{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T02:33:44Z","timestamp":1789698824635,"version":"4.0.1"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2013,1,8]],"date-time":"2013-01-08T00:00:00Z","timestamp":1357603200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0053336","type":"journal-article","created":{"date-parts":[[2013,1,9]],"date-time":"2013-01-09T05:54:26Z","timestamp":1357710866000},"page":"e53336","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["The Microbial Capsular Polysaccharide Galactoxylomannan Inhibits IL-17A Production in Circulating T Cells from Rheumatoid Arthritis Patients"],"prefix":"10.1371","volume":"8","author":[{"given":"Eva","family":"Pericolini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Alunno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Gabrielli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Bartoloni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elio","family":"Cenci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siu-Kei","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Bistoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Casadevall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Gerli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Vecchiarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,1,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1056\/NEJMra1004965","article-title":"The pathogenesis of rheumatoid arthritis","volume":"365","author":"IB McInnes","year":"2011","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S1471-4906(00)01829-9","article-title":"Role of CD30+ T cells in rheumatoid arthritis: a counter-regulatory paradigm for Th1-driven diseases","volume":"22","author":"R Gerli","year":"2001","journal-title":"Trends Immunol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1002\/art.1780381109","article-title":"Double-blind, placebo-controlled multicenter trial using chimeric monoclonal anti-CD4 antibody, cM-T412, in rheumatoid arthritis patients receiving concomitant methotrexate","volume":"38","author":"LW Moreland","year":"1995","journal-title":"Arthritis Rheum"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1093\/rheumatology\/41.10.1142","article-title":"Repeat-cycle study of high-dose intravenous 4162W94 anti-CD4 humanized monoclonal antibody in rheumatoid arthritis. A randomized placebo-controlled trial","volume":"41","author":"EH Choy","year":"2002","journal-title":"Rheumatology (Oxford)"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/nm.1984","article-title":"Targeted depletion of lymphotoxin-alpha-expressing TH1 and TH17 cells inhibits autoimmune disease","volume":"15","author":"EY Chiang","year":"2009","journal-title":"Nat Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1089\/hum.2009.217","article-title":"Amelioration of rat collagen-induced arthritis through CD4+ T cells apoptosis and synovial interleukin-17 reduction by indoleamine 2,3-dioxygenase gene therapy","volume":"22","author":"SY Chen","year":"2011","journal-title":"Hum Gene Ther"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/sj.cr.7290049","article-title":"DNA fragmentation in apoptosis","volume":"10","author":"JH Zhang","year":"2000","journal-title":"Cell Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1462-5822.2005.00619.x","article-title":"Cryptococcus neoformans capsular polysaccharide component galactoxylomannan induces apoptosis of human T-cells through activation of caspase-8","volume":"8","author":"E Pericolini","year":"2006","journal-title":"Cell Microbiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"597","DOI":"10.2174\/1566524013363429","article-title":"Regulation of apoptosis and cell cycle activity in rheumatoid arthritis","volume":"1","author":"H Perlman","year":"2001","journal-title":"Curr Mol Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.4049\/jimmunol.174.6.3461","article-title":"Cryptococcus neoformans capsular glucuronoxylomannan induces expression of fas ligand in macrophages","volume":"174","author":"C Monari","year":"2005","journal-title":"J Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/sj.cr.7290345","article-title":"The role of apoptosis in the development and function of T lymphocytes","volume":"15","author":"N Zhang","year":"2005","journal-title":"Cell Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1126\/science.7539157","article-title":"Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity","volume":"268","author":"F Rieux-Laucat","year":"1995","journal-title":"Science"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/rheumatology\/kei113","article-title":"Fas (CD95)-related apoptosis and rheumatoid arthritis","volume":"45","author":"SL Peng","year":"2006","journal-title":"Rheumatology (Oxford)"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.1002\/art.27729","article-title":"Monoclonal anti-CD8 therapy induces disease amelioration in the K\/BxN mouse model of spontaneous chronic polyarthritis","volume":"62","author":"BR Raposo","year":"2010","journal-title":"Arthritis Rheum"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.imlet.2011.04.004","article-title":"Selective elimination of pathogenic synovial fluid T-cells from rheumatoid arthritis and juvenile idiopathic arthritis by targeted activation of Fas-apoptotic signaling","volume":"138","author":"E Bremer","year":"2011","journal-title":"Immunol Lett"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nri2094","article-title":"Cytokines in the pathogenesis of rheumatoid arthritis","volume":"7","author":"IB McInnes","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1136\/ard.2010.143768","article-title":"Effects of interleukin (IL)-17A and IL-17F in human rheumatoid arthritis synoviocytes","volume":"70","author":"A Hot","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nri2295","article-title":"TH17 cells in development: an updated view of their molecular identity and genetic programming","volume":"8","author":"C Dong","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S1016-8478(23)13153-0","article-title":"Expression of IL-17 homologs and their receptors in the synovial cells of rheumatoid arthritis patients","volume":"19","author":"SY Hwang","year":"2005","journal-title":"Mol Cells"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.bbrc.2010.05.111","article-title":"The role of interleukin-17 in mediating joint destruction in rheumatoid arthritis","volume":"397","author":"X Li","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"6003","DOI":"10.4049\/jimmunol.0803833","article-title":"Involvement of glycoreceptors in galactoxylomannan-induced T cell death","volume":"182","author":"E Pericolini","year":"2009","journal-title":"J Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e12720","DOI":"10.1371\/journal.pone.0012720","article-title":"Role of CD45 signaling pathway in galactoxylomannan-induced T cell damage","volume":"5","author":"E Pericolini","year":"2010","journal-title":"PLoS One"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0065-2164(09)01204-0","article-title":"The capsule of the fungal pathogen Cryptococcus neoformans","volume":"68","author":"O Zaragoza","year":"2009","journal-title":"Adv Appl Microbiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1128\/EC.00331-08","article-title":"Capsular localization of the Cryptococcus neoformans polysaccharide component galactoxylomannan","volume":"8","author":"M De Jesus","year":"2009","journal-title":"Eukaryot Cell"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"500","DOI":"10.4161\/viru.1.6.13451","article-title":"Glucuronoxylomannan, galactoxylomannan, and mannoprotein occupy spatially separate and discrete regions in the capsule of Cryptococcus neoformans","volume":"1","author":"MD Jesus","year":"2010","journal-title":"Virulence"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1128\/EC.00268-09","article-title":"Galactoxylomannans from Cryptococcus neoformans varieties neoformans and grubii are structurally and antigenically variable","volume":"9","author":"M De Jesus","year":"2010","journal-title":"Eukaryot Cell"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"997","DOI":"10.2217\/imt.11.86","article-title":"Cryptococcus neoformans galactoxylomannan is a potent negative immunomodulator, inspiring new approaches in anti-inflammatory immunotherapy","volume":"3","author":"A Vecchiarelli","year":"2011","journal-title":"Immunotherapy"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.cellsig.2009.10.003","article-title":"Modulation of immune cell signalling by the leukocyte common tyrosine phosphatase, CD45","volume":"22","author":"AE Saunders","year":"2010","journal-title":"Cell Signal"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/nature07036","article-title":"Induction and effector functions of T(H)17 cells","volume":"453","author":"E Bettelli","year":"2008","journal-title":"Nature"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1093\/rheumatology\/kem203","article-title":"Cytokines in arthritis\u2013the \u2018big numbers\u2019 move centre stage","volume":"47","author":"JS Gaston","year":"2008","journal-title":"Rheumatology (Oxford)"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.clim.2009.03.522","article-title":"Breaking old paradigms: Th17 cells in autoimmune arthritis","volume":"132","author":"A Peck","year":"2009","journal-title":"Clin Immunol"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Marrelli A, Cipriani P, Liakouli V, Carubbi F, Perricone C, <etal>et al<\/etal>.. (2011) Angiogenesis in rheumatoid arthritis: A disease specific process or a common response to chronic inflammation? Autoimmun Rev.","DOI":"10.1016\/j.autrev.2011.04.020"},{"key":"ref33","first-page":"587","article-title":"Abnormal distribution of CD45 isoforms expressed by CD4+ and CD8+ T cells in rheumatoid arthritis","volume":"15","author":"A Mamoune","year":"2000","journal-title":"Histol Histopathol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"12099","DOI":"10.1073\/pnas.0705268104","article-title":"IL-6-dependent and -independent pathways in the development of interleukin 17-producing T helper cells","volume":"104","author":"A Kimura","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"191","DOI":"10.4049\/jimmunol.0804144","article-title":"A microbial polysaccharide reduces the severity of rheumatoid arthritis by influencing Th17 differentiation and proinflammatory cytokines production","volume":"183","author":"C Monari","year":"2009","journal-title":"J Immunol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"e17766","DOI":"10.1371\/journal.pone.0017766","article-title":"An alternate STAT6-independent pathway promotes eosinophil influx into blood during allergic airway inflammation","volume":"6","author":"W Wang","year":"2011","journal-title":"PLoS One"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1161\/01.CIR.0000131450.66017.B3","article-title":"CD4+CD28- T lymphocytes contribute to early atherosclerotic damage in rheumatoid arthritis patients","volume":"109","author":"R Gerli","year":"2004","journal-title":"Circulation"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1172\/JCI119396","article-title":"Treatment with depleting CD4 monoclonal antibody results in a preferential loss of circulating naive T cells but does not affect IFN-gamma secreting TH1 cells in humans","volume":"99","author":"MH Rep","year":"1997","journal-title":"J Clin Invest"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"3350","DOI":"10.1002\/art.11322","article-title":"Suppression of osteoclastogenesis in rheumatoid arthritis by induction of apoptosis in activated CD4+ T cells","volume":"48","author":"Y Ogawa","year":"2003","journal-title":"Arthritis Rheum"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.4049\/jimmunol.0900449","article-title":"Galactoxylomannan-mediated immunological paralysis results from specific B cell depletion in the context of widespread immune system damage","volume":"183","author":"M De Jesus","year":"2009","journal-title":"J Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/S0092-8674(00)00209-9","article-title":"An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity","volume":"103","author":"R Majeti","year":"2000","journal-title":"Cell"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"R784","DOI":"10.1186\/ar1733","article-title":"Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin","volume":"7","author":"K Raza","year":"2005","journal-title":"Arthritis Res Ther"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.mce.2010.05.018","article-title":"Estrogens in rheumatoid arthritis; the immune system and bone","volume":"335","author":"U Islander","year":"2010","journal-title":"Mol Cell Endocrinol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1136\/ard.59.3.190","article-title":"Increased expression of CD40 ligand (CD154) on CD4+ T cells as a marker of disease activity in rheumatoid arthritis","volume":"59","author":"B Berner","year":"2000","journal-title":"Ann Rheum Dis"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1002\/art.30457","article-title":"Increased sensitivity to apoptosis induced by methotrexate is mediated by JNK","volume":"63","year":"2011","journal-title":"Arthritis Rheum"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1128\/IAI.60.3.1084-1088.1992","article-title":"Galactoxylomannans of Cryptococcus neoformans","volume":"60","author":"PG James","year":"1992","journal-title":"Infect Immun"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0008-6215(00)84168-3","article-title":"Preparation and properties of fluorescein-labelled hyaluronate","volume":"44","author":"AN de Belder","year":"1975","journal-title":"Carbohydr Res"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","article-title":"The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis","volume":"31","author":"FC Arnett","year":"1988","journal-title":"Arthritis Rheum"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1182\/blood.V81.5.1352.1352","article-title":"Interleukin-4 protects double-negative and CD4 single-positive thymocytes from dexamethasone-induced apoptosis","volume":"81","author":"G Migliorati","year":"1993","journal-title":"Blood"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"e43972","DOI":"10.1371\/journal.pone.0043972","article-title":"Antibody Constant Region Peptides Can Display Immunomodulatory Activity through Activation of the Dectin-1 Signalling Pathway","volume":"7","author":"E Gabrielli","year":"2012","journal-title":"PLoS One"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1002\/art.23655","article-title":"Increased numbers of circulating polyfunctional Th17 memory cells in patients with seronegative spondylarthritides","volume":"58","author":"C Jandus","year":"2008","journal-title":"Arthritis Rheum"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1158\/0008-5472.CAN-09-2468","article-title":"Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells","volume":"70","author":"L Lin","year":"2010","journal-title":"Cancer Res"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"e8187","DOI":"10.1371\/journal.pone.0008187","article-title":"Antibody complementarity-determining regions (CDRs): a bridge between adaptive and innate immunity","volume":"4","author":"E Gabrielli","year":"2009","journal-title":"PLoS One"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0053336","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T13:44:58Z","timestamp":1714830298000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0053336"}},"subtitle":[],"editor":[{"given":"Gernot","family":"Zissel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,1,8]]},"references-count":53,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,1,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0053336","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,8]]}}}