{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T07:55:17Z","timestamp":1780732517574,"version":"3.54.1"},"reference-count":22,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2013,1,25]],"date-time":"2013-01-25T00:00:00Z","timestamp":1359072000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0054772","type":"journal-article","created":{"date-parts":[[2013,1,25]],"date-time":"2013-01-25T17:18:44Z","timestamp":1359134324000},"page":"e54772","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":37,"title":["Analysis of RAD51D in Ovarian Cancer Patients and Families with a History of Ovarian or Breast Cancer"],"prefix":"10.1371","volume":"8","author":[{"given":"Ella R.","family":"Thompson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone M.","family":"Rowley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Sawyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"kConFab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana M.","family":"Eccles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison H.","family":"Trainer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian G.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,1,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"3296","DOI":"10.1101\/gad.947001","article-title":"Identification and purification of two distinct complexes containing the five RAD51 paralogs","volume":"15","author":"J-Y Masson","year":"2001","journal-title":"Genes & Development"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1158\/0008-5472.CAN-04-2079","article-title":"Extensive Chromosomal Instability in Rad51d-Deficient Mouse Cells","volume":"65","author":"PG Smiraldo","year":"2005","journal-title":"Cancer Research"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/ng.893","article-title":"Germline mutations in RAD51D confer susceptibility to ovarian cancer","volume":"43","author":"C Loveday","year":"2011","journal-title":"Nat Genet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1038\/bjc.2012.87","article-title":"Mutation analysis of RAD51D in non-BRCA1\/2 ovarian and breast cancer families","volume":"106","author":"DJ Osher","year":"2012","journal-title":"Br J Cancer"},{"key":"ref5","article-title":"A Finnish founder mutation in RAD51D: analysis in breast, ovarian, prostate, and colorectal cancer","author":"LM Pelttari","year":"2012","journal-title":"J Med Genet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.ygyno.2011.01.020","article-title":"Frequencies of BRCA1 and BRCA2 mutations among 1,342 unselected patients with invasive ovarian cancer","volume":"121","author":"S Zhang","year":"2011","journal-title":"Gynecol Oncol"},{"key":"ref7","article-title":"BRCA Mutation Frequency and Patterns of Treatment Response in BRCA Mutation\u2013Positive Women With Ovarian Cancer: A Report From the Australian Ovarian Cancer Study Group","author":"K Alsop","year":"2012","journal-title":"Journal of Clinical Oncology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3278","DOI":"10.1093\/hmg\/ddr229","article-title":"RAD51C is a susceptibility gene for ovarian cancer","volume":"20","author":"LM Pelttari","year":"2011","journal-title":"Hum Mol Genet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/humu.21625","article-title":"Analysis of RAD51C Germline Mutations in High-Risk Breast and Ovarian Cancer Families and Ovarian Cancer Patients","volume":"33","author":"ER Thompson","year":"2011","journal-title":"Hum Mutat"},{"key":"ref10","first-page":"719","article-title":"Localization of an ovarian cancer tumor suppressor gene to a 0.5-cM region between D22S284 and CYP2D, on chromosome 22q","volume":"56","author":"EJ Bryan","year":"1996","journal-title":"Cancer Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"R12","DOI":"10.1186\/bcr1377","article-title":"Analysis of cancer risk and BRCA1 and BRCA2 mutation prevalence in the kConFab familial breast cancer resource","volume":"8","author":"GJ Mann","year":"2006","journal-title":"Breast Cancer Res"},{"key":"ref12","first-page":"211","article-title":"Transforming growth factor beta receptor 1 polyalanine polymorphism and exon 5 mutation analysis in breast and ovarian cancer","volume":"11","author":"SW Baxter","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1593\/neo.08718","article-title":"Mutation and methylation analysis of the chromodomain-helicase-DNA binding 5 gene in ovarian cancer","volume":"10","author":"KL Gorringe","year":"2008","journal-title":"Neoplasia"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nmeth0410-248","article-title":"A method and server for predicting damaging missense mutations","volume":"7","author":"IA Adzhubei","year":"2010","journal-title":"Nat Methods"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1002\/humu.21047","article-title":"Functional annotations improve the predictive score of human disease-related mutations in proteins","volume":"30","author":"R Calabrese","year":"2009","journal-title":"Hum Mutat"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1093\/bioinformatics\/btp528","article-title":"Automated inference of molecular mechanisms of disease from amino acid substitutions","volume":"25","author":"B Li","year":"2009","journal-title":"Bioinformatics"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.1093\/bioinformatics\/bti486","article-title":"PMUT: a web-based tool for the annotation of pathological mutations on proteins","volume":"21","author":"C Ferrer-Costa","year":"2005","journal-title":"Bioinformatics"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/nmeth0810-575","article-title":"MutationTaster evaluates disease-causing potential of sequence alterations","volume":"7","author":"JM Schwarz","year":"2010","journal-title":"Nat Methods"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1093\/nar\/gkp215","article-title":"Human Splicing Finder: an online bioinformatics tool to predict splicing signals","volume":"37","author":"FO Desmet","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.ygyno.2012.09.009","article-title":"Loss of function germline mutations in RAD51D in women with ovarian carcinoma","volume":"127","author":"A Wickramanyake","year":"2012","journal-title":"Gynecol Oncol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/nature09534","article-title":"A map of human genome variation from population-scale sequencing","volume":"467","year":"2010","journal-title":"Nature"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1126\/science.185.4154.862","article-title":"Amino acid difference formula to help explain protein evolution","volume":"185","author":"R Grantham","year":"1974","journal-title":"Science"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0054772","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T19:25:09Z","timestamp":1540322709000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0054772"}},"subtitle":[],"editor":[{"given":"Nathan A.","family":"Ellis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,1,25]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,1,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0054772","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,25]]}}}