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conditioning","volume":"111","author":"CR Pugh","year":"1997","journal-title":"Behav Neurosci"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1006\/nlme.1996.3765","article-title":"Glucocorticoid receptor agonist and antagonist administration into the basolateral but not central amygdala modulates memory storage","volume":"67","author":"B Roozendaal","year":"1997","journal-title":"Neurobiol Learn Mem"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0006-8993(99)01085-9","article-title":"Adrenocortical suppression blocks the enhancement of memory storage produced by exposure to psychological stress in rats","volume":"821","author":"L Liu","year":"1999","journal-title":"Brain Res"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1101\/lm.61704","article-title":"A facilitative role for corticosterone in the acquisition of a spatial task under moderate stress","volume":"11","author":"I Akirav","year":"2004","journal-title":"Learn Mem"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0006-8993(94)91778-7","article-title":"Repeated stress causes reversible impairments of spatial memory performance","volume":"639","author":"V Luine","year":"1994","journal-title":"Brain Res"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1037\/0735-7044.110.4.661","article-title":"Psychological stress impairs spatial working memory: relevance to electrophysiological studies of hippocampal function","volume":"110","author":"DM Diamond","year":"1996","journal-title":"Behav Neurosci"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/29542","article-title":"Stress and glucocorticoids impair retrieval of long-term spatial memory","volume":"394","author":"DJ de Quervain","year":"1998","journal-title":"Nature"},{"key":"ref80","first-page":"799","article-title":"Prolonged zidovudine administration induces a moderate increase in the growth and steroidogenic capacity of the rat adrenal cortex","volume":"23","author":"C Tortorella","year":"2009","journal-title":"Int J Mol Med"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/S0140-6736(99)07219-0","article-title":"Persistent mitochondrial dysfunction and perinatal exposure to antiretroviral nucleoside analogues","volume":"354","author":"S Blanche","year":"1999","journal-title":"Lancet"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/em.10210","article-title":"Genetic damage detected in CD-1 mouse pups exposed perinatally to 3\u2032-azido-3\u2032-deoxythymidine and dideoxyinosine via maternal dosing, nursing, and direct gavage","volume":"43","author":"JB Bishop","year":"2004","journal-title":"Environ Mol Mutagen"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/em.20201","article-title":"Transplacentally exposed human and monkey newborn infants show similar evidence of nucleoside reverse transcriptase inhibitor-induced mitochondrial toxicity","volume":"48","author":"RL Divi","year":"2007","journal-title":"Environ Mol Mutagen"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1046\/j.1432-1033.2002.02954.x","article-title":"Azidothymidine causes functional and structural destruction of mitochondria, glutathione deficiency and HIV-1 promoter sensitization","volume":"269","author":"T Yamaguchi","year":"2002","journal-title":"Eur J Biochem"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1196\/annals.1296.004","article-title":"Role of GABA and glutamate circuitry in hypothalamo-pituitary-adrenocortical stress integration","volume":"1018","author":"JP Herman","year":"2004","journal-title":"Ann N Y Acad Sci"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1385\/ENDO:28:3:287","article-title":"Control of ACTH secretion by excitatory amino acids: functional significance and clinical implications","volume":"28","author":"D Jezova","year":"2005","journal-title":"Endocrine"},{"key":"ref87","first-page":"R112","article-title":"Paraventricular stimulation with glutamate elicits bradycardia and pituitary responses","volume":"256","author":"DN Darlington","year":"1989","journal-title":"Am J Physiol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1159\/000122400","article-title":"Effect of intraventricular glutamate on ACTH release","volume":"18","author":"GB Makara","year":"1975","journal-title":"Neuroendocrinology"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0167-4943(92)90048-9","article-title":"In vivo effect of acetyl-L-carnitine on succinate oxidation, adenine nucleotide pool and lipid composition of synaptic and non-synaptic mitochondria from cerebral hemispheres of senescent rats","volume":"14","author":"V Petruzzella","year":"1992","journal-title":"Arch Gerontol Geriatr"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1126\/science.1179689","article-title":"Regulation of cellular metabolism by protein lysine acetylation","volume":"327","author":"S Zhao","year":"2010","journal-title":"Science"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/00002030-199702000-00008","article-title":"Acetyl-carnitine deficiency in AIDS patients with neurotoxicity on treatment with antiretroviral nucleoside analogues","volume":"11","author":"G Famularo","year":"1997","journal-title":"AIDS"},{"key":"ref92","first-page":"44","article-title":"Acetyl-carnitine deficiency and mitochondrial DNA-depletion in HIV patients treated with antiretroviral therapy","volume":"6","author":"G Friese","year":"2001","journal-title":"Antivi Ther"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1085-9489.2006.00066.x","article-title":"Acetyl-l-carnitine in the treatment of painful antiretroviral toxic neuropathy in human immunodeficiency virus patients: an open label study","volume":"11","author":"M Osio","year":"2006","journal-title":"J Peripher Nerv Syst"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1097\/01.aids.0000131354.14408.fb","article-title":"Acetyl-l-carnitine: a pathogenesis based treatment for HIV-associated antiretroviral toxic neuropathy","volume":"18","author":"AM Hart","year":"2004","journal-title":"AIDS"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"467","DOI":"10.2165\/00002018-200629060-00002","article-title":"Treating HIV during pregnancy: an update on safety issues","volume":"29","author":"DH Watts","year":"2006","journal-title":"Drug Saf"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1097\/QAI.0b013e318221c56a","article-title":"Antiretroviral drugs for preventing mother-to-child transmission of HIV: a review of potential effects on HIV-exposed but uninfected 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