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Andersen","year":"1995","journal-title":"Hippocampus"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00421-007-0450-7","article-title":"Brain temperature fluctuations during physiological and pathological conditions","volume":"101","author":"EA Kiyatkin","year":"2007","journal-title":"Eur J Appl Physiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/j.1528-1157.1992.tb02311.x","article-title":"Induction of epileptiform activity by temperature elevation in hippocampal slices from young rats: an in vitro model for febrile seizures?","volume":"33","author":"V Tancredi","year":"1992","journal-title":"Epilepsia"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1471-2202-2-18","article-title":"Gamma oscillation underlies hyperthermia-induced epileptiform-like spikes in immature rat hippocampal slices","volume":"2","author":"J Wu","year":"2001","journal-title":"BMC 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menthol","volume":"3","author":"XB Zhang","year":"2008","journal-title":"PLoS One"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1124\/jpet.102.045674","article-title":"N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic properties","volume":"306","author":"KJ Valenzano","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"12512","DOI":"10.1523\/JNEUROSCI.3752-06.2006","article-title":"Contribution of TRPM8 channels to cold transduction in primary sensory neurons and peripheral nerve terminals","volume":"26","author":"R Madrid","year":"2006","journal-title":"J Neurosci"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1113\/jphysiol.2006.123059","article-title":"Bidirectional shifts of TRPM8 channel 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Neurophysiol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1523\/JNEUROSCI.4463-06.2007","article-title":"M-channels (Kv7\/KCNQ channels) that regulate synaptic integration, excitability, and spike pattern of CA1 pyramidal cells are located in the perisomatic region","volume":"27","author":"H Hu","year":"2007","journal-title":"J Neurosci"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1093\/emboj\/19.11.2483","article-title":"TREK-1 is a heat-activated background K(+) channel","volume":"19","author":"F Maingret","year":"2000","journal-title":"EMBO J"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1113\/jphysiol.2004.081059","article-title":"Thermosensitivity of the two-pore domain K+ channels TREK-2 and TRAAK","volume":"564","author":"D Kang","year":"2005","journal-title":"J 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Duprat","year":"2000","journal-title":"Mol Pharmacol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1523\/JNEUROSCI.2791-10.2011","article-title":"Activation of TREK currents by the neuroprotective agent riluzole in mouse sympathetic neurons","volume":"31","author":"A Cadaveira-Mosquera","year":"2011","journal-title":"J Neurosci"},{"key":"ref72","first-page":"555","article-title":"Therapeutic potential of neuronal two-pore domain potassium-channel modulators","volume":"8","author":"A Mathie","year":"2007","journal-title":"Curr Opin Investig Drugs"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/8084","article-title":"Inhalational anesthetics activate two-pore-domain background K+ channels","volume":"2","author":"AJ Patel","year":"1999","journal-title":"Nat Neurosci"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1210\/me.16.3.621","article-title":"TASK-3 dominates the background potassium conductance in rat adrenal glomerulosa cells","volume":"16","author":"G Czirjak","year":"2002","journal-title":"Mol Endocrinol"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"14677","DOI":"10.1074\/jbc.M602495200","article-title":"Targeting of calcineurin to an NFAT-like docking site is required for the calcium-dependent activation of the background K+ channel, TRESK","volume":"281","author":"G Czirjak","year":"2006","journal-title":"J Biol Chem"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1124\/jpet.107.125245","article-title":"Potent inhibition of native TREK-1 K+ channels by selected dihydropyridine Ca2+ channel antagonists","volume":"323","author":"H Liu","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000094900","article-title":"Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca channels with distinct inhibitory mechanisms","volume":"78","author":"TS Lee","year":"2006","journal-title":"Pharmacology"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/nn.3000","article-title":"TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3","volume":"15","author":"E Shigetomi","year":"2012","journal-title":"Nat Neurosci"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s12013-007-0007-8","article-title":"Biophysical, pharmacological, and functional characteristics of cloned and native mammalian two-pore domain K+ channels","volume":"47","author":"DP Lotshaw","year":"2007","journal-title":"Cell Biochem Biophys"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0306-4522(01)00030-6","article-title":"Distribution and expression of TREK-1, a two-pore-domain potassium channel, in the adult rat CNS","volume":"103","author":"GJ Hervieu","year":"2001","journal-title":"Neuroscience"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.neuron.2005.10.034","article-title":"Threshold behavior in the initiation of hippocampal population bursts","volume":"49","author":"LM de la Prida","year":"2006","journal-title":"Neuron"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"13758","DOI":"10.1073\/pnas.0707492105","article-title":"Development of input connections in neural cultures","volume":"105","author":"J Soriano","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/306371a0","article-title":"Single neurones can initiate synchronized population discharge in the hippocampus","volume":"306","author":"R Miles","year":"1983","journal-title":"Nature"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1113\/jphysiol.1989.sp017762","article-title":"Giant synaptic potentials in immature rat CA3 hippocampal neurones","volume":"416","author":"Y Ben Ari","year":"1989","journal-title":"J Physiol"},{"key":"ref85","first-page":"219","article-title":"Developmental profile and synaptic origin of early network oscillations in the CA1 region of rat neonatal hippocampus","volume":"1)","author":"O Garaschuk","year":"1998","journal-title":"J Physiol 507 ( Pt"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jphysparis.2003.10.004","article-title":"Developmental patterns and plasticities: the hippocampal model","volume":"97","author":"X Leinekugel","year":"2003","journal-title":"J Physiol Paris"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0166-2236(00)01813-0","article-title":"Developing networks play a similar melody","volume":"24","author":"Y Ben Ari","year":"2001","journal-title":"Trends Neurosci"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1126\/science.1071111","article-title":"Correlated bursts of activity in the neonatal hippocampus in vivo","volume":"296","author":"X Leinekugel","year":"2002","journal-title":"Science"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1113\/jphysiol.2003.044602","article-title":"Cellular and network mechanisms underlying spontaneous sharp wave-ripple complexes in mouse hippocampal slices","volume":"550","author":"N Maier","year":"2003","journal-title":"J Physiol"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0165-0173(83)90037-1","article-title":"Cellular bases of hippocampal EEG in the behaving rat","volume":"287","author":"G Buzsaki","year":"1983","journal-title":"Brain Res"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/sleep\/13.1.1","article-title":"Sleep-onset insomniacs have delayed temperature rhythms","volume":"13","author":"M Morris","year":"1990","journal-title":"Sleep"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1038\/nn1749","article-title":"Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype","volume":"9","author":"C Heurteaux","year":"2006","journal-title":"Nat Neurosci"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/sj.bjp.0706068","article-title":"Inhibition of the human two-pore domain potassium channel, TREK-1, by fluoxetine and its metabolite norfluoxetine","volume":"144","author":"LE Kennard","year":"2005","journal-title":"Br J Pharmacol"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/BF02245412","article-title":"Fluoxetine decreases brain temperature and REM sleep in Syrian hamsters","volume":"106","author":"B Gao","year":"1992","journal-title":"Psychopharmacology 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