{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T09:26:17Z","timestamp":1770283577238,"version":"3.49.0"},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2013,1,28]],"date-time":"2013-01-28T00:00:00Z","timestamp":1359331200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0055018","type":"journal-article","created":{"date-parts":[[2013,1,29]],"date-time":"2013-01-29T00:37:31Z","timestamp":1359419851000},"page":"e55018","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":29,"title":["Dengue Virus Enhances Thrombomodulin and ICAM-1 Expression through the Macrophage Migration Inhibitory Factor Induction of the MAPK and PI3K Signaling Pathways"],"prefix":"10.1371","volume":"8","author":[{"given":"Trai-Ming","family":"Yeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Hsiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kao-Chang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chieh","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Yun","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzuu-Yuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Ren","family":"Yen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong-Kun","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lien-Cheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsai-Feng","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,1,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1128\/CMR.11.3.480","article-title":"Dengue and dengue hemorrhagic fever","volume":"11","author":"DJ Gubler","year":"1998","journal-title":"Clin Microbiol Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S1473-3099(03)00487-0","article-title":"Is clinical outcome of dengue-virus infections influenced by coagulation and fibrinolysis? A critical review of the evidence","volume":"3","author":"AT Mairuhu","year":"2003","journal-title":"Lancet Infect Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/1096-9071(200103)63:3<247::AID-JMV1008>3.0.CO;2-F","article-title":"Activation of coagulation and fibrinolysis during dengue virus infection","volume":"63","author":"YH Huang","year":"2001","journal-title":"J Med Virol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1046\/j.1365-2141.2001.02710.x","article-title":"Activation of coagulation factor XI, without detectable contact activation in dengue haemorrhagic fever","volume":"113","author":"EC van Gorp","year":"2001","journal-title":"Br J Haematol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1055\/s-0037-1612941","article-title":"The role of cytokines in activation of coagulation and fibrinolysis in dengue shock syndrome","volume":"87","author":"C Suharti","year":"2002","journal-title":"Thromb Haemost"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/jmv.10137","article-title":"Impaired fibrinolysis in the pathogenesis of dengue hemorrhagic fever","volume":"67","author":"EC Van Gorp","year":"2002","journal-title":"Journal of medical virology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1086\/341410","article-title":"Coagulation abnormalities in dengue hemorrhagic Fever: serial investigations in 167 Vietnamese children with Dengue shock syndrome","volume":"35","author":"BA Wills","year":"2002","journal-title":"Clinical infectious diseases: an official publication of the Infectious Diseases Society of America"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"S254","DOI":"10.1097\/01.CCM.0000128036.64448.9e","article-title":"Novel functions of thrombomodulin in inflammation","volume":"32","author":"M Van de Wouwer","year":"2004","journal-title":"Critical care medicine"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1046\/j.1538-7836.2003.00306.x","article-title":"Thrombomodulin","volume":"1","author":"H Weiler","year":"2003","journal-title":"Journal of thrombosis and haemostasis : JTH"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"142","DOI":"10.4269\/ajtmh.2006.74.142","article-title":"Correlation of serum levels of macrophage migration inhibitory factor with disease severity and clinical outcome in dengue patients","volume":"74","author":"LC Chen","year":"2006","journal-title":"The American journal of tropical medicine and hygiene"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1097\/01.inf.0000237918.85330.b9","article-title":"Elevated soluble thrombomodulin in the febrile stage related to patients at risk for dengue shock syndrome","volume":"25","author":"P Butthep","year":"2006","journal-title":"The Pediatric infectious disease journal"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"6338","DOI":"10.4049\/jimmunol.161.11.6338","article-title":"Dengue virus infection of human endothelial cells leads to chemokine production, complement activation, and apoptosis","volume":"161","author":"P Avirutnan","year":"1998","journal-title":"J Immunol"},{"key":"ref13","first-page":"32","article-title":"Dengue viruses induce cell proliferation and morphological changes of endothelial cells","volume":"28","author":"A Bunyaratvej","year":"1997","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1086\/383043","article-title":"Localization of dengue virus in naturally infected human tissues, by immunohistochemistry and in situ hybridization","volume":"189","author":"K Jessie","year":"2004","journal-title":"J Infect Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"71","DOI":"10.4269\/ajtmh.2000.63.71","article-title":"Dengue virus infects human endothelial cells and induces IL-6 and IL-8 production","volume":"63","author":"YH Huang","year":"2000","journal-title":"The American journal of tropical medicine and hygiene"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1002\/jmv.10438","article-title":"Tissue plasminogen activator induced by dengue virus infection of human endothelial cells","volume":"70","author":"YH Huang","year":"2003","journal-title":"J Med Virol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"435","DOI":"10.4269\/ajtmh.2002.66.435","article-title":"Platelet adhesion to dengue-2 virus-infected endothelial cells","volume":"66","author":"C Krishnamurti","year":"2002","journal-title":"The American journal of tropical medicine and hygiene"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1097\/00003246-200201001-00004","article-title":"Macrophage migration inhibitory factor","volume":"30","author":"JA Baugh","year":"2002","journal-title":"Critical care medicine"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/nri1200","article-title":"Macrophage migration inhibitory factor: a regulator of innate immunity","volume":"3","author":"T Calandra","year":"2003","journal-title":"Nature reviews Immunology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1084\/jem.20030286","article-title":"MIF signal transduction initiated by binding to CD74","volume":"197","author":"L Leng","year":"2003","journal-title":"The Journal of experimental medicine"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/72262","article-title":"Protection from septic shock by neutralization of macrophage migration inhibitory factor","volume":"6","author":"T Calandra","year":"2000","journal-title":"Nature medicine"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"S385","DOI":"10.1086\/374752","article-title":"Macrophage migration inhibitory factor and host innate immune defenses against bacterial sepsis","volume":"187","author":"T Calandra","year":"2003","journal-title":"The Journal of infectious diseases"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/S0015-0282(00)01789-1","article-title":"Dynamics of the development of multiple follicles during ovarian stimulation for in vitro fertilization using recombinant follicle-stimulating hormone (Puregon) and various doses of the gonadotropin-releasing hormone antagonist ganirelix (Orgalutran\/Antagon)","volume":"75","author":"D de Jong","year":"2001","journal-title":"Fertility and sterility"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1089\/10799900050151012","article-title":"Macrophage migration inhibitory factor (MIF): its essential role in the immune system and cell growth","volume":"20","author":"J Nishihira","year":"2000","journal-title":"Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1182\/blood-2005-05-2011","article-title":"Migration inhibitory factor up-regulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 via Src, PI3 kinase, and NFkappaB","volume":"107","author":"MA Amin","year":"2006","journal-title":"Blood"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.thromres.2011.08.011","article-title":"Macrophage migration inhibitory factor induces ICAM-1and thrombomobulin expression in vitro","volume":"129","author":"LY Shyu","year":"2012","journal-title":"Thrombosis research"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3109\/s10165-011-0466-z","article-title":"Elevated serum levels of macrophage migration inhibitory factor and their significant correlation with rheumatoid vasculitis disease activity","volume":"22","author":"K Wakabayashi","year":"2012","journal-title":"Modern rheumatology\/the Japan Rheumatism Association"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.immuni.2006.08.020","article-title":"CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex","volume":"25","author":"X Shi","year":"2006","journal-title":"Immunity"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1182\/blood.V99.1.290","article-title":"Effects of anti-CD44 monoclonal antibodies on differentiation and apoptosis of human myeloid leukemia cell lines","volume":"99","author":"RS Charrad","year":"2002","journal-title":"Blood"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1096\/fj.09-139469","article-title":"Contribution of macrophage migration inhibitory factor to the pathogenesis of dengue virus infection","volume":"24","author":"I Assuncao-Miranda","year":"2010","journal-title":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology"},{"key":"ref31","unstructured":"World Health Orgaization (1997) Dengue Hemorrhagic Fever: Diagnosis, Treatment, Prevention and Control. Second edition. Geneva: World Health Organization."},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1172\/JCI112225","article-title":"Thrombomodulin is present in human plasma and urine","volume":"76","author":"H Ishii","year":"1985","journal-title":"The Journal of clinical investigation"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0049-3848(01)00358-9","article-title":"Separation and characterization of the molecular species of thrombomodulin in the plasma of diabetic patients","volume":"104","author":"S Uehara","year":"2001","journal-title":"Thrombosis research"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"7179","DOI":"10.1073\/pnas.86.18.7179","article-title":"Transcription of thrombomodulin mRNA in mouse hemangioma cells is increased by cycloheximide and thrombin","volume":"86","author":"WA Dittman","year":"1989","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1006\/excr.1997.3812","article-title":"Thrombomodulin-dependent anticoagulant activity is regulated by vascular endothelial growth factor","volume":"238","author":"DS Calnek","year":"1998","journal-title":"Experimental cell research"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1161\/01.RES.74.5.852","article-title":"Endothelial expression of thrombomodulin is reversibly regulated by fluid shear stress","volume":"74","author":"AM Malek","year":"1994","journal-title":"Circulation research"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"4765","DOI":"10.1182\/blood-2002-08-2428","article-title":"Oxidized phospholipids in oxidized low-density lipoprotein down-regulate thrombomodulin transcription in vascular endothelial cells through a decrease in the binding of RARbeta-RXRalpha heterodimers and Sp1 and Sp3 to their binding sequences in the TM promoter","volume":"101","author":"H Ishii","year":"2003","journal-title":"Blood"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1055\/s-0038-1653873","article-title":"Transforming growth factor beta 1 and beta 2 induce down-modulation of thrombomodulin in human umbilical vein endothelial cells","volume":"73","author":"T Ohji","year":"1995","journal-title":"Thrombosis and haemostasis"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0925-5710(97)00080-7","article-title":"Differential effect of tumor necrosis factor-alpha on thrombomodulin gene expression by human monocytoid (THP-1) cell versus endothelial cells","volume":"67","author":"ST Grey","year":"1998","journal-title":"International journal of hematology"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/MBC.0b013e32801481cb","article-title":"Lipopolysaccharide down-regulates the thrombomodulin expression of peripheral blood monocytes: effect of serum on thrombomodulin expression in the THP-1 monocytic cell line","volume":"18","author":"HK Kim","year":"2007","journal-title":"Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/jcb.21206","article-title":"Pravastatin induces thrombomodulin expression in TNFalpha-treated human aortic endothelial cells by inhibiting Rac1 and Cdc42 translocation and activity","volume":"101","author":"SJ Lin","year":"2007","journal-title":"Journal of cellular biochemistry"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1161\/01.ATV.0000060461.64771.F0","article-title":"Pitavastatin-induced thrombomodulin expression by endothelial cells acts via inhibition of small G proteins of the Rho family","volume":"23","author":"K Masamura","year":"2003","journal-title":"Arteriosclerosis, thrombosis, and vascular biology"},{"key":"ref43","first-page":"3910","article-title":"Regulation of endothelial thrombomodulin expression by inflammatory cytokines is mediated by activation of nuclear factor-kappa B. Blood","volume":"105","author":"RH Sohn","year":"2005"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.thromres.2004.10.010","article-title":"Effects of TNF-alpha and curcumin on the expression of thrombomodulin and endothelial protein C receptor in human endothelial cells","volume":"115","author":"B Nan","year":"2005","journal-title":"Thrombosis research"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.jinf.2009.02.018","article-title":"Dengue virus induces thrombomodulin expression in human endothelial cells and monocytes in vitro","volume":"58","author":"LC Chen","year":"2009","journal-title":"The Journal of infection"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jinf.2007.10.008","article-title":"Dengue virus infection induces passive release of high mobility group box 1 protein by epithelial cells","volume":"56","author":"LC Chen","year":"2008","journal-title":"The Journal of infection"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"14144","DOI":"10.1021\/bi00251a025","article-title":"Purification, bioactivity, and secondary structure analysis of mouse and human macrophage migration inhibitory factor (MIF)","volume":"33","author":"J Bernhagen","year":"1994","journal-title":"Biochemistry"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0055018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T00:41:58Z","timestamp":1687999318000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0055018"}},"subtitle":[],"editor":[{"given":"Gernot","family":"Zissel","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,1,28]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,1,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0055018","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,28]]}}}