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Geneva, Switzerland: WHO."},{"key":"ref33","unstructured":"(2007) Quantum II and Quantum X Bioelectrical Impedance Analyzers."},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1093\/ajcn\/82.5.1074","article-title":"Appetite assessment: simple appetite questionnaire predicts weight loss in community-dwelling adults and nursing home residents","volume":"82","author":"MM Wilson","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.clnu.2008.02.002","article-title":"Screening malnutrition in hospital outpatients. 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