{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:28:46Z","timestamp":1791170926350,"version":"4.1.0"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2013,1,11]],"date-time":"2013-01-11T00:00:00Z","timestamp":1357862400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0054013","type":"journal-article","created":{"date-parts":[[2013,1,11]],"date-time":"2013-01-11T19:05:53Z","timestamp":1357931153000},"page":"e54013","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":48,"title":["Reduced Placental Telomere Length during Pregnancies Complicated by Intrauterine Growth Restriction"],"prefix":"10.1371","volume":"8","author":[{"given":"J\u00e9r\u00f4me","family":"Toutain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Prochazkova-Carlotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Cappellen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Jarne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Chevret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacky","family":"Ferrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamina","family":"Idrissi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Pelluard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Carles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Maugey-Laulon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Lacombe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Horovitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Merlio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Saura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,1,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1053\/j.semperi.2008.04.010","article-title":"Fetal growth restriction","volume":"32","author":"J Miller","year":"2008","journal-title":"Semin Perinatol"},{"key":"ref2","first-page":"6","article-title":"Obstetric management of IUGR","volume":"3","author":"M Militello","year":"2009","journal-title":"J Prenat Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/S1357-4310(95)90793-9","article-title":"Intrauterine programming of adult disease","volume":"9","author":"DJ Barker","year":"1995","journal-title":"Mol Med Today"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/00003081-200606000-00009","article-title":"Adult consequences of fetal growth restriction","volume":"49","author":"DJ Barker","year":"2006","journal-title":"Clin Obstet Gynecol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.ajog.2010.08.055","article-title":"Intrauterine growth restriction: new concepts in antenatal surveillance, diagnosis, and management","volume":"204","author":"F Figueras","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1097\/00006254-199606000-00023","article-title":"Idiopathic fetal growth restriction: a pathophysiologic approach","volume":"51","author":"A Ghidini","year":"1996","journal-title":"Obstet Gynecol Surv"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.bpobgyn.2009.05.003","article-title":"Aetiology and pathogenesis of IUGR","volume":"23","author":"S Sankaran","year":"2009","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0140-6736(05)71003-5","article-title":"Pre-eclampsia","volume":"365","author":"B Sibai","year":"2005","journal-title":"Lancet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jgyn.2007.08.003","article-title":"Pathophysiology of preeclampsia","volume":"37","author":"V Tsatsaris","year":"2008","journal-title":"J Gynecol Obstet Biol Reprod"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"S109","DOI":"10.1016\/j.placenta.2010.12.013","article-title":"Review: Oxygen and trophoblast biology\u2013a source of controversy","volume":"32","author":"MG Tuuli","year":"2011","journal-title":"Placenta"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/cyto.a.20006","article-title":"Telomere length assessment in tissue sections by quantitative FISH: image analysis algorithms","volume":"58","author":"JN O\u2019Sullivan","year":"2004","journal-title":"Cytometry A"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.freeradbiomed.2007.10.001","article-title":"Telomere length assessment: biomarker of chronic oxidative stress?","volume":"44","author":"JM Houben","year":"2008","journal-title":"Free Radic Biol Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1042\/CS20100385","article-title":"Healthy aging and disease: role for telomere biology?","volume":"120","author":"H Zhu","year":"2011","journal-title":"Clin Sci (Lond)"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1007\/s13238-011-1093-3","article-title":"Molecular regulation of telomerase activity in aging","volume":"2","author":"C Nicholls","year":"2011","journal-title":"Protein Cell"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0968-0004(02)02110-2","article-title":"Oxidative stress shortens telomeres","volume":"27","author":"T von Zglinicki","year":"2002","journal-title":"Trends Biochem Sci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e31136","DOI":"10.1371\/journal.pone.0031136","article-title":"Short fetal leukocyte telomere length and preterm prelabor rupture of the membranes","volume":"7","author":"R Menon","year":"2012","journal-title":"PLoS One"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.placenta.2009.03.005","article-title":"Fetal growth restriction is associated with accelerated telomere shortening and increased expression of cell senescence markers in the placenta","volume":"30","author":"P Davy","year":"2009","journal-title":"Placenta"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"381.e1","DOI":"10.1016\/j.ajog.2010.01.036","article-title":"Short telomeres may play a role in placental dysfunction in preeclampsia and intrauterine growth restriction","volume":"202","author":"T Biron-Shental","year":"2010","journal-title":"Am J Obstet Gynecol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.earlhumdev.2010.08.024","article-title":"TERC telomerase subunit gene copy number in placentas from pregnancies complicated with intrauterine growth restriction","volume":"87","author":"T Biron-Shental","year":"2011","journal-title":"Early Hum Dev"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1159\/000329714","article-title":"Telomeres in trisomy 21 amniocytes","volume":"135","author":"R Sukenik-Halevy","year":"2011","journal-title":"Cytogenet Genome Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"214365","DOI":"10.1155\/2011\/214365","article-title":"Maternal preeclampsia and neonatal outcomes","volume":"2011","author":"CH Backes","year":"2011","journal-title":"J Pregnancy"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/pd.2476","article-title":"A freehand ultrasonographically guided technique in transabdominal chorionic villus sampling in more than 24 000 consecutive cases","volume":"30","author":"R Saura","year":"2010","journal-title":"Prenat Diagn"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/pd.1970060406","article-title":"Estimation of the weight of chorionic villus samples obtained from first trimester pregnancies by transcervical aspiration","volume":"6","author":"M Newport","year":"1986","journal-title":"Prenat Diagn"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1002\/pd.2776","article-title":"Prenatal diagnosis on chorionic villi using molecular techniques should be performed from mesenchymal core rather than from direct villi","volume":"31","author":"J Toutain","year":"2011","journal-title":"Prenat Diagn"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ejogrb.2009.12.015","article-title":"First-trimester prenatal diagnosis performed on pregnant women with fetal ultrasound abnormalities: the reliability of interphase fluorescence in situ hybridization (FISH) on mesenchymal core for the main aneuploidies","volume":"149","author":"J Toutain","year":"2010","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1136\/jcp.2008.055236","article-title":"The placenta in pre-eclampsia and intrauterine growth restriction","volume":"61","author":"DJ Roberts","year":"2008","journal-title":"J Clin Pathol"},{"key":"ref27","first-page":"675","article-title":"Advantages and limitations of chorionic villous sampling","volume":"193","author":"D Carles","year":"2009","journal-title":"Bull Acad Natl Med"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ejogrb.2010.05.006","article-title":"Morphological characteristics of placentas associated with idiopathic intrauterine growth retardation: a clinicopathologic study","volume":"152","author":"SZ Tomas","year":"2010","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ejogrb.2010.11.017","article-title":"Placental pathology in fetal growth restriction","volume":"155","author":"N Vedmedovska","year":"2011","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1002\/pd.2631","article-title":"Confined placental mosaicism and pregnancy outcome: a distinction needs to be made between types 2 and 3","volume":"30","author":"J Toutain","year":"2010","journal-title":"Prenat Diagn"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1002\/gcc.20469","article-title":"Common chromosomal abnormalities in mycosis fungoides transformation","volume":"46","author":"M Prochazkova","year":"2007","journal-title":"Genes Chromosomes Cancer"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/30.10.e47","article-title":"Telomere measurement by quantitative PCR","volume":"30","author":"RM Cawthon","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1093\/bioinformatics\/btg157","article-title":"Q-Gene: processing quantitative real-time RT-PCR data","volume":"19","author":"P Simon","year":"2003","journal-title":"Bioinformatics"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/pd.578","article-title":"Feasibility, accuracy and safety of chorionic villus sampling: a report of 10741 cases","volume":"23","author":"JL Brun","year":"2003","journal-title":"Prenat Diagn"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"e134","DOI":"10.1093\/nar\/gkr634","article-title":"Impartial comparative analysis of measurement of leukocyte telomere length\/DNA content by Southern blots and qPCR","volume":"39","author":"A Aviv","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1053\/plac.1998.0386","article-title":"Expression of telomerase subunits and localization of telomerase activation in hydatidiform mole","volume":"20","author":"H Nishi","year":"1999","journal-title":"Placenta"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/00016340500317096","article-title":"Expression of human telomerase reverse transcriptase and correlation with telomerase activity in placentas with and without intrauterine growth retardation","volume":"85","author":"T Izutsu","year":"2006","journal-title":"Acta Obstet Gynecol Scand"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0054013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T23:25:02Z","timestamp":1539991502000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0054013"}},"subtitle":[],"editor":[{"given":"Xiuhcun (Cindy)","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,1,11]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,1,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0054013","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,11]]}}}