{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:13:37Z","timestamp":1773418417345,"version":"3.50.1"},"reference-count":68,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T00:00:00Z","timestamp":1358208000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0053831","type":"journal-article","created":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T22:23:56Z","timestamp":1358288636000},"page":"e53831","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Transcriptional Effects of E3 Ligase Atrogin-1\/MAFbx on Apoptosis, Hypertrophy and Inflammation in Neonatal Rat Cardiomyocytes"],"prefix":"10.1371","volume":"8","author":[{"given":"Yong","family":"Zeng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Xia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Bin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang-Jun","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao-Shu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Hua","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,1,15]]},"reference":[{"key":"ref1","first-page":"167","article-title":"Bacterial lipopolysaccharides and innate immunity","volume":"7","author":"C Alexander","year":"2001","journal-title":"Journal of endotoxin research"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1172\/JCI6709","article-title":"Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium","volume":"104","author":"S Frantz","year":"1999","journal-title":"The Journal of clinical investigation"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.jacc.2006.10.043","article-title":"Lipopolysaccharide activates calcineurin in ventricular myocytes","volume":"49","author":"J Suzuki","year":"2007","journal-title":"Journal of the American College of Cardiology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1161\/CIRCRESAHA.109.208801","article-title":"Sent to destroy: the ubiquitin proteasome system regulates cell signaling and protein quality control in cardiovascular development and disease","volume":"106","author":"MS Willis","year":"2010","journal-title":"Circ Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1172\/JCI200422220","article-title":"Atrogin-1\/muscle atrophy F-box inhibits calcineurin-dependent cardiac hypertrophy by participating in an SCF ubiquitin ligase complex","volume":"114","author":"HH Li","year":"2004","journal-title":"The Journal of clinical investigation"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1172\/JCI31757","article-title":"Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins","volume":"117","author":"HH Li","year":"2007","journal-title":"The Journal of clinical investigation"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e21104","DOI":"10.1371\/journal.pone.0021104","article-title":"Overexpression of Nrdp1 in the heart exacerbates doxorubicin-induced cardiac dysfunction in mice","volume":"6","author":"Y Zhang","year":"2011","journal-title":"PloS one"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.cardiores.2006.10.026","article-title":"Myocardial expression of Murf-1 and MAFbx after induction of chronic heart failure: Effect on myocardial contractility","volume":"73","author":"V Adams","year":"2007","journal-title":"Cardiovasc Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"14440","DOI":"10.1073\/pnas.251541198","article-title":"Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy","volume":"98","author":"MD Gomes","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1126\/science.1065874","article-title":"Identification of ubiquitin ligases required for skeletal muscle atrophy","volume":"294","author":"SC Bodine","year":"2001","journal-title":"Science"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1083\/jcb.200402033","article-title":"Muscle ring finger protein-1 inhibits PKC{epsilon} activation and prevents cardiomyocyte hypertrophy","volume":"167","author":"R Arya","year":"2004","journal-title":"The Journal of cell biology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1161\/CIRCRESAHA.110.238717","article-title":"Endogenous Muscle Atrophy F-Box Mediates Pressure Overload-Induced Cardiac Hypertrophy Through Regulation of Nuclear Factor-{kappa}B","volume":"109","author":"S Usui","year":"2011","journal-title":"Circ Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1016\/j.biocel.2005.04.018","article-title":"Skeletal muscle hypertrophy and atrophy signaling pathways","volume":"37","author":"DJ Glass","year":"2005","journal-title":"Int J Biochem Cell Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1096\/fj.04-2364com","article-title":"TNF-alpha acts via p38 MAPK to stimulate expression of the ubiquitin ligase atrogin1\/MAFbx in skeletal muscle","volume":"19","author":"YP Li","year":"2005","journal-title":"Faseb J"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0092-8674(04)00400-3","article-title":"Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy","volume":"117","author":"M Sandri","year":"2004","journal-title":"Cell"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"4413","DOI":"10.1074\/jbc.M807641200","article-title":"MAFbx\/Atrogin-1 controls the activity of the initiation factor eIF3-f in skeletal muscle atrophy by targeting multiple C-terminal lysines","volume":"284","author":"A Csibi","year":"2009","journal-title":"J Biol Chem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1074\/jbc.M411346200","article-title":"Degradation of MyoD mediated by the SCF (MAFbx) ubiquitin ligase","volume":"280","author":"LA Tintignac","year":"2005","journal-title":"J Biol Chem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"5488","DOI":"10.1074\/jbc.M806487200","article-title":"Atrogin-1\/MAFbx enhances simulated ischemia\/reperfusion-induced apoptosis in cardiomyocytes through degradation of MAPK phosphatase-1 and sustained JNK activation","volume":"284","author":"P Xie","year":"2009","journal-title":"J Biol Chem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1038\/emboj.2008.52","article-title":"The initiation factor eIF3-f is a major target for atrogin1\/MAFbx function in skeletal muscle atrophy","volume":"27","author":"J Lagirand-Cantaloube","year":"2008","journal-title":"Embo J"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"20814","DOI":"10.1074\/jbc.M500528200","article-title":"The FOXO3a transcription factor regulates cardiac myocyte size downstream of AKT signaling","volume":"280","author":"C Skurk","year":"2005","journal-title":"The Journal of biological chemistry"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1093\/eurjhf\/hfq102","article-title":"Myocardial expression of FOXO3a-Atrogin-1 pathway in human heart failure","volume":"12","author":"G Galasso","year":"2010","journal-title":"Eur J Heart Fail"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"14863","DOI":"10.1073\/pnas.95.25.14863","article-title":"Cluster analysis and display of genome-wide expression patterns","volume":"95","author":"MB Eisen","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s10495-010-0552-2","article-title":"Granulocyte macrophage-colony stimulating factor shows anti-apoptotic activity in neural progenitor cells via JAK\/STAT5-Bcl-2 pathway","volume":"16","author":"JK Choi","year":"2011","journal-title":"Apoptosis"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.yjmcc.2006.10.001","article-title":"Actions and therapeutic potential of G-CSF and GM-CSF in cardiovascular disease","volume":"42","author":"JC Kovacic","year":"2007","journal-title":"J Mol Cell Cardiol"},{"key":"ref25","article-title":"Colony-stimulating Factor 2 Inhibits Induction of Apoptosis in the Bovine Preimplantation Embryo","author":"B Loureiro","year":"2011","journal-title":"Am J Reprod Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"27429","DOI":"10.1074\/jbc.M110.142752","article-title":"Inhibition of STAT3 signaling blocks the anti-apoptotic activity of IL-6 in human liver cancer cells","volume":"285","author":"Y Liu","year":"2010","journal-title":"J Biol Chem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1002\/jcp.20307","article-title":"Role of interleukin-6 in cardiomyocyte\/cardiac fibroblast interactions during myocyte hypertrophy and fibroblast proliferation","volume":"204","author":"S Fredj","year":"2005","journal-title":"J Cell Physiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1006\/cyto.2002.1033","article-title":"Secretion of IL-6, IL-11 and LIF by human cardiomyocytes in primary culture","volume":"18","author":"C Ancey","year":"2002","journal-title":"Cytokine"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/1476-4598-7-87","article-title":"ALDH isozymes downregulation affects cell growth, cell motility and gene expression in lung cancer cells","volume":"7","author":"JS Moreb","year":"2008","journal-title":"Mol Cancer"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1167\/iovs.02-0317","article-title":"Microphthalmia resulting from MSX2-induced apoptosis in the optic vesicle","volume":"44","author":"LY Wu","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.mod.2006.10.002","article-title":"Impaired neural development caused by inducible expression of Axin in transgenic mice","volume":"124","author":"HM Yu","year":"2007","journal-title":"Mech Dev"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1158\/1055-9965.EPI-09-1154","article-title":"PTGER2 overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype","volume":"19","author":"Y Baba","year":"2010","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cmet.2010.05.003","article-title":"PKCzeta-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intolerance","volume":"12","author":"SJ Lee","year":"2010","journal-title":"Cell Metab"},{"key":"ref34","first-page":"33","article-title":"Genetic polymorphisms of prostacyclin synthase gene and cardiovascular disease","volume":"29","author":"T Nakayama","year":"2010","journal-title":"Int Angiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/ng.413","article-title":"Mutations in PYCR1 cause cutis laxa with progeroid features","volume":"41","author":"B Reversade","year":"2009","journal-title":"Nat Genet"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1741-7007-8-23","article-title":"ASB9 interacts with ubiquitous mitochondrial creatine kinase and inhibits mitochondrial function","volume":"8","author":"S Kwon","year":"2010","journal-title":"BMC Biol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1161\/CIRCULATIONAHA.104.507699","article-title":"Alpha-myosin heavy chain: a sarcomeric gene associated with dilated and hypertrophic phenotypes of cardiomyopathy","volume":"112","author":"E Carniel","year":"2005","journal-title":"Circulation"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"12668","DOI":"10.1074\/jbc.M411973200","article-title":"Aberrant localization of intracellular organelles, Ca2+ signaling, and exocytosis in Mist1 null mice","volume":"280","author":"X Luo","year":"2005","journal-title":"J Biol Chem"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.yjmcc.2009.03.013","article-title":"Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene","volume":"47","author":"KB Andersson","year":"2009","journal-title":"J Mol Cell Cardiol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1038\/mt.2008.61","article-title":"Lentiviral vector-mediated SERCA2 gene transfer protects against heart failure and left ventricular remodeling after myocardial infarction in rats","volume":"16","author":"K Niwano","year":"2008","journal-title":"Mol Ther"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1172\/JCI21149","article-title":"Foxa2 regulates multiple pathways of insulin secretion","volume":"114","author":"KA Lantz","year":"2004","journal-title":"J Clin Invest"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1161\/01.CIR.0000165117.71483.0C","article-title":"p38 MAP kinase mediates inflammatory cytokine induction in cardiomyocytes and extracellular matrix remodeling in heart","volume":"111","author":"M Li","year":"2005","journal-title":"Circulation"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"11064","DOI":"10.1074\/jbc.M801359200","article-title":"Prostaglandin E2 attenuates preoptic expression of GABAA receptors via EP3 receptors","volume":"283","author":"H Tsuchiya","year":"2008","journal-title":"J Biol Chem"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.4049\/jimmunol.174.4.2280","article-title":"Heparin binds to lipopolysaccharide (LPS)-binding protein, facilitates the transfer of LPS to CD14, and enhances LPS-induced activation of peripheral blood monocytes","volume":"174","author":"M Heinzelmann","year":"2005","journal-title":"J Immunol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1016\/j.cellsig.2008.07.003","article-title":"P38 MAPK mediates COX-2 gene expression by corticosterone in cardiomyocytes","volume":"20","author":"H Sun","year":"2008","journal-title":"Cell Signal"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1385\/IR:21:2-3:203","article-title":"Role of chemokines in inflammation and immunoregulation","volume":"21","author":"L Feng","year":"2000","journal-title":"Immunol Res"},{"key":"ref47","first-page":"ii84","article-title":"Chemokines: role in inflammation and immune surveillance","volume":"63 Suppl 2","author":"B Moser","year":"2004","journal-title":"Ann Rheum Dis"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1084\/jem.20101326","article-title":"Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production","volume":"207","author":"JM Gonzalez-Navajas","year":"2010","journal-title":"J Exp Med"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s11010-008-9754-0","article-title":"Lipopolysaccharide induces cellular hypertrophy through calcineurin\/NFAT-3 signaling pathway in H9c2 myocardiac cells","volume":"313","author":"CJ Liu","year":"2008","journal-title":"Molecular and cellular biochemistry"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1152\/physrev.00054.2009","article-title":"Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale","volume":"90","author":"BA Rose","year":"2010","journal-title":"Physiol Rev"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1002\/jcb.21060","article-title":"Curcumin prevents lipopolysaccharide-induced atrogin-1\/MAFbx upregulation and muscle mass loss","volume":"100","author":"B Jin","year":"2007","journal-title":"Journal of cellular biochemistry"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1096\/fj.02-0759com","article-title":"TNF-alpha increases ubiquitin-conjugating activity in skeletal muscle by up-regulating UbcH2\/E220k","volume":"17","author":"YP Li","year":"2003","journal-title":"Faseb J"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/cvr\/cvn076","article-title":"Atrogin-1 ubiquitin ligase is upregulated by doxorubicin via p38-MAP kinase in cardiac myocytes","volume":"79","author":"Y Yamamoto","year":"2008","journal-title":"Cardiovascular research"},{"key":"ref54","first-page":"H1565","article-title":"IGF-1 prevents ANG II-induced skeletal muscle atrophy via Akt- and Foxo-dependent inhibition of the ubiquitin ligase atrogin-1 expression","volume":"298","author":"T Yoshida","year":"2010","journal-title":"American journal of physiology"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1159\/000329967","article-title":"Stability of F-box protein atrogin-1 is regulated by p38 mitogen-activated protein kinase pathway in cardiac H9c2 cells","volume":"27","author":"JJ Li","year":"2011","journal-title":"Cell Physiol Biochem"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.yjmcc.2004.11.004","article-title":"STRESS signaling pathways that modulate cardiac myocyte apoptosis","volume":"38","author":"CP Baines","year":"2005","journal-title":"J Mol Cell Cardiol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1128\/MCB.22.4.1172-1183.2002","article-title":"Wnt\/beta-catenin\/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway","volume":"22","author":"EH Jho","year":"2002","journal-title":"Mol Cell Biol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1210\/en.2007-1595","article-title":"Protein kinase C-zeta phosphorylates insulin receptor substrate-1, -3, and -4 but not -2: isoform specific determinants of specificity in insulin signaling","volume":"149","author":"S Lee","year":"2008","journal-title":"Endocrinology"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.1093\/emboj\/cdf407","article-title":"Role of zeta PKC in B-cell signaling and function","volume":"21","author":"P Martin","year":"2002","journal-title":"Embo J"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s10741-010-9161-y","article-title":"The role of inflammatory and fibrogenic pathways in heart failure associated with aging","volume":"15","author":"W Chen","year":"2010","journal-title":"Heart failure reviews"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/nrg2468","article-title":"Metabolic syndrome: from epidemiology to systems biology","volume":"9","author":"AJ Lusis","year":"2008","journal-title":"Nature reviews"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1084\/jem.20061617","article-title":"Vascular wall-produced prostaglandin E2 exacerbates arterial thrombosis and atherothrombosis through platelet EP3 receptors","volume":"204","author":"S Gross","year":"2007","journal-title":"J Exp Med"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"9443","DOI":"10.1074\/jbc.M900206200","article-title":"Identification of myo-inositol-3-phosphate synthase isoforms: characterization, expression, and putative role of a 16-kDa gamma(c) isoform","volume":"284","author":"RS Seelan","year":"2009","journal-title":"J Biol Chem"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1073\/pnas.94.7.2897","article-title":"Expression cloning and characterization of a cDNA encoding a novel membrane protein required for the formation of O-acetylated ganglioside: a putative acetyl-CoA transporter","volume":"94","author":"A Kanamori","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.ajhg.2008.11.003","article-title":"A missense mutation in SLC33A1, which encodes the acetyl-CoA transporter, causes autosomal-dominant spastic paraplegia (SPG42)","volume":"83","author":"P Lin","year":"2008","journal-title":"Am J Hum Genet"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s002100000363","article-title":"Mitogen-activated protein kinases in the heart","volume":"363","author":"MC Michel","year":"2001","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1159\/000315079","article-title":"Transcriptomic analysis of mild hypothermia-dependent alterations during endothelial reperfusion injury","volume":"25","author":"D Yang","year":"2010","journal-title":"Cell Physiol Biochem"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0267947","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000}},{"DOI":"10.1371\/annotation\/97e1be8b-a068-4e4b-9e8d-14315bb34e7e","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2013,7,3]],"date-time":"2013-07-03T00:00:00Z","timestamp":1372809600000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0053831","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T07:49:01Z","timestamp":1540367341000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0053831"}},"subtitle":[],"editor":[{"given":"Tianqing","family":"Peng","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,1,15]]},"references-count":68,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,1,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0053831","relation":{"correction":[{"id-type":"doi","id":"10.1371\/annotation\/97e1be8b-a068-4e4b-9e8d-14315bb34e7e","asserted-by":"object"},{"id-type":"doi","id":"10.1371\/journal.pone.0267947","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,15]]}}}