{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:37:29Z","timestamp":1790699849029,"version":"4.1.0"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2013,1,17]],"date-time":"2013-01-17T00:00:00Z","timestamp":1358380800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0054008","type":"journal-article","created":{"date-parts":[[2013,1,17]],"date-time":"2013-01-17T17:13:11Z","timestamp":1358442791000},"page":"e54008","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Evidence for the Role of Epstein Barr Virus Infections in the Pathogenesis of Acute Coronary Events"],"prefix":"10.1371","volume":"8","author":[{"given":"Philip F.","family":"Binkley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glen E.","family":"Cooke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Lesinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mackenzie","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryon","family":"Laskowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. James","family":"Waldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria E.","family":"Ariza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marshall V.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah A.","family":"Knight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Glaser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,1,17]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0889-1591(91)90018-6","article-title":"Stress-related activation of epstein-barr virus","volume":"5","author":"R Glaser","year":"1991","journal-title":"Brain Behav Immun"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.bbi.2004.09.001","article-title":"Stress-associated changes in the steady-state expression of latent epstein-barr virus: Implications for chronic fatigue syndrome and cancer","volume":"19","author":"R Glaser","year":"2005","journal-title":"Brain Behav Immun"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S1386-6532(99)00064-5","article-title":"The possible role of human cytomegalovirus (HCMV) in the origin of atherosclerosis","volume":"16","author":"R Horvath","year":"2000","journal-title":"J Clin Virol"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1517\/13543784.7.5.691","article-title":"Persistent infection and vascular disease: A systematic review","volume":"7","author":"J Danesh","year":"1998","journal-title":"Expert Opin Investig Drugs"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jcv.2004.06.010","article-title":"Detection of herpes simplex virus, cytomegalovirus and epstein-barr virus DNA in atherosclerotic plaques and in unaffected bypass grafts","volume":"32","author":"AI Ibrahim","year":"2005","journal-title":"J Clin Virol"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1067\/mhj.2001.118118","article-title":"Chlamydia pneumoniae and cytomegalovirus seropositivity, inflammatory markers, and the risk of myocardial infarction at a young age","volume":"142","author":"M Gattone","year":"2001","journal-title":"Am Heart J"},{"issue":"9","key":"ref7","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1136\/jcp.53.9.647","article-title":"Microorganisms in the aetiology of atherosclerosis","volume":"53","author":"SA Morre","year":"2000","journal-title":"J Clin Pathol"},{"issue":"1","key":"ref8","first-page":"85","article-title":"Infection and atherosclerosis. An alternative view on an outdated hypothesis","volume":"60","author":"FR Stassen","year":"2008","journal-title":"Pharmacol Rep"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jcv.2005.11.007","article-title":"Immune activation following cytomegalovirus infection: More important than direct viral effects in cardiovascular disease?","volume":"35","author":"FR Stassen","year":"2006","journal-title":"J Clin Virol"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.atherosclerosis.2004.12.035","article-title":"Mouse cytomegalovirus antigenic immune stimulation is sufficient to aggravate atherosclerosis in hypercholesterolemic mice","volume":"181","author":"I Vliegen","year":"2005","journal-title":"Atherosclerosis"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1055\/s-0030-1248724","article-title":"Influenza and cardiovascular disease: Does swine-origin, 2009 H1N1 flu virus represent a risk factor, an acute trigger, or both?","volume":"36","author":"G Lippi","year":"2010","journal-title":"Semin Thromb Hemost"},{"issue":"14","key":"ref12","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1093\/eurheartj\/ehr004","article-title":"Influenza vaccination reduces cardiovascular events in patients with acute coronary syndrome","volume":"32","author":"A Phrommintikul","year":"2011","journal-title":"Eur Heart J"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S1473-3099(09)70233-6","article-title":"Influenza as a trigger for acute myocardial infarction or death from cardiovascular disease: A systematic review","volume":"9","author":"C Warren-Gash","year":"2009","journal-title":"Lancet Infectious Diseases"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/s10753-008-9074-2","article-title":"Influenza virus infection and risk of acute myocardial infarction","volume":"31","author":"XR Guan","year":"2008","journal-title":"Inflammation"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.atherosclerosis.2003.09.005","article-title":"Influenza\u2013a trigger for acute myocardial infarction","volume":"172","author":"A Dvorakova","year":"2004","journal-title":"Atherosclerosis"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jacc.2012.02.049","article-title":"Human papillomavirus and cardiovascular disease","volume":"60","author":"JL Pretet","year":"2012","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.bbi.2007.07.007","article-title":"Epstein-barr virus-encoded dUTPase enhances proinflammatory cytokine production by macrophages in contact with endothelial cells: Evidence for depression-induced atherosclerotic risk","volume":"22","author":"WJ Waldman","year":"2008","journal-title":"Brain Behav Immun"},{"issue":"9","key":"ref18","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1161\/hc0902.104353","article-title":"Inflammation and atherosclerosis","volume":"105","author":"P Libby","year":"2002","journal-title":"Circulation"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis\u2013an inflammatory disease","volume":"340","author":"R Ross","year":"1999","journal-title":"N Engl J Med"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1056\/NEJM199201303260506","article-title":"The pathogenesis of coronary artery disease and the acute coronary syndromes (2)","volume":"326","author":"V Fuster","year":"1992","journal-title":"N Engl J Med"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"e78","DOI":"10.1371\/journal.pmed.0050078","article-title":"Long-term interleukin-6 levels and subsequent risk of coronary heart disease: Two new prospective studies and a systematic review","volume":"5","author":"J Danesh","year":"2008","journal-title":"PLoS Med"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.amjcard.2006.01.045","article-title":"Interleukin-6 and the risk of future cardiovascular events in patients with angina pectoris and\/or healed myocardial infarction","volume":"98","author":"EZ Fisman","year":"2006","journal-title":"Am J Cardiol"},{"issue":"17","key":"ref23","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1001\/jama.286.17.2107","article-title":"Relationship between interleukin 6 and mortality in patients with unstable coronary artery disease: Effects of an early invasive or noninvasive strategy","volume":"286","author":"E Lindmark","year":"2001","journal-title":"JAMA"},{"issue":"5","key":"ref24","first-page":"1077","article-title":"Plasma markers of endothelial damage\/dysfunction, inflammation and thrombogenesis in relation to TIMI risk stratification in acute coronary syndromes","volume":"94","author":"KW Lee","year":"2005","journal-title":"Thromb Haemost"},{"issue":"4","key":"ref25","first-page":"889","article-title":"Various cell types in human atherosclerotic lesions express ICAM-1. further immunocytochemical and immunochemical studies employing monoclonal antibody 10F3","volume":"140","author":"OY Printseva","year":"1992","journal-title":"Am J Pathol"},{"issue":"16","key":"ref26","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1093\/eurheartj\/ehn331","article-title":"Contribution of novel biomarkers to incident stable angina and acute coronary syndrome: The PRIME study","volume":"29","author":"JP Empana","year":"2008","journal-title":"Eur Heart J"},{"issue":"12","key":"ref27","doi-asserted-by":"crossref","first-page":"4219","DOI":"10.1161\/01.CIR.96.12.4219","article-title":"Circulating adhesion molecules VCAM-1, ICAM-1, and E-selectin in carotid atherosclerosis and incident coronary heart disease cases: The atherosclerosis risk in communities (ARIC) study","volume":"96","author":"SJ Hwang","year":"1997","journal-title":"Circulation"},{"issue":"9096","key":"ref28","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0140-6736(97)09032-6","article-title":"Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men","volume":"351","author":"PM Ridker","year":"1998","journal-title":"Lancet"},{"issue":"7","key":"ref29","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/S0735-1097(02)01728-X","article-title":"Soluble intercellular adhesion molecule-1 and long-term risk of acute coronary events in patients with chronic coronary heart disease. data from the bezafibrate infarction prevention (BIP) study","volume":"39","author":"M Haim","year":"2002","journal-title":"J Am Coll Cardiol"},{"issue":"12","key":"ref30","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1161\/hc3701.095949","article-title":"Circulating cell adhesion molecules and death in patients with coronary artery disease","volume":"104","author":"S Blankenberg","year":"2001","journal-title":"Circulation"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.virol.2005.10.034","article-title":"EBV-encoded dUTPase induces immune dysregulation: Implications for the pathophysiology of EBV-associated disease","volume":"346","author":"R Glaser","year":"2006","journal-title":"Virology"},{"issue":"2","key":"ref32","doi-asserted-by":"crossref","first-page":"851","DOI":"10.4049\/jimmunol.182.2.851","article-title":"The EBV-encoded dUTPase activates NF-kappa B through the TLR2 and MyD88-dependent signaling pathway","volume":"182","author":"ME Ariza","year":"2009","journal-title":"J Immunol"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/0042-6822(87)90408-9","article-title":"Characterization of a herpes simplex virus type 2 deoxyuridine triphosphate nucleotidohydrolase and mapping of a gene conferring type specificity for the enzyme","volume":"156","author":"MV Williams","year":"1987","journal-title":"Virology"},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/0042-6822(85)90341-1","article-title":"Induction of a deoxyuridine triphosphate nucleotidohydrolase activity in epstein-barr virus-infected cells","volume":"142","author":"MV Williams","year":"1985","journal-title":"Virology"},{"issue":"9","key":"ref35","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1001\/archinte.1988.00380090047012","article-title":"Antibodies to epstein-barr virus-specific DNase and DNA polymerase in the chronic fatigue syndrome","volume":"148","author":"JF Jones","year":"1988","journal-title":"Arch Intern Med"},{"issue":"3","key":"ref36","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/jmv.20196","article-title":"Epstein-barr virus-encoded dUTPase modulates immune function and induces sickness behavior in mice","volume":"74","author":"DA Padgett","year":"2004","journal-title":"J Med Virol"},{"issue":"2","key":"ref37","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1182\/blood-2004-03-1106","article-title":"Circulating endothelial cells, von willebrand factor, interleukin-6, and prognosis in patients with acute coronary syndromes","volume":"105","author":"KW Lee","year":"2005","journal-title":"Blood"},{"issue":"3","key":"ref38","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.clinbiochem.2007.09.001","article-title":"Circulating soluble adhesion molecules ICAM-1 and VCAM-1 and their association with clinical outcome, troponin T and C-reactive protein in patients with acute coronary syndromes","volume":"41","author":"AS Postadzhiyan","year":"2008","journal-title":"Clin Biochem"},{"issue":"7","key":"ref39","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1161\/01.ATV.19.7.1595","article-title":"Cross-sectional study of soluble intercellular adhesion molecule-1 and cardiovascular risk factors in apparently healthy men","volume":"19","author":"LE Rohde","year":"1999","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"4","key":"ref40","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/00006842-199107000-00001","article-title":"Spousal caregivers of dementia victims: Longitudinal changes in immunity and health","volume":"53","author":"JK Kiecolt-Glaser","year":"1991","journal-title":"Psychosom Med"},{"issue":"13","key":"ref41","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.jacc.2007.12.024","article-title":"Psychological stress and cardiovascular disease","volume":"51","author":"JE Dimsdale","year":"2008","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"ref42","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.pcad.2006.11.002","article-title":"Emotional triggers of acute coronary syndromes: Strength of evidence, biological processes, and clinical implications","volume":"49","author":"MR Bhattacharyya","year":"2007","journal-title":"Prog Cardiovasc Dis"},{"issue":"5","key":"ref43","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.jacc.2004.12.005","article-title":"The epidemiology, pathophysiology, and management of psychosocial risk factors in cardiac practice: The emerging field of behavioral cardiology","volume":"45","author":"A Rozanski","year":"2005","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"ref44","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1161\/CIRCHEARTFAILURE.110.951509","article-title":"Mind-body medicine in chronic heart failure: A translational science challenge","volume":"3","author":"S Emani","year":"2010","journal-title":"Circ Heart Fail"}],"updated-by":[{"DOI":"10.1371\/annotation\/834e21b0-6acb-40ae-8735-f7ad120c989a","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2013,8,8]],"date-time":"2013-08-08T00:00:00Z","timestamp":1375920000000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0054008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T23:24:42Z","timestamp":1539991482000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0054008"}},"subtitle":[],"editor":[{"given":"Carmen","family":"Infante-Duarte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,1,17]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,1,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0054008","relation":{"correction":[{"id-type":"doi","id":"10.1371\/annotation\/834e21b0-6acb-40ae-8735-f7ad120c989a","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,17]]}}}