{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:15:38Z","timestamp":1791296138021,"version":"4.1.0"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T00:00:00Z","timestamp":1360713600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0056286","type":"journal-article","created":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T21:56:01Z","timestamp":1360792561000},"page":"e56286","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":31,"title":["Morphology and Nanomechanics of Sensory Neurons Growth Cones following Peripheral Nerve Injury"],"prefix":"10.1371","volume":"8","author":[{"given":"Marta","family":"Martin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ouafa","family":"Benzina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivien","family":"Szabo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila-Gergely","family":"V\u00e9gh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Lucas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Cloitre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Scamps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Csilla","family":"Gergely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,2,13]]},"reference":[{"key":"ref1","unstructured":"Lawson S (1992) Morphological and biochemical cell types of sensory neurons. Sensory Neurons. Diversity, Development, and Plasticity.Oxford University Press, New York. 27\u201359."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"34131","DOI":"10.1074\/jbc.M104271200","article-title":"Identification of genes induced in peripheral nerve after injury. Expression profiling and novel gene discovery","volume":"276","author":"T Araki","year":"2001","journal-title":"J Biol Chem"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"8360","DOI":"10.1073\/pnas.122231899","article-title":"Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain","volume":"99","author":"HS Xiao","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.mcn.2006.04.004","article-title":"Gene profiling during development and after a peripheral nerve traumatism reveals genes specifically induced by injury in dorsal root ganglia","volume":"32","author":"I Mechaly","year":"2006","journal-title":"Mol Cell Neurosci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.molbrainres.2005.01.008","article-title":"Early changes in gene expression in the dorsal root ganglia after transection of the sciatic nerve; effects of amphiregulin and PAI-1 on regeneration","volume":"136","author":"A Nilsson","year":"2005","journal-title":"Brain Res Mol Brain Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.expneurol.2009.09.006","article-title":"A conditioning lesion induces changes in gene expression and axonal transport that enhance regeneration by increasing the intrinsic growth state of axons","volume":"223","author":"PN Hoffman","year":"2010","journal-title":"Exp Neurol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1146\/annurev.neuro.30.051606.094337","article-title":"Peripheral regeneration","volume":"30","author":"ZL Chen","year":"2007","journal-title":"Annu Rev Neurosci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0014-4886(92)90022-I","article-title":"Myelinated fiber regeneration after sciatic nerve crush: morphometric observations in young adult and aging mice and the effects of macrophage suppression and conditioning lesions","volume":"118","author":"K Tanaka","year":"1992","journal-title":"Exp Neurol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.expneurol.2007.06.020","article-title":"The role of cyclic AMP signaling in promoting axonal regeneration after spinal cord injury","volume":"209","author":"SS Hannila","year":"2008","journal-title":"Exp Neurol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1523\/JNEUROSCI.17-02-00646.1997","article-title":"A transcription-dependent switch controls competence of adult neurons for distinct modes of axon growth","volume":"17","author":"DS Smith","year":"1997","journal-title":"J Neurosc"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3764","DOI":"10.1152\/jn.00449.2003","article-title":"Axotomy-induced expression of calcium-activated chloride current in subpopulations of mouse dorsal root ganglion neurons","volume":"90","author":"S Andre","year":"2003","journal-title":"J Neurophysiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"6751","DOI":"10.1523\/JNEUROSCI.1337-07.2007","article-title":"NKCC1 phosphorylation stimulates neurite growth of injured adult sensory neurons","volume":"27","author":"S Pieraut","year":"2007","journal-title":"J Neurosc"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"13516","DOI":"10.1523\/JNEUROSCI.3382-11.2011","article-title":"An autocrine neuronal interleukin-6 loop mediates chloride accumulation and NKCC1 phosphorylation in axotomized sensory neurons","volume":"31","author":"S Pieraut","year":"2011","journal-title":"J Neurosc"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/978-0-387-76715-4_9","article-title":"The Hedgehog, TGF-beta\/BMP and Wnt families of morphogens in axon guidance","volume":"621","author":"F Charron","year":"2007","journal-title":"Adv Exp Med Biol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1083\/jcb.200111076","article-title":"Functional binding interaction identified between the axonal CAM L1 and members of the ERM family","volume":"157","author":"TC Dickson","year":"2002","journal-title":"J Cell Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/35060164","article-title":"The cell biology of neuronal navigation","volume":"3","author":"HJ Song","year":"2001","journal-title":"Nat Cell Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1146\/annurev.neuro.26.010302.081139","article-title":"Signaling at the growth cone: Ligand-Receptor Complexes and the Control of Axon Growth and Guidance","volume":"26","author":"AB Huber","year":"2003","journal-title":"Annual Review of Neuroscience"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0896-6273(03)00633-0","article-title":"Cytoskeletal dynamics and transport in growth cone motility and axon guidance","volume":"40","author":"EW Dent","year":"2003","journal-title":"Neuron"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1155\/2004\/482680","article-title":"Single-cell elastography: probing for disease with the atomic force microscope","volume":"19","author":"KD Costa","year":"2003","journal-title":"Dis Markers"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.pneurobio.2011.04.002","article-title":"The emerging role of forces in axonal elongation","volume":"94","author":"DM Suter","year":"2011","journal-title":"Prog Neurobiol"},{"key":"ref21","first-page":"5060","article-title":"Topography and nanomechanics of live neuronal growth cones analyzed by atomic force microscopy","volume":"96","author":"Y Xiong","year":"2009","journal-title":"Biophys"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1172\/JCI111234","article-title":"Static and dynamic rigidities of normal and sickle erythrocytes. Major influence of cell hemoglobin concentration","volume":"73","author":"E Evans","year":"1984","journal-title":"J Clin Invest"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1016\/S0006-3495(01)75800-6","article-title":"Elastic thickness compressibilty of the red cell membrane","volume":"81","author":"V Heinrich","year":"2001","journal-title":"Biophys J"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/S0006-3495(95)80274-2","article-title":"Mechanical properties of neuronal growth cone membranes studied by tether formation with laser optical tweezers","volume":"68","author":"J Dai","year":"1995","journal-title":"Biophys J"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1016\/S0006-3495(99)77139-0","article-title":"Elasticity of the red cell membrane and its relation to hemolytic disorders: an optical tweezers study","volume":"77","author":"J Sleep","year":"1999","journal-title":"Biophys J"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0006-3495(99)77225-5","article-title":"Measurement of local viscoelasticity and forces in living cells by magnetic tweezers","volume":"76","author":"AR Bausch","year":"1999","journal-title":"Biophys J"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1109\/51.582176","article-title":"Measuring the elastic properties of biological samples with the AFM","volume":"16","author":"M Radmacher","year":"1997","journal-title":"IEEE Eng Med Biol Mag"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/S0021-9290(01)00149-X","article-title":"Endothelial, cardiac muscle and skeletal muscle exhibit different viscous and elastic properties as determined by atomic force microscopy","volume":"34","author":"AB Mathur","year":"2001","journal-title":"J Biomech"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/BF02682270","article-title":"Effects of ethanol and acetaldehyde on isolated nerve ending membranes: study by atomic-forced microscopy","volume":"130","author":"OV Chumakova","year":"2000","journal-title":"Bull Exp Biol Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jneumeth.2009.10.021","article-title":"Neuronal elasticity as measured by atomic force microscopy","volume":"186","author":"M Mustata","year":"2010","journal-title":"J Neurosci Meth"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1152\/ajpcell.1995.269.1.C275","article-title":"Imaging real-time neurite outgrowth and cytoskeletal reorganization with an atomic force microscope","volume":"269","author":"R Lal","year":"1995","journal-title":"Am J Physiol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0306-4522(00)00320-1","article-title":"Three-dimensional characterization of interior structures of exocytotic apertures of nerve cells using atomic force microscopy","volume":"101","author":"T Tojima","year":"2000","journal-title":"Neuroscience"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1023\/B:NEUR.0000030700.48612.0b","article-title":"Three-dimensional imaging of living and dying neurons with atomic force microscopy","volume":"33","author":"HA McNally","year":"2004","journal-title":"J Neurocytol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jneumeth.2004.08.018","article-title":"Comparative three-dimensional imaging of living neurons with confocal and atomic force microscopy","volume":"142","author":"HA McNally","year":"2005","journal-title":"J Neurosci Methods"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.bpj.2012.08.005","article-title":"Elasticity maps of living neurons measured by combined fluorescence and atomic force microscopy","volume":"113","author":"E Spedden","year":"2012","journal-title":"Biophys J"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nmat1925","article-title":"Nanoscale compositional mapping with gentle forces","volume":"6","author":"R Garc\u00eda","year":"2007","journal-title":"Nat Mater"},{"issue":"1","key":"ref37","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/(SICI)1096-9861(19980202)391:1<11::AID-CNE2>3.0.CO;2-U","article-title":"Mechanisms of Enhancement of Neurite Regeneration In Vitro Following a Conditioning Sciatic Nerve Lesion","volume":"391","author":"L Lankford K","year":"1998","journal-title":"J Comp Neurol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jsb.2009.09.005","article-title":"A morphological analysis of growth cones of DRG neurons combining atomic force and confocal microscopy","volume":"168","author":"J Laishram","year":"2009","journal-title":"J Struct Biol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrm2593","article-title":"Environmental sensing through focal adhesions","volume":"10","author":"B Geiger","year":"2009","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1101\/gad.1062303","article-title":"How does an axon grow?","volume":"17","author":"JL Goldberg","year":"2008","journal-title":"Genes Dev"},{"issue":"4","key":"ref41","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1023\/B:JMSM.0000021100.71256.29","article-title":"Controlling the supramolecular organisation of adsorbed collagen layers","volume":"15","author":"ChC Dupont-Gillain","year":"2004","journal-title":"J Mater Sci Mater Med"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.neulet.2005.01.068","article-title":"Calcium dependence of axotomized sensory neurons excitability","volume":"380","author":"C Hilaire","year":"2005","journal-title":"Neurosci Lett"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.1529\/biophysj.105.067496","article-title":"Force microscopy of nonadherent cells: A comparison of leukimia cell deformability","volume":"90","author":"MJ Rosenbluth","year":"2006","journal-title":"Biophys J"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/S0006-3495(96)79602-9","article-title":"Measuring the viscoelastic properties of human platelets with the atomic force microscope","volume":"70","author":"M Radmacher","year":"1996","journal-title":"Biophys J"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.jbiotec.2006.02.016","article-title":"Mechanical properties of single living cells encapsulated in polyelectrolyte matrixes","volume":"124","author":"TS Lanero","year":"2006","journal-title":"J Biotechnol"},{"key":"ref46","first-page":"156","article-title":"Uber die Beruhrung Fester Elastischer Korper","volume":"92","author":"MG Hertz","year":"1881","journal-title":"J Reine Angew Math"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0020-7225(65)90019-4","article-title":"The relation between load and penetration in axisymmetric Boussinesq problem for a punch of arbitrary profile","volume":"3","author":"IN Sneddon","year":"1965","journal-title":"Int J Engr Sci"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1088\/0957-4484\/4\/2\/006","article-title":"Deformation and height anomaly of soft surfaces studied with an AFM","volume":"4","author":"AL Weisenhorn","year":"1993","journal-title":"Nanotechnology"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0014-5793(98)00592-4","article-title":"Measuring elasticity of biological materials by atomic force microscopy","volume":"430","author":"A Vinckier","year":"1998","journal-title":"FEBS Lett"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.surfrep.2005.08.003","article-title":"Force measurements with the atomic force microscope: Technique, interpretation and applications","volume":"59","author":"H-J Butt","year":"2005","journal-title":"Surf Sci Reports"},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"Butt H-J, Kappl M (2010) Surface and interfacial Forces. WILEY-VCH Verlag GmbH &amp; Co. KGaA, Weinheim.","DOI":"10.1002\/9783527629411"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0056286","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T00:59:35Z","timestamp":1588985975000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0056286"}},"subtitle":[],"editor":[{"given":"Igor","family":"Sokolov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,2,13]]},"references-count":51,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,2,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0056286","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,13]]}}}