visse","year":"2003","journal-title":"Circ Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"29130","DOI":"10.1074\/jbc.274.41.29130","article-title":"The transcription factors Sp1, Sp3, and AP-2 are required for constitutive matrix metalloproteinase-2 gene expression in astroglioma cells","volume":"274","author":"HW Qin","year":"1999","journal-title":"Journal of Biological Chemistry"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Goffin L, Seguin-Estevez Q, Alvarez M, Reith W, Chizzolini C (2010) Transcriptional regulation of matrix metalloproteinase-1 and collagen 1A2 explains the anti-fibrotic effect exerted by proteasome inhibition in human dermal fibroblasts. Arthritis Research &amp; Therapy 12.","DOI":"10.1186\/ar2991"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.canlet.2006.12.016","article-title":"TGF-beta-induced transcriptional activation of MMP-2 is mediated by activating transcription factor (ATF)2 in human breast epithelial cells","volume":"252","author":"ES Kim","year":"2007","journal-title":"Cancer Letters"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1158\/1541-7786.MCR-11-0023","article-title":"MT1-MMP cooperates with Kras(G12D) to promote pancreatic fibrosis through increased TGF-beta signaling","volume":"9","author":"SB Krantz","year":"2011","journal-title":"Mol Cancer Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1080\/003655201300051216","article-title":"Differential activation of cytokine secretion in primary human colonic fibroblast\/myofibroblast cultures","volume":"36","author":"G Rogler","year":"2001","journal-title":"Scand J Gastroenterol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1177\/002215540104900606","article-title":"Transforming growth factor-beta messenger RNA and protein in murine colitis","volume":"49","author":"CV Whiting","year":"2001","journal-title":"J Histochem Cytochem"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1016\/S0002-9440(10)64831-6","article-title":"The role of up-regulated serine proteases and matrix metalloproteinases in the pathogenesis of a murine model of colitis","volume":"157","author":"JF Tarlton","year":"2000","journal-title":"Am J Pathol"},{"key":"ref23","first-page":"365","article-title":"Primer3 on the WWW for general users and for biologist programmers","volume":"132","author":"S Rozen","year":"2000","journal-title":"Methods Mol Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1006\/abio.2001.5564","article-title":"Elimination of primer-dimer artifacts and genomic coamplification using a two-step SYBR green I real-time RT-PCR","volume":"303","author":"J Vandesompele","year":"2002","journal-title":"Anal Biochem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jim.2005.05.005","article-title":"Validation of computer-assisted, pixel-based analysis of multiple-colour immunofluorescence histology","volume":"302","author":"CF Inman","year":"2005","journal-title":"J Immunol Methods"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.clim.2008.08.008","article-title":"NK and NKT cells in liver injury and fibrosis","volume":"130","author":"G Notas","year":"2009","journal-title":"Clin Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1097\/00054725-200409000-00014","article-title":"Intestinal interleukin-13 in pediatric inflammatory bowel disease patients","volume":"10","author":"K Kadivar","year":"2004","journal-title":"Inflamm Bowel Dis"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1006\/cyto.2000.0744","article-title":"Colonic expression and synthesis of interleukin 13 and interleukin 15 in inflammatory bowel disease","volume":"12","author":"B Vainer","year":"2000","journal-title":"Cytokine"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1111\/j.1572-0241.1999.01372.x","article-title":"Characterization of cytokine expression in the rectal mucosa of ulcerative colitis: correlation with disease activity","volume":"94","author":"S Inoue","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.jaci.2007.02.011","article-title":"Mechanisms of tissue inhibitor of metalloproteinase 1 augmentation by IL-13 on TGF-beta 1-stimulated primary human fibroblasts","volume":"119","author":"X Zhou","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/ni.1962","article-title":"The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling","volume":"12","author":"H Spits","year":"2011","journal-title":"Nat Immunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1053\/j.gastro.2005.10.055","article-title":"Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners","volume":"130","author":"S Radaeva","year":"2006","journal-title":"Gastroenterology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1002\/hep.24190","article-title":"Suppression of innate immunity (natural killer cell\/interferon-gamma) in the advanced stages of liver fibrosis in mice","volume":"53","author":"WI Jeong","year":"2011","journal-title":"Hepatology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1007\/s10620-010-1296-0","article-title":"Loss of matrix metalloproteinase-2 amplifies murine toxin-induced liver fibrosis by upregulating collagen I expression","volume":"56","author":"BD Radbill","year":"2011","journal-title":"Dig Dis Sci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"491","DOI":"10.4049\/jimmunol.176.1.491","article-title":"Functional importance of regional differences in localized gene expression of receptors for IL-13 in murine gut","volume":"176","author":"M Morimoto","year":"2006","journal-title":"J Immunol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1136\/gut.2007.125401","article-title":"Anti-inflammatory role of sympathetic nerves in chronic intestinal inflammation","volume":"57","author":"RH Straub","year":"2008","journal-title":"Gut"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Zhao A, McDermott J, Urban JF, Jr., Gause W, Madden KB, <etal>et al<\/etal>.. (2003) Dependence of IL-4, IL-13, and Nematode-Induced Alterations in Murine Small Intestinal Smooth Muscle Contractility on Stat6 and Enteric Nerves. 948\u2013954.","DOI":"10.4049\/jimmunol.171.2.948"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S1357-4310(97)01193-3","article-title":"Regulation of cardiovascular collagen deposition by mechanical forces","volume":"4","author":"JE Bishop","year":"1998","journal-title":"Mol Med Today"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1053\/j.gastro.2006.04.022","article-title":"IL-13 receptor alpha2 promotes epithelial cell regeneration from radiation-induced small intestinal injury in mice","volume":"131","author":"R Kawashima","year":"2006","journal-title":"Gastroenterology"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"5859","DOI":"10.4049\/jimmunol.178.9.5859","article-title":"Induction of IL-13 triggers TGF-beta1-dependent tissue fibrosis in chronic 2,4,6-trinitrobenzene sulfonic acid colitis","volume":"178","author":"S Fichtner-Feigl","year":"2007","journal-title":"J Immunol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0052332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T11:31:27Z","timestamp":1745926287000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0052332"}},"subtitle":[],"editor":[{"given":"Niels Olsen Saraiva","family":"C\u00e2mara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,12,31]]},"references-count":40,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2012,12,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0052332","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,31]]}}}