{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:14:21Z","timestamp":1791321261647,"version":"4.3.1"},"reference-count":59,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2013,1,14]],"date-time":"2013-01-14T00:00:00Z","timestamp":1358121600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0053881","type":"journal-article","created":{"date-parts":[[2013,1,14]],"date-time":"2013-01-14T23:28:46Z","timestamp":1358206126000},"page":"e53881","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["The V Protein of Tioman Virus Is Incapable of Blocking Type I Interferon Signaling in Human Cells"],"prefix":"10.1371","volume":"8","author":[{"given":"Gr\u00e9gory","family":"Caignard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Lucas-Hourani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin P.","family":"Dhondt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Labernardi\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Petit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Jacob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Branka","family":"Horvat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Tangy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Olivier","family":"Vidalain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,1,14]]},"reference":[{"key":"ref1","unstructured":"Lamb RA, Parks GD (2007) <italic>Paramyxoviridae<\/italic>: the viruses and their replication. In: David M. Knipe PMH, editor. Fields Virology, 5th ed: Wolters Kluwer, Lippincott Williams &amp; Wilkins. 1449\u20131496."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1111\/j.1462-2920.2009.01962.x","article-title":"Europe, the bull and the Minotaur: the biological legacy of a Neolithic love story","volume":"11","author":"H Brussow","year":"2009","journal-title":"Environ Microbiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.patbio.2008.04.006","article-title":"Henipaviruses: a new family of emerging Paramyxoviruses","volume":"57","author":"TF Wild","year":"2009","journal-title":"Pathol Biol (Paris)"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1126\/science.288.5470.1432","article-title":"Nipah virus: A recently emergent deadly paramyxovirus","volume":"288","author":"KB Chua","year":"2000","journal-title":"Science"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1006\/viro.2000.0882","article-title":"Tioman virus, a novel paramyxovirus isolated from fruit bats in Malaysia","volume":"283","author":"KB Chua","year":"2001","journal-title":"Virology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1086\/520817","article-title":"Serological evidence of possible human infection with Tioman virus, a newly described paramyxovirus of bat origin","volume":"196","author":"KC Yaiw","year":"2007","journal-title":"Journal of Infectious Diseases"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1007\/s00705-008-0059-0","article-title":"Viral morphogenesis and morphological changes in human neuronal cells following Tioman and Menangle virus infection","volume":"153","author":"KC Yaiw","year":"2008","journal-title":"Archives of Virology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.immuni.2006.08.007","article-title":"Type I interferons in host defense","volume":"25","author":"DB Stetson","year":"2006","journal-title":"Immunity"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.immuni.2006.08.014","article-title":"Complex modulation of cell type-specific signaling in response to type I Interferons","volume":"25","author":"AHH van Boxel-Dezaire","year":"2006","journal-title":"Immunity"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.virol.2006.09.023","article-title":"mda-5, but not RIG-I, is a common target for paramyxovirus V proteins","volume":"359","author":"K Childs","year":"2007","journal-title":"Virology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1128\/JVI.01768-08","article-title":"Mechanism of mda-5 Inhibition by Paramyxovirus V Proteins","volume":"83","author":"KS Childs","year":"2009","journal-title":"Journal of Virology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"7252","DOI":"10.1128\/JVI.00153-09","article-title":"A Shared Interface Mediates Paramyxovirus Interference with Antiviral RNA Helicases MDA5 and LGP2","volume":"83","author":"JP Parisien","year":"2009","journal-title":"Journal of Virology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1128\/JVI.06405-11","article-title":"Paramyxovirus V Proteins Interact with the RNA Helicase LGP2 To Inhibit RIG-I-Dependent Interferon Induction","volume":"86","author":"K Childs","year":"2012","journal-title":"Journal of Virology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1089\/jir.2009.0070","article-title":"Paramyxovirus disruption of interferon signal transduction: STATus report","volume":"29","author":"A Ramachandran","year":"2009","journal-title":"J Interferon Cytokine Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1006\/viro.1998.9317","article-title":"The V protein of the paramyxovirus SV5 interacts with damage-specific DNA binding protein","volume":"249","author":"GY Lin","year":"1998","journal-title":"Virology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"9928","DOI":"10.1128\/JVI.73.12.9928-9933.1999","article-title":"The V protein of simian virus 5 inhibits interferon signalling by targeting STAT1 for proteasome-mediated degradation","volume":"73","author":"L Didcock","year":"1999","journal-title":"Journal of Virology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1006\/bbrc.2001.4764","article-title":"C terminal CYS-RICH region of mumps virus structural V protein correlates with block of interferon alpha and gamma signal transduction pathway through decrease of STAT 1-alpha","volume":"283","author":"T Kubota","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"11379","DOI":"10.1128\/JVI.76.22.11379-11386.2002","article-title":"The p127 subunit (DDB1) of the UV-DNA damage repair binding protein is essential for the targeted degradation of STAT1 by the V protein of the paramyxovirus simian virus 5","volume":"76","author":"J Andrejeva","year":"2002","journal-title":"Journal of Virology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1006\/viro.2002.1509","article-title":"The carboxyl segment of the mumps virus V protein associates with Stat proteins in vitro via a tryptophan-rich motif","volume":"300","author":"M Nishio","year":"2002","journal-title":"Virology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"12683","DOI":"10.1128\/JVI.76.24.12683-12690.2002","article-title":"C-terminal region of STAT-1alpha is not necessary for its ubiquitination and degradation caused by mumps virus V protein","volume":"76","author":"N Yokosawa","year":"2002","journal-title":"Journal of Virology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1006\/viro.2002.1773","article-title":"Paramyxoviruses SV5 and HPIV2 assemble STAT protein ubiquitin ligase complexes from cellular components","volume":"304","author":"CM Ulane","year":"2002","journal-title":"Virology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"13434","DOI":"10.1128\/JVI.79.21.13434-13441.2005","article-title":"Simian virus 5 V protein acts as an adaptor, linking DDB1 to STAT2, to facilitate the ubiquitination of STAT1","volume":"79","author":"B Precious","year":"2005","journal-title":"Journal of Virology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"10180","DOI":"10.1128\/JVI.79.16.10180-10189.2005","article-title":"Composition and assembly of STAT-targeting ubiquitin ligase complexes: Paramyxovirus V protein carboxyl terminus is an oligomerization domain","volume":"79","author":"CM Ulane","year":"2005","journal-title":"Journal of Virology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.virol.2007.06.024","article-title":"Catalytic turnover of STAT1 allows PIV5 to dismantle the interferon-induced anti-viral state of cells","volume":"368","author":"BL Precious","year":"2007","journal-title":"Virology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1006\/viro.2000.0240","article-title":"Paramyxoviridae use distinct virus-specific mechanisms to circumvent the interferon response","volume":"269","author":"DF Young","year":"2000","journal-title":"Virology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1006\/viro.2001.0856","article-title":"The V protein of human parainfluenza virus 2 antagonizes type I interferon responses by destabilizing signal transducer and activator of transcription 2","volume":"283","author":"JP Parisien","year":"2001","journal-title":"Virology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"4190","DOI":"10.1128\/JVI.76.9.4190-4198.2002","article-title":"Selective STAT protein degradation induced by paramyxoviruses requires both STAT1 and STAT2 but is independent of alpha\/beta interferon signal transduction","volume":"76","author":"JP Parisien","year":"2002","journal-title":"Journal of Virology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"6385","DOI":"10.1128\/JVI.77.11.6385-6393.2003","article-title":"STAT3 ubiquitylation and degradation by mumps virus suppress cytokine and oncogene signaling","volume":"77","author":"CM Ulane","year":"2003","journal-title":"Journal of Virology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"6347","DOI":"10.1128\/JVI.00596-09","article-title":"A point mutation, E95D, in the mumps virus V protein disengages STAT3 targeting from STAT1 targeting","volume":"83","author":"M Puri","year":"2009","journal-title":"Journal of Virology"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"D371","DOI":"10.1093\/nar\/gkp1000","article-title":"ViralORFeome: an integrated database to generate a versatile collection of viral ORFs","volume":"38","author":"J Pellet","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/oxfordjournals.jbchem.a021379","article-title":"Autocrine amplification of type I interferon gene expression mediated by interferon stimulated gene factor 3 (ISGF3)","volume":"120","author":"M Yoneyama","year":"1996","journal-title":"J Biochem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"3138","DOI":"10.4049\/jimmunol.1003115","article-title":"Type III IFNs in pteropid bats: differential expression patterns provide evidence for distinct roles in antiviral immunity","volume":"186","author":"P Zhou","year":"2011","journal-title":"J Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/nature05175","article-title":"Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery","volume":"443","author":"S Angers","year":"2006","journal-title":"Nature"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cell.2005.10.033","article-title":"Structure of DDB1 in complex with a paramyxovirus V protein: viral hijack of a propeller cluster in ubiquitin ligase","volume":"124","author":"T Li","year":"2006","journal-title":"Cell"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1099\/vir.0.82261-0","article-title":"A single amino acid substitution in the V protein of Nipah virus alters its ability to block interferon signalling in cells from different species","volume":"87","author":"K Hagmaier","year":"2006","journal-title":"J Gen Virol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"11842","DOI":"10.1128\/JVI.77.21.11842-11845.2003","article-title":"Hendra virus V protein inhibits interferon signaling by preventing STAT1 and STAT2 nuclear accumulation","volume":"77","author":"JJ Rodriguez","year":"2003","journal-title":"Journal of Virology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1128\/JVI.75.7.3363-3370.2001","article-title":"Single amino acid substitution in the V protein of simian virus 5 differentiates its ability to block interferon signaling in human and murine cells","volume":"75","author":"DF Young","year":"2001","journal-title":"Journal of Virology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"6435","DOI":"10.1128\/JVI.76.13.6435-6441.2002","article-title":"STAT2 acts as a host range determinant for species-specific paramyxovirus interferon antagonism and simian virus 5 replication","volume":"76","author":"JP Parisien","year":"2002","journal-title":"Journal of Virology"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.virol.2007.10.001","article-title":"Enabled interferon signaling evasion in an immune-competent transgenic mouse model of parainfluenza virus 5 infection","volume":"371","author":"TA Kraus","year":"2008","journal-title":"Virology"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.virol.2008.03.034","article-title":"Virus growth and antibody responses following respiratory tract infection of ferrets and mice with WT and P\/V mutants of the paramyxovirus Simian Virus 5","volume":"376","author":"GA Capraro","year":"2008","journal-title":"Virology"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.3201\/eid1612.100879","article-title":"Prevalence of henipavirus and rubulavirus antibodies in pteropid bats, Papua New Guinea","volume":"16","author":"AC Breed","year":"2010","journal-title":"Emerg Infect Dis"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3201\/eid1301.060791","article-title":"Henipavirus and Tioman virus antibodies in pteropodid bats, Madagascar","volume":"13","author":"C Iehle","year":"2007","journal-title":"Emerg Infect Dis"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1006\/viro.2001.1302","article-title":"Differences in interferon sensitivity and biological properties of two related isolates of simian virus 5: a model for virus persistence","volume":"293","author":"N Chatziandreou","year":"2002","journal-title":"Virology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"17264","DOI":"10.1073\/pnas.0407639101","article-title":"The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter","volume":"101","author":"J Andrejeva","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"10109","DOI":"10.1128\/JVI.76.20.10109-10121.2002","article-title":"Naturally occurring substitutions in the P\/V gene convert the noncytopathic paramyxovirus simian virus 5 into a virus that induces alpha\/beta interferon synthesis and cell death","volume":"76","author":"EK Wansley","year":"2002","journal-title":"J Virol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1006\/viro.2002.1737","article-title":"The V proteins of simian virus 5 and other paramyxoviruses inhibit induction of interferon-beta","volume":"303","author":"E Poole","year":"2002","journal-title":"Virology"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"642","DOI":"10.5694\/j.1326-5377.1995.tb126050.x","article-title":"Infection of humans and horses by a newly described morbillivirus","volume":"162","author":"LA Selvey","year":"1995","journal-title":"Med J Aust"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3201\/eid0402.980215","article-title":"Probable human infection with a newly described virus in the family Paramyxoviridae. The NSW Expert Group","volume":"4","author":"K Chant","year":"1998","journal-title":"Emerg Infect Dis"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"e8266","DOI":"10.1371\/journal.pone.0008266","article-title":"Establishment, immortalisation and characterisation of pteropid bat cell lines","volume":"4","author":"G Crameri","year":"2009","journal-title":"PLoS One"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"e22488","DOI":"10.1371\/journal.pone.0022488","article-title":"Interferon production and signaling pathways are antagonized during henipavirus infection of fruit bat cell lines","volume":"6","author":"ER Virtue","year":"2011","journal-title":"PLoS One"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"14756","DOI":"10.1128\/JVI.79.23.14756-14768.2005","article-title":"Human parainfluenza virus type 4 is incapable of evading the interferon-induced antiviral effect","volume":"79","author":"M Nishio","year":"2005","journal-title":"Journal of Virology"},{"key":"ref52","unstructured":"Karron RA, Collins PL (2007) Parainfluenza viruses. In: David M. Knipe PMH, editor. Fields Virology, 5th ed: Wolters Kluwer, Lippincott Williams &amp; Wilkins. 1497\u20131526."},{"key":"ref53","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.virol.2010.07.011","article-title":"Recombinant human parainfluenza virus type 2 with mutations in V that permit cellular interferon signaling are not attenuated in non-human primates","volume":"406","author":"A Schaap-Nutt","year":"2010","journal-title":"Virology"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1128\/JVI.02542-10","article-title":"Identification of human parainfluenza virus type 2 (HPIV-2) V protein amino acid residues that reduce binding of V to MDA5 and attenuate HPIV-2 replication in nonhuman primates","volume":"85","author":"A Schaap-Nutt","year":"2011","journal-title":"Journal of Virology"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1128\/JVI.00802-10","article-title":"A recombinant measles virus unable to antagonize STAT1 function cannot control inflammation and is attenuated in rhesus monkeys","volume":"85","author":"P Devaux","year":"2011","journal-title":"Journal of Virology"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.virol.2008.10.014","article-title":"Inhibition of IFN-alpha\/beta signaling by two discrete peptides within measles virus V protein that specifically bind STAT1 and STAT2","volume":"383","author":"G Caignard","year":"2009","journal-title":"Virology"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"12420","DOI":"10.1128\/JVI.02576-05","article-title":"Human papillomavirus type 5 E6 oncoprotein represses the transforming growth factor beta signaling pathway by binding to SMAD3","volume":"80","author":"JA Mendoza","year":"2006","journal-title":"Journal of Virology"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"6342","DOI":"10.1128\/MCB.20.17.6342-6353.2000","article-title":"Selective DNA binding and association with the CREB binding protein coactivator contribute to differential activation of alpha\/beta interferon genes by interferon regulatory factors 3 and 7","volume":"20","author":"R Lin","year":"2000","journal-title":"Mol Cell Biol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.virol.2007.06.037","article-title":"Measles virus V protein blocks Jak1-mediated phosphorylation of STAT1 to escape IFN-alpha\/beta signaling","volume":"368","author":"G Caignard","year":"2007","journal-title":"Virology"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0053881","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T10:24:29Z","timestamp":1595240669000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0053881"}},"subtitle":[],"editor":[{"given":"Bumsuk","family":"Hahm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,1,14]]},"references-count":59,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,1,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0053881","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,14]]}}}