{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:19:54Z","timestamp":1777558794731,"version":"3.51.4"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T00:00:00Z","timestamp":1360713600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0055899","type":"journal-article","created":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T22:38:00Z","timestamp":1360795080000},"page":"e55899","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Effects of TRAP-1-Like Protein (TLP) Gene on Collagen Synthesis Induced by TGF-\u03b2\/Smad Signaling in Human Dermal Fibroblasts"],"prefix":"10.1371","volume":"8","author":[{"given":"Xue","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunliang","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danru","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,2,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1524-4725.2008.34406.x","article-title":"Hypertrophic scars and keloids\u2013a review of their pathophysiology, risk factors, and therapeutic management","volume":"35","author":"D Wolfram","year":"2009","journal-title":"Dermatol Surg"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1096\/fj.03-1273rev","article-title":"TGF-beta signaling and the fibrotic response","volume":"18","author":"A Leask","year":"2004","journal-title":"FASEB J"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1097\/00006534-200108000-00022","article-title":"Differential expression of transforming growth factor-beta receptors I and II and activation of Smad 3 in keloid fibroblasts","volume":"108","author":"GS Chin","year":"2001","journal-title":"Plast Reconstr Surg"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1096\/fj.02-0103fje","article-title":"Synthetic TGF-beta antagonist accelerates wound healing and reduces scarring","volume":"16","author":"JS Huang","year":"2002","journal-title":"FASEB J"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1097\/BCR.0b013e31819a6369","article-title":"A novel TGF-beta antagonist speeds reepithelialization and reduces scarring of partial thickness porcine burns","volume":"30","author":"AJ Singer","year":"2009","journal-title":"J Burn Care Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1002\/j.1460-2075.1995.tb07214.x","article-title":"GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex","volume":"14","author":"R Wieser","year":"1995","journal-title":"EMBO J"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"4984","DOI":"10.2741\/3057","article-title":"Smad7 as a therapeutic agent for chronic kidney diseases","volume":"13","author":"HY Lan","year":"2008","journal-title":"Front Biosci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/j.1365-2133.1994.tb04978.x","article-title":"Systemic glucocorticoids decrease the synthesis of type I and type III collagen in human skin in vivo, whereas isotretinoin treatment has little effect","volume":"131","author":"P Autio","year":"1994","journal-title":"Br J Dermatol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"19495","DOI":"10.1074\/jbc.M006473200","article-title":"Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone","volume":"276","author":"JU Wurthner","year":"2001","journal-title":"J Biol Chem"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"4465","DOI":"10.1093\/emboj\/cdg428","article-title":"TLP, a novel modulator of TGF-beta signaling, has opposite effects on Smad2- and Smad3-dependent signaling","volume":"22","author":"A Felici","year":"2003","journal-title":"EMBO J"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1006\/jsre.1999.5761","article-title":"Downregulation of apoptosis-related genes in keloid tissues","volume":"87","author":"DN Sayah","year":"1999","journal-title":"J Surg Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1111\/j.1365-2133.2008.08449.x","article-title":"Coexistence and upregulation of three types of opioid receptors, mu, delta and kappa, in human hypertrophic scars","volume":"158","author":"B Cheng","year":"2008","journal-title":"Br J Dermatol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1042\/BJ20070545","article-title":"The essential role for c-Ski in mediating TGF-beta1-induced bi-directional effects on skin fibroblast proliferation through a feedback loop","volume":"409","author":"X Liu","year":"2008","journal-title":"Biochem J"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1600-0625.2010.01186.x","article-title":"Inhibiting scar formation in vitro and in vivo by adenovirus-mediated mutant Smad4: a preliminary report","volume":"20","author":"WQ Tan","year":"2011","journal-title":"Exp Dermatol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1093\/rheumatology\/keq208","article-title":"Modulation of collagen type I, fibronectin and dermal fibroblast function and activity, in systemic sclerosis by the antioxidant epigallocatechin-3-gallate","volume":"49","author":"A Dooley","year":"2010","journal-title":"Rheumatology (Oxford)"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.clindermatol.2006.09.007","article-title":"Pathophysiology of acute wound healing","volume":"25","author":"J Li","year":"2007","journal-title":"Clin Dermatol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1152\/physrev.2003.83.3.835","article-title":"Regulation of wound healing by growth factors and cytokines","volume":"83","author":"S Werner","year":"2003","journal-title":"Physiol Rev"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1111\/j.1524-475X.2007.00219.x","article-title":"Cellular and molecular pathology of HTS: basis for treatment","volume":"15","author":"A Armour","year":"2007","journal-title":"Wound Repair Regen"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.bbaexp.2006.11.001","article-title":"Regulation of Smad activities","volume":"1759","author":"L Xu","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.3748\/wjg.v13.i22.3056","article-title":"Transforming growth factor-beta and fibrosis","volume":"13","author":"F Verrecchia","year":"2007","journal-title":"World J Gastroenterol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"4359","DOI":"10.1242\/jcs.114.24.4359","article-title":"Smad regulation in TGF-beta signal transduction","volume":"114","author":"A Moustakas","year":"2001","journal-title":"J Cell Sci"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/37284","article-title":"TGF-beta signalling from cell membrane to nucleus through SMAD proteins","volume":"390","author":"CH Heldin","year":"1997","journal-title":"Nature"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jdermsci.2003.12.006","article-title":"TGF-beta-induced SMAD signaling and gene regulation: consequences for extracellular matrix remodeling and wound healing","volume":"35","author":"M Schiller","year":"2004","journal-title":"J Dermatol Sci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1590\/S0100-879X2009007500017","article-title":"Mechanism of the transforming growth factor-beta induction of fibronectin expression in hepatic stem-like cells","volume":"43","author":"W Cui","year":"2010","journal-title":"Braz J Med Biol Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1046\/j.1523-1747.1999.00477.x","article-title":"Stimulation of type I collagen transcription in human skin fibroblasts by TGF-beta: involvement of Smad 3","volume":"112","author":"SJ Chen","year":"1999","journal-title":"J Invest Dermatol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.bjps.2006.05.007","article-title":"Inhibition of Smad3 expression decreases collagen synthesis in keloid disease fibroblasts","volume":"60","author":"Z Wang","year":"2007","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"4214","DOI":"10.1091\/mbc.E05-02-0149","article-title":"Smad2 and Smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organization","volume":"16","author":"M Uemura","year":"2005","journal-title":"Mol Biol Cell"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.0959-9673.2004.00377.x","article-title":"Smad3 as a mediator of the fibrotic response","volume":"85","author":"KC Flanders","year":"2004","journal-title":"Int J Exp Pathol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"19945","DOI":"10.1074\/jbc.M102382200","article-title":"Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts","volume":"276","author":"E Piek","year":"2001","journal-title":"J Biol Chem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.4049\/jimmunol.173.3.2099","article-title":"Smad3 null mice develop airspace enlargement and are resistant to TGF-beta-mediated pulmonary fibrosis","volume":"173","author":"P Bonniaud","year":"2004","journal-title":"J Immunol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.1093\/ndt\/gfq239","article-title":"Triptolide inhibits extracellular matrix protein synthesis by suppressing the Smad2 but not the MAPK pathway in TGF-beta1-stimulated NRK-49F cells","volume":"25","author":"B Zhu","year":"2010","journal-title":"Nephrol Dial Transplant"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1254\/jphs.11065FP","article-title":"Effect of efonidipine on TGF-\u03b21-induced cardiac fibrosis through Smad2-dependent pathway in rat cardiac fibroblasts","volume":"117","author":"B Lei","year":"2011","journal-title":"J Pharmacol Sci"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1177\/153537020222700502","article-title":"Factors involved in the regulation of type I collagen gene expression: implication in fibrosis","volume":"227","author":"AK Ghosh","year":"2002","journal-title":"Exp Biol Med (Maywood)"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1083\/jcb.200102142","article-title":"Human Vam6p promotes lysosome clustering and fusion in vivo","volume":"154","author":"S Caplan","year":"2001","journal-title":"J Cell Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1242\/dev.006098","article-title":"The zebrafish mutant lbk\/vam6 resembles human multisystemic disorders caused by aberrant trafficking of endosomal vesicles","volume":"135","author":"HB Schonthaler","year":"2008","journal-title":"Development"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.imbio.2010.07.006","article-title":"The TGF-\u03b2 signaling modulators TRAP1\/TGFBRAP1 and VPS39\/Vam6\/TLP are essential for early embryonic development","volume":"216","author":"S Messler","year":"2011","journal-title":"Immunobiology"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0055899","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T17:51:44Z","timestamp":1644342704000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0055899"}},"subtitle":[],"editor":[{"given":"Marie Jose","family":"Goumans","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,2,13]]},"references-count":36,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,2,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0055899","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,13]]}}}