{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:14:56Z","timestamp":1791112496866,"version":"4.1.0"},"reference-count":62,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2013,1,31]],"date-time":"2013-01-31T00:00:00Z","timestamp":1359590400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0055683","type":"journal-article","created":{"date-parts":[[2013,1,31]],"date-time":"2013-01-31T22:00:52Z","timestamp":1359669652000},"page":"e55683","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Expression and Activation of STAT3 in the Astrocytes of Optic Nerve in a Rat Model of Transient Intraocular Hypertension"],"prefix":"10.1371","volume":"8","author":[{"given":"Shaodan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel S.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,1,31]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1167\/iovs.04-1070","article-title":"Glaucoma: Macrocosm to microcosm the Friedenwald lecture","volume":"46","author":"HA Quigley","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"ref2","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/glia.20962","article-title":"Glaucomatous Optic Nerve Injury Involves Early Astrocyte Reactivity and Late Oligodendrocyte Loss","volume":"58","author":"JL Son","year":"2010","journal-title":"Glia"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S1350-9462(98)00014-7","article-title":"Neuronal death in glaucoma","volume":"18","author":"HA Quigley","year":"1999","journal-title":"Prog Retin Eye Res"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1083\/jcb.200506099","article-title":"Retinal ganglion cell degeneration is topological but not cell type specific in DBA\/2J mice","volume":"171","author":"TC Jakobs","year":"2005","journal-title":"J Cell Biol"},{"issue":"7","key":"ref5","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1083\/jcb.200706181","article-title":"Axons of retinal ganglion cells are insulted in the optic nerve early in DBA\/2J glaucoma","volume":"179","author":"GR Howell","year":"2007","journal-title":"J Cell Biol"},{"issue":"11","key":"ref6","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1523\/JNEUROSCI.4443-07.2008","article-title":"Progressive ganglion cell degeneration precedes neuronal loss in a mouse model of glaucoma","volume":"28","author":"BP Buckingham","year":"2008","journal-title":"J Neurosci"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1523\/JNEUROSCI.3714-07.2008","article-title":"Retinal Ganglion Cells Downregulate Gene Expression and Lose Their Axons within the Optic Nerve Head in a Mouse Glaucoma Model","volume":"28","author":"I Soto","year":"2008","journal-title":"J Neurosci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0079-6123(08)01125-4","article-title":"Astrocytes in glaucomatous optic neuropathy","volume":"173","author":"JD Pena","year":"2008","journal-title":"Prog Brain Res"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.22058","article-title":"The morphology and spatial arrangement of astrocytes in the optic nerve head of the mouse","volume":"516","author":"D Sun","year":"2009","journal-title":"J Comp Neurol"},{"key":"ref10","first-page":"2303","article-title":"Increased elastin expression in astrocytes of the lamina cribrosa in response to elevated intraocular pressure","volume":"42","author":"MR Hernandez","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"28","key":"ref11","doi-asserted-by":"crossref","first-page":"7532","DOI":"10.1523\/JNEUROSCI.1004-06.2006","article-title":"Epidermal growth factor receptor activation: an upstream signal for transition of quiescent astrocytes into reactive astrocytes after neural injury","volume":"26","author":"B Liu","year":"2006","journal-title":"J Neurosci"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s12035-011-8163-7","article-title":"Signalling pathways in reactive astrocytes, a genetic perspective","volume":"43","author":"W Kang","year":"2011","journal-title":"Mol Neurobiol"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0014-4835(03)00002-2","article-title":"Expression and activation of STAT proteins during mouse retina development","volume":"76","author":"SS Zhang","year":"2003","journal-title":"Exp Eye Res"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.neuroscience.2006.06.034","article-title":"P2 purinergic receptors signal to STAT3 in astrocytes: Difference in STAT3 responses to P2Y and P2X receptor activation","volume":"142","author":"KB Washburn","year":"2006","journal-title":"Neuroscience"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"e9532","DOI":"10.1371\/journal.pone.0009532","article-title":"Disruption of astrocyte STAT3 signalling decreases mitochondrial function and increases oxidative stress in vitro","volume":"5","author":"TA Sarafian","year":"2010","journal-title":"PLoS One"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/glia.10186","article-title":"Upregulation of gp130 and STAT3 activation in the rat hippocampus following transient forebrain ischemia","volume":"41","author":"JS Choi","year":"2003","journal-title":"Glia"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1111\/j.1460-9568.1996.tb01556.x","article-title":"Induction of Stat3, a signal transducer and transcription factor, in reactive microglia following transient focal cerebral ischaemia","volume":"8","author":"AM Planas","year":"1996","journal-title":"Eur J Neurosci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/(SICI)1098-1136(200005)30:3<253::AID-GLIA5>3.0.CO;2-O","article-title":"Activation of the JAK\/STAT pathway following transient focal cerebral ischemia:signalling through Jak1 and Stat3 in astrocytes","volume":"30","author":"C Justicia","year":"2000","journal-title":"Glia"},{"issue":"28","key":"ref19","doi-asserted-by":"crossref","first-page":"7231","DOI":"10.1523\/JNEUROSCI.1709-08.2008","article-title":"STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury","volume":"28","author":"JE Herrmann","year":"2008","journal-title":"J Neurosci"},{"issue":"Pt 4","key":"ref20","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1093\/brain\/awr025","article-title":"JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats","volume":"134","author":"M Tsuda","year":"2011","journal-title":"Brain"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"5383","DOI":"10.1167\/iovs.03-0451","article-title":"Mitogen-activated protein kinases and retinal ischemia","volume":"44","author":"S Roth","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.exer.2005.08.011","article-title":"Induciblenitric oxide synthase inhibitors abolished histological protection by lateischemic preconditioning in rat retina","volume":"82","author":"K Sakamoto","year":"2006","journal-title":"Exp Eye Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/glia.20207","article-title":"Astrocyte activation and reactive gliosis","volume":"50","author":"M Pekny","year":"2005","journal-title":"Glia"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1177\/1073858405278321","article-title":"Reactive astrocytes in neural repair and protection","volume":"5","author":"MV Sofroniew","year":"2005","journal-title":"Neuroscientist"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/ncpneuro0355","article-title":"Mechanisms of Disease: astrocytes in neurodegenerative disease","volume":"2","author":"NJ Maragakis","year":"2006","journal-title":"Nat Clin Pract Neurol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/01.jnen.0000248555.53079.d5","article-title":"Molecular mechanisms of astrogliosis: new approaches with mouse genetics","volume":"66","author":"LS Correa-Cerro","year":"2007","journal-title":"J Neuropathol Exp Neurol"},{"issue":"12","key":"ref27","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.tins.2009.08.002","article-title":"Molecular dissection of reactive astrogliosis and glial scar formation","volume":"32","author":"MV Sofroniew","year":"2009","journal-title":"Trends Neurosci"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0896-6273(00)80781-3","article-title":"Leukocyte infiltration, neuronal degeneration and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice","volume":"23","author":"TG Bush","year":"1999","journal-title":"Neuron"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0896-6273(00)80086-0","article-title":"Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate","volume":"16","author":"JD Rothstein","year":"1996","journal-title":"Neuron"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2174\/1566524043479185","article-title":"Astrocyte influences on ischemic neuronal death","volume":"4","author":"RA Swanson","year":"2004","journal-title":"Curr Mol Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1046\/j.1471-4159.2001.00374.x","article-title":"Astrocytes protect neurons from nitric oxide toxicity by a glutathione-dependent mechanism","volume":"77","author":"Y Chen","year":"2001","journal-title":"J Neurochem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"3394","DOI":"10.1523\/JNEUROSCI.23-08-03394.2003","article-title":"Coordinate regulation of glutathione biosynthesis and release by Nrf2-expressing glia potently protects neurons from oxidative stress","volume":"23","author":"AY Shih","year":"2003","journal-title":"J Neurosci"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1523\/JNEUROSCI.3827-07.2008","article-title":"A central role of connexin 43 in hypoxic preconditioning","volume":"28","author":"JH Lin","year":"2008","journal-title":"J Neurosci"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/83679","article-title":"Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease","volume":"27","author":"M Brenner","year":"2001","journal-title":"Nat Genet"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/nn1885","article-title":"Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell based ALS model","volume":"10","author":"FP Di Giorgio","year":"2007","journal-title":"Nat Neurosci"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/nn1876","article-title":"Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons","volume":"10","author":"M Nagai","year":"2007","journal-title":"Nat Neurosci"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0079-6123(08)01125-4","article-title":"Astrocytes in glaucomatous optic neuropathy","volume":"173","author":"MR Hernandez","year":"2008","journal-title":"Prog Brain Res"},{"issue":"2","key":"ref38","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1460-9568.2009.06814.x","article-title":"Inactivation of astroglial NF-kappa B promotes survival of retinal neurons following ischemic injury","volume":"30","author":"G Dvoriantchikova","year":"2009","journal-title":"Eur J Neurosci"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.brainres.2011.06.005","article-title":"Glial cell response and iNOS expression in the optic nerve head and retina of the rat following acute high IOP ischemia-reperfusion","volume":"1403","author":"KJ Cho","year":"2011","journal-title":"Brain Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/glia.1099","article-title":"Rapid morphological changes in astrocytes are accompanied by redistribution but not by quantitative changes of cytoskeletal proteins","volume":"36","author":"S Safavi-Abbasi","year":"2001","journal-title":"Glia"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1126\/science.1071545","article-title":"A road map for those who don&apos;t know Jak-STAT","volume":"296","author":"DS Aaronson","year":"2002","journal-title":"Science"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1523\/JNEUROSCI.14-02-00846.1994","article-title":"Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines","volume":"14","author":"V Balasingam","year":"1994","journal-title":"J Neurosci"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/(SICI)1098-1136(199703)19:3<227::AID-GLIA5>3.0.CO;2-W","article-title":"Impaired neuroglial activation in interleukin-6 deficient mice","volume":"19","author":"MA Klein","year":"1997","journal-title":"Glia"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/1098-1136(200012)32:3<328::AID-GLIA110>3.0.CO;2-7","article-title":"IL-6-type cytokines enhance epidermal growth factor-stimulated astrocyte proliferation","volume":"32","author":"SW Levison","year":"2000","journal-title":"Glia"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1006\/exnr.2001.7834","article-title":"Ciliary neurotrophic factor activates spinal cord astrocytes, stimulating their production and release of fibroblast growth factor-2, to increase motor neuron survival","volume":"173","author":"PJ Albrecht","year":"2002","journal-title":"Exp Neurol"},{"issue":"19","key":"ref46","doi-asserted-by":"crossref","first-page":"19936","DOI":"10.1074\/jbc.M309304200","article-title":"Induction of gp130-related cytokines and activation of JAK2\/STAT3 pathway in astrocytes precedes up-regulation of glial fibrillary acidic protein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of neurodegeneration: key signaling pathway for astrogliosis in vivo?","volume":"7;279","author":"K Sriram","year":"2004","journal-title":"J Biol Chem"},{"issue":"4","key":"ref47","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1111\/j.1471-4159.2005.03559.x","article-title":"Activation of JAK\/STAT signalling in neurons following spinal cord injury in mice","volume":"96","author":"K Yamauchi","year":"2006","journal-title":"J Neurochem"},{"issue":"28","key":"ref48","doi-asserted-by":"crossref","first-page":"7231","DOI":"10.1523\/JNEUROSCI.1709-08.2008","article-title":"STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury","volume":"9;28","author":"JE Herrmann","year":"2008","journal-title":"J Neurosci"},{"issue":"2","key":"ref49","first-page":"265","article-title":"Eur J Neurosci. CNTF promotes survival of retinal ganglion cells after induction of ocular hypertension in rats: the possible involvement of STAT3 pathway","volume":"19","author":"JZ Ji","year":"2004"},{"issue":"1","key":"ref50","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.exer.2005.01.016","article-title":"STAT3 activation in response to growth factors or cytokines participates in retina precursor proliferation","volume":"81","author":"SS Zhang","year":"2005","journal-title":"Exp Eye Res"},{"issue":"6","key":"ref51","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.exer.2008.03.020","article-title":"STAT3 activation protects retinal ganglion cell layer neurons in response to stress","volume":"86","author":"C Zhang","year":"2008","journal-title":"Exp Eye Res"},{"issue":"50","key":"ref52","doi-asserted-by":"crossref","first-page":"21389","DOI":"10.1073\/pnas.0906156106","article-title":"Preconditioning-induced protection of photoreceptors requires activation of the signal-transducing receptor gp130 in photoreceptors","volume":"15;106","author":"Y Ueki","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0306-4522(85)90044-2","article-title":"A demonstration of glial filament distribution in astrocytes isolated from rat cerebral cortex","volume":"16","author":"JR Connor","year":"1985","journal-title":"Neuroscience"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1523\/JNEUROSCI.22-01-00183.2002","article-title":"Protoplasmic astrocytes in CA1 stratum radiatum occupy separate anatomical domains","volume":"22","author":"EA Bushong","year":"2002","journal-title":"J Neurosci"},{"issue":"42","key":"ref55","doi-asserted-by":"crossref","first-page":"14008","DOI":"10.1523\/JNEUROSCI.3605-10.2010","article-title":"Structural remodeling of fibrous astrocytes after axonal injury","volume":"30","author":"D Sun","year":"2010","journal-title":"J Neuroscience"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj20030407","article-title":"Principles of interleukin (IL)-6-type cytokine signalling and its regulation","volume":"374","author":"PC Heinrich","year":"2003","journal-title":"Biochem J"},{"issue":"1\u20132","key":"ref57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-1119(02)00398-0","article-title":"Signaling through the JAK\/STAT pathway, recent advances and future challenges","volume":"20;285","author":"T Kisseleva","year":"2002","journal-title":"Gene"},{"issue":"4","key":"ref58","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1080\/02713680801932891","article-title":"Increased plasma and optic nerve levels of IL-6, TNF-alpha, and MIP-2 following induction of ischemic optic neuropathy in mice","volume":"33","author":"BC Avraham","year":"2008","journal-title":"Curr Eye Res"},{"issue":"1","key":"ref59","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1167\/iovs.10-5317","article-title":"Cell proliferation and interleukin-6-type cytokine signaling are implicated by gene expression responses in early optic nerve head injury in rat glaucoma","volume":"25;52","author":"EC Johnson","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref60","first-page":"2511","article-title":"Expression profiles of nestin and synemin in reactive astrocytes and muller cells following retinal injury: a comparison with glial fibrillar acidic protein and vimentin","volume":"27;16","author":"G Luna","year":"2010","journal-title":"Mol Vis"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/1471-2148-7-164","article-title":"Molecular evolution of type VI intermediate filament proteins","volume":"13; 7","author":"D Gu\u00e9rette","year":"2007","journal-title":"BMC Evol Biol"},{"issue":"2","key":"ref62","first-page":"665","article-title":"Nestin structure and predicted function in cellular cytoskeletal organisation","volume":"20","author":"K Michalczyk","year":"2005","journal-title":"Histol Histopathol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0055683","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,5]],"date-time":"2024-05-05T10:23:56Z","timestamp":1714904636000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0055683"}},"subtitle":[],"editor":[{"given":"Demetrios","family":"Vavvas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,1,31]]},"references-count":62,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,1,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0055683","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,31]]}}}