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Protect Patients Against Preventable Harm from Improper Use of Single\u2013Dose\/Single\u2013Use Vials. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.cdc.gov\/injectionsafety\/cdcposition-SingleUseVial.html\" xlink:type=\"simple\">http:\/\/www.cdc.gov\/injectionsafety\/cdcposition-SingleUseVial.html<\/ext-link>. Accessed 2012 Sep 3."},{"key":"ref4","first-page":"501","article-title":"Invasive <italic>Staphylococcus aureus<\/italic> Infections Associated with Pain Injections and Reuse of Single-Dose Vials \u2013 Arizona and Delaware","volume":"61","author":"S Anderson","year":"2012","journal-title":"Morb Mortal Wkly Rep"},{"key":"ref5","first-page":"425","article-title":"Infection control practices (safe injection and medication vial utilization) for interventional techniques: are they based on relative risk management or evidence?","volume":"14","author":"L Manchikanti","year":"2011","journal-title":"Pain Physician"},{"key":"ref6","first-page":"440","article-title":"Am J Infect Control","volume":"38","author":"RD Lobo","year":"2010"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1001\/archsurg.2010.249","article-title":"Evaluating an evidence-based bundle for preventing surgical site infection - a randomized trial","volume":"146","author":"T Anthony","year":"2011","journal-title":"Arch Surg"},{"key":"ref8","unstructured":"Stone PW, Harrison MI, Feldman P, Linzer M, Peng T, <etal>et al<\/etal>.. (2005) Organizational Climate of Staff Working Conditions and Safety\u2013An Integrative Model. In: Henriksen K, Battles JB, Marks ES, Lewin DI, editors. Advances in Patient Safety: From Research to Implementation (Volume 2: Concepts and Methodology). Rockville (MD): Agency for Healthcare Research and Quality (US)."},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1097\/CCM.0b013e3181e47888","article-title":"Nurse staffing and patient outcomes in critical care: A concise review","volume":"38","author":"DA Penoyer","year":"2010","journal-title":"Crit Care Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1097\/00003246-198510000-00009","article-title":"APACHE II: a severity of disease classification system","volume":"13","author":"WA Knaus","year":"1985","journal-title":"Crit Care Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1001\/jama.1993.03510240069035","article-title":"A new simplified acute physiology score (SAPS II) based on a European\/North American multicenter study","volume":"270","author":"GallJR Le","year":"1993","journal-title":"J Am Med Assoc"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/BF01709751","article-title":"The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction\/failure","volume":"22","author":"JL Vincent","year":"1996","journal-title":"Intensive Care Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: development and validation","volume":"40","author":"ME Charlson","year":"1987","journal-title":"J Chronic Dis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0895-4356(98)00160-7","article-title":"Chronic comorbidity and outcome of hospital care: length of stay, mortality and readmission at 30 and 365 days","volume":"52","author":"J Librero","year":"1999","journal-title":"J Clin Epidemiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1097\/01.CCM.0000045567.78801.CC","article-title":"Nursing activities score","volume":"31","author":"DR Miranda","year":"2003","journal-title":"Crit Care Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ajic.2008.03.002","article-title":"CDC\/NHSN surveillance definition of health care\u2013associated infection and criteria for specific types of infections in the acute care setting","volume":"36","author":"TC Horan","year":"2008","journal-title":"Am J Infect Control"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1056\/NEJM198908173210725","article-title":"A study of medical injury and medical malpractice","volume":"321","author":"HH Hiatt","year":"1989","journal-title":"N Engl J Med"},{"key":"ref18","unstructured":"World Health Organization: World Alliance for Patient Safety, Taxonomy (2009) The Conceptual Framework for the International Classification for Patient Safety. Final Technical Report. Version 1,1."},{"key":"ref19","unstructured":"World Health Organization: World Alliance for Patient Safety (2008) Summary of the evidence on patient safety: implications for research."},{"key":"ref20","unstructured":"Khon LT, Corrigan JM, Donaldson MS (1999) To err is human: building a safer health system. Institute of Medicine Report. Washington, DC: National Academic Press."},{"key":"ref21","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1136\/bmj.320.7237.774","article-title":"Epidemiology of medical error","volume":"320","author":"SN Weingart","year":"2000","journal-title":"Brit Med J"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1086\/591696","article-title":"Hospital Staffing and health care-associated infections: a systematic review of the literature","volume":"47","author":"PW Stone","year":"2008","journal-title":"Clin Infect Dis"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.ajic.2012.02.029","article-title":"Nurse staffing, burnout, and health care-associated infection","volume":"40","author":"JP Cimiotti","year":"2012","journal-title":"Am J Infect Control"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/00003246-197403000-00001","article-title":"Therapeutic intervention scoring system: a method for quantitative comparison of patient care","volume":"2","author":"DJ Cullen","year":"1974","journal-title":"Crit Care Med"},{"key":"ref25","first-page":"162","article-title":"Propagation of methicillin-resistant <italic>Staphylococcus aureus<\/italic> due to the overloading of medical nurses in intensive care units. J Hosp Infect","volume":"63","author":"J Blatnik","year":"2006"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1136\/bmj.320.7237.768","article-title":"Human error: models and management","volume":"320","author":"J Reason","year":"2000","journal-title":"Brit Med J"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1136\/bmj.328.7433.199","article-title":"Comparison of three methods for estimating rates of adverse events and rates of preventable adverse events in acute care hospitals","volume":"328","author":"P Michel","year":"2004","journal-title":"Brit Med J"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/00063110-200504000-00005","article-title":"Adverse events and death in stroke patients admitted to the emergency department of a tertiary university hospital","volume":"12","author":"R Daud-Gallotti","year":"2005","journal-title":"Eur J Emerg Med"},{"key":"ref29","unstructured":"World Health Organization: World Alliance for patient safety (2008) The Second Global Patient Safety Challenge: Safe Surgery Saves Lives. 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