{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:14:48Z","timestamp":1791310488660,"version":"4.3.1"},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2013,2,6]],"date-time":"2013-02-06T00:00:00Z","timestamp":1360108800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0055797","type":"journal-article","created":{"date-parts":[[2013,2,6]],"date-time":"2013-02-06T21:56:56Z","timestamp":1360187816000},"page":"e55797","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":45,"title":["Mouse Model of Lymph Node Metastasis via Afferent Lymphatic Vessels for Development of Imaging Modalities"],"prefix":"10.1371","volume":"8","author":[{"given":"Li","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoki","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Kodama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,2,6]]},"reference":[{"key":"ref1","unstructured":"Roitt I, Brostoff J, Male D (2001) Immunology. Edinburgh: Mosby."},{"key":"ref2","unstructured":"Warwick, Roger; Peter L Williams (1973) [1858]. Angiology, Chapter 6. Gray&apos;s anatomy. illustrated by Richard E. M. Moore (Thirty-fifth ed.). London: Longman. p. 588\u2013785."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.pathophys.2009.11.003","article-title":"Lymphangiogenesis and lymphatic metastasis in breast cancer","volume":"17","author":"S Ran","year":"2010","journal-title":"Pathophysiology"},{"key":"ref4","first-page":"1853","article-title":"Characterization of a novel lymph node metastasis model from human colonic cancer and its preclinical use for comparison of anti-metastatic efficacy between oral S-1 and UFT\/LV. Cancer Sci","volume":"101(8)","author":"Y Ito","year":"2010"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ygyno.2005.11.032","article-title":"Pelvic lymph node count is an important prognostic variable for FIGO stage I and II endometrial carcinoma with high-risk histology","volume":"102","author":"CV Lutman","year":"2006","journal-title":"Gynecol Oncol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1038\/nm.1727","article-title":"Adenovirus-mediated gene expression imaging to directly detect sentinel lymph node metastasis of prostate cancer","volume":"14","author":"JB Burton","year":"2008","journal-title":"Nat Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s00109-011-0764-0","article-title":"Animal models and molecular imaging tools to investigate lymph node metastases","volume":"89","author":"EL Servais","year":"2011","journal-title":"J Mol Med (Berl)"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1093\/carcin\/bgh261","article-title":"Modeling metastasis in vivo","volume":"26","author":"C Khanna","year":"2005","journal-title":"Carcinogenesis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"5231","DOI":"10.1158\/0008-5472.CAN-05-0440","article-title":"Three-dimensional high-frequency ultrasound imaging for longitudinal evaluation of liver metastases in preclinical models","volume":"65","author":"KC Graham","year":"2005","journal-title":"Cancer Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3823","DOI":"10.1158\/0008-5472.CAN-04-2631","article-title":"Mouse models of subcutaneous spleen reservoir for multiple portal venous injections to treat liver malignancies","volume":"65","author":"H Kasuya","year":"2005","journal-title":"Cancer Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/978-0-387-69219-7_10","article-title":"Preclinical models of regional lymph node tumor metastasis","volume":"135","author":"SD Nathanson","year":"2007","journal-title":"Cancer Treat Res"},{"key":"ref12","first-page":"2535","article-title":"Establishment and characterization of a human lung cancer cell line NCI-H460-LNM35 with consistent lymphogenous metastasis via both subcutaneous and orthotopic propagation","volume":"60","author":"K Kozaki","year":"2000","journal-title":"Cancer Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/sj.bjc.6690178","article-title":"Mediastinal lymph node metastasis model by orthotopic intrapulmonary implantation of Lewis lung carcinoma cells in mice","volume":"79","author":"Y Doki","year":"1999","journal-title":"Br J Cancer"},{"key":"ref14","first-page":"39","article-title":"Blue liposomes for identification of the sentinel lymph nodes in pigs","volume":"36","author":"M Dieter","year":"2003","journal-title":"Lymphology"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Soltesz EG, Kim S, Laurence RG, DeGrand AM, Parungo CP, <etal>et al<\/etal>.. (2005) Intraoperative sentinel lymph node mapping of the lung using near-infrared fluorescent quantum dots. Ann Thorac Surg 79: 269\u2013277; discussion 269\u2013277.","DOI":"10.1016\/j.athoracsur.2004.06.055"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"8223","DOI":"10.1158\/0008-5472.CAN-07-1237","article-title":"Real-time imaging of tumor-cell shedding and trafficking in lymphatic channels","volume":"67","author":"K Hayashi","year":"2007","journal-title":"Cancer Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1158\/1078-0432.CCR-08-2666","article-title":"A potent, imaging adenoviral vector driven by the cancer-selective mucin-1 promoter that targets breast cancer metastasis","volume":"15","author":"ST Huyn","year":"2009","journal-title":"Clin Cancer Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e1075","DOI":"10.1371\/journal.pone.0001075","article-title":"A near-infrared cell tracker reagent for multiscopic in vivo imaging and quantification of leukocyte immune responses","volume":"2","author":"FK Swirski","year":"2007","journal-title":"PLoS One"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.ejca.2003.11.021","article-title":"Orthotopic models of cancer for preclinical drug evaluation: advantages and disadvantages","volume":"40","author":"MC Bibby","year":"2004","journal-title":"Eur J Cancer"},{"key":"ref20","unstructured":"Murphy ED, Roths JB (1978) Autoimmunity and lymphoproliferation: induction by mutant gene lpr, and acceleration by a male-associated factor in strain BXSB mice; Rose N, Bigazzi P, Warner L, editors. New York: Elsevier\/North-Holland. p. 207\u2013221."},{"key":"ref21","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3844\/ajisp.2009.89.97","article-title":"Mast cells inhibit CD8+ T cell-mediated rejection of a malignant fibrous histiocytoma-like tumor: Involvement of Fas-Fas ligand axis","volume":"5","author":"H Furukawa","year":"2009","journal-title":"Am J Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1002\/art.11231","article-title":"Antagonist of monocyte chemoattractant protein 1 ameliorates the initiation and progression of lupus nephritis and renal vasculitis in MRL\/lpr mice","volume":"48","author":"H Hasegawa","year":"2003","journal-title":"Arthritis Rheum"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3785","DOI":"10.4049\/jimmunol.138.11.3785","article-title":"Cryoglobulinemia induced by monoclonal immunoglobulin G rheumatoid factors derived from autoimmune MRL\/MpJ-lpr\/lpr mice","volume":"138","author":"Y Gyotoku","year":"1987","journal-title":"J Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.jpedsurg.2007.02.027","article-title":"In vivo bioluminescence imaging for early detection and monitoring of disease progression in a murine model of neuroblastoma","volume":"42","author":"PV Dickson","year":"2007","journal-title":"J Pediatr Surg"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.ejvs.2007.09.001","article-title":"Indocyanine green fluorescence angiography for intraoperative assessment of blood flow: a feasibility study","volume":"35","author":"N Unno","year":"2008","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/jmicro\/dfp056","article-title":"Morphological study of acoustic liposomes using transmission electron microscopy","volume":"59","author":"T Kodama","year":"2010","journal-title":"J Electron Microsc"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.ultrasmedbio.2010.04.016","article-title":"Evaluation of transfection efficiency in skeletal muscle using nano\/microbubbles and ultrasound","volume":"36","author":"T Kodama","year":"2010","journal-title":"Ultrasound Med Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"6957","DOI":"10.1158\/0008-5472.CAN-11-2389","article-title":"Volumetric and angiogenic evaluation of antitumor effects with acoustic liposome and high-frequency ultrasound","volume":"71","author":"T Kodama","year":"2011","journal-title":"Cancer Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1007\/s11095-010-0247-y","article-title":"Investigating the effect of polymeric approaches on circulation time and physical properties of nanobubbles","volume":"28","author":"LC du Toit","year":"2011","journal-title":"Pharm Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.7863\/jum.2008.27.12.1699","article-title":"A method for assessing the microvasculature in a murine tumor model using contrast-enhanced ultrasonography","volume":"27","author":"ME Loveless","year":"2008","journal-title":"J Ultrasound Med"},{"key":"ref31","first-page":"6387","article-title":"A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs","volume":"46","author":"Y Matsumura","year":"1986","journal-title":"Cancer Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s00330-005-2701-5","article-title":"Improved correlation of histological data with DCE MRI parameter maps by 3D reconstruction, reslicing and parameterization of the histological images","volume":"15","author":"F Kiessling","year":"2005","journal-title":"Eur Radiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/356314a0","article-title":"Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis","volume":"356","author":"R Watanabe-Fukunaga","year":"1992","journal-title":"Nature"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/0092-8674(94)90375-1","article-title":"Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand","volume":"76","author":"T Takahashi","year":"1994","journal-title":"Cell"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1098\/rstb.1994.0107","article-title":"Apoptosis regulated by a death factor and its receptor: Fas ligand and Fas","volume":"345","author":"S Nagata","year":"1994","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/bjc.1974.201","article-title":"The colony forming efficiency of single cells and cell aggregates from a spontaneous mouse mammary tumour using the lung colony assay","volume":"30","author":"SC Thompson","year":"1974","journal-title":"Br J Cancer"},{"key":"ref37","first-page":"661","article-title":"Pulmonary and lymph node metastasis is associated with primary tumor interstitial fluid pressure in human melanoma xenografts","volume":"62","author":"EK Rofstad","year":"2002","journal-title":"Cancer Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1093\/jnci\/djn343","article-title":"Non-sentinel lymph node metastases associated with isolated breast cancer cells in the sentinel node","volume":"100","author":"CH van Deurzen","year":"2008","journal-title":"J Natl Cancer Inst"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"4679","DOI":"10.1200\/JCO.2008.19.0686","article-title":"Impact of micrometastases in the sentinel node of patients with invasive breast cancer","volume":"27","author":"NM Hansen","year":"2009","journal-title":"J Clin Oncol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"176","DOI":"10.4321\/S1130-01082010000300004","article-title":"Prognostic value of lymph node micrometastasis in patients with colorectal cancer in Dukes stages A and B (T1\u2013T4, N0, M0)","volume":"102","author":"R Uribarrena-Amezaga","year":"2010","journal-title":"Rev Esp Enferm Dig"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1056\/NEJMoa0904832","article-title":"Micrometastases or isolated tumor cells and the outcome of breast cancer","volume":"361","author":"M de Boer","year":"2009","journal-title":"N Engl J Med"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1093\/jnci\/djq008","article-title":"Breast cancer prognosis and occult lymph node metastases, isolated tumor cells, and micrometastases","volume":"102","author":"M de Boer","year":"2010","journal-title":"J Natl Cancer Inst"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1245\/s10434-007-9513-6","article-title":"The prognostic significance of micrometastases in breast cancer: a SEER population-based analysis","volume":"14","author":"SL Chen","year":"2007","journal-title":"Ann Surg Oncol"},{"key":"ref44","first-page":"695","article-title":"The size of lymph nodes in the neck on sonograms as a radiologic criterion for metastasis: how reliable is it?","volume":"19","author":"MW van den Brekel","year":"1998","journal-title":"AJNR Am J Neuroradiol"},{"key":"ref45","first-page":"3","article-title":"Detection of lymph node metastases in the neck: radiologic criteria","volume":"22","author":"JA Castelijns","year":"2001","journal-title":"AJNR Am J Neuroradiol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"343","DOI":"10.2214\/ajr.177.2.1770343","article-title":"Detection of pelvic lymph node metastases in gynecologic malignancy: a comparison of CT, MR imaging, and positron emission tomography","volume":"177","author":"AD Williams","year":"2001","journal-title":"AJR Am J Roentgenol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/jnci\/82.1.4","article-title":"What is the evidence that tumors are angiogenesis dependent?","volume":"82","author":"J Folkman","year":"1990","journal-title":"J Natl Cancer Inst"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1200\/JCO.2002.07.089","article-title":"Tumor microvessel density as a predictor of recurrence after resection of hepatocellular carcinoma: a prospective study","volume":"20","author":"RT Poon","year":"2002","journal-title":"J Clin Oncol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0092-8674(00)80108-7","article-title":"Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis","volume":"86","author":"D Hanahan","year":"1996","journal-title":"Cell"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/00000658-197203000-00014","article-title":"Anti-angiogenesis: new concept for therapy of solid tumors","volume":"175","author":"J Folkman","year":"1972","journal-title":"Ann Surg"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/1097-0142(196303)16:3<364::AID-CNCR2820160311>3.0.CO;2-K","article-title":"Some observations on the deposition of metastatic carcinoma within cervical lymph nodes","volume":"16","author":"C Toker","year":"1963","journal-title":"Cancer"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nrc3235","article-title":"Cancer imaging by optical coherence tomography: preclinical progress and clinical potential","volume":"12","author":"BJ Vakoc","year":"2012","journal-title":"Nat Rev Cancer"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0055797","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T08:50:17Z","timestamp":1688028617000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0055797"}},"subtitle":[],"editor":[{"given":"Kazuaki","family":"Takabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,2,6]]},"references-count":52,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,2,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0055797","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,6]]}}}