{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:28:44Z","timestamp":1791772124726,"version":"4.3.4"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T00:00:00Z","timestamp":1360713600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0055937","type":"journal-article","created":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T17:37:38Z","timestamp":1360777058000},"page":"e55937","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":176,"title":["Neutering Dogs: Effects on Joint Disorders and Cancers in Golden Retrievers"],"prefix":"10.1371","volume":"8","author":[{"given":"Gretel","family":"Torres de la Riva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin L.","family":"Hart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas B.","family":"Farver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita M.","family":"Oberbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Locksley L. McV.","family":"Messam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Willits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynette A.","family":"Hart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,2,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"898","DOI":"10.2460\/javma.238.7.898","article-title":"Epidemiology of surgical castration of dogs and cats in the United States","volume":"238","author":"R Trevejo","year":"2011","journal-title":"J Am Vet Med Assoc"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Sallander M, Hedhammer A, Rundgren M, Lindberg JE (2001) Demographic data of population of insured Swedish dogs measured in a questionnaire study. Acta Vet Scand 71\u201380.","DOI":"10.1186\/1751-0147-42-71"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.beproc.2009.04.004","article-title":"Dog and owner demographic characteristicsand dog personality trait associations","volume":"81","author":"E Kubinyi","year":"2009","journal-title":"Behav Processes"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1136\/vr.b4798","article-title":"Survey of veterinary practice policies andopinions on neutering dogs","volume":"166","author":"G Diesel","year":"2010","journal-title":"Vet Rec"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1090-0233(98)80059-2","article-title":"Host related risk factors for canine osteosarcoma","volume":"156","author":"G Ru","year":"1998","journal-title":"Vet J"},{"key":"ref6","first-page":"1434","article-title":"Endogenous gonadal hormone exposure and bone sarcoma risk","volume":"11","author":"DM Cooley","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prevent"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1939-1676.1999.tb01136.x","article-title":"Cardiac tumors in dogs: 1982\u20131995","volume":"13","author":"WA Ware","year":"1999","journal-title":"J Vet Intern Med"},{"key":"ref8","first-page":"706","article-title":"Epidemiologic, clinical, pathologic, and prognostic characteristics of splenic hemangiosarcoma and splenic hematoma in dogs: 217 cases (1985)","volume":"193","author":"C Prymak","year":"1988","journal-title":"J Am Vet Med Assoc"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2009\/591753","article-title":"Hormonal and sex impact on the epidemiology of canine lymphoma","volume":"2009","author":"JA Villamil","year":"2009","journal-title":"J Cancer Epidemiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0303-7207(02)00261-7","article-title":"Canine prostate carcinoma: epidemiological evidence of an increased risk in castrated dogs","volume":"197","author":"E Teske","year":"2002","journal-title":"Mol Cell Endocrinol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"210","DOI":"10.5326\/JAAHA-MS-5621","article-title":"Cutaneous MCTs: Associations with spay\/neuter status, breed, body size, and phylogenetic cluster","volume":"47","author":"CR White","year":"2011","journal-title":"J Am Anim Hosp Assoc"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.2460\/javma.231.11.1665","article-title":"Determining the optimal age for gonadectomy of dogs and cats","volume":"231","author":"MV Root Kustritz","year":"2007","journal-title":"J Am Vet Med Assoc"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1748-5827.2011.01220.x","article-title":"The effect of neutering on the risk of mammary tumours in dogs \u2013 a systematic review","volume":"53","author":"W Beauvais","year":"2012","journal-title":"J Small Anim Pract"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.2460\/javma.231.11.1688","article-title":"Risk factors for excessive tibial plateau angle in large-breed dogs with cranial cruciate disease","volume":"231","author":"FM Duerr","year":"2007","journal-title":"J Am Vet Med Assoc"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.2460\/javma.232.12.1818","article-title":"Prevalence of, and risk factors for, hip dysplasia and cranial cruciate ligament deficiency in dogs","volume":"232","author":"TH Witsberger","year":"2008","journal-title":"J Am Vet Med Assoc"},{"key":"ref16","unstructured":"Glickman L (1998\u20131999) Golden Retriever Club of America National Health Survey. Golden Retriever Club of America."},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Kasstr\u00f6m H (1975) Nutrition, weight gain and development of hip dysplasia. An experimental investigation in growing dogs with special reference to the effect of feeding intensity. Acta Radiologica 344: 135\u2013179, Supplementum.","DOI":"10.1177\/0284185175016S34412"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"811","DOI":"10.2460\/javma.1999.215.06.811","article-title":"Breed, sex, and body weight as risk factors for rupture of the cranial cruciate ligament in young dogs","volume":"215","author":"JM Duval","year":"1999","journal-title":"J Am Vet Med Assoc"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric estimation from incomplete observations","volume":"53","author":"EL Kaplan","year":"1958","journal-title":"J Am Stat Assoc"},{"key":"ref20","unstructured":"Rothman KJ and Greenland S (1998) Modern Epidemiology. Philadelphia: Lippincott Williams &amp; Wilkins."},{"key":"ref21","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.prevetmed.2005.01.014","article-title":"Incidence of, and survival after, mammary tumors in a population of over 80,000 insured female dogs in Sweden from 1995 to 2002","volume":"69","author":"A Egenvall","year":"2005","journal-title":"Prevent Vet Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2754\/avb200574010103","article-title":"Breed and age as risk factors for canine mammary tumours","volume":"74","author":"J Zatlouka","year":"2005","journal-title":"Acta Vet Brno"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.2460\/javma.1991.198.07.1193","article-title":"Gonadectomy in immature dogs: Effects on skeletal, physical, and behavioral development","volume":"198","author":"KR Salmeri","year":"1991","journal-title":"J Am Vet Med Assoc"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1515\/jpem-2000-s619","article-title":"Estrogen, bone growth and sex: a sea of change in conventional wisdom","volume":"13","author":"M Grumbach","year":"2000","journal-title":"J Ped Endocrinol Metab"},{"key":"ref25","first-page":"126","article-title":"Estrogens reduce and withdrawal of estrogens increase risk of microsatellite instability-positive colon cancer","volume":"61","author":"ML Slattery","year":"2001","journal-title":"Cancer Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2460\/javma.2001.219.51","article-title":"Effects of gonadectomy on subsequent development of age-related cognitive impairment in dogs","volume":"219","author":"BL Hart","year":"2001","journal-title":"J Am Vet Med Assoc"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"781","DOI":"10.3109\/07357900009012210","article-title":"Spontaneously occurring tumors of companion animals as models for human cancer","volume":"18","author":"DM Vail","year":"2002","journal-title":"Cancer Invest"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1038\/nbt0906-1065b","article-title":"The dog as a cancer model","volume":"24","author":"C Khanna","year":"2006","journal-title":"Nat Biotechnol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0055937","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,5]],"date-time":"2024-05-05T21:19:37Z","timestamp":1714943977000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0055937"}},"subtitle":[],"editor":[{"given":"Bart O.","family":"Williams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,2,13]]},"references-count":28,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,2,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0055937","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,13]]}}}