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Berriman","year":"2005","journal-title":"Science"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1002\/pmic.200800477","article-title":"A comprehensive analysis of Trypanosoma brucei mitochondrial proteome","volume":"9","author":"AK Panigrahi","year":"2009","journal-title":"Proteomics"},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"Gafken PR (2009) An overview of the qualitative analysis of phosphoproteins by mass spectrometry. 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