{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:20:27Z","timestamp":1792736427398,"version":"4.5.0"},"reference-count":23,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2013,2,7]],"date-time":"2013-02-07T00:00:00Z","timestamp":1360195200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0055867","type":"journal-article","created":{"date-parts":[[2013,2,7]],"date-time":"2013-02-07T22:05:05Z","timestamp":1360274705000},"page":"e55867","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":41,"title":["Chronic Over-Expression of Heat Shock Protein 27 Attenuates Atherogenesis and Enhances Plaque Remodeling: A Combined Histological and Mechanical Assessment of Aortic Lesions"],"prefix":"10.1371","volume":"8","author":[{"given":"Charles M.","family":"Cuerrier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Xiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Tremblay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katey","family":"Rayner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"McNulty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XiaoLing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R. J.","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"de BelleRoche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew E.","family":"Pelling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward R.","family":"O'Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,2,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/978-0-387-39975-1_2","article-title":"The cellular \u201cnetworking\u201d of mammalian Hsp27 and its functions in the control of protein folding, redox state and apoptosis","volume":"594","author":"AP Arrigo","year":"2007","journal-title":"Adv Exp Med Biol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.1016\/j.febslet.2007.04.044","article-title":"Extracellular heat shock proteins in cell signaling","volume":"581","author":"SK Calderwood","year":"2007","journal-title":"FEBS Lett"},{"key":"ref3","article-title":"Extracellular HSP27 Acts as a Signaling Molecule to Activates NF-\u03baB in Macrophages","author":"S Salari","year":"2012","journal-title":"Cell Stress & Chaperones"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1161\/01.ATV.0000156536.89752.8e","article-title":"Modulation of estrogen signaling by the novel interaction of heat shock protein 27, a biomarker for atherosclerosis, and estrogen receptor \u03b2","volume":"25","author":"H Miller","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1161\/01.CIR.0000136814.87170.B1","article-title":"Identification by a differential proteomic approach of heat shock protein 27 as a potential marker of atherosclerosis","volume":"110","author":"JL Martin-Ventura","year":"2004","journal-title":"Circulation"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1161\/CIRCULATIONAHA.105.541219","article-title":"Expression of heat shock protein 27 in human atherosclerotic plaques and increased plasma level of heat shock protein 27 in patients with acute coronary syndrome","volume":"114","author":"HK Park","year":"2006","journal-title":"Circulation"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1161\/CIRCRESAHA.108.172155","article-title":"Extracellular release of the atheroprotective heat shock protein 27 is mediated by estrogen and competitively inhibits acLDL binding to scavenger receptor-A","volume":"103","author":"K Rayner","year":"2008","journal-title":"Circ Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1161\/ATVBAHA.109.193656","article-title":"Heat shock protein 27 protects against atherogenesis via an estrogen-dependent mechanism: Role of selective estrogen receptor beta modulation","volume":"29","author":"K Rayner","year":"2009","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.expneurol.2005.12.031","article-title":"Heat shock protein 27 rescues motor neurons following nerve injury and preserves muscle function","volume":"198","author":"P Sharp","year":"2006","journal-title":"Exp Neurol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1161\/CIRCRESAHA.106.146183","article-title":"Genetic Deletion of Pregnancy-Associated Plasma Protein-A Is Associated With Resistance to Atherosclerotic Lesion Development in Apolipoprotein E Deficient Mice Challenged With a High-Fat Diet","volume":"100","author":"SC Harrington","year":"2007","journal-title":"Circ Res"},{"key":"ref11","first-page":"201","article-title":"Localization of unesterified cholesterol in human atherosclerotic lesions. Demonstration of filipin-positive, oil-red-O-negative particles","volume":"114","author":"HS Kruth","year":"1984","journal-title":"Am J Pathol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3721","DOI":"10.1161\/01.CIR.0000146790.51331.BA","article-title":"Novel anti-inflammatory vascular benefits of systemic and stent-based delivery of ethylisopropylamiloride","volume":"110","author":"Y-X Chen","year":"2004","journal-title":"Circulation"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jsbmb.2007.07.006","article-title":"Discovery of NM23-H2 as an Estrogen Receptor-\u03b2 Associated Protein: Role in Estrogen-Induced Gene Transcription and Cell Migration","volume":"108","author":"K Rayner","year":"2008","journal-title":"Journal of Steroid Biochemistry and Molecular Biology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1369\/jhc.5A6824.2006","article-title":"Comparison of processing and sectioning methodologies for arteries containing metallic stents","volume":"54","author":"P Rippstein","year":"2006","journal-title":"J Histochem Cytochem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/BF01002772","article-title":"Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections","volume":"11","author":"L Junqueira","year":"1979","journal-title":"Histochem J"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0008-6363(98)00203-X","article-title":"The time course and importance of neoadventitial formation in arterial remodeling following balloon angioplasty of porcine coronary arteries","volume":"41","author":"M Labinaz","year":"1999","journal-title":"Cardiovasc Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1161\/01.ATV.0000184783.04864.9f","article-title":"Consequences and therapeutic implications of macrophage apoptosis in atherosclerosis: the importance of lesion stage and phagocytic efficiency","volume":"25","author":"I Tabas","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1023\/A:1021601103096","article-title":"On the role of Hsp27 in regulating apoptosis","volume":"8","author":"CG Concannon","year":"2003","journal-title":"Apoptosis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0008-6363(98)00321-6","article-title":"Collagen synthesis in atherosclerosis: too much and not enough","volume":"41","author":"MD Rekhter","year":"1999","journal-title":"Cardiovasc Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.athoracsur.2009.07.023","article-title":"A comparison of mechanical properties of materials used in aortic arch reconstruction","volume":"88","author":"D Tremblay","year":"2009","journal-title":"Ann Thorac Surg"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s12192-008-0087-4","article-title":"Unfolding the relationship between secreted molecular chaperones and macrophage activation states","volume":"14","author":"B Henderson","year":"2009","journal-title":"Cell Stress & Chaperones"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"A544","DOI":"10.1161\/atvb.32.suppl_1.A544","article-title":"Extracellular Heat Shock Protein 27 Inhibits Foam Cell Formation by Targeting Scavenger Receptor-A in the vessel wall","volume":"32","author":"JE Raizman","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/S0008-6363(96)00097-1","article-title":"The importance of thrombus organization and stellate cell phenotype in collagen I gene expression in human, coronary atherosclerotic and restenotic lesions","volume":"32","author":"MD Rekhter","year":"1996","journal-title":"Cardiovasc Res"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0055867","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T02:12:37Z","timestamp":1644286357000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0055867"}},"subtitle":[],"editor":[{"given":"Ali A.","family":"Sovari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,2,7]]},"references-count":23,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,2,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0055867","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,7]]}}}