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Drug Approval Package: Avandia (Rosiglitazone Maleate) NDA# 21\u2013071. Approval date: 5\/25\/1999. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/99\/21071_Avandia.cfm\" xlink:type=\"simple\">http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/99\/21071_Avandia.cfm<\/ext-link>. Accessed 2010 Dec 5."},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.2337\/diacare.25.12.2230","article-title":"Variation in diabetes care among states: do patient characteristics matter?","volume":"25","author":"DR Arday","year":"2002","journal-title":"Diabetes care"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1093\/epirev\/mxh002","article-title":"Socioeconomic position and health among persons with diabetes mellitus: a conceptual framework and review of the literature","volume":"26","author":"AF Brown","year":"2004","journal-title":"Epidemiologic reviews"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1111\/1475-6773.01102","article-title":"Whom should we profile? Examining diabetes care practice variation among primary care providers, provider groups, and health care facilities","volume":"37","author":"SL Krein","year":"2002","journal-title":"Health services research"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1056\/NEJMhpr066212","article-title":"Information technology comes to medicine","volume":"356","author":"D Blumenthal","year":"2007","journal-title":"The New England journal of medicine"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"PA Harris","year":"2009","journal-title":"Journal of biomedical informatics"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.3324\/haematol.2011.040121","article-title":"Rationale for an international consortium to study inherited genetic susceptibility to childhood acute lymphoblastic leukemia","volume":"96","author":"AL Sherborne","year":"2011","journal-title":"Haematologica"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"725","DOI":"10.2337\/diacare.26.3.725","article-title":"The diabetes risk score: a practical tool to predict type 2 diabetes risk","volume":"26","author":"J Lindstrom","year":"2003","journal-title":"Diabetes care"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"b4731","DOI":"10.1136\/bmj.b4731","article-title":"Risk of cardiovascular disease and all cause mortality among patients with type 2 diabetes prescribed oral antidiabetes drugs: retrospective cohort study using UK general practice research database","volume":"339","author":"I Tzoulaki","year":"2009","journal-title":"BMJ"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/1472-6963-6-84","article-title":"Comorbidity in patients with diabetes mellitus: impact on medical health care utilization","volume":"6","author":"JN Struijs","year":"2006","journal-title":"BMC health services research"},{"key":"ref20","article-title":"Diabetes Successes And Opportunities For Population-Based Prevention And Control","year":"2011","journal-title":"Center Disease Control"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"101S","DOI":"10.1177\/1077558707305409","article-title":"Diabetes health disparities: a systematic review of health care interventions","volume":"64","author":"ME Peek","year":"2007","journal-title":"Medical care research and review : MCRR"},{"key":"ref22","unstructured":"SHRINE Open Source Website (2011) Harvard Catalyst. 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Rockville, MD: Agency for Healthcare Research and Quality."},{"key":"ref40","unstructured":"Murphy SL, Xu JQ, Kochanek KD (2012) National Center for Health Statistics."},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1007\/s10916-010-9573-1","article-title":"PKI security in large-scale healthcare networks","volume":"36","author":"G Mantas","year":"2012","journal-title":"Journal of Medical Systems"},{"key":"ref42","unstructured":"World Wide Web Consortium website (2008) XML Signature Syntax and Processing (Second Edition). Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.w3.org\/TR\/xmldsig-core\/\" xlink:type=\"simple\">http:\/\/www.w3.org\/TR\/xmldsig-core\/<\/ext-link>.Accessed 2011 Aug 1."},{"key":"ref43","unstructured":"Nalichowski R, Keogh D, Chueh HC, Murphy SN (2006) Calculating the benefits of a Research Patient Data Repository. AMIA Annual Symposium proceedings \/ AMIA Symposium AMIA Symposium: 1044."},{"key":"ref44","unstructured":"Murphy SN, Chueh HC (2002) A security architecture for query tools used to access large biomedical databases. Proceedings \/ AMIA Annual Symposium AMIA Symposium: 552\u2013556."},{"key":"ref45","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/1471-2288-9-70","article-title":"Evaluating the informatics for integrating biology and the bedside system for clinical research","volume":"9","author":"VG Deshmukh","year":"2009","journal-title":"BMC medical research methodology"},{"key":"ref46","unstructured":"i2b2 Open Source Software website. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.i2b2.org\/software\/\" xlink:type=\"simple\">http:\/\/www.i2b2.org\/software\/<\/ext-link>. Accessed 2013 Jan 5."},{"key":"ref47","doi-asserted-by":"crossref","first-page":"228701","DOI":"10.1103\/PhysRevLett.92.228701","article-title":"Weighted evolving networks: coupling topology and weight dynamics","volume":"92","author":"A Barrat","year":"2004","journal-title":"Physical review letters"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"5234","DOI":"10.1103\/PhysRevLett.85.5234","article-title":"Topology of evolving networks: local events and universality","volume":"85","author":"R Albert","year":"2000","journal-title":"Physical review letters"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"W541","DOI":"10.1093\/nar\/gkr469","article-title":"BioPortal: enhanced functionality via new Web services from the National Center for Biomedical Ontology to access and use ontologies in software applications","volume":"39","author":"PL Whetzel","year":"2011","journal-title":"Nucleic acids research"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/amiajnl-2011-000492","article-title":"A translational engine at the national scale: informatics for integrating biology and the bedside","volume":"19","author":"IS Kohane","year":"2012","journal-title":"Journal of the American Medical Informatics Association : JAMIA"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"90cm17","DOI":"10.1126\/scitranslmed.3002747","article-title":"Reengineering translational science: the time is right","volume":"3","author":"FS Collins","year":"2011","journal-title":"Science translational medicine"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1471-2407-7-37","article-title":"Availability and quality of paraffin blocks identified in pathology archives: a multi-institutional study by the Shared Pathology Informatics Network (SPIN)","volume":"7","author":"AA Patel","year":"2007","journal-title":"BMC cancer"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1101\/gr.094615.109","article-title":"Instrumenting the health care enterprise for discovery research in the genomic era","volume":"19","author":"S Murphy","year":"2009","journal-title":"Genome research"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"e210","DOI":"10.1371\/journal.pmed.0040210","article-title":"An epidemiological network model for disease outbreak detection","volume":"4","author":"BY Reis","year":"2007","journal-title":"PLoS medicine"},{"key":"ref55","article-title":"Design specifications for network prototype and cooperative to conduct population-based studies and safety surveillance. Effective Health Care Research Report No. 13","author":"J Brown","year":"2009","journal-title":"Prepared by the DEcIDE Centers at the HMO Research Network Center for Education and Research on Therapeutics and the University of Pennsylvania Under Contract No HHSA29020050033I T05"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1097\/MLR.0b013e3181d9919f","article-title":"Distributed health data networks: a practical and preferred approach to multi-institutional evaluations of comparative effectiveness, safety, and quality of care","volume":"48","author":"JS Brown","year":"2010","journal-title":"Medical care"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1197\/jamia.M2846","article-title":"Prediction of chronic obstructive pulmonary disease (COPD) in asthma patients using electronic medical records","volume":"16","author":"BE Himes","year":"2009","journal-title":"Journal of the American Medical Informatics Association : JAMIA"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1197\/jamia.M2437","article-title":"Mayo clinic NLP system for patient smoking status identification","volume":"15","author":"GK Savova","year":"2008","journal-title":"Journal of the American Medical Informatics Association : JAMIA"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1197\/jamia.M3115","article-title":"Recognizing obesity and comorbidities in sparse data","volume":"16","author":"O Uzuner","year":"2009","journal-title":"Journal of the American Medical Informatics Association : JAMIA"},{"key":"ref60","unstructured":"Goryachev S, Kim H, Zeng-Treitler Q (2008) Identification and extraction of family history information from clinical reports. AMIA Annual Symposium proceedings \/ AMIA Symposium AMIA Symposium: 247\u2013251."},{"key":"ref61","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1472-6947-6-30","article-title":"Extracting principal diagnosis, co-morbidity and smoking status for asthma research: evaluation of a natural language processing system","volume":"6","author":"QT Zeng","year":"2006","journal-title":"BMC medical informatics and decision making"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1136\/jamia.2009.001560","article-title":"Mayo clinical Text Analysis and Knowledge Extraction System (cTAKES): architecture, component evaluation and applications","volume":"17","author":"GK Savova","year":"2010","journal-title":"Journal of the American Medical Informatics Association : JAMIA"},{"key":"ref63","unstructured":"Schadow G, McDonald CJ (2003) Extracting structured information from free text pathology reports. 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