{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:00:56Z","timestamp":1767852056903,"version":"3.49.0"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2012,12,27]],"date-time":"2012-12-27T00:00:00Z","timestamp":1356566400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0053040","type":"journal-article","created":{"date-parts":[[2012,12,27]],"date-time":"2012-12-27T23:49:44Z","timestamp":1356652184000},"page":"e53040","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Macroautophagy Abnormality in Essential Tremor"],"prefix":"10.1371","volume":"7","author":[{"given":"Sheng-Han","family":"Kuo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guomei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Babij","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etty","family":"Cortes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Paul G.","family":"Vonsattel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phyllis L.","family":"Faust","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Sulzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elan D.","family":"Louis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2012,12,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/mds.22838","article-title":"How common is the most common adult movement disorder? Update on the worldwide prevalence of essential tremor","volume":"25","author":"ED Louis","year":"2010","journal-title":"Mov Disord"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1001\/archneurol.2007.8","article-title":"Reduced Purkinje cell number in essential tremor: a postmortem study","volume":"65","author":"JE Axelrad","year":"2008","journal-title":"Arch Neurol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1093\/brain\/awm266","article-title":"Neuropathological changes in essential tremor: 33 cases compared with 21 controls","volume":"130","author":"ED Louis","year":"2007","journal-title":"Brain"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/NEN.0b013e3181d1ad04","article-title":"\u201cHairy baskets\u201d associated with degenerative Purkinje cell changes in essential tremor","volume":"69","author":"CR Erickson-Davis","year":"2010","journal-title":"J Neuropathol Exp Neurology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1136\/jnnp.2010.213330","article-title":"Increased number of heterotopic Purkinje cells in essential tremor","volume":"82","author":"SH Kuo","year":"2011","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1212\/01.wnl.0000218162.80315.b9","article-title":"Neuropathologic findings in essential tremor","volume":"66","author":"ED Louis","year":"2006","journal-title":"Neurology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00401-010-0776-9","article-title":"Parallel fiber counts and parallel fiber integrated density are similar in essential tremor cases and controls","volume":"121","author":"SH Kuo","year":"2011","journal-title":"Acta Neuropathol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1001\/archneurol.2009.217","article-title":"Essential tremors: a family of neurodegenerative disorders?","volume":"66","author":"ED Louis","year":"2009","journal-title":"Arch Neurol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/14734220600699373","article-title":"Purkinje cell death: differences between developmental cell death and neurodegenerative death in mutant mice","volume":"5","author":"I Dusart","year":"2006","journal-title":"Cerebellum"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/nn.2575","article-title":"Autophagy gone awry in neurodegenerative diseases","volume":"13","author":"E Wong","year":"2010","journal-title":"Nat Neurosci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nature04724","article-title":"Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice","volume":"441","author":"T Hara","year":"2006","journal-title":"Nature"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/nature04723","article-title":"Loss of autophagy in the central nervous system causes neurodegeneration in mice","volume":"441","author":"M Komatsu","year":"2006","journal-title":"Nature"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.cell.2010.05.008","article-title":"Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations","volume":"141","author":"JH Lee","year":"2010","journal-title":"Cell"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/nn.2528","article-title":"Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease","volume":"13","author":"M Martinez-Vicente","year":"2010","journal-title":"Nat Neurosci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e9313","DOI":"10.1371\/journal.pone.0009313","article-title":"Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy","volume":"5","author":"L Crews","year":"2010","journal-title":"PloS One"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"13578","DOI":"10.1523\/JNEUROSCI.4390-09.2009","article-title":"Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases","volume":"29","author":"B Spencer","year":"2009","journal-title":"J Neurosci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e1000298","DOI":"10.1371\/journal.pbio.1000298","article-title":"PINK1 is selectively stabilized on impaired mitochondria to activate Parkin","volume":"8","author":"DP Narendra","year":"2010","journal-title":"PLoS Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1002\/mds.20583","article-title":"Essential tremor centralized brain repository: diagnostic validity and clinical characteristics of a highly selected group of essential tremor cases","volume":"20","author":"ED Louis","year":"2005","journal-title":"Mov Disord"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s00401-007-0311-9","article-title":"Twenty-first century brain banking. Processing brains for research: the Columbia University methods","volume":"115","author":"JP Vonsattel","year":"2008","journal-title":"Acta Neuropathol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"736","DOI":"10.2353\/ajpath.2009.080928","article-title":"Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein","volume":"175","author":"WH Yu","year":"2009","journal-title":"Am J Pathol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0076-6879(08)04011-1","article-title":"Autophagy in neurite injury and neurodegeneration: in vitro and in vivo models","volume":"453","author":"CT Chu","year":"2009","journal-title":"Methods Enzymol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1756-6606-2-24","article-title":"Autophagy activation and enhanced mitophagy characterize the Purkinje cells of pcd mice prior to neuronal death","volume":"29","author":"L Chakrabarti","year":"2009","journal-title":"Mol Brain"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"151","DOI":"10.4161\/auto.5338","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes","volume":"4","author":"DJ Klionsky","year":"2008","journal-title":"Autophagy"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1093\/hmg\/ddr475","article-title":"Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease","volume":"21","author":"UP Shirendeb","year":"2012","journal-title":"Hum Mol Genet"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ceb.2009.11.014","article-title":"Mammalian autophagy: core molecular machinery and signaling regulation","volume":"22","author":"Z Yang","year":"2010","journal-title":"Curr Opin Cell Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1528-1167.2008.01493.x","article-title":"Tuberous sclerosis: a primary pathology of astrocytes?","volume":"49 Suppl 2","author":"AA Sosunov","year":"2008","journal-title":"Epilepsia"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/brain\/awp292","article-title":"Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3","volume":"133","author":"FM Menzies","year":"2010","journal-title":"Brain"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1001\/archneurol.2010.198","article-title":"Chaperone-mediated autophagy markers in Parkinson disease brains","volume":"67","author":"L Alvarez-Erviti","year":"2010","journal-title":"Arch Neurol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"6926","DOI":"10.1523\/JNEUROSCI.0800-08.2008","article-title":"Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease","volume":"28","author":"B Boland","year":"2008","journal-title":"J Neurosci"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1097\/NEN.0b013e318211c86a","article-title":"Localization of MAP1-LC3 in vulnerable neurons and Lewy bodies in brains of patients with dementia with Lewy bodies","volume":"70","author":"S Higashi","year":"2011","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref31","first-page":"2190","article-title":"The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice","volume":"118","author":"F Pickford","year":"2008","journal-title":"J Clin Invest"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1093\/brain\/awr047","article-title":"Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease","volume":"134","author":"I Nascimento-Ferreira","year":"2011","journal-title":"Brain"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"14474","DOI":"10.1074\/jbc.M600364200","article-title":"Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1","volume":"281","author":"M Shibata","year":"2006","journal-title":"J Biol Chem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S0896-6273(02)00861-9","article-title":"A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice","volume":"35","author":"Z Yue","year":"2002","journal-title":"Neuron"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/nrm2708","article-title":"Dynamics and diversity in autophagy mechanisms: lessons from yeast","volume":"10","author":"H Nakatogawa","year":"2009","journal-title":"Nature reviews Mol Cell Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"14489","DOI":"10.1073\/pnas.0701311104","article-title":"Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration","volume":"104","author":"M Komatsu","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"591","DOI":"10.4161\/auto.4964","article-title":"Aberrant membranes and double-membrane structures accumulate in the axons of Atg5-null Purkinje cells before neuronal death","volume":"3","author":"J Nishiyama","year":"2007","journal-title":"Autophagy"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"12535","DOI":"10.1523\/JNEUROSCI.1920-10.2010","article-title":"Pathogenic lysosomal depletion in Parkinson's disease","volume":"30","author":"B Dehay","year":"2010","journal-title":"J Neurosci"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.cell.2009.03.018","article-title":"Acetylation targets mutant huntingtin to autophagosomes for degradation","volume":"137","author":"H Jeong","year":"2009","journal-title":"Cell"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.neulet.2008.11.043","article-title":"Structural study of Purkinje cell axonal torpedoes in essential tremor","volume":"450","author":"ED Louis","year":"2009","journal-title":"Neurosci Lett"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0053040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T02:14:15Z","timestamp":1540520055000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0053040"}},"subtitle":[],"editor":[{"given":"Alice Y. W.","family":"Chang","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,12,27]]},"references-count":40,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2012,12,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0053040","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,27]]}}}