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RCOG Press, London. 28\u201360."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/j.1471-0528.1993.tb15300.x","article-title":"Final report of the Medical Research Council\/Royal College of Obstetricians and Gynaecologists multicentre randomised trial of cervical cerclage","volume":"100","author":"Cerclage MRC\/RCOG Working Party on Cervical","year":"1993","journal-title":"BJOG"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/01.AOG.0000168435.17200.53","article-title":"Cerclage for short cervix on ultrasonography: meta-analysis of trials using individual patient-level data","volume":"106","author":"V Berghella","year":"2005","journal-title":"Obstet Gynecol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ajog.2005.12.002","article-title":"The role of cervical cerclage in obstetric practice: can the patient who could benefit from this procedure be identified?","volume":"194","author":"R Romero","year":"2006","journal-title":"Am J Obstet Gynecol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/S0140-6736(04)16351-4","article-title":"Fetal Medicine Foundation Second Trimester Screening Group Cervical cerclage for prevention of preterm delivery in women with short cervix: randomised controlled trial","volume":"363","author":"MS To","year":"2004","journal-title":"Lancet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"375.e1","DOI":"10.1016\/j.ajog.2009.08.015","article-title":"Multicenter randomised trial of cerclage for preterm birth prevention in high-risk women with shortened midtrimester cervical length","volume":"201","author":"J Owen","year":"2009","journal-title":"Am J Obstet Gynecol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"351.e1","DOI":"10.1016\/j.ajog.2010.02.019","article-title":"Vaginal Ultrasound Trial Consortium 17-alpha-hydoxyprogesterone caproate for the prevention of preterm birth in women with prior preterm birth and a short cervical length","volume":"202","author":"V Berghella","year":"2010","journal-title":"Am J Obstet Gynecol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"623.e1","DOI":"10.1016\/j.ajog.2009.03.010","article-title":"A randomised controlled trial of cervical scanning vs history to determine cerclage in women at high risk of preterm birth (CIRCLE trial)","volume":"200","author":"R Simcox","year":"2009","journal-title":"Am J Obstet Gynecol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1056\/NEJMoa067815","article-title":"Progesterone and the risk of preterm birth among women with a short cervix","volume":"357","author":"EB Da Fonseca","year":"2007","journal-title":"N Engl J Med"},{"key":"ref11","unstructured":"Dodd JM, Flenady V, Cincotta R, Crowther CA (2006) Prenatal administration of progesterone for preventing preterm birth (review). Cochrane Database Syst Rev CD004947."},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1056\/NEJM200005183422007","article-title":"Intrauterine infection and preterm delivery","volume":"342","author":"RL Goldenberg","year":"2000","journal-title":"N Engl J Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1097\/GRF.0b013e31811ebef6","article-title":"The fetal inflammatory response syndrome","volume":"50","author":"F Gotsch","year":"2007","journal-title":"Clin Obstet Gynecol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1515\/JPM.2006.002","article-title":"A sonographic short cervix as the only clinical manifestation of intra-amniotic infection","volume":"34","author":"SS Hassan","year":"2006","journal-title":"J Perinat Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0095-5108(18)30286-0","article-title":"Premature labour and intra-amniotic infection. Clinical aspects and role of the cytokines in diagnosis and pathophysiology","volume":"22","author":"R Gomez","year":"1995","journal-title":"Clin Perinatol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1053\/plac.2002.0948","article-title":"Cytokines, prostaglandins and parturition \u2013 a review","volume":"24","author":"JA Keelan","year":"2003","journal-title":"Placenta"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/S0002-9378(98)70142-5","article-title":"Microbial invasion of the amniotic cavity with Ureaplasma urealyticum is associated with a robust host response in fetal, amniotic and maternal compartments","volume":"179","author":"BH Yoon","year":"1998","journal-title":"Am J Obstet Gynecol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/0002-9378(89)90409-2","article-title":"Infection and labour V: prevalence, microbiology and clinical significance of intraamniotic infection in women with preterm labour and intact membranes","volume":"161","author":"R Romero","year":"1989","journal-title":"Am J Obstet Gynecol"},{"key":"ref19","first-page":"941","article-title":"The relationship of amniotic fluid cytokines and preterm delivery, amniotic fluid infection, histologic chorioamnionitis, and chorioamnion infection","volume":"81","author":"SL Hillier","year":"1993","journal-title":"Obstet Gynecol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/0002-9378(93)90050-S","article-title":"Amniotic fluid interleukin-6 levels correlate with histologic chorioamnionitis and amniotic fluid cultures in patients with premature labour with intact membranes","volume":"169","author":"PC Greig","year":"1993","journal-title":"Am J Obstet Gynecol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1067\/S0002-9378(03)00518-0","article-title":"Decreased cervical proinflammatory cytokines permit subsequent upper genital tract infection during pregnancy","volume":"189","author":"HN Simhan","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"ref22","first-page":"393","article-title":"Inflammatory cytokines and spontaneous preterm birth in asymptomatic women: a systematic review","volume":"1)","author":"SQ Wei","year":"2010","journal-title":"Obstet Gynecol 116 (2 Pt"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ajog.2005.06.014","article-title":"Evaluation of effectiveness of prophylactic cerclage of a short cervix according to interleukin-8 in cervical mucus","volume":"194","author":"M Sakai","year":"2006","journal-title":"Am J Obstet Gynecol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jri.2007.06.051","article-title":"Maternal plasma cytokines in early- and mid-gestation of normal human pregnancy and their association with maternal factors","volume":"77","author":"AE Curry","year":"2008","journal-title":"J Reprod Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"126.e1","DOI":"10.1016\/j.ajog.2010.03.013","article-title":"Mid-trimester cervical inflammatory milieu and sonographic cervical length","volume":"203","author":"AM Kalan","year":"2010","journal-title":"Am J Obstet Gynecol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jri.2008.11.003","article-title":"Cervical cytokine network patterns during pregnancy: the role of bacterial vaginosis and geographic ancestry","volume":"79","author":"KK Ryckman","year":"2009","journal-title":"J Reprod Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"377.e1","DOI":"10.1016\/j.ajog.2008.10.038","article-title":"First-trimester cervical inflammatory milieu and subsequent early preterm birth","volume":"200","author":"HN Simhan","year":"2009","journal-title":"Am J Obstet Gynecol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1097\/00003081-200312000-00026","article-title":"Ultrasound assessment of the cervix","volume":"46","author":"V Berghella","year":"2003","journal-title":"Clin Obstet Gynecol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/j.1365-2826.2008.01668.x","article-title":"Cytokine networks and the regulation of uterine function in pregnancy and parturition","volume":"20","author":"NM Orsi","year":"2008","journal-title":"Journal of Neuroendocrinology"},{"key":"ref30","unstructured":"Cytokines (2007) In <italic>Kuby\u2019s Immunology<\/italic>. Kindt TJ, Goldsby RA, Osborne BA, editors. WH Freeman and Company, New York. 302\u2013322."},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1542\/peds.2008-1222","article-title":"Differential patterns of 27 cord blood immune biomarkers across gestational age","volume":"123","author":"N Matoba","year":"2009","journal-title":"Pediatrics"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1080\/14767050500141329","article-title":"Monocyte chemotactic protein-1 is increased in the amniotic fluid of women who deliver preterm in the presence or absence of intra-amniotic infection","volume":"17","author":"MS Esplin","year":"2005","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1016\/j.ajog.2004.01.001","article-title":"A polymorphism in the promoter region of TNF and bacterial vaginosis: preliminary evidence of gene-environment interaction in the aetiology of spontaneous preterm birth","volume":"190","author":"GA Macones","year":"2004","journal-title":"Am J Obstet Gynecol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"533.e1","DOI":"10.1016\/j.ajog.2007.11.025","article-title":"Racial disparity in amniotic fluid concentrations of tumour necrosis factor (TNF)-\u03b1 and soluble TNF receptors in spontaneous preterm birth","volume":"198","author":"R Menon","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"ref35","unstructured":"March of Dimes (2011) March of Dimes Welcomes FDA Approval of Progesterone Injection. United States: March of Dimes. March of Dimes website. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.marchofdimes.com\/feb4_2011.html\" xlink:type=\"simple\">http:\/\/www.marchofdimes.com\/feb4_2011.html<\/ext-link>. Accessed 2011 Aug."},{"key":"ref36","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/uog.9017","article-title":"Vaginal progesterone reduces the rate of preterm birth in women with a sonographic short cervix: a multicenter, randomized, double-blind, placebo-controlled trial","volume":"38","author":"SS Hassan","year":"2011","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"124.e1","DOI":"10.1016\/j.ajog.2011.12.003","article-title":"Vaginal progesterone in women with an asymptomatic sonographic short cervix in the midtrimester decreases preterm delivery and neonatal morbidity: a systematic review and metaanalysis of individual patient data","volume":"206","author":"R Romero","year":"2012","journal-title":"Am J Obstet Gynecol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1055\/s-0031-1272967","article-title":"The effect of 17\u03b1-hydroxyprogesterone caproate on preterm birth in women with an ultrasound-indicated cerclage","volume":"28","author":"TJ Rafael","year":"2011","journal-title":"Am J Perinatol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1080\/14767050801923680","article-title":"Medroxyprogesterone acetate modulates the immune response in the uterus, cervix and placenta in a mouse model of preterm birth","volume":"21","author":"MA Elovitz","year":"2008","journal-title":"J Matern Fetal Neonatal Med"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0052412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,7]],"date-time":"2019-07-07T12:03:27Z","timestamp":1562501007000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0052412"}},"subtitle":[],"editor":[{"given":"Eduard","family":"Gratacos","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,12,26]]},"references-count":39,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2012,12,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0052412","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,26]]}}}