{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T01:36:04Z","timestamp":1789781764192,"version":"4.0.1"},"reference-count":67,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2013,2,7]],"date-time":"2013-02-07T00:00:00Z","timestamp":1360195200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0055599","type":"journal-article","created":{"date-parts":[[2013,2,7]],"date-time":"2013-02-07T22:27:55Z","timestamp":1360276075000},"page":"e55599","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":38,"title":["Metabolic Profiling Provides a System Understanding of Hypothyroidism in Rats and Its Application"],"prefix":"10.1371","volume":"8","author":[{"given":"Si","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangguo","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyang","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifeng","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,2,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1017\/S146479310000556X","article-title":"Thyroid hormones and their effects: a new perspective","volume":"75","author":"AJ Hulbert","year":"2000","journal-title":"Biol Rev Camb Philos Soc"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"641","DOI":"10.18388\/abp.2006_3292","article-title":"Thyroid hormones and their receptors in the regulation of cell proliferation","volume":"53","author":"M Puzianowska-Kuznicka","year":"2006","journal-title":"Acta Biochim Pol"},{"key":"ref3","first-page":"380","article-title":"Actions of thyroid hormones in bone","volume":"60","author":"GR Williams","year":"2009","journal-title":"Endokrynol Pol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1177\/1076029609350890","article-title":"Thrombin-activatable fibrinolysis inhibitor (TAFI) antigen and activity assay in patients with primary hypothyroidism","volume":"16","author":"N Ermantas","year":"2010","journal-title":"Clin Appl Thromb Hemost"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1586\/erc.10.141","article-title":"Hypothyroidism and hypertension","volume":"8","author":"S Stabouli","year":"2010","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1210\/er.2009-0041","article-title":"Thyroid function and human reproductive health","volume":"31","author":"GE Krassas","year":"2010","journal-title":"Endocr Rev"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s11011-010-9208-8","article-title":"Structural and functional alterations in the hippocampus due to hypothyroidism","volume":"25","author":"C Koromilas","year":"2010","journal-title":"Metab Brain Dis"},{"key":"ref8","first-page":"74","article-title":"Thyroid hormone replacement therapy","volume":"56 Suppl 1","author":"WM Wiersinga","year":"2001","journal-title":"Horm Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2165\/00024677-200403040-00003","article-title":"Optimizing treatment of hypothyroidism","volume":"3","author":"N Clarke","year":"2004","journal-title":"Treat Endocrinol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1210\/jc.2009-1625","article-title":"Serum thyroid-stimulating hormone concentration and morbidity from cardiovascular disease and fractures in patients on long-term thyroxine therapy","volume":"95","author":"RW Flynn","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"ref11","first-page":"475","article-title":"L-thyroxin treatment and post-menopausal osteoporosis: relevance of the risk profile present in clinical history","volume":"60","author":"S La Vignera","year":"2008","journal-title":"Minerva Ginecol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1136\/bmj.291.6493.427","article-title":"Raised plasma glutathione S-transferase values in hyperthyroidism and in hypothyroid patients receiving thyroxine replacement: evidence for hepatic damage","volume":"291","author":"GJ Beckett","year":"1985","journal-title":"Br Med J (Clin Res Ed)"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"4826","DOI":"10.1073\/pnas.0712365105","article-title":"Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia","volume":"105","author":"L Wang","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/bib\/bbp063","article-title":"Molecular networks for the study of TCM pharmacology","volume":"11","author":"J Zhao","year":"2010","journal-title":"Brief Bioinform"},{"key":"ref15","unstructured":"Xiang N (2005) Hypothyroidism. Beijing: People&apos;s Education Press. 65 p."},{"key":"ref16","first-page":"195","article-title":"Relation of hypothyroidism and deficiency of kidney yang","volume":"13","author":"LL Zha","year":"1993","journal-title":"Chinese journal of integrated traditional and Western medicine"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1142\/S0192415X09006953","article-title":"Identification of Linkage Disequilibrium SNPs from a Kidney-Yang Deficiency Syndrome Pedigree","volume":"37","author":"WJ Ding","year":"2009","journal-title":"Am J Chin Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.talanta.2010.09.026","article-title":"Metabonomic study on \u2018Kidney-Yang Deficiency syndrome\u2019 and intervention effects of Rhizoma Drynariae extracts in rats using ultra performance liquid chromatography coupled with mass spectrometry","volume":"83","author":"X Lu","year":"2011","journal-title":"Talanta"},{"key":"ref19","first-page":"415","article-title":"Effect of regulation of kidney-yin and kidney-yang on hypothalamus-pituitary-adrenal-thymus axis in monosodium L-glutamate rats","volume":"19","author":"D Cai","year":"1999","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"ref20","article-title":"Study on effect of various extract of Sini Decoction on reproductive organ and sexual hormone of hypothyroidism rats with syndrome of yang deficiency","author":"P Miaorong","year":"2010","journal-title":"China Journal of Traditional Chinese Medicine and Pharmacy"},{"key":"ref21","unstructured":"Chinese Pharmacopoeia Commission (2010) Pharmacopeia of the People&apos;s Republic of China. Beijing: People&apos;s Medicine Publishing House. 650 p."},{"key":"ref22","first-page":"1269","article-title":"Effect of delayed preconditioning induced by Sini decoction on myocardial cell apoptosis and its mitochondrial mechanism","volume":"31","author":"Y Liu","year":"2006","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"ref23","first-page":"1860","article-title":"Protective effects of sini decoction on adriamycin-induced heart failure and its mechanism","volume":"32","author":"MQ Zhao","year":"2009","journal-title":"Zhong Yao Cai"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e27683","DOI":"10.1371\/journal.pone.0027683","article-title":"Potential biomarkers in mouse myocardium of doxorubicin-induced cardiomyopathy: a metabonomic method and its application","volume":"6","author":"G Tan","year":"2011","journal-title":"PLoS One"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e34157","DOI":"10.1371\/journal.pone.0034157","article-title":"Metabonomic profiles delineate the effect of traditional chinese medicine sini decoction on myocardial infarction in rats","volume":"7","author":"G Tan","year":"2012","journal-title":"PLoS One"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1080\/004982599238047","article-title":"\u2018Metabonomics\u2019: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data","volume":"29","author":"JK Nicholson","year":"1999","journal-title":"Xenobiotica"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1039\/b914024g","article-title":"Bridging the gap between traditional Chinese medicine and systems biology: the connection of Cold Syndrome and NEI network","volume":"6","author":"T Ma","year":"2010","journal-title":"Mol Biosyst"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1021\/pr1009299","article-title":"Metabonomic study of Chinese medicine Shuanglong formula as an effective treatment for myocardial infarction in rats","volume":"10","author":"X Liang","year":"2011","journal-title":"J Proteome Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1021\/pr2009725","article-title":"Metabolic transformation of DMBA-induced carcinogenesis and inhibitory effect of salvianolic acid b and breviscapine treatment","volume":"11","author":"J Wei","year":"2012","journal-title":"J Proteome Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.toxlet.2007.05.021","article-title":"The use of metabolomics for the discovery of new biomarkers of effect","volume":"172","author":"B van Ravenzwaay","year":"2007","journal-title":"Toxicol Lett"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.reprotox.2012.05.096","article-title":"Feasibility of the extended one-generation reproductive toxicity study (OECD 443)","volume":"34","author":"I Fegert","year":"2012","journal-title":"Reprod Toxicol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.mrgentox.2012.01.006","article-title":"Metabolomics: a tool for early detection of toxicological effects and an opportunity for biology based grouping of chemicals-from QSAR to QBAR","volume":"746","author":"B van Ravenzwaay","year":"2012","journal-title":"Mutat Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1021\/pr100699m","article-title":"GC-MS metabolomic analysis reveals significant alterations in cerebellar metabolic physiology in a mouse model of adult onset hypothyroidism","volume":"10","author":"C Constantinou","year":"2011","journal-title":"J Proteome Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1039\/b604498k","article-title":"A pragmatic and readily implemented quality control strategy for HPLC-MS and GC-MS-based metabonomic analysis","volume":"131","author":"T Sangster","year":"2006","journal-title":"Analyst"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.aca.2009.03.039","article-title":"Metabonomics study of liver cancer based on ultra performance liquid chromatography coupled to mass spectrometry with HILIC and RPLC separations","volume":"650","author":"J Chen","year":"2009","journal-title":"Anal Chim Acta"},{"issue":"5","key":"ref36","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1021\/pr801086k","article-title":"Metabonomics Approach to Understanding Acute and Chronic stress in rat models","volume":"8","author":"X Wang","year":"2008","journal-title":"J Proteome Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1021\/pr900333h","article-title":"Metabonomic evaluation of melamine-induced acute renal toxicity in rats","volume":"9","author":"G Xie","year":"2010","journal-title":"J Proteome Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1055\/s-0030-1250542","article-title":"Metabolomics: towards understanding traditional Chinese medicine","volume":"76","author":"A Zhang","year":"2010","journal-title":"Planta Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"C1114","DOI":"10.1152\/ajpcell.00216.2006","article-title":"Tricarboxylic acid cycle dysfunction as a cause of human diseases and tumor formation","volume":"291","author":"JJ Briere","year":"2006","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"3953","DOI":"10.1210\/en.2008-1755","article-title":"Hypothyroidism decreases the biogenesis in free mitochondria and neuronal oxygen consumption in the cerebral cortex of developing rats","volume":"150","author":"B Martinez","year":"2009","journal-title":"Endocrinology"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1039\/c1mb05029j","article-title":"Serum metabolic profiling and features of papillary thyroid carcinoma and nodular goiter","volume":"7","author":"Z Yao","year":"2011","journal-title":"Mol Biosyst"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4419-6741-1_1","article-title":"An overview of sphingolipid metabolism: from synthesis to breakdown","volume":"688","author":"CR Gault","year":"2010","journal-title":"Adv Exp Med Biol"},{"key":"ref43","first-page":"912","article-title":"Role of thyroid hormones in regulation of sphingomyelin metabolism in the liver","volume":"64","author":"NA Babenko","year":"1999","journal-title":"Biochemistry (Mosc)"},{"key":"ref44","first-page":"89","article-title":"Effect of hypothyreosis on the content of ceramides in rat tissues","volume":"54","author":"M Gorska","year":"2003","journal-title":"J Physiol Pharmacol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1139\/o76-003","article-title":"Effect of propylthiouracil-induced hypothyroidism on phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin synthesis in chick liver microsomes","volume":"54","author":"EM Lyman","year":"1976","journal-title":"Can J Biochem"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1539S","DOI":"10.1093\/jn\/137.6.1539S","article-title":"Tyrosine, phenylalanine, and catecholamine synthesis and function in the brain","volume":"137","author":"JD Fernstrom","year":"2007","journal-title":"J Nutr"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1530\/eje.0.1390493","article-title":"L-thyroxine treatment and neurotransmitter levels in the cerebrospinal fluid of hypothyroid patients: a pilot study","volume":"139","author":"S Sjoberg","year":"1998","journal-title":"Eur J Endocrinol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/0306-4522(90)90340-A","article-title":"Neonatal hypothyroidism induces striatal dopaminergic dysfunction","volume":"35","author":"A Vaccari","year":"1990","journal-title":"Neuroscience"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1093\/jn\/113.9.1756","article-title":"Effect of a tryptophan deficiency on thyroid gland, growth hormone and testicular functions in chickens","volume":"113","author":"LB Carew Jr","year":"1983","journal-title":"J Nutr"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1159\/000054449","article-title":"Effects of experimental hypothyroidism on 5-HT1A, 5-HT2A receptors, 5-HT uptake sites and tryptophan hydroxylase activity in mature rat brain1","volume":"69","author":"A Kulikov","year":"1999","journal-title":"Neuroendocrinology"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1530\/acta.0.0890100","article-title":"Neurotransmitter control of thyrotrophin secretion in hypothyroid rats","volume":"89","author":"PT Mannisto","year":"1978","journal-title":"Acta Endocrinol (Copenh)"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1111\/j.1440-1681.2007.04615.x","article-title":"High-dose taurine supplementation increases serum paraoxonase and arylesterase activities in experimental hypothyroidism","volume":"34","author":"M Dirican","year":"2007","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/cbf.1198","article-title":"The effect of taurine supplementation on oxidative stress in experimental hypothyroidism","volume":"24","author":"S Tas","year":"2006","journal-title":"Cell Biochem Funct"},{"key":"ref54","first-page":"1559","article-title":"[Effects of Sini decoction on vascular stenosis after iliac artery balloon injury and oxidative stress in rabbits]","volume":"26","author":"Y Liu","year":"2006","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"ref55","first-page":"1681","article-title":"Study on activity and mechanism of Sini Decoction anti-mitochondrial oxidation injury caused by myocardial ischemia\/reperfusion","volume":"31","author":"DY Zhao","year":"2008","journal-title":"Zhong Yao Cai"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1093\/jat\/33.9.588","article-title":"Development and validation of a high-performance liquid chromatography-tandem mass spectrometry method for the rapid simultaneous quantification of aconitine, mesaconitine, and hypaconitine in rat plasma after oral administration of Sini decoction","volume":"33","author":"LP He","year":"2009","journal-title":"J Anal Toxicol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jep.2009.07.031","article-title":"Aconitum in traditional Chinese medicine: a valuable drug or an unpredictable risk?","volume":"126","author":"J Singhuber","year":"2009","journal-title":"J Ethnopharmacol"},{"key":"ref58","first-page":"75","article-title":"The comparative studies between Chinese medicine and western medicines (Zhongxi Bijiao Yiyaoxue Gailun)","author":"Z Min","year":"2006","journal-title":"Higher Education Press"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1080\/10408391003698669","article-title":"Update on the chemopreventive effects of ginger and its phytochemicals","volume":"51","author":"MS Baliga","year":"2011","journal-title":"Crit Rev Food Sci Nutr"},{"key":"ref60","first-page":"13","article-title":"Altertion in effective constituents in the Sini Tang oral liquor before and after the combination of Radix Aconiti lateralis preparata and rhizoma zingberis","volume":"19","author":"Z Yu","year":"1996","journal-title":"Heilongjiang Medicine and Pharmacy"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1002\/bmc.1544","article-title":"Characterization of constituents in Sini decoction and rat plasma by high-performance liquid chromatography with diode array detection coupled to time-of-flight mass spectrometry","volume":"25","author":"G Tan","year":"2011","journal-title":"Biomed Chromatogr"},{"key":"ref62","article-title":"Hypothyroidism improves random-pattern skin flap survival in rats","author":"S Rahimpour","year":"2012","journal-title":"J Surg Res"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1007\/s11033-011-0849-4","article-title":"Expression of antioxidant genes in renal cortex of PTU-induced hypothyroid rats: effect of vitamin E and curcumin","volume":"39","author":"S Jena","year":"2012","journal-title":"Mol Biol Rep"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1002\/jnr.22806","article-title":"Hypothyroidism reduces glutamate-synaptic release by ouabain depolarization in rat CA3-hippocampal region","volume":"90","author":"KB Sanchez-Huerta","year":"2012","journal-title":"J Neurosci Res"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/hipo.20476","article-title":"Levothyroxin restores hypothyroidism-induced impairment of hippocampus-dependent learning and memory: Behavioral, electrophysiological, and molecular studies","volume":"19","author":"KH Alzoubi","year":"2009","journal-title":"Hippocampus"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1021\/ac051437y","article-title":"XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification","volume":"78","author":"CA Smith","year":"2006","journal-title":"Anal Chem"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1021\/ac051495j","article-title":"Large-scale human metabolomics studies: a strategy for data (pre-) processing and validation","volume":"78","author":"S Bijlsma","year":"2006","journal-title":"Anal Chem"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0055599","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T02:03:24Z","timestamp":1595383404000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0055599"}},"subtitle":[],"editor":[{"given":"Denise Pires de","family":"Carvalho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,2,7]]},"references-count":67,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,2,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0055599","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,7]]}}}