{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T21:55:58Z","timestamp":1775858158939,"version":"3.50.1"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2013,1,28]],"date-time":"2013-01-28T00:00:00Z","timestamp":1359331200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0054773","type":"journal-article","created":{"date-parts":[[2013,1,28]],"date-time":"2013-01-28T19:41:50Z","timestamp":1359402110000},"page":"e54773","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["Effects of Nucleoside Analogue on Patients with Chronic Hepatitis B-Associated Liver Failure: Meta-Analysis"],"prefix":"10.1371","volume":"8","author":[{"given":"Feng","family":"Xie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiongjiong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changying","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Ying","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongxi","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiamei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,1,28]]},"reference":[{"key":"ref1","unstructured":"Hepatitis B: fact sheet N\u00b0204. Geneva: World Health Organization, July 2012. (Accessed September 13, 2004, at <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/mediacentre\/factsheets\/fs204\/en\/\" xlink:type=\"simple\">http:\/\/www.who.int\/mediacentre\/factsheets\/fs204\/en\/<\/ext-link>)."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s12072-008-9106-x","article-title":"Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL)","volume":"3","author":"SK Sarin","year":"2009","journal-title":"Hepatol Int"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1164\/rccm.200303-361UP","article-title":"Advances in critical care hepatology","volume":"168","author":"J Marrero","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1572-0241.2004.04032.x","article-title":"Management of decompensated HBV cirrhosis:lamivudine and beyond","volume":"99","author":"RJ Fontana","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jhep.2012.02.010","article-title":"EASL Clinical Practice Guidelines: Management of chronic hepatitis B virus infection","volume":"57","year":"2012","journal-title":"J Hepatol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/hep.23190","article-title":"Chronic hepatitis B: update 2009","volume":"50","author":"AS Lok","year":"2009","journal-title":"Hepatology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/0016-5085(92)91198-D","article-title":"Hepatitis B-related end-stage liver disease","volume":"103","author":"JE Everhart","year":"1992","journal-title":"Gastroenterology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1056\/NEJMoa033364","article-title":"Lamivudine for patients with chronic hepatitis B and advanced liver disease","volume":"351","author":"YF Liaw","year":"2004","journal-title":"N Engl J Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/j.1440-1746.2009.06089.x","article-title":"Influential factors of prognosis in lamivudine treatment for patients with acute-on-chronic hepatitis B liver failure","volume":"25","author":"LJ Sun","year":"2010","journal-title":"J Gastroenterol Hepatol"},{"key":"ref10","first-page":"1419","article-title":"Adefovir dipivoxil therapy for lamivudine-resistant hepatitis B in pre- and post-liver transplantation patients","volume":"38","author":"ER Schiff","year":"2003","journal-title":"Hepatology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jhep.2009.11.007","article-title":"Efficacy of entecavir in treatment-naive patients with hepatitis B virus-related decom-pensated cirrhosis","volume":"52","author":"JH Shim","year":"2010","journal-title":"J Hepatol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/hep.23952","article-title":"Tenofovir disoproxil fumarate (TDF), emtricitabine\/TDF, and entecavir in patients with decompensated chronic hepatitis B liver disease","volume":"53","author":"YF Liaw","year":"2011","journal-title":"Hepatology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1111\/j.1365-2893.2012.01600.x","article-title":"Randomized clinical trial: efficacy and safety of telbivudine and lamivudine in treatment-na\u00efve patients with HBV-related decompensated cirrhosis","volume":"19","author":"HLY Chan","year":"2012","journal-title":"J Viral Hepat"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1440-1746.2004.03534.x","article-title":"Lamivudine monotherapy for spontaneous severe acute exacerbation of chronic hepatitis B","volume":"20","author":"A Tsubota","year":"2005","journal-title":"J Gastroenterol Hepatol"},{"key":"ref15","first-page":"261","article-title":"Short-term entecavir therapy of chronic severe hepatitis B","volume":"8","author":"J Chen","year":"2009","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/S0168-8278(02)00419-1","article-title":"The effect of lamivudine therapy in hepatic decompensation during acute exacerbation of chronic hepatitis B","volume":"38","author":"RN Chien","year":"2003","journal-title":"J Hepatol"},{"key":"ref17","first-page":"324","article-title":"National viral hepatitis control programme","volume":"6","year":"2000","journal-title":"Chin J Hepatol"},{"key":"ref18","first-page":"643","article-title":"Diagnostic and treatment guidelines for liver failure","volume":"14","year":"2006","journal-title":"Chin J Hepatol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0197-2456(95)00134-4","article-title":"Assessing the quality of reports of randomized clinical trials: is blinding necessary?","volume":"17","author":"AR Jadad","year":"1996","journal-title":"Control Clin Trials"},{"key":"ref20","unstructured":"Deeks JJ, Higgins JPT, Altman DG (2008) Chapter 9: Analyzing data and undertaking meta-analyses. In: Higgins JPT, Green S, editors. Cochrane handbook for systematic reviews of interventions version 5.0.0 (updated February 2008). The Cochrane Collaboration. Available from <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.cochrane-handbook.org\" xlink:type=\"simple\">http:\/\/www.cochrane-handbook.org<\/ext-link>."},{"key":"ref21","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"JP Higgins","year":"2003","journal-title":"British Medical Journal"},{"key":"ref22","first-page":"331","article-title":"Investigation of the liver failure patients infected with hepatitis B virus treated with entecavir","volume":"25","author":"X Zhong","year":"2009","journal-title":"Chin J Clini Hepatol"},{"key":"ref23","first-page":"758","article-title":"Antiviral effect of entecavir in patients with severe chronic hepatitis B","volume":"25","author":"R Zhao","year":"2009","journal-title":"Chin J Public Health"},{"key":"ref24","first-page":"1100","article-title":"Baraclude for treatment of 55 patients with chronic severe hepatitis B","volume":"15","author":"H Yang","year":"2008","journal-title":"J Practical Medical Technology"},{"key":"ref25","first-page":"289","article-title":"Clinieal Observation of entecavir in Treatment of patients with chronic severe hepatitis B","volume":"16","author":"Y Guo","year":"2008","journal-title":"Chin J Prev Contr Chron Non-commun Dis"},{"key":"ref26","first-page":"188","article-title":"Observation on the eficiency and safety of entecavir on chronic hepatitis B","volume":"25","author":"Z Han","year":"2009","journal-title":"Chin J Clini Hepatol"},{"key":"ref27","first-page":"214","article-title":"Observation of short-term therapeutic effect of lamivudine on patients with chronic Severe hepatitis B","volume":"7","author":"J Xun","year":"2004","journal-title":"J Clini Hepatol"},{"key":"ref28","first-page":"313","article-title":"The effect of lamivudine in the treatment of chronic fulminant hepatitis B","volume":"20","author":"J Guo","year":"2003","journal-title":"China Journal of Modern Applied Pharmacy"},{"key":"ref29","first-page":"190","article-title":"Short-term observation of telbivudine in treatment of chronic severe hepatitis B","volume":"25","author":"S Qiu","year":"2009","journal-title":"Chin J Clini Hepatol"},{"key":"ref30","first-page":"55","article-title":"Analysis of therapeutic effect of telbivudine on severe chronic hepatitis B","volume":"12","author":"R Qin","year":"2012","journal-title":"Modern Hospital"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1002\/hep.24109","article-title":"Tenofovir improves the outcome in patients with spontaneous reactivation of hepatitis B presenting as acute-on-chronic liver failure","volume":"53(3)","author":"H Garg","year":"2011","journal-title":"Hepatology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1007\/s10620-010-1257-7","article-title":"Nucleoside analogue can improve the long-term prognosis of patients with hepatitis B virus infection-associated acute on chronic liver failure","volume":"55","author":"YL Cui","year":"2010","journal-title":"Dig Dis Sci"},{"key":"ref33","first-page":"152","article-title":"Living donor liver transplantation for fulminant hepatic failure","volume":"70","author":"S Uemoto","year":"2000","journal-title":"Transplantation"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1053\/gast.2002.35352","article-title":"Determinants of early mortality in patients with decompensated chronic hepatitis B treated with antiviral therapy","volume":"123","author":"RJ Fontana","year":"2002","journal-title":"Gastroenterology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1056\/NEJMoa042957","article-title":"Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B","volume":"352","author":"SJ Hadziyannis","year":"2005","journal-title":"N Engl J Med"},{"key":"ref36","first-page":"410","article-title":"The impact of HBeAg positivity\/negativity and HBV-DNA loads on the prognosis of chronic severe hepatitis B","volume":"14","author":"QF Sun","year":"2006","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0168-8278(88)80475-6","article-title":"Transplantation of liver in adults and children with fulminant liver failure","volume":"7","author":"C Vickers","year":"1988","journal-title":"J Hepatol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/hep.24361","article-title":"Efficacy and safety of entecavir versus adefovir in chronic hepatitis B patients with hepatic decompensation: a randomized, open-label study","volume":"54","author":"YF Liaw","year":"2011","journal-title":"Hepatology"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0054773","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T09:02:11Z","timestamp":1540198931000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0054773"}},"subtitle":[],"editor":[{"given":"Sang-Hoon","family":"Ahn","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,1,28]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,1,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0054773","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717985118.793472624","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,28]]}}}