{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T07:32:12Z","timestamp":1791099132184,"version":"4.1.0"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2012,12,28]],"date-time":"2012-12-28T00:00:00Z","timestamp":1356652800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0052754","type":"journal-article","created":{"date-parts":[[2012,12,28]],"date-time":"2012-12-28T22:28:17Z","timestamp":1356733697000},"page":"e52754","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":121,"title":["Cancer Progression Mediated by Horizontal Gene Transfer in an In Vivo Model"],"prefix":"10.1371","volume":"7","author":[{"given":"Catalina","family":"Trejo-Becerril","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"P\u00e9rez-C\u00e1rdenas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda","family":"Taja-Chayeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Anker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Herrera-Goepfert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis A.","family":"Medina-Vel\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Hidalgo-Miranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delia","family":"P\u00e9rez-Montiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alma","family":"Ch\u00e1vez-Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Cruz-Vel\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"D\u00edaz-Ch\u00e1vez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Gaxiola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Due\u00f1as-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2012,12,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00203-011-0677-x","article-title":"Phylogenetics","volume":"193","author":"RD Sleator","year":"2011","journal-title":"Arch Microbiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.bcp.2011.02.011","article-title":"Exosomes as intercellular signalosomes and pharmacological effectors","volume":"81","author":"M Record","year":"2011","journal-title":"Biochem Pharmacol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1159\/000226740","article-title":"Neoplastic characteristics of the DNA found in the plasma of cancer patients","volume":"46","author":"M Stroun","year":"1989","journal-title":"Oncology"},{"key":"ref4","first-page":"869","article-title":"[Transformation of NIH\/3T3 cells and SW480 cells displaying K-ras mutation]. [Article in French]","volume":"317","author":"P Anker","year":"1994","journal-title":"CR Acad Sci III"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1158\/0008-5472.CAN-09-3513","article-title":"Cell-free nucleic acids circulating in the plasma of colorectal cancer patients induce the oncogenic transformation of susceptible cultured cells","volume":"70","author":"DC Garc\u00eda-Olmo","year":"2010","journal-title":"Cancer Res"},{"key":"ref6","first-page":"241","article-title":"Les acides nucl\u00e9iques du plasma sanguine chez l\u2019homme","volume":"142","author":"P Mendel","year":"1948","journal-title":"C R Acad Sci Paris"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/227607a0","article-title":"Natural release of nucleic acids from bacteria into plant cells","volume":"227","author":"M Strou","year":"1970","journal-title":"Nature"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"00P","DOI":"10.1042\/bj1280100Pb","article-title":"Nucleic acids acid spontaneously by living frog auricles","volume":"128","author":"M Stroun","year":"1972","journal-title":"Biochem J"},{"key":"ref9","first-page":"2375","article-title":"Spontaneous release of DNA by human blood lymphocytes as shown in an in vitro system","volume":"35","author":"P Anker","year":"1975","journal-title":"Cancer Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1744-313X.1980.tb00742.x","article-title":"The role of extracelular DNA in the transfer of information from T to B human lymphocytes in the course of an immune response","volume":"7","author":"P Anker","year":"1980","journal-title":"J Immunogenet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/cbf.290020110","article-title":"Nude mice injected with DNA released by antigen stimulated human T lymphocytes produce specific antibodies expressing human characteristics","volume":"2","author":"P Anker","year":"1984","journal-title":"Cell Biochem Funct"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/219932a0","article-title":"Bacterial nature of radioactive DNA found in tomato plants incubated in the presence of bacterial DNA-3H","volume":"219","author":"P Anker","year":"1968","journal-title":"Nature"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/1951115a0","article-title":"Cytoplasmic localization of deoxyribonucleic acid in Allium cepa","volume":"195","author":"PB Gahan","year":"1962","journal-title":"Nature"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0074-7696(08)60555-0","article-title":"Cytoplasmic deoxyribonucleic acid","volume":"18","author":"PB Gahan","year":"1965","journal-title":"Int Rev Cytol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/219162a0","article-title":"Turnover of DNA and function","volume":"219","author":"SR Pelc","year":"1968","journal-title":"Nature"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/0020-711X(85)90001-1","article-title":"The problem of cytoplasmic DNA: its extrusion\/uptake by cultured cells and its possible role in cell-cell information transfer","volume":"17","author":"DH Adams","year":"1985","journal-title":"Int J Biochem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/215975b0","article-title":"Translocation of DNA of bacterial origin in Lycopersicon esculentum by ultra-centrifugation and caesium chloride gradient","volume":"215","author":"M Stroun","year":"1967","journal-title":"Nature"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1093\/oxfordjournals.aob.a084735","article-title":"An autoradiographic study of bacterial DNA in Lycopersicon esculentum","volume":"37","author":"PB Gahan","year":"1973","journal-title":"Ann Bot"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0006-2952(60)90056-3","article-title":"Modifications de caract\u00e8res raciaux du canard P\u00e9kin par l\u2019acide d\u00e9soxyribonucl\u00e9ique de canard khaki Campbell et leur transmission \u00e0 la descendence","volume":"4","author":"J Benoit","year":"1960","journal-title":"Biochem Pharmacol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/BF02921036","article-title":"The influence of exogenous DNA of different origin on the mitosis and chromosomes of irradiated meristematic cells of Vicia faba","volume":"10","author":"J Slotov\u00e1","year":"1968","journal-title":"Biol Plant (Praha)"},{"key":"ref21","first-page":"216","article-title":"Influence of exogenous DNA on ypenyl-treated chromosomes of Vicia faba L. Biol Plant (Praha)","volume":"10","author":"J Slotov\u00e1","year":"1969"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/191776a0","article-title":"Induction of mutations by DNA in Drosophila melanogaster","volume":"191","author":"OG Fahmy","year":"1961","journal-title":"Nature"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/cbf.986","article-title":"Evidence that direct DNA uptake through cut shoots leads to genetic transformation of Solanum aviculare Forst","volume":"21","author":"PB Gahan","year":"2003","journal-title":"Cell Biochem Funct"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1073\/pnas.67.3.1608","article-title":"DNA-induced transformation in Drosophila: locus-specificity and the establishment of transferred stocks","volume":"67","author":"AS Fox","year":"1970","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/genetics\/58.4.573","article-title":"Hereditary changes in Ephestia after treatment with DNA","volume":"58","author":"S Nawa","year":"1968","journal-title":"Genetics"},{"key":"ref26","first-page":"286","article-title":"Versuche zur Transformation an h\u00f6heren Pflanzen: Wiederholung der Anthocyan-Induktion bei Petunia und erste Charakterisierung des transformierenden Prinzips","volume":"61","author":"D Hess","year":"1969","journal-title":"Zeit Pflanzenphysiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0168-9452(91)90109-L","article-title":"Direct DNA uptake during the imbibition of dry cells","volume":"79","author":"T Senaratna","year":"1991","journal-title":"Plant Sci"},{"key":"ref28","first-page":"6407","article-title":"Horizontal transfer of oncogenes by uptake of apoptotic bodies Proc Natl Acad Sci USA","volume":"98","author":"A Bergsmedh A. Szeles","year":"2001"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1002\/cbf.1690","article-title":"The virtosome-a novel cytosolic informative entity and intercellular messenger","volume":"28","author":"PB Gahan","year":"2010","journal-title":"Cell Biochem Funct"},{"key":"ref30","first-page":"151","article-title":"Neoplastic transformation assays","volume":"165","author":"L Raptis","year":"2001","journal-title":"Methods Mol Biol"},{"key":"ref31","first-page":"61","article-title":"The dimethylhydrazine induced colorectal tumours in rat-experimental colorectal carcinogenesis","volume":"39","author":"M Perse","year":"2005","journal-title":"Radiol Oncol"},{"key":"ref32","first-page":"PL237","article-title":"Proteinases reduce matastatic dissemination and increase survival time in C<sub>57<\/sub>B<sub>16<\/sub> mice with the Lewis lung carcinoma","volume":"63","author":"M Wald","year":"1998","journal-title":"Pharmacol Lett"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0003-2697(03)00081-2","article-title":"Human DNA quantitation using Alu element-based polymerase chain reaction","volume":"315","author":"JA Walker","year":"2003","journal-title":"Anal Biochem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/BF02101690","article-title":"Rat LINE1: the origin and evolution of a family of long interspersed middle repetitive DNA elements","volume":"22","author":"MB Soares","year":"1985","journal-title":"J Mol Evol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/BF02263683","article-title":"Mapping of a new MAP kinase activated protein kinase gene (3PK) to human chromosome band 3p21.2 and ordering of 3PK and two cosmid markers in the 3p22-p21 tumour-suppressor region by two-colour fluorescence in situ hybridization","volume":"4","author":"A Szeles","year":"1996","journal-title":"Chromosome Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cca.2009.08.011","article-title":"Characterisation of circulating DNA by parallel tagged sequencing on the 454 platform","volume":"409","author":"M Van der Vaart","year":"2009","journal-title":"Clin Chim Acta"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.clinbiochem.2008.11.006","article-title":"Unequal representation of different unique genomic DNA sequences in the cell-free plasma DNA of individual donors","volume":"42","author":"WM Puszyk","year":"2009","journal-title":"Clin Biochem"},{"key":"ref38","first-page":"273","article-title":"Circulating nucleic acids in plasma and serum: past, present and future","volume":"6","author":"B Taback","year":"2004","journal-title":"Curr Opin Mol Ther"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nrc3066","article-title":"Cell-free nucleic acids as biomarkers in cancer patients","volume":"11","author":"H Schwarzenbach","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ccr.2007.12.003","article-title":"Systemic spread is an early step in breast cancer","volume":"13","author":"Y H\u00fcsemann","year":"2008","journal-title":"Cancer Cell"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s00281-011-0250-3","article-title":"Microvesicles as mediators of intercellular communication in cancer-the emerging science of cellular \u2018debris\u2019","volume":"33","author":"TH Lee","year":"2011","journal-title":"Semin Immunopathol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e36766","DOI":"10.1371\/journal.pone.0036766","article-title":"Apoptotic HPV positive cancer cells exhibit transforming properties","volume":"7","author":"E Gaiffe","year":"2012","journal-title":"PLoS One"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.cell.2008.04.045","article-title":"Systemic endocrine instigation of indolent tumor growth requires osteopontin","volume":"133","author":"SS McAllister","year":"2008","journal-title":"Cell"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/192052a0","article-title":"Action of deoxyribonuclease and ribonuclease on the growth of Ehrlich ascites carcinoma in mice","volume":"192","author":"G De Lamirande","year":"1961","journal-title":"Nature"},{"key":"ref45","first-page":"689","article-title":"Inhibition of metastasis development by daily administration of ultralow doses of RNase A and DNase I. Biochimie","volume":"93","author":"O Patutina","year":"2011"},{"key":"ref46","first-page":"108","article-title":"Cancer-suppressive effect of RNase A and DNase I. Dokl Biochem Biophys","volume":"420","author":"OA Shklyaeva","year":"2008"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1177\/1534735408327251","article-title":"Proteolytic enzyme therapy in evidence-based complementary oncology: fact or fiction?","volume":"7","author":"J Beuth","year":"2008","journal-title":"Integr Cancer Ther"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"769","DOI":"10.2165\/00003495-200059040-00004","article-title":"Systemic enzyme therapy in oncology: effect and mode of action","volume":"59","author":"J Leipner","year":"2000","journal-title":"Drugs"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0052754","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T20:21:53Z","timestamp":1644006113000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0052754"}},"subtitle":[],"editor":[{"given":"Brian","family":"Lichty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,12,28]]},"references-count":48,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2012,12,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0052754","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,28]]}}}