{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:55:36Z","timestamp":1790430936140,"version":"4.1.0"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T00:00:00Z","timestamp":1357776000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0054029","type":"journal-article","created":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T22:11:11Z","timestamp":1357855871000},"page":"e54029","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":59,"title":["Prognostic Significance of B-Cells and pSTAT3 in Patients with Ovarian Cancer"],"prefix":"10.1371","volume":"8","author":[{"given":"Chunmei","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heehyoung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Jove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiehui","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Forman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanh H.","family":"Dellinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Wakabayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumanta","family":"Pal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,1,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1056\/NEJMoa020177","article-title":"Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer","volume":"348","author":"L Zhang","year":"2003","journal-title":"New England Journal of Medicine"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.ygyno.2011.09.039","article-title":"Prognostic significance of tumor-infiltrating T cells in ovarian cancer: a meta-analysis","volume":"124","author":"WT Hwang","year":"2012","journal-title":"Gynecol Oncol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1002\/cncr.24317","article-title":"Intraepithelial T cells and tumor proliferation: impact on the benefit from surgical cytoreduction in advanced serous ovarian cancer","volume":"115","author":"SF Adams","year":"2009","journal-title":"Cancer"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"7667","DOI":"10.1158\/1078-0432.CCR-08-0479","article-title":"Increased HLA-DMB expression in the tumor epithelium is associated with increased CTL infiltration and improved prognosis in advanced-stage serous ovarian cancer","volume":"14","author":"MJ Callahan","year":"2008","journal-title":"Clin Cancer Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/modpathol.2008.191","article-title":"Intraepithelial T cells and prognosis in ovarian carcinoma: novel associations with stage, tumor type, and BRCA1 loss","volume":"22","author":"B Clarke","year":"2009","journal-title":"Mod Pathol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.1073\/pnas.0611533104","article-title":"Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer","volume":"104","author":"J Hamanishi","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"3372","DOI":"10.1158\/1078-0432.CCR-07-4433","article-title":"HLA class I antigen processing machinery component expression and intratumoral T-Cell infiltrate as independent prognostic markers in ovarian carcinoma","volume":"14","author":"LY Han","year":"2008","journal-title":"Clin Cancer Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s00262-008-0583-5","article-title":"Prognostic significance of tumor-infiltrating T-lymphocytes in primary and metastatic lesions of advanced stage ovarian cancer","volume":"58","author":"N Leffers","year":"2009","journal-title":"Cancer Immunol Immunother"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"18538","DOI":"10.1073\/pnas.0509182102","article-title":"Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+\/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer","volume":"102","author":"E Sato","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1038\/sj.bjc.6605274","article-title":"Intraepithelial CD8-positive T lymphocytes predict survival for patients with serous stage III ovarian carcinomas: relevance of clonal selection of T lymphocytes","volume":"101","author":"M Stumpf","year":"2009","journal-title":"Br J Cancer"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.ygyno.2007.10.016","article-title":"Prognostic significance of CD3+ tumor-infiltrating lymphocytes in ovarian carcinoma","volume":"108","author":"M Tomsova","year":"2008","journal-title":"Gynecol Oncol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.ygyno.2009.11.020","article-title":"Ovarian cancer tumor infiltrating T-regulatory (T(reg)) cells are associated with a metastatic phenotype","volume":"116","author":"JC Barnett","year":"2010","journal-title":"Gynecol Oncol"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Fialova A, Partlova S, Sojka L, Hromadkova H, Brtnicky T, <etal>et al<\/etal>.. (2012) Dynamics of T-cell infiltration during the course of ovarian cancer: The gradual shift from a Th17 effector cell response to a predominant infiltration by regulatory T-cells. Int J Cancer.","DOI":"10.1002\/ijc.27759"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4977","DOI":"10.4049\/jimmunol.1001323","article-title":"CD20+ B Cells: The Other Tumor-Infiltrating Lymphocytes","volume":"185","author":"BH Nelson","year":"2010","journal-title":"The Journal of Immunology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/ijc.21177","article-title":"Increased rejection of primary tumors in mice lacking B cells: inhibition of anti-tumor CTL and TH1 cytokine responses by B cells","volume":"117","author":"S Shah","year":"2005","journal-title":"Int J Cancer"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/PL00006672","article-title":"B lymphocyte pathology in human colorectal cancer. Experimental and clinical therapeutic effects of partial B cell depletion","volume":"48","author":"E Barbera-Guillem","year":"2000","journal-title":"Cancer Immunol Immunother"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nm0598-627","article-title":"B cells inhibit induction of T cell-dependent tumor immunity","volume":"4","author":"Z Qin","year":"1998","journal-title":"Nat Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e6412","DOI":"10.1371\/journal.pone.0006412","article-title":"Systematic Analysis of Immune Infiltrates in High-Grade Serous Ovarian Cancer Reveals CD20, FoxP3 and TIA-1 as Positive Prognostic Factors","volume":"4","author":"K Milne","year":"2009","journal-title":"PLoS ONE"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1038\/nm1325","article-title":"Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity","volume":"11","author":"M Kortylewski","year":"2005","journal-title":"Nat Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nm976","article-title":"Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells","volume":"10","author":"T Wang","year":"2004","journal-title":"Nat Med"},{"key":"ref21","first-page":"501","article-title":"Prolonged disease-free period in patients with advanced epithelial ovarian cancer after adoptive transfer of tumor-infiltrating lymphocytes","volume":"1","author":"K Fujita","year":"1995","journal-title":"Clin Cancer Res"},{"key":"ref22","first-page":"190","article-title":"Immunomodulation in patients with epithelial ovarian cancer after adoptive transfer of tumor-infiltrating lymphocytes","volume":"54","author":"H Ikarashi","year":"1994","journal-title":"Cancer Res"},{"key":"ref23","first-page":"1934","article-title":"Use of adoptive transfer of tumor-infiltrating lymphocytes alone or in combination with cisplatin-containing chemotherapy in patients with epithelial ovarian cancer","volume":"51","author":"Y Aoki","year":"1991","journal-title":"Cancer Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.1172\/JCI35213","article-title":"Stat3 mediates myeloid cell-dependent tumor angiogenesis in mice","volume":"118","author":"M Kujawski","year":"2008","journal-title":"J Clin Invest"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1038\/nm1325","article-title":"Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity","volume":"11","author":"M Kortylewski","year":"2005","journal-title":"Nat Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/nbt.1564","article-title":"In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses","volume":"27","author":"M Kortylewski","year":"2009","journal-title":"Nat Biotechnol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1056\/NEJMoa052985","article-title":"Intraperitoneal cisplatin and paclitaxel in ovarian cancer","volume":"354","author":"DK Armstrong","year":"2006","journal-title":"N Engl J Med"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.ccr.2009.10.015","article-title":"The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors","volume":"16","author":"M Hedvat","year":"2009","journal-title":"Cancer Cell"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1200\/JCO.2010.32.8021","article-title":"Safety and efficacy of TG101348, a selective JAK2 inhibitor, in myelofibrosis","volume":"29","author":"A Pardanani","year":"2011","journal-title":"J Clin Oncol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e6412","DOI":"10.1371\/journal.pone.0006412","article-title":"Systematic analysis of immune infiltrates in high-grade serous ovarian cancer reveals CD20, FoxP3 and TIA-1 as positive prognostic factors","volume":"4","author":"K Milne","year":"2009","journal-title":"PLoS One"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0140-6736(10)61268-8","article-title":"Early versus delayed treatment of relapsed ovarian cancer (MRC OV05\/EORTC 55955): a randomised trial","volume":"376","author":"GJ Rustin","year":"2010","journal-title":"Lancet"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ejca.2009.10.003","article-title":"Autoantibody profiling to identify biomarkers of key pathogenic pathways in mucinous ovarian cancer","volume":"46","author":"L Tang","year":"2010","journal-title":"Eur J Cancer"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0140-6736(10)61268-8","article-title":"Early versus delayed treatment of relapsed ovarian cancer (MRC OV05\/EORTC 55955): a randomised trial","volume":"376","author":"GJS Rustin","year":"2010","journal-title":"The Lancet"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0054029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T01:48:35Z","timestamp":1588988915000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0054029"}},"subtitle":[],"editor":[{"given":"Goli","family":"Samimi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,1,10]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,1,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0054029","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,10]]}}}