{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:25:05Z","timestamp":1790411105481,"version":"4.1.0"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2012,12,20]],"date-time":"2012-12-20T00:00:00Z","timestamp":1355961600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0052657","type":"journal-article","created":{"date-parts":[[2012,12,20]],"date-time":"2012-12-20T22:40:51Z","timestamp":1356043251000},"page":"e52657","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["Anti-Chlamydial Th17 Responses Are Controlled by the Inducible Costimulator Partially through Phosphoinositide 3-Kinase Signaling"],"prefix":"10.1371","volume":"7","author":[{"given":"Xiaoling","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Gigoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Leconte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woong-Kyung","family":"Suh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,12,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/nri1551","article-title":"Immunology of Chlamydia infection: implications for a Chlamydia trachomatis vaccine","volume":"5","author":"RC Brunham","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"4374","DOI":"10.1128\/IAI.00622-10","article-title":"CD4+ T cells and antibody are required for optimal major outer membrane protein vaccine-induced immunity to Chlamydia muridarum genital infection","volume":"78","author":"CM Farris","year":"2010","journal-title":"Infect Immun"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.4049\/jimmunol.180.5.3375","article-title":"Antigen-specific CD4+ T cells produce sufficient IFN-gamma to mediate robust protective immunity against genital Chlamydia muridarum infection","volume":"180","author":"W Li","year":"2008","journal-title":"J Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.4049\/jimmunol.0900295","article-title":"T cell responses in the absence of IFN-gamma exacerbate uterine infection with Chlamydia trachomatis","volume":"183","author":"DC Gondek","year":"2009","journal-title":"J Immunol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"6324","DOI":"10.4049\/jimmunol.169.11.6324","article-title":"GM-CSF transgene-based adjuvant allows the establishment of protective mucosal immunity following vaccination with inactivated Chlamydia trachomatis","volume":"169","author":"H Lu","year":"2002","journal-title":"J Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1128\/IAI.55.10.2387-2390.1987","article-title":"Primary murine Chlamydia trachomatis pneumonia in B-cell-deficient mice","volume":"55","author":"DM Williams","year":"1987","journal-title":"Infect Immun"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1046\/j.1365-2567.1997.00378.x","article-title":"B-cell-deficient mice develop complete immune protection against genital tract infection with Chlamydia trachomatis","volume":"92","author":"M Johansson","year":"1997","journal-title":"Immunology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"5886","DOI":"10.4049\/jimmunol.0901584","article-title":"IL-17\/Th17 promotes type 1 T cell immunity against pulmonary intracellular bacterial infection through modulating dendritic cell function","volume":"183","author":"H Bai","year":"2009","journal-title":"J Immunol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.4049\/jimmunol.0803075","article-title":"A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum","volume":"183","author":"X Zhang","year":"2009","journal-title":"J Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e39214","DOI":"10.1371\/journal.pone.0039214","article-title":"IL-17A Synergizes with IFN-gamma to Upregulate iNOS and NO Production and Inhibit Chlamydial Growth","volume":"7","author":"Y Zhang","year":"2012","journal-title":"PLoS One"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/16717","article-title":"ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28","volume":"397","author":"A Hutloff","year":"1999","journal-title":"Nature"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/35051100","article-title":"ICOS co-stimulatory receptor is essential for T-cell activation and function","volume":"409","author":"C Dong","year":"2001","journal-title":"Nature"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/35051113","article-title":"ICOS is essential for effective T-helper-cell responses","volume":"409","author":"A Tafuri","year":"2001","journal-title":"Nature"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/35051107","article-title":"ICOS is critical for CD40-mediated antibody class switching","volume":"409","author":"AJ McAdam","year":"2001","journal-title":"Nature"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S1074-7613(00)00011-X","article-title":"The CD28-related molecule ICOS is required for effective T cell-dependent immune responses","volume":"13","author":"AJ Coyle","year":"2000","journal-title":"Immunity"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"5917","DOI":"10.4049\/jimmunol.172.10.5917","article-title":"The inducible costimulator plays the major costimulatory role in humoral immune responses in the absence of CD28","volume":"172","author":"WK Suh","year":"2004","journal-title":"J Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/ni1261","article-title":"A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17","volume":"6","author":"H Park","year":"2005","journal-title":"Nat Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/immu.200310013","article-title":"ICOS+ Th cells produce distinct cytokines in different mucosal immune responses","volume":"33","author":"K Bonhagen","year":"2003","journal-title":"Eur J Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/ni.1690","article-title":"The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells","volume":"10","author":"AT Bauquet","year":"2009","journal-title":"Nat Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1189\/jlb.0409238","article-title":"ICOS promotes IL-17 synthesis in colonic intraepithelial lymphocytes in IL-10\u2212\/\u2212 mice","volume":"87","author":"JS Schaefer","year":"2010","journal-title":"J Leukoc Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/89750","article-title":"The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE","volume":"2","author":"JB Rottman","year":"2001","journal-title":"Nat Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"20371","DOI":"10.1073\/pnas.0911573106","article-title":"Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase","volume":"106","author":"M Gigoux","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3780","DOI":"10.4049\/jimmunol.0901384","article-title":"Th1 cytokine responses fail to effectively control Chlamydia lung infection in ICOS ligand knockout mice","volume":"184","author":"K Kadkhoda","year":"2010","journal-title":"J Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3456","DOI":"10.4049\/jimmunol.181.5.3456","article-title":"IL-17A produced by gammadelta T cells plays a critical role in innate immunity against listeria monocytogenes infection in the liver","volume":"181","author":"S Hamada","year":"2008","journal-title":"J Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1093\/intimm\/dxn069","article-title":"IL-17A is produced by Th17, gammadelta T cells and other CD4-lymphocytes during infection with Salmonella enterica serovar Enteritidis and has a mild effect in bacterial clearance","volume":"20","author":"SM Schulz","year":"2008","journal-title":"Int Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"423","DOI":"10.4161\/viru.1.5.12862","article-title":"IL-17 in protective immunity to intracellular pathogens","volume":"1","author":"SA Khader","year":"2010","journal-title":"Virulence"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3786","DOI":"10.4049\/jimmunol.178.6.3786","article-title":"IL-17-mediated regulation of innate and acquired immune response against pulmonary Mycobacterium bovis bacille Calmette-Guerin infection","volume":"178","author":"M Umemura","year":"2007","journal-title":"J Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1165\/ajrcmb.25.3.4424","article-title":"Interleukin-17 and lung host defense against Klebsiella pneumoniae infection","volume":"25","author":"P Ye","year":"2001","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.immuni.2009.08.025","article-title":"Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis","volume":"31","author":"Y Lin","year":"2009","journal-title":"Immunity"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1146\/annurev.immunol.021908.132710","article-title":"IL-17 and Th17 Cells","volume":"485\u2013517","author":"T Korn","year":"2009","journal-title":"Annu Rev Immunol 27"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1093\/infdis\/156.6.993","article-title":"Interferon in recovery from pneumonia due to Chlamydia trachomatis in the mouse","volume":"156","author":"GI Byrne","year":"1987","journal-title":"J Infect Dis"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1128\/IAI.56.11.3004-3006.1988","article-title":"Role in vivo for gamma interferon in control of pneumonia caused by Chlamydia trachomatis in mice","volume":"56","author":"DM Williams","year":"1988","journal-title":"Infect Immun"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.4049\/jimmunol.181.3.2092","article-title":"Type I IFNs enhance susceptibility to Chlamydia muridarum lung infection by enhancing apoptosis of local macrophages","volume":"181","author":"H Qiu","year":"2008","journal-title":"J Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1128\/IAI.00984-10","article-title":"Interleukin-17 contributes to generation of Th1 immunity and neutrophil recruitment during Chlamydia muridarum genital tract infection but is not required for macrophage influx or normal resolution of infection","volume":"79","author":"AM Scurlock","year":"2011","journal-title":"Infect Immun"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"6187","DOI":"10.4049\/jimmunol.171.11.6187","article-title":"Toll-like receptor-2, but not Toll-like receptor-4, is essential for development of oviduct pathology in chlamydial genital tract infection","volume":"171","author":"T Darville","year":"2003","journal-title":"J Immunol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jaut.2011.02.006","article-title":"PI3Kdelta drives the pathogenesis of experimental autoimmune encephalomyelitis by inhibiting effector T cell apoptosis and promoting Th17 differentiation","volume":"36","author":"S Haylock-Jacobs","year":"2011","journal-title":"J Autoimmun"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"55ra78","DOI":"10.1126\/scitranslmed.3000448","article-title":"The inducible costimulator (ICOS) is critical for the development of human T(H)17 cells","volume":"2","author":"CM Paulos","year":"2010","journal-title":"Sci Transl Med"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"7067","DOI":"10.4049\/jimmunol.177.10.7067","article-title":"Adoptive transfer of CD8alpha+ dendritic cells (DC) isolated from mice infected with Chlamydia muridarum are more potent in inducing protective immunity than CD8alpha-DC","volume":"177","author":"L Bilenki","year":"2006","journal-title":"J Immunol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"401","DOI":"10.4049\/jimmunol.1002519","article-title":"NK cells promote type 1 T cell immunity through modulating the function of dendritic cells during intracellular bacterial infection","volume":"187","author":"L Jiao","year":"2011","journal-title":"J Immunol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"4338","DOI":"10.4049\/jimmunol.156.11.4338","article-title":"Genetically determined differences in IL-10 and IFN-gamma responses correlate with clearance of Chlamydia trachomatis mouse pneumonitis infection","volume":"156","author":"X Yang","year":"1996","journal-title":"J Immunol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0052657","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:15:56Z","timestamp":1687911356000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0052657"}},"subtitle":[],"editor":[{"given":"Samithamby","family":"Jeyaseelan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,12,20]]},"references-count":40,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2012,12,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0052657","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,20]]}}}