{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T19:27:57Z","timestamp":1774466877761,"version":"3.50.1"},"reference-count":23,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T00:00:00Z","timestamp":1360713600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0056325","type":"journal-article","created":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T21:56:41Z","timestamp":1360792601000},"page":"e56325","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":67,"title":["Associations between Methylation of Paternally Expressed Gene 3 (PEG3), Cervical Intraepithelial Neoplasia and Invasive Cervical Cancer"],"prefix":"10.1371","volume":"8","author":[{"given":"Monica D.","family":"Nye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathrine","family":"Hoyo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana C.","family":"Vidal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frances","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francine","family":"Overcash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer S.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandi","family":"Vasquez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenda","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britta","family":"Swai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olola","family":"Oneko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pendo","family":"Mlay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Obure","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilie D.","family":"Gammon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Bartlett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan K.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,2,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1002\/ijc.25516","article-title":"Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008","volume":"127","author":"J Ferlay","year":"2010","journal-title":"Int J Cancer"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F","article-title":"Human papillomavirus is a necessary cause of invasive cervical cancer worldwide","volume":"189","author":"JM Walboomers","year":"1999","journal-title":"J Pathol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ypmed.2009.09.001","article-title":"Psychosocial predictors of adherence to risk-appropriate cervical cancer screening guidelines: a cross sectional study of women in Ohio Appalachia participating in the Community Awareness Resources and Education (CARE) project","volume":"50","author":"ED Paskett","year":"2010","journal-title":"Prev Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1159\/000214918","article-title":"Molecular mechanisms of human papillomavirus-induced carcinogenesis","volume":"12","author":"M Lehoux","year":"2009","journal-title":"Public Health Genomics"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/S0140-6736(07)61416-0","article-title":"Human papillomavirus and cervical cancer","volume":"370","author":"M Schiffman","year":"2007","journal-title":"Lancet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1476-4598-4-38","article-title":"Epigenetics of cervical cancer. An overview and therapeutic perspectives","volume":"4","author":"A Duenas-Gonzalez","year":"2005","journal-title":"Mol Cancer"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.ygyno.2008.10.012","article-title":"Utility of methylation markers in cervical cancer early detection: appraisal of the state-of-the-science","volume":"112","author":"N Wentzensen","year":"2009","journal-title":"Gynecol Oncol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"12050","DOI":"10.1073\/pnas.97.22.12050","article-title":"Peg3\/Pw1 promotes p53-mediated apoptosis by inducing Bax translocation from cytosol to mitochondria","volume":"97","author":"Y Deng","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"23000","DOI":"10.1074\/jbc.M201907200","article-title":"Peg3\/Pw1 is a mediator between p53 and Bax in DNA damage-induced neuronal death","volume":"277","author":"MD Johnson","year":"2002","journal-title":"J Biol Chem"},{"key":"ref10","article-title":"Integrative genome-wide expression and promoter DNA methylation profiling identifies a potential novel panel of ovarian cancer epigenetic biomarkers","author":"BS Gloss","year":"2011","journal-title":"Cancer Lett"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.ygyno.2005.05.036","article-title":"Biallelic methylation and silencing of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines","volume":"99","author":"SC Dowdy","year":"2005","journal-title":"Gynecol Oncol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1002\/cncr.23323","article-title":"Imprinted tumor suppressor genes ARHI and PEG3 are the most frequently down-regulated in human ovarian cancers by loss of heterozygosity and promoter methylation","volume":"112","author":"W Feng","year":"2008","journal-title":"Cancer"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/mc.1034","article-title":"Epigenetic silencing of PEG3 gene expression in human glioma cell lines","volume":"31","author":"S Maegawa","year":"2001","journal-title":"Mol Carcinog"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2183\/pjab.85.157","article-title":"Aberrant promoter methylation and expression of the imprinted PEG3 gene in glioma","volume":"85","author":"S Otsuka","year":"2009","journal-title":"Proc Jpn Acad Ser B Phys Biol Sci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1750-9378-6-20","article-title":"Distribution of HPV genotypes in cervical intraepithelial lesions and cervical cancer in Tanzanian women","volume":"6","author":"AC Vidal","year":"2011","journal-title":"Infect Agent Cancer"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/ijc.10538","article-title":"Human papillomavirus genotype prevalence in high-grade squamous intraepithelial lesions and colposcopically normal women from Zimbabwe","volume":"100","author":"PE Gravitt","year":"2002","journal-title":"Int J Cancer"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/sj.ejhg.5201993","article-title":"Clinical characterisation of the multiple maternal hypomethylation syndrome in siblings","volume":"16","author":"SE Boonen","year":"2008","journal-title":"Eur J Hum Genet"},{"key":"ref18","first-page":"1982","article-title":"Promoter hypermethylation of multiple genes in carcinoma of the uterine cervix","volume":"7","author":"SM Dong","year":"2001","journal-title":"Clin Cancer Res"},{"key":"ref19","first-page":"584","article-title":"Aberrant methylation during cervical carcinogenesis","volume":"7","author":"AK Virmani","year":"2001","journal-title":"Clin Cancer Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1476-4598-2-24","article-title":"Frequent promoter methylation of CDH1, DAPK, RARB, and HIC1 genes in carcinoma of cervix uteri: its relationship to clinical outcome","volume":"2","author":"G Narayan","year":"2003","journal-title":"Mol Cancer"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1093\/carcin\/bgp006","article-title":"Epigenetic profiling reveals etiologically distinct patterns of DNA methylation in head and neck squamous cell carcinoma","volume":"30","author":"CJ Marsit","year":"2009","journal-title":"Carcinogenesis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/jcb.240590910","article-title":"Cervical intraepithelial neoplasia","volume":"Suppl 23","author":"CP Crum","year":"1995","journal-title":"J Cell Biochem"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1093\/jnci\/djq357","article-title":"Persistent HPV infection and cervical cancer risk: is the scientific rationale for changing the screening paradigm enough?","volume":"102","author":"EL Franco","year":"2010","journal-title":"J Natl Cancer Inst"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0056325","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T23:26:33Z","timestamp":1540337193000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0056325"}},"subtitle":[],"editor":[{"given":"Lorenzo","family":"Chiariotti","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,2,13]]},"references-count":23,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,2,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0056325","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,13]]}}}