{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:45:41Z","timestamp":1791405941505,"version":"4.3.3"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2013,1,8]],"date-time":"2013-01-08T00:00:00Z","timestamp":1357603200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0053587","type":"journal-article","created":{"date-parts":[[2013,1,9]],"date-time":"2013-01-09T05:48:30Z","timestamp":1357710510000},"page":"e53587","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":52,"title":["Cerebrospinal Fluid PKR Level Predicts Cognitive Decline in Alzheimer\u2019s Disease"],"prefix":"10.1371","volume":"8","author":[{"given":"Julien","family":"Dumurgier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Mouton-Liger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Lapalus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali","family":"Prevot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Laplanche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Hugon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Paquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Groupe d\u2019Investigation du Liquide Cephalorachidien (GIL) Study Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,1,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"b158","DOI":"10.1136\/bmj.b158","article-title":"Alzheimer&apos;s disease","volume":"338","author":"A Burns","year":"2009","journal-title":"Bmj"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jalz.2009.05.665","article-title":"Disease progression meta-analysis model in Alzheimer&apos;s disease","volume":"6","author":"K Ito","year":"2010","journal-title":"Alzheimers Dement"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00401-009-0532-1","article-title":"Classification and basic pathology of Alzheimer disease","volume":"118","author":"C Duyckaerts","year":"2009","journal-title":"Acta Neuropathol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nrneurol.2010.4","article-title":"Cerebrospinal fluid and plasma biomarkers in Alzheimer disease","volume":"6","author":"K Blennow","year":"2010","journal-title":"Nat Rev Neurol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0197-4580(00)00164-0","article-title":"Relationship between apoE genotype and CSF beta-amyloid (1\u201342) and tau in patients with probable and definite Alzheimer&apos;s disease","volume":"21","author":"T Tapiola","year":"2000","journal-title":"Neurobiol Aging"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1212\/WNL.0b013e3182563bd0","article-title":"CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings","volume":"78","author":"TT Seppala","year":"2012","journal-title":"Neurology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/ana.21009","article-title":"Cognitive impact of subcortical vascular and Alzheimer&apos;s disease pathology","volume":"60","author":"HC Chui","year":"2006","journal-title":"Ann Neurol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.nbd.2010.07.007","article-title":"Inverse association between CSF Abeta 42 levels and years of education in mild form of Alzheimer&apos;s disease: the cognitive reserve theory","volume":"40","author":"J Dumurgier","year":"2010","journal-title":"Neurobiol Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.biochi.2007.03.001","article-title":"The dsRNA protein kinase PKR: virus and cell control","volume":"89","author":"MA Garcia","year":"2007","journal-title":"Biochimie"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.bbadis.2012.01.009","article-title":"Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2alpha pathway","volume":"1822","author":"F Mouton-Liger","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1750-3639.2010.00437.x","article-title":"Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer&apos;s disease","volume":"21","author":"A Bose","year":"2011","journal-title":"Brain Pathol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e21456","DOI":"10.1371\/journal.pone.0021456","article-title":"Activation of PKR causes amyloid ss-peptide accumulation via de-repression of BACE1 expression","volume":"6","author":"G Ill-Raga","year":"2011","journal-title":"PLoS One"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.biopsych.2011.11.031","article-title":"Increased Cerebrospinal Fluid Levels of Double-Stranded RNA-Dependant Protein Kinase in Alzheimer&apos;s Disease","volume":"71","author":"F Mouton-Liger","year":"2012","journal-title":"Biol Psychiatry"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer&apos;s disease: recommendations from the National Institute on Aging-Alzheimer&apos;s Association workgroups on diagnostic guidelines for Alzheimer&apos;s disease","volume":"7","author":"GM McKhann","year":"2011","journal-title":"Alzheimers Dement"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1212\/WNL.0b013e3181dd4dd8","article-title":"CSF biomarkers predict a more malignant outcome in Alzheimer disease","volume":"74","author":"AK Wallin","year":"2010","journal-title":"Neurology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1212\/WNL.0b013e3181bd8271","article-title":"CSF biomarkers predict rate of cognitive decline in Alzheimer disease","volume":"73","author":"MI Kester","year":"2009","journal-title":"Neurology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1523\/JNEUROSCI.3785-09.2010","article-title":"CSF biomarkers in prediction of cerebral and clinical change in mild cognitive impairment and Alzheimer&apos;s disease","volume":"30","author":"AM Fjell","year":"2010","journal-title":"J Neurosci"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Wang L, Fagan AM, Shah AR, Beg MF, Csernansky JG, <etal>et al<\/etal>. (2011) Cerebrospinal Fluid Proteins Predict Longitudinal Hippocampal Degeneration in Early-stage Dementia of the Alzheimer Type. Alzheimer Dis Assoc Disord.","DOI":"10.1097\/WAD.0b013e31823c0cf4"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1212\/WNL.0b013e3181b879ac","article-title":"Baseline CSF p-tau levels independently predict progression of hippocampal atrophy in Alzheimer disease","volume":"73","author":"WJ Henneman","year":"2009","journal-title":"Neurology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/ana.22448","article-title":"Visinin-like protein-1: diagnostic and prognostic biomarker in Alzheimer disease","volume":"70","author":"R Tarawneh","year":"2011","journal-title":"Ann Neurol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1212\/WNL.0b013e318248e568","article-title":"CSF VILIP-1 predicts rates of cognitive decline in early Alzheimer disease","volume":"78","author":"R Tarawneh","year":"2012","journal-title":"Neurology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1046\/j.1471-4159.2002.01237.x","article-title":"Involvement of double-stranded RNA-dependent protein kinase and phosphorylation of eukaryotic initiation factor-2alpha in neuronal degeneration","volume":"83","author":"RC Chang","year":"2002","journal-title":"J Neurochem"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nrneurol.2010.17","article-title":"Microglia in neurodegenerative disease","volume":"6","author":"VH Perry","year":"2010","journal-title":"Nat Rev Neurol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1128\/MCB.20.4.1278-1290.2000","article-title":"NF-kappaB activation by double-stranded-RNA-activated protein kinase (PKR) is mediated through NF-kappaB-inducing kinase and IkappaB kinase","volume":"20","author":"M Zamanian-Daryoush","year":"2000","journal-title":"Mol Cell Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/ana.22628","article-title":"An operational approach to National Institute on Aging-Alzheimer&apos;s Association criteria for preclinical Alzheimer disease","volume":"71","author":"CR Jack Jr","year":"2012","journal-title":"Ann Neurol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/ana.21953","article-title":"Effect of apolipoprotein E on biomarkers of amyloid load and neuronal pathology in Alzheimer disease","volume":"67","author":"P Vemuri","year":"2010","journal-title":"Ann Neurol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1586\/ern.09.92","article-title":"Could PKR inhibition modulate human neurodegeneration","volume":"9","author":"J Hugon","year":"2009","journal-title":"Expert Rev Neurother"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0053587","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T13:44:37Z","timestamp":1714830277000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0053587"}},"subtitle":[],"editor":[{"given":"Kewei","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,1,8]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,1,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0053587","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,8]]}}}