{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:11:48Z","timestamp":1785773508805,"version":"3.56.0"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T00:00:00Z","timestamp":1360713600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0056019","type":"journal-article","created":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T22:27:31Z","timestamp":1360794451000},"page":"e56019","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["1,25-Dihydroxyvitamin D and the Vitamin D Receptor Gene Polymorphism Apa1 Influence Bone Mineral Density in Primary Hyperparathyroidism"],"prefix":"10.1371","volume":"8","author":[{"given":"Monika H. E.","family":"Christensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen M.","family":"Apalset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yngve","family":"Nordb\u00f8","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Erik","family":"Varhaug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Mellgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernst A.","family":"Lien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,2,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0140-6736(09)60507-9","article-title":"Hyperparathyroidism","volume":"374","author":"WD Fraser","year":"2009","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1210\/jc.2006-1836","article-title":"Medical observation, compared with parathyroidectomy, for asymptomatic primary hyperparathyroidism: a prospective, randomized trial","volume":"92","author":"J Bollerslev","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1136\/bmj.321.7261.598","article-title":"Cohort study of risk of fracture before and after surgery for primary hyperparathyroidism","volume":"321","author":"P Vestergaard","year":"2000","journal-title":"BMJ"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1146\/annurev.nutr.22.120501.150216","article-title":"Hydroxylase enzymes of the vitamin D pathway: expression, function, and regulation","volume":"22","author":"JL Omdahl","year":"2002","journal-title":"Annu Rev Nutr"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1096\/fj.06-6374fje","article-title":"Evidence for auto\/paracrine actions of vitamin D in bone: 1alpha-hydroxylase expression and activity in human bone cells","volume":"20","author":"M van Driel","year":"2006","journal-title":"FASEB J"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.jsbmb.2004.03.058","article-title":"Effects of calcium and of the Vitamin D system on skeletal and calcium homeostasis: lessons from genetic models","volume":"89\u201390","author":"D Goltzman","year":"2004","journal-title":"J Steroid Biochem Mol Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1210\/edrv.22.4.0437","article-title":"Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications","volume":"22","author":"P Lips","year":"2001","journal-title":"Endocr Rev"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/BF03344140","article-title":"A very high incidence of low 25 hydroxy-vitamin D serum concentration in a French population of patients with primary hyperparathyroidism","volume":"29","author":"P Boudou","year":"2006","journal-title":"J Endocrinol Invest"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/j.1365-2265.2005.02371.x","article-title":"Vitamin D status, seasonal variations, parathyroid adenoma weight and bone mineral density in primary hyperparathyroidism","volume":"63","author":"B Moosgaard","year":"2005","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Jones G, Prosser DE, Kaufmann M (2011) 25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): Its important role in the degradation of vitamin D. Arch Biochem Biophys.","DOI":"10.1016\/j.abb.2011.11.003"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.mce.2004.07.012","article-title":"Characterization of vitamin D-mediated induction of the CYP 24 transcription","volume":"226","author":"K Tashiro","year":"2004","journal-title":"Mol Cell Endocrinol"},{"key":"ref12","first-page":"638S","article-title":"Environmental factors that influence the cutaneous production of vitamin D. Am J Clin Nutr","volume":"61","author":"MF Holick","year":"1995"},{"key":"ref13","first-page":"996","article-title":"Vitamin D status in postmenopausal women living at higher latitudes in the UK in relation to bone health, overweight, sunlight exposure and dietary vitamin D. Bone","volume":"42","author":"HM Macdonald","year":"2008"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3109\/00365511003797172","article-title":"Seasonal and age-related differences in serum 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D and parathyroid hormone in patients from Western Norway","volume":"70","author":"MH Christensen","year":"2010","journal-title":"Scand J Clin Lab Invest"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1359\/jbmr.2001.16.2.371","article-title":"Genetic contribution to bone metabolism, calcium excretion, and vitamin D and parathyroid hormone regulation","volume":"16","author":"D Hunter","year":"2001","journal-title":"J Bone Miner Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0039-128X(01)00167-2","article-title":"Molecular tools for study of genomic and rapid signal transduction responses initiated by 1 alpha,25(OH)(2)-vitamin D(3)","volume":"67","author":"AW Norman","year":"2002","journal-title":"Steroids"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1210\/jc.2006-1134","article-title":"Vitamin D receptor gene haplotype is associated with body height and bone size","volume":"92","author":"Y Fang","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1530\/EJE-10-0150","article-title":"Effect of smoking on the serum levels of 25-hydroxyvitamin D depends on the assay employed","volume":"163","author":"G Grimnes","year":"2010","journal-title":"Eur J Endocrinol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1373\/49.2.286","article-title":"Determination of choline, betaine, and dimethylglycine in plasma by a high-throughput method based on normal-phase chromatography-tandem mass spectrometry","volume":"49","author":"PI Holm","year":"2003","journal-title":"Clin Chem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1373\/clinchem.2006.077180","article-title":"Expressing the Modification of Diet in Renal Disease Study equation for estimating glomerular filtration rate with standardized serum creatinine values","volume":"53","author":"AS Levey","year":"2007","journal-title":"Clin Chem"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/j.1463-1326.2008.00879.x","article-title":"Gestational diabetes mellitus and vitamin D deficiency: genetic contribution of CYP27B1 and CYP2R1 polymorphisms","volume":"10","author":"E Ramos-Lopez","year":"2008","journal-title":"Diabetes Obes Metab"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1161\/ATVBAHA.110.211805","article-title":"Association of the vitamin D metabolism gene CYP24A1 with coronary artery calcification","volume":"30","author":"H Shen","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1007\/s00415-011-6001-5","article-title":"Genetic predictors of 25-hydroxyvitamin D levels and risk of multiple sclerosis","volume":"258","author":"KC Simon","year":"2011","journal-title":"J Neurol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"255","DOI":"10.7326\/0003-4819-145-4-200608150-00005","article-title":"The association between common vitamin D receptor gene variations and osteoporosis: a participant-level meta-analysis","volume":"145","author":"AG Uitterlinden","year":"2006","journal-title":"Ann Intern Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0140-6736(10)60588-0","article-title":"Common genetic determinants of vitamin D insufficiency: a genome-wide association study","volume":"376","author":"TJ Wang","year":"2010","journal-title":"Lancet"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1097\/01.bor.0000229521.95384.7d","article-title":"Bone biology and the pathogenesis of osteoporosis","volume":"18","author":"RG Russell","year":"2006","journal-title":"Curr Opin Rheumatol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.bone.2011.11.009","article-title":"Physical activity, body mass index and bone mineral density-associations in a prospective population-based cohort of women and men: the Canadian Multicentre Osteoporosis Study (CaMos)","volume":"50","author":"L Langsetmo","year":"2012","journal-title":"Bone"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"S Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/j.1365-2265.2007.03109.x","article-title":"Vitamin D metabolites and skeletal consequences in primary hyperparathyroidism","volume":"68","author":"B Moosgaard","year":"2008","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/jcb.10623","article-title":"In vivo administration of 1,25-dihydroxyvitamin D3 suppresses the expression of RANKL mRNA in bone of thyroparathyroidectomized rats constantly infused with PTH","volume":"90","author":"Y Ueno","year":"2003","journal-title":"J Cell Biochem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0092-8674(00)81569-X","article-title":"Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation","volume":"93","author":"DL Lacey","year":"1998","journal-title":"Cell"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"3540","DOI":"10.1073\/pnas.96.7.3540","article-title":"Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand","volume":"96","author":"H Hsu","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/jcb.10331","article-title":"Vitamin D and bone","volume":"88","author":"T Suda","year":"2003","journal-title":"J Cell Biochem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/jbmr.5650040302","article-title":"Skeletal disease in primary hyperparathyroidism","volume":"4","author":"SJ Silverberg","year":"1989","journal-title":"J Bone Miner Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"3462","DOI":"10.1210\/jc.2007-1215","article-title":"The natural history of primary hyperparathyroidism with or without parathyroid surgery after 15 years","volume":"93","author":"MR Rubin","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/8756-3282(93)90207-Q","article-title":"Primary hyperparathyroidism: iliac crest cortical thickness, structure, and remodeling evaluated by histomorphometric methods","volume":"14","author":"P Christiansen","year":"1993","journal-title":"Bone"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline","volume":"96","author":"MF Holick","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"ref38","unstructured":"IOM (2010) Dietary reference intakes for calcium and vitamin D. National Academies Press: Institute of Medicine."},{"key":"ref39","first-page":"277","article-title":"Reducing fracture risk with calcium and vitamin D. Clin Endocrinol (Oxf)","volume":"73","author":"P Lips","year":"2010"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/978-0-387-77574-6_5","article-title":"Optimal serum 25-hydroxyvitamin D levels for multiple health outcomes","volume":"624","author":"HA Bischoff-Ferrari","year":"2008","journal-title":"Adv Exp Med Biol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1210\/jc.2008-1763","article-title":"Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the third international workshop","volume":"94","author":"JP Bilezikian","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1530\/EJE-11-0589","article-title":"Current evidence for recommendation of surgery, medical treatment and vitamin D repletion in mild primary hyperparathyroidism","volume":"165","author":"J Bollerslev","year":"2011","journal-title":"Eur J Endocrinol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1530\/EC-12-0008","article-title":"Prolonged treatment with vitamin D in postmenopausal women with primary hyperparathyroidism","volume":"01","author":"RR Rao","year":"2012","journal-title":"Endocrine connections"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1210\/jc.2004-1772","article-title":"Vitamin D repletion in patients with primary hyperparathyroidism and coexistent vitamin D insufficiency","volume":"90","author":"A Grey","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"ref45","first-page":"3541","article-title":"Bone mineral density increases with vitamin D repletion in patients with coexistent vitamin D insufficiency and primary hyperparathyroidism","volume":"85","author":"V Kantorovich","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/8756-3282(91)90020-J","article-title":"Effect of a short course of 1,25-dihydroxyvitamin D3 on biochemical markers of bone remodeling in adult male volunteers","volume":"12","author":"J Bollerslev","year":"1991","journal-title":"Bone"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0169-6009(89)90006-8","article-title":"Determinants for serum 1,25-dihydroxycholecalciferol in primary hyperparathyroidism","volume":"5","author":"L Mosekilde","year":"1989","journal-title":"Bone Miner"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1007\/s10067-009-1220-1","article-title":"Evidence of association of vitamin D receptor Apa I gene polymorphism with bone mineral density in postmenopausal women with osteoporosis","volume":"28","author":"U Dundar","year":"2009","journal-title":"Clin Rheumatol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1002\/jbmr.5650101102","article-title":"Bone density determinants in elderly women: a twin study","volume":"10","author":"L Flicker","year":"1995","journal-title":"J Bone Miner Res"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0056019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T18:23:05Z","timestamp":1562696585000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0056019"}},"subtitle":[],"editor":[{"given":"Andrzej T.","family":"Slominski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,2,13]]},"references-count":49,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,2,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0056019","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,13]]}}}