{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:19:37Z","timestamp":1790623177243,"version":"4.1.0"},"reference-count":26,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T00:00:00Z","timestamp":1360713600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0054920","type":"journal-article","created":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T17:18:30Z","timestamp":1360775910000},"page":"e54920","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Exon-Skipping Strategy by Ratio Modulation between Cytoprotective versus Pro-Apoptotic Clusterin Forms Increased Sensitivity of LNCaP to Cell Death"],"prefix":"10.1371","volume":"8","author":[{"given":"Abdellatif","family":"Essabbani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jos\u00e8","family":"Zonetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Fisco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Pucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Chiocchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,2,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S1357-2725(01)00155-8","article-title":"Clusterin","volume":"34","author":"SE Jones","year":"2002","journal-title":"Int J Biochem Cell Biol"},{"key":"ref2","first-page":"139","article-title":"Chapter 8: Clusterin: A multifacet protein at the crossroad of inflammation and autoimmunity","volume":"104","author":"G Falgarone","year":"2009","journal-title":"Adv Cancer Res"},{"key":"ref3","first-page":"289","article-title":"Interleukin-32, CCL2, PF4F1 and GFD10 are the only cytokine\/chemokine genes differentially expressed by in vitro cultured rheumatoid and osteoarthritis fibroblast-like synoviocytes","volume":"16","author":"N Cagnard","year":"2005","journal-title":"Eur Cytokine Netw"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"4273","DOI":"10.1074\/jbc.C109.057133","article-title":"Identification of clusterin domain involved in NF-kappaB pathway regulation","volume":"285","author":"A Essabbani","year":"2010","journal-title":"J Biol Chem"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"15233","DOI":"10.1021\/bi9703507","article-title":"Effects of clusterin overexpression on TNFalpha- and TGFbeta-mediated death of L929 cells","volume":"36","author":"D Humphreys","year":"1997","journal-title":"Biochemistry"},{"key":"ref6","first-page":"2431","article-title":"Prevention of cell death induced by tumor necrosis factor alpha in LNCaP cells by overexpression of sulfated glycoprotein-2 (clusterin)","volume":"55","author":"JA Sensibar","year":"1995","journal-title":"Cancer Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/pros.20087","article-title":"Protection of androgen-dependent human prostate cancer cells from oxidative stress-induced DNA damage by overexpression of clusterin and its modulation by androgen","volume":"61","author":"H Miyake","year":"2004","journal-title":"Prostate"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1172\/JCI117043","article-title":"Human clusterin gene expression is confined to surviving cells during in vitro programmed cell death","volume":"93","author":"LE French","year":"1994","journal-title":"J Clin Invest"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1677\/joe.0.1620057","article-title":"Up-regulation of clusterin (sulfated glycoprotein-2) in pancreatic islet cells upon streptozotocin injection to rats","volume":"162","author":"IS Park","year":"1999","journal-title":"J Endocrinol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/ncb1291","article-title":"Clusterin inhibits apoptosis by interacting with activated Bax","volume":"7","author":"H Zhang","year":"2005","journal-title":"Nat Cell Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"11590","DOI":"10.1074\/jbc.M209233200","article-title":"Synthesis and functional analyses of nuclear clusterin, a cell death protein","volume":"278","author":"KS Leskov","year":"2003","journal-title":"J Biol Chem"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3784","DOI":"10.1111\/j.1742-4658.2009.07093.x","article-title":"Vanadium-induced apoptosis of HaCaT cells is mediated by c-fos and involves nuclear accumulation of clusterin","volume":"276","author":"S Markopoulou","year":"2009","journal-title":"Febs J"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1093\/nar\/27.10.2165","article-title":"Isolation of Ku70-binding proteins (KUBs)","volume":"27","author":"CR Yang","year":"1999","journal-title":"Nucleic Acids Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1196\/annals.1299.095","article-title":"Nuclear translocation of a clusterin isoform is associated with induction of anoikis in SV40-immortalized human prostate epithelial cells","volume":"1010","author":"AE Caccamo","year":"2003","journal-title":"Ann N Y Acad Sci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/sj.cdd.4401491","article-title":"Ca2+ depletion induces nuclear clusterin, a novel effector of apoptosis in immortalized human prostate cells","volume":"12","author":"AE Caccamo","year":"2005","journal-title":"Cell Death Differ"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1158\/0008-5472.CAN-03-2664","article-title":"Silencing expression of the clusterin\/apolipoprotein j gene in human cancer cells using small interfering RNA induces spontaneous apoptosis, reduced growth ability, and cell sensitization to genotoxic and oxidative stress","volume":"64","author":"IP Trougakos","year":"2004","journal-title":"Cancer Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1196\/annals.1297.033","article-title":"Functional analysis of clusterin\/apolipoprotein J in cellular death induced by severe genotoxic stress","volume":"1019","author":"IP Trougakos","year":"2004","journal-title":"Ann N Y Acad Sci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s00345-004-0474-0","article-title":"Use of antisense oligonucleotides targeting the cytoprotective gene, clusterin, to enhance androgen- and chemo-sensitivity in prostate cancer","volume":"23","author":"M Gleave","year":"2005","journal-title":"World J Urol"},{"key":"ref19","first-page":"265","article-title":"Targeting Clusterin in prostate cancer","volume":"59","author":"F Rizzi","year":"2008","journal-title":"J Physiol Pharmacol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nrg775","article-title":"Listening to silence and understanding nonsense: exonic mutations that affect splicing","volume":"3","author":"L Cartegni","year":"2002","journal-title":"Nat Rev Genet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1126\/science.1104297","article-title":"Rescue of dystrophic muscle through U7 snRNA-mediated exon skipping","volume":"306","author":"A Goyenvalle","year":"2004","journal-title":"Science"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.stem.2007.09.016","article-title":"Restoration of human dystrophin following transplantation of exon-skipping-engineered DMD patient stem cells into dystrophic mice","volume":"1","author":"R Benchaouir","year":"2007","journal-title":"Cell Stem Cell"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/S0090-4295(02)01806-X","article-title":"Suppression of clusterin expression enhanced cisplatin-induced cytotoxicity on renal cell carcinoma cells","volume":"60","author":"CH Lee","year":"2002","journal-title":"Urology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.canlet.2003.07.008","article-title":"Enhanced chemosensitivity of bladder cancer cells to cisplatin by suppression of clusterin in vitro","volume":"203","author":"J Chung","year":"2004","journal-title":"Cancer Lett"},{"key":"ref25","first-page":"3276","article-title":"Enhanced radiation sensitivity in prostate cancer by inhibition of the cell survival protein clusterin","volume":"8","author":"T Zellweger","year":"2002","journal-title":"Clin Cancer Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"4779","DOI":"10.1093\/nar\/gkg675","article-title":"Cell cycle arrest and apoptosis provoked by UV radiation-induced DNA damage are transcriptionally highly divergent responses","volume":"31","author":"M Gentile","year":"2003","journal-title":"Nucleic Acids Res"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0054920","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T18:54:33Z","timestamp":1540493673000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0054920"}},"subtitle":[],"editor":[{"given":"Surinder K.","family":"Batra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,2,13]]},"references-count":26,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,2,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0054920","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,13]]}}}