{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T14:07:07Z","timestamp":1745503627564},"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T00:00:00Z","timestamp":1358985600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0054901","type":"journal-article","created":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T22:30:48Z","timestamp":1359066648000},"page":"e54901","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Crosstalk between Thyroid Hormone Receptor and Liver X Receptor in the Regulation of Selective Alzheimer\u2019s Disease Indicator-1 Gene Expression"],"prefix":"10.1371","volume":"8","author":[{"given":"Emi","family":"Ishida","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koshi","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichi","family":"Okada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsurou","family":"Satoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanobu","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatomo","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,1,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0140-6736(06)69113-7","article-title":"Alzheimer\u2019s disease","volume":"368","author":"K Blennow","year":"2006","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/nrn3012","article-title":"Linking lipids to Alzheimer\u2019s disease: cholesterol and beyond","volume":"12","author":"G Di Paolo","year":"2011","journal-title":"Nature reviews Neuroscience"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2008.03.006","article-title":"Multigenic control of thyroid hormone functions in the nervous system","volume":"287","author":"J Nunez","year":"2008","journal-title":"Molecular and cellular endocrinology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1023\/A:1021828218454","article-title":"Thyroid hormone actions on neural cells","volume":"22","author":"S Konig","year":"2002","journal-title":"Cellular and molecular neurobiology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1507\/endocrj.EJ11-0114","article-title":"Crosstalk of thyroid hormone receptor and liver X receptor in lipid metabolism and beyond","volume":"58","author":"K Hashimoto","year":"2011","journal-title":"Endocrine journal"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S1043-2760(02)00043-7","article-title":"Thyroid hormone receptors: lessons from knockout and knock-in mutant mice","volume":"14","author":"F Flamant","year":"2003","journal-title":"Trends in endocrinology and metabolism"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1089\/105072503770867228","article-title":"The thyroid hormone receptor beta gene: structure and functions in the brain and sensory systems","volume":"13","author":"I Jones","year":"2003","journal-title":"Thyroid"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1002\/j.1460-2075.1990.tb08270.x","article-title":"Contrasting developmental and tissue-specific expression of alpha and beta thyroid hormone receptor genes","volume":"9","author":"D Forrest","year":"1990","journal-title":"The EMBO journal"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1210\/mend-5-9-1339","article-title":"Independent expression of the alpha and beta c-erbA genes in developing rat brain","volume":"5","author":"B Mellstrom","year":"1991","journal-title":"Molecular endocrinology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1523\/JNEUROSCI.12-06-02288.1992","article-title":"Spatial and temporal expression of alpha- and beta-thyroid hormone receptor mRNAs, including the beta 2-subtype, in the developing mammalian nervous system","volume":"12","author":"DJ Bradley","year":"1992","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1001\/archinte.158.13.1413","article-title":"Neurocognitive aspects of hypothyroidism","volume":"158","author":"AT Dugbartey","year":"1998","journal-title":"Archives of internal medicine"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s11920-003-0073-6","article-title":"Cognitive and neuropsychiatric aspects of subclinical hypothyroidism: significance in the elderly","volume":"5","author":"JD Davis","year":"2003","journal-title":"Current psychiatry reports"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"3998","DOI":"10.1073\/pnas.051454698","article-title":"An unliganded thyroid hormone receptor causes severe neurological dysfunction","volume":"98","author":"K Hashimoto","year":"2001","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.neuropharm.2009.12.020","article-title":"Thyroid hormone prevents cognitive deficit in a mouse model of Alzheimer\u2019s disease","volume":"58","author":"AL Fu","year":"2010","journal-title":"Neuropharmacology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/hipo.20476","article-title":"Levothyroxin restores hypothyroidism-induced impairment of hippocampus-dependent learning and memory: Behavioral, electrophysiological, and molecular studies","volume":"19","author":"KH Alzoubi","year":"2009","journal-title":"Hippocampus"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1601-183X.2007.00321.x","article-title":"Thyroid hormones, learning and memory","volume":"6","author":"M Rivas","year":"2007","journal-title":"Genes, brain, and behavior"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1093\/ije\/20.Supplement_2.S36","article-title":"Medical history and the risk of Alzheimer\u2019s disease: a collaborative re-analysis of case-control studies. EURODEM Risk Factors Research Group","volume":"20","author":"MM Breteler","year":"1991","journal-title":"International journal of epidemiology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/0006-3223(95)00489-0","article-title":"Association between dementia and elevated TSH: a community-based study","volume":"40","author":"M Ganguli","year":"1996","journal-title":"Biological psychiatry"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1046\/j.1365-2265.2000.01146.x","article-title":"Subclinical hyperthyroidism and the risk of dementia. The Rotterdam study","volume":"53","author":"S Kalmijn","year":"2000","journal-title":"Clinical endocrinology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1210\/jc.2006-0449","article-title":"Thyroid hormones, dementia, and atrophy of the medial temporal lobe","volume":"91","author":"FJ de Jong","year":"2006","journal-title":"The Journal of clinical endocrinology and metabolism"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"7345","DOI":"10.1523\/JNEUROSCI.20-19-07345.2000","article-title":"The human DIMINUTO\/DWARF1 homolog seladin-1 confers resistance to Alzheimer\u2019s disease-associated neurodegeneration and oxidative stress","volume":"20","author":"I Greeve","year":"2000","journal-title":"The Journal of neuroscience : the official journal of the Society for Neuroscience"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/sj.emboj.7600938","article-title":"The role of seladin-1\/DHCR24 in cholesterol biosynthesis, APP processing and Abeta generation in vivo","volume":"25","author":"A Crameri","year":"2006","journal-title":"The EMBO journal"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1128\/MCB.00584-07","article-title":"Prosurvival effect of DHCR24\/Seladin-1 in acute and chronic responses to oxidative stress","volume":"28","author":"K Kuehnle","year":"2008","journal-title":"Molecular and cellular biology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1086\/323473","article-title":"Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis","volume":"69","author":"HR Waterham","year":"2001","journal-title":"American journal of human genetics"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.bbalip.2010.03.011","article-title":"Brain cholesterol in normal and pathological aging","volume":"1801","author":"M Martin","year":"2010","journal-title":"Biochimica et biophysica acta"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1111\/j.1582-4934.2008.00216.x","article-title":"Seladin-1\/DHCR24 protects neuroblastoma cells against Abeta toxicity by increasing membrane cholesterol content","volume":"12","author":"C Cecchi","year":"2008","journal-title":"Journal of cellular and molecular medicine"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1677\/JOE-07-0324","article-title":"Thyroid hormones promote cell differentiation and up-regulate the expression of the seladin-1 gene in in vitro models of human neuronal precursors","volume":"197","author":"S Benvenuti","year":"2008","journal-title":"The Journal of endocrinology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"7025","DOI":"10.1128\/MCB.14.10.7025","article-title":"A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid\/thyroid hormone receptor subfamily","volume":"14","author":"R Apfel","year":"1994","journal-title":"Molecular and cellular biology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1124\/mol.62.6.1299","article-title":"Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue","volume":"62","author":"TM Stulnig","year":"2002","journal-title":"Molecular pharmacology"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1210\/mend.16.6.0835","article-title":"Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system","volume":"16","author":"KD Whitney","year":"2002","journal-title":"Molecular endocrinology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"4079","DOI":"10.1074\/jbc.M411420200","article-title":"The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease","volume":"280","author":"RP Koldamova","year":"2005","journal-title":"The Journal of biological chemistry"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.mcn.2007.01.011","article-title":"The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer\u2019s disease","volume":"34","author":"DR Riddell","year":"2007","journal-title":"Molecular and cellular neurosciences"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1111\/j.1471-4159.2006.03925.x","article-title":"The effects of ABCA1 on cholesterol efflux and Abeta levels in vitro and in vivo","volume":"98","author":"MP Burns","year":"2006","journal-title":"Journal of neurochemistry"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1124\/mol.108.048538","article-title":"The selective Alzheimer\u2019s disease indicator-1 gene (Seladin-1\/DHCR24) is a liver X receptor target gene","volume":"74","author":"Y Wang","year":"2008","journal-title":"Molecular pharmacology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S0165-6147(00)01859-9","article-title":"Comparing nuclear receptors in worms, flies and humans","volume":"22","author":"E Enmark","year":"2001","journal-title":"Trends in pharmacological sciences"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.mad.2004.05.005","article-title":"Convergence of lipid homeostasis through liver X and thyroid hormone receptors","volume":"125","author":"A Berkenstam","year":"2004","journal-title":"Mechanisms of ageing and development"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"4292","DOI":"10.1210\/en.2006-0116","article-title":"Mouse sterol response element binding protein-1c gene expression is negatively regulated by thyroid hormone","volume":"147","author":"K Hashimoto","year":"2006","journal-title":"Endocrinology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1210\/en.2009-0059","article-title":"Carbohydrate response element binding protein gene expression is positively regulated by thyroid hormone","volume":"150","author":"K Hashimoto","year":"2009","journal-title":"Endocrinology"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1074\/jbc.M005894200","article-title":"Thyroid hormone stimulates acetyl-coA carboxylase-alpha transcription in hepatocytes by modulating the composition of nuclear receptor complexes bound to a thyroid hormone response element","volume":"276","author":"Y Zhang","year":"2001","journal-title":"The Journal of biological chemistry"},{"key":"ref40","first-page":"1739","article-title":"Thyroid hormone receptor beta-deficient mice show complete loss of the normal cholesterol 7alpha-hydroxylase (CYP7A) response to thyroid hormone but display enhanced resistance to dietary cholesterol","volume":"14","author":"H Gullberg","year":"2000","journal-title":"Molecular endocrinology"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1074\/jbc.M507877200","article-title":"Cross-talk between thyroid hormone receptor and liver X receptor regulatory pathways is revealed in a thyroid hormone resistance mouse model","volume":"281","author":"K Hashimoto","year":"2006","journal-title":"The Journal of biological chemistry"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1021\/bi0301643","article-title":"Regulation of ATP-binding cassette transporter A1 transcription by thyroid hormone receptor","volume":"43","author":"J Huuskonen","year":"2004","journal-title":"Biochemistry"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"4667","DOI":"10.1210\/en.2007-0150","article-title":"Liver X receptor-alpha gene expression is positively regulated by thyroid hormone","volume":"148","author":"K Hashimoto","year":"2007","journal-title":"Endocrinology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.mce.2004.10.005","article-title":"Thyrotropin-releasing hormone (TRH) specific interaction between amino terminus of P-Lim and CREB binding protein (CBP)","volume":"229","author":"K Hashimoto","year":"2005","journal-title":"Molecular and cellular endocrinology"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"27919","DOI":"10.1074\/jbc.271.44.27919","article-title":"Negative regulation of the gene for the preprothyrotropin-releasing hormone from the mouse by thyroid hormone requires additional factors in conjunction with thyroid hormone receptors","volume":"271","author":"T Satoh","year":"1996","journal-title":"The Journal of biological chemistry"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"3963","DOI":"10.1080\/03610928908830135","article-title":"The 2-Sample T-Test Versus Satterthwaite Approximate F-Test","volume":"18","author":"BK Moser","year":"1989","journal-title":"Communications in Statistics-Theory and Methods"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1093\/beheco\/ark016","article-title":"The unequal variance t-test is an underused alternative to Student\u2019s t-test and the Mann-Whitney U test","volume":"17","author":"GD Ruxton","year":"2006","journal-title":"Behavioral Ecology"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"12305","DOI":"10.1073\/pnas.1006162107","article-title":"Liver X receptor beta and thyroid hormone receptor alpha in brain cortical layering","volume":"107","author":"XJ Tan","year":"2010","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1074\/jbc.M207264200","article-title":"Thyroid hormone receptor DNA binding is required for both positive and negative gene regulation","volume":"278","author":"N Shibusawa","year":"2003","journal-title":"The Journal of biological chemistry"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1210\/mend-5-3-327","article-title":"A homozygous deletion in the c-erbA beta thyroid hormone receptor gene in a patient with generalized thyroid hormone resistance: isolation and characterization of the mutant receptor","volume":"5","author":"SJ Usala","year":"1991","journal-title":"Molecular endocrinology"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1210\/mend.11.1.9867","article-title":"Isoform variable action among thyroid hormone receptor mutants provides insight into pituitary resistance to thyroid hormone","volume":"11","author":"JD Safer","year":"1997","journal-title":"Molecular endocrinology"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"32713","DOI":"10.1016\/S0021-9258(20)30048-X","article-title":"A novel C-terminal domain in the thyroid hormone receptor selectively mediates thyroid hormone inhibition","volume":"269","author":"TR Flynn","year":"1994","journal-title":"The Journal of biological chemistry"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1073\/pnas.94.1.248","article-title":"A natural transactivation mutation in the thyroid hormone beta receptor: impaired interaction with putative transcriptional mediators","volume":"94","author":"TN Collingwood","year":"1997","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.mce.2008.06.012","article-title":"Xenopus laevis as a model for studying thyroid hormone signalling: from development to metamorphosis","volume":"293","author":"G Morvan-Dubois","year":"2008","journal-title":"Molecular and cellular endocrinology"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0960-0760(02)00271-6","article-title":"Estrogen can protect neurons: modes of action","volume":"83","author":"C Behl","year":"2002","journal-title":"The Journal of steroid biochemistry and molecular biology"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1146\/annurev.physiol.66.032802.154945","article-title":"Estrogens in the nervous system: mechanisms and nonreproductive functions","volume":"66","author":"A Maggi","year":"2004","journal-title":"Annual review of physiology"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1210\/jc.2004-0066","article-title":"Estrogen and selective estrogen receptor modulators exert neuroprotective effects and stimulate the expression of selective Alzheimer\u2019s disease indicator-1, a recently discovered antiapoptotic gene, in human neuroblast long-term cell cultures","volume":"90","author":"S Benvenuti","year":"2005","journal-title":"The Journal of clinical endocrinology and metabolism"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"4256","DOI":"10.1210\/en.2007-1795","article-title":"Seladin-1 is a fundamental mediator of the neuroprotective effects of estrogen in human neuroblast long-term cell cultures","volume":"149","author":"P Luciani","year":"2008","journal-title":"Endocrinology"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1210\/me.2005-0101","article-title":"Thyroid hormone-regulated target genes have distinct patterns of coactivator recruitment and histone acetylation","volume":"20","author":"Y Liu","year":"2006","journal-title":"Molecular endocrinology"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/377454a0","article-title":"A transcriptional co-repressor that interacts with nuclear hormone receptors","volume":"377","author":"JD Chen","year":"1995","journal-title":"Nature"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/377397a0","article-title":"Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor","volume":"377","author":"AJ Horlein","year":"1995","journal-title":"Nature"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"19544","DOI":"10.1073\/pnas.0804604105","article-title":"The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo","volume":"105","author":"I Astapova","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"65","DOI":"10.4065\/84.1.65","article-title":"Subclinical hypothyroidism: an update for primary care physicians","volume":"84","author":"V Fatourechi","year":"2009","journal-title":"Mayo Clinic proceedings Mayo Clinic"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1001\/jama.291.2.228","article-title":"Subclinical thyroid disease: scientific review and guidelines for diagnosis and management","volume":"291","author":"MI Surks","year":"2004","journal-title":"JAMA : the journal of the American Medical Association"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0054901","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,5]],"date-time":"2024-05-05T05:17:55Z","timestamp":1714886275000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0054901"}},"subtitle":[],"editor":[{"given":"Michelina","family":"Plateroti","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,1,24]]},"references-count":64,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,1,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0054901","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,24]]}}}