{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:54:46Z","timestamp":1787061286089,"version":"build-2736575974"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T00:00:00Z","timestamp":1357776000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0054087","type":"journal-article","created":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T17:12:27Z","timestamp":1357837947000},"page":"e54087","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":50,"title":["Monomer DJ-1 and Its N-Terminal Sequence Are Necessary for Mitochondrial Localization of DJ-1 Mutants"],"prefix":"10.1371","volume":"8","author":[{"given":"Chinatsu","family":"Maita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Maita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanae M. M.","family":"Iguchi-Ariga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyoshi","family":"Ariga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,1,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1006\/bbrc.1997.6132","article-title":"DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras","volume":"231","author":"D Nagakubo","year":"1997","journal-title":"Biochem Biophys Res Commum"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1126\/science.1077209","article-title":"Mutations in the DJ-1 gene associated with autosomal recessive early-onset Parkinsonism","volume":"299","author":"V Bonifati","year":"2003","journal-title":"Science"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"9103","DOI":"10.1073\/pnas.0402959101","article-title":"The Parkinson\u2019s disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization","volume":"101","author":"RM Canet-Aviles","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1093\/hmg\/ddi211","article-title":"Mitochondrial localization of the Parkinson\u2019s disease related protein DJ-1: implications for pathogenesis","volume":"14","author":"L Zhang","year":"2005","journal-title":"Hum Mol Genet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/sj.cdd.4401704","article-title":"Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities","volume":"13","author":"Y Shinbo","year":"2006","journal-title":"Cell Death Diff"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"37556","DOI":"10.1074\/jbc.M101730200","article-title":"DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx to the receptor","volume":"276","author":"K Takahashi","year":"2001","journal-title":"J Biol Chem"},{"key":"ref7","first-page":"247","article-title":"DJBP: A novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex","volume":"1","author":"T Niki","year":"2003","journal-title":"Mol Cancer Res"},{"key":"ref8","first-page":"641","article-title":"DJ-1 restores p53 transcription activity inhibited by Topors\/p53BP3","volume":"26","author":"Y Shinbo","year":"2005","journal-title":"Int J Oncol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"20940","DOI":"10.1074\/jbc.M601935200","article-title":"DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factor","volume":"281","author":"N Zhong","year":"2006","journal-title":"J Biol Chem"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"15091","DOI":"10.1073\/pnas.0607260103","article-title":"DJ-1, a cancer- and Parkinson\u2019s disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2","volume":"103","author":"CM Clements","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"4630","DOI":"10.1158\/0008-5472.CAN-06-4556","article-title":"DJ-1 binds androgen receptor directly and mediates its activity in hormonally treated prostate cancer cells","volume":"67","author":"JE Tillman","year":"2007","journal-title":"Cancer Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"28832","DOI":"10.1074\/jbc.M109.019950","article-title":"Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1","volume":"284","author":"S Ishikawa","year":"2009","journal-title":"J Biol Chem"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"4022","DOI":"10.1074\/jbc.M707176200","article-title":"DJ-1 decreases bax expression through repressing p53 transcriptional activity","volume":"283","author":"J Fan","year":"2008","journal-title":"J Biol Chem"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/hmg\/ddi134","article-title":"The Parkinson\u2019s disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis","volume":"14","author":"J Xu","year":"2005","journal-title":"Hum Mol Genet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/sj.embor.7400074","article-title":"DJ-1 has a role in antioxidative stress to prevent cell death","volume":"5","author":"T Taira","year":"2004","journal-title":"EMBO Rep"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.bbrc.2004.03.110","article-title":"Cysteine-106 of DJ-1 is the most sensitive cysteine residue to hydrogen peroxide-mediated oxidation in vivo in human umbilical vein endothelial cells","volume":"317","author":"T Kinumi","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e327","DOI":"10.1371\/journal.pbio.0020327","article-title":"Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: An ES derived cell model of primary Parkinsonism","volume":"2","author":"C Martinat","year":"2004","journal-title":"PLoS Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.nbd.2006.06.004","article-title":"PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson\u2019s disease rat model","volume":"24","author":"M Inden","year":"2006","journal-title":"Neurobiol Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"36","DOI":"10.4161\/oxim.2.1.7985","article-title":"Oxidative stress induction of DJ-1 protein in reactive astrocytes scavenges free radicals and reduces cell injury","volume":"2","author":"T Yanagida","year":"2009","journal-title":"Oxid Med Cell Longev"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e362","DOI":"10.1371\/journal.pbio.0020362","article-title":"DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation","volume":"2","author":"S Shendelman","year":"2004","journal-title":"PLoS Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.jmb.2005.12.030","article-title":"The oxidation state of DJ-1 regulates its chaperone activity toward \u03b1-synuclein","volume":"356","author":"W Zhou","year":"2006","journal-title":"J Mol Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"8506","DOI":"10.1074\/jbc.M311017200","article-title":"Familial Parkinson\u2019s disease-associated L166P mutation disrupts DJ-1 protein folding and function","volume":"279","author":"JA Olzmann","year":"2004","journal-title":"J Biol Chem"},{"key":"ref23","first-page":"885","article-title":"DJ-1 degrades transthyretin and an inactive form of DJ-1 is secreted in familial amyloidotic polyneuropathy","volume":"19","author":"S Koide-Yoshida","year":"2007","journal-title":"Int J Mol Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1093\/hmg\/ddq113","article-title":"Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage","volume":"19","author":"J Chen","year":"2010","journal-title":"Hum Mol Genet"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/toxsci\/kfi278","article-title":"Induction of reactive oxygen species by bisphenol A and abrogation of bisphenol A-induced cell injury by DJ-1","volume":"88","author":"H Ooe","year":"2005","journal-title":"Toxicol Sci"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1080\/10715760500260348","article-title":"Association of DJ-1 with chaperones and enhanced association and colocalization with mitochondrial Hsp70 by oxidative stress","volume":"39","author":"HM Li","year":"2005","journal-title":"Free Radic Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/jnr.21831","article-title":"Mitochondrial localization of DJ-1 leads to enhanced neuroprotection","volume":"87","author":"E Junn","year":"2009","journal-title":"J Neurosci Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.bbrc.2009.10.025","article-title":"DJ-1 binds to mitochondrial complex I and maintains its activity","volume":"390","author":"T Hayashi","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e32629","DOI":"10.1371\/journal.pone.0032629","article-title":"DJ-1 null dopaminergic neuronal cells exhibit defects in mitochondrial function and structure: involvement of mitochondrial complex I assembly","volume":"7","author":"JY Heo","year":"2012","journal-title":"PLoS One"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"35308","DOI":"10.1074\/jbc.M110.207134","article-title":"Oxidized DJ-1 interacts with the mitochondrial protein BCL-XL","volume":"286","author":"H Ren","year":"2011","journal-title":"J Biol Chem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1093\/hmg\/ddq430","article-title":"DJ-1 acts in parallel to the PINK1\/parkin pathway to control mitochondrial function and autophagy","volume":"20","author":"KJ Thomas","year":"2011","journal-title":"Hum Mol Genet"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.1093\/hmg\/ddq288","article-title":"Loss of the Parkinson\u2019s disease-linked gene DJ-1 perturbs mitochondrial dynamics","volume":"19","author":"I Irrcher","year":"2010","journal-title":"Hum Mol Genet"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"9747","DOI":"10.1073\/pnas.0911175107","article-title":"DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function","volume":"107","author":"LY Hao","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"e9367","DOI":"10.1371\/journal.pone.0009367","article-title":"Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson\u2019s disease-associated protein DJ-1","volume":"5","author":"G Krebiehl","year":"2010","journal-title":"PLoS One"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1111\/j.1471-4159.2012.07734.x","article-title":"Parkinson\u2019s disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction","volume":"121","author":"X Wang","year":"2012","journal-title":"J Neurochem"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1093\/brain\/awh054","article-title":"The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson\u2019s disease","volume":"127","author":"R Bandopadhyay","year":"2004","journal-title":"Brain"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"10816","DOI":"10.1074\/jbc.M509079200","article-title":"Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases","volume":"281","author":"J Choi","year":"2006","journal-title":"J Biol Chem"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1016\/0006-291X(89)91141-8","article-title":"Deficiencies in complex I subunits of the respiratory chain in Parkinson\u2019s disease","volume":"163","author":"Y Mizuno","year":"1989","journal-title":"Biochem Biophys Res Commun"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1002\/ana.410260606","article-title":"Abnormalities of the electron transport chain in idiopathic Parkinson\u2019s disease","volume":"26","author":"WD Parker Jr","year":"1989","journal-title":"Ann Neurol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/j.1471-4159.1990.tb02325.x","article-title":"Mitochondrial complex I deficiency in Parkinson\u2019s disease","volume":"54","author":"AH Schapira","year":"1990","journal-title":"J Neurochem"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0197-0186(01)00124-3","article-title":"Mitochondrial involvement in Parkinson\u2019s disease","volume":"40","author":"M Orth","year":"2002","journal-title":"Neurochem Int"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1046\/j.1471-4159.1998.71030893.x","article-title":"Neurochemical and neurogenetic correlates of Parkinson\u2019s disease","volume":"71","author":"Y Mizuno","year":"1998","journal-title":"J Neurochem"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"e40501","DOI":"10.1371\/journal.pone.0040501","article-title":"Loss of DJ-1 does not affect mitochondrial respiration but increases ROS production and mitochondrial permeability transition pore opening","volume":"7","author":"E Giaime","year":"2012","journal-title":"PLoS One"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1016\/j.febslet.2010.08.010","article-title":"DJ-1, an oncogene and causative gene for familial Parkinson\u2019s disease, is essential for SV40 transformation in mouse fibroblasts through up-regulation of c-Myc","volume":"584","author":"YC Kim","year":"2010","journal-title":"FEBS Lett"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"6476","DOI":"10.1074\/jbc.M806599200","article-title":"Formation of a stabilized cysteine sulfinic acid is critical for the mitochondrial function of the parkinsonism protein DJ-1","volume":"284","author":"J Blackinton","year":"2009","journal-title":"J Biol Chem"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"7430","DOI":"10.1021\/bi800282d","article-title":"Cysteine pKa depression by a protonated glutamic acid in human DJ-1","volume":"47","author":"AC Witt","year":"2008","journal-title":"Biochemistry"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"31380","DOI":"10.1074\/jbc.M305878200","article-title":"The crystal structure of DJ-1, a protein related to male fertility and Parkinson\u2019s disease","volume":"278","author":"K Honbou","year":"2003","journal-title":"J Biol Chem"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"5776","DOI":"10.1021\/bi7001778","article-title":"Destabilization of DJ-1 by familial substitution and oxidative modifications: implications for Parkinson\u2019s disease","volume":"46","author":"JD Hulleman","year":"2007","journal-title":"Biochemistry"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.bbrc.2004.05.187","article-title":"Reduced anti-oxidative stress activities of DJ-1 mutants found in Parkinson\u2019s disease patients","volume":"320","author":"K Takahashi-Niki","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"531","DOI":"10.4161\/auto.7.5.14684","article-title":"DJ-1 regulation of mitochondrial function and autophagy through oxidative stress","volume":"7","author":"MK McCoy","year":"2011","journal-title":"Autophagy"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0054087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T10:16:58Z","timestamp":1589019418000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0054087"}},"subtitle":[],"editor":[{"given":"Ross Frederick","family":"Waller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,1,10]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,1,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0054087","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,10]]}}}