{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T14:52:30Z","timestamp":1760885550291},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T00:00:00Z","timestamp":1358208000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0053988","type":"journal-article","created":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T22:22:22Z","timestamp":1358288542000},"page":"e53988","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":27,"title":["Graptopetalum Paraguayense Ameliorates Chemical-Induced Rat Hepatic Fibrosis In Vivo and Inactivates Stellate Cells and Kupffer Cells In Vitro"],"prefix":"10.1371","volume":"8","author":[{"given":"Li-Jen","family":"Su","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Chuan","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-Hsueh","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shur-Jong","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Chin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Mei","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzu-Ling","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Ying F.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih-Lan","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,1,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0098-2997(00)00004-2","article-title":"Pathogenesis of liver fibrosis: role of oxidative stress","volume":"21","author":"G Poli","year":"2000","journal-title":"Mol Aspects Med"},{"key":"ref2","first-page":"361","article-title":"Molecular pathogenesis of liver fibrosis","volume":"120","author":"DA Brenner","year":"2009","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"159","DOI":"10.7326\/0003-4819-152-3-201002020-00007","article-title":"Rosenbloom J, Castro SV, Jimenez SA Narrative review: fibrotic diseases: cellular and molecular mechanisms and novel therapies","volume":"152","journal-title":"Ann Intern Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/00005176-199210000-00001","article-title":"Hepatic fibrogenesis and its modulation by growth factors","volume":"15","author":"TW Lissoos","year":"1992","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1056\/NEJM199306243282508","article-title":"Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies","volume":"328","author":"SL Friedman","year":"1993","journal-title":"N Engl J Med"},{"key":"ref6","first-page":"111","article-title":"Perspectives in the treatment of liver fibrosis","volume":"22","author":"P Mavier","year":"1995","journal-title":"J Hepatol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1053\/gast.1997.v113.agast971131408","article-title":"Hepatotoxicity of herbal remedies: insights into the intricacies of plant-animal warfare and cell death","volume":"113","author":"N Kaplowitz","year":"1997","journal-title":"Gastroenterology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.foodchem.2004.06.022","article-title":"Studies on the antioxidative activity of Graptopetalum paraguayense E. Walther","volume":"91","author":"YC Chung","year":"2005","journal-title":"Food Chemistry"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1142\/S0192415X08005837","article-title":"In vitro antioxidant and antiproliferative activity of the stem extracts from Graptopetalum paraguayense","volume":"36","author":"SJ Chen","year":"2008","journal-title":"Am J Chin Med"},{"key":"ref10","first-page":"5","article-title":"Studies on the inhibitory effect of Graptopetalum paraguayense E. Walther extracts on the angiotensin converting enzyme","volume":"100","author":"SJ Chen","year":"2007","journal-title":"Food Chemistry"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jep.2010.06.029","article-title":"Hepatoprotective and antioxidant effects of the methanolic extract from Halenia elliptica","volume":"131","author":"B Huang","year":"2010","journal-title":"J Ethnopharmacol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0168-8278(97)80186-9","article-title":"Halofuginone, a specific inhibitor of collagen type I synthesis, prevents dimethylnitrosamine-induced liver cirrhosis","volume":"27","author":"M Pines","year":"1997","journal-title":"J Hepatol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1142\/S0192415X9300008X","article-title":"Evaluation of the anti-inflammatory and liver-protective effects of anoectochilus formosanus, ganoderma lucidum and gynostemma pentaphyllum in rats","volume":"21","author":"JM Lin","year":"1993","journal-title":"Am J Chin Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/hep.1840010511","article-title":"Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis","volume":"1","author":"RG Knodell","year":"1981","journal-title":"Hepatology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/0168-8278(95)80226-6","article-title":"Histological grading and staging of chronic hepatitis","volume":"22","author":"K Ishak","year":"1995","journal-title":"J Hepatol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3727\/000000006783991872","article-title":"Global gene expression profiling of dimethylnitrosamine-induced liver fibrosis: from pathological and biochemical data to microarray analysis","volume":"13","author":"LJ Su","year":"2006","journal-title":"Gene Expr"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1177\/37.3.2465335","article-title":"Estimation of collagen content of liver specimens. Variation among animals and among hepatic lobes in cirrhotic rats","volume":"37","author":"M Gascon-Barre","year":"1989","journal-title":"J Histochem Cytochem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0003-2697(74)90043-8","article-title":"An improved method for determining specific radioactivities of proline-14C and hydroxyproline-14C in collagen and in noncollagenous proteins","volume":"57","author":"M Rojkind","year":"1974","journal-title":"Anal Biochem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1172\/JCI18212","article-title":"NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis","volume":"112","author":"R Bataller","year":"2003","journal-title":"J Clin Invest"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"18234","DOI":"10.1016\/S0021-9258(17)44743-0","article-title":"Two distinct pathways of platelet-activating factor-induced hydrolysis of phosphoinositides in primary cultures of rat Kupffer cells","volume":"265","author":"CR Gandhi","year":"1990","journal-title":"J Biol Chem"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0163-7258(89)90050-8","article-title":"Mechanisms of carbon tetrachloride toxicity","volume":"43","author":"RO Recknagel","year":"1989","journal-title":"Pharmacol Ther"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S0168-8278(87)80570-6","article-title":"A morphological study of the early stages of hepatic fibrosis induced by low doses of dimethylnitrosamine in the rat","volume":"5","author":"AM Jezequel","year":"1987","journal-title":"J Hepatol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"307","DOI":"10.2174\/187152809789352230","article-title":"Monocytes and macrophages as cellular targets in liver fibrosis","volume":"8","author":"F Heymann","year":"2009","journal-title":"Inflamm Allergy Drug Targets"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"G256","DOI":"10.1152\/ajpgi.00550.2001","article-title":"Lipopolysaccharides in liver injury: molecular mechanisms of Kupffer cell activation","volume":"283","author":"GL Su","year":"2002","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0016-5085(98)70211-2","article-title":"Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin","volume":"115","author":"N Enomoto","year":"1998","journal-title":"Gastroenterology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/hep.510240135","article-title":"Role of Kupffer cells and the spleen in modulation of endotoxin-induced liver injury after partial hepatectomy","volume":"24","author":"S Suzuki","year":"1996","journal-title":"Hepatology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"51S","DOI":"10.1111\/j.1530-0277.2001.tb02418.x","article-title":"Kupffer cell sensitization by alcohol involves increased permeability to gut-derived endotoxin","volume":"25","author":"N Enomoto","year":"2001","journal-title":"Alcohol Clin Exp Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1111\/j.1440-1746.2006.04658.x","article-title":"Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis","volume":"22","author":"T Kisseleva","year":"2007","journal-title":"J Gastroenterol Hepatol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s12016-008-8091-0","article-title":"Inflammatory pathways in liver homeostasis and liver injury","volume":"36","author":"F Tacke","year":"2009","journal-title":"Clin Rev Allergy Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1055\/s-2007-1007337","article-title":"Kupffer cells: their activation and role in animal models of liver injury and human liver disease","volume":"13","author":"PJ Winwood","year":"1993","journal-title":"Semin Liver Dis"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1111\/j.1478-3231.2006.01342.x","article-title":"Role of Kupffer cells in host defense and liver disease","volume":"26","author":"M Bilzer","year":"2006","journal-title":"Liver Int"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S0006-2952(03)00443-X","article-title":"Depletion of Kupffer cell function by gadolinium chloride attenuates thioacetamide-induced hepatotoxicity. Expression of metallothionein and HSP70","volume":"66","author":"D Andres","year":"2003","journal-title":"Biochem Pharmacol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/hep.1840200227","article-title":"Inactivation of Kupffer cells prevents early alcohol-induced liver injury","volume":"20","author":"Y Adachi","year":"1994","journal-title":"Hepatology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1055\/s-2008-1040485","article-title":"Nonparenchymal cells and hepatotoxicity","volume":"10","author":"DL Laskin","year":"1990","journal-title":"Semin Liver Dis"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.immuni.2008.03.002","article-title":"Cytokine signaling modules in inflammatory responses","volume":"28","author":"JJ O\u2019Shea","year":"2008","journal-title":"Immunity"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1002\/hep.510250614","article-title":"Production and role of interleukin-10 in concanavalin A-induced hepatitis in mice","volume":"25","author":"H Louis","year":"1997","journal-title":"Hepatology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1053\/gast.1997.v112.pm9041256","article-title":"Hepatoprotective role of interleukin 10 in galactosamine\/lipopolysaccharide mouse liver injury","volume":"112","author":"H Louis","year":"1997","journal-title":"Gastroenterology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"5743","DOI":"10.4049\/jimmunol.155.12.5743","article-title":"IL-10 is involved in the protective effect of dibutyryl cyclic adenosine monophosphate on endotoxin-induced inflammatory liver injury","volume":"155","author":"T Arai","year":"1995","journal-title":"J Immunol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1172\/JCI117618","article-title":"Interleukin-10 modulates type I collagen and matrix metalloprotease gene expression in cultured human skin fibroblasts","volume":"94","author":"S Reitamo","year":"1994","journal-title":"J Clin Invest"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1083\/jcb.124.4.569","article-title":"Interleukin 10 inhibits transforming growth factor-beta (TGF-beta) synthesis required for osteogenic commitment of mouse bone marrow cells","volume":"124","author":"P Van Vlasselaer","year":"1994","journal-title":"J Cell Biol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1002\/hep.510280621","article-title":"Interleukin-10 controls neutrophilic infiltration, hepatocyte proliferation, and liver fibrosis induced by carbon tetrachloride in mice","volume":"28","author":"H Louis","year":"1998","journal-title":"Hepatology"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1002\/hep.510280620","article-title":"Interleukin-10 expression and function in experimental murine liver inflammation and fibrosis","volume":"28","author":"K Thompson","year":"1998","journal-title":"Hepatology"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0053988","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T18:23:55Z","timestamp":1687976635000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0053988"}},"subtitle":[],"editor":[{"given":"David L.","family":"McCormick","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,1,15]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,1,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0053988","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,15]]}}}