{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:23:09Z","timestamp":1790623389241,"version":"4.1.0"},"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2013,2,21]],"date-time":"2013-02-21T00:00:00Z","timestamp":1361404800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0056343","type":"journal-article","created":{"date-parts":[[2013,2,21]],"date-time":"2013-02-21T23:47:43Z","timestamp":1361490463000},"page":"e56343","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":67,"title":["Exploring the Dynamic Core Microbiome of Plaque Microbiota during Head-and-Neck Radiotherapy Using Pyrosequencing"],"prefix":"10.1371","volume":"8","author":[{"given":"Yue-jian","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-yang","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-tao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-sheng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-ping","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng-wei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,2,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1034\/j.1399-302X.2001.160607.x","article-title":"Irradiation-induced oral candidiasis in an experimental murine model","volume":"16","author":"CS Farah","year":"2001","journal-title":"Oral Microbiol Immunol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/01.cco.0000219256.37843.83","article-title":"Evaluation, prevention and management of radiotherapy-induced xerostomia in head and neck cancer patients","volume":"18","author":"GJ de Castro","year":"2006","journal-title":"Curr Opin Oncol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1080\/1024533021000037216","article-title":"Oral mucositis: time for more studies","volume":"7","author":"Y Alvarado","year":"2002","journal-title":"Hematology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1177\/08959374000140010701","article-title":"Xerostomia and hyposalivation","volume":"14","author":"T Nederfors","year":"2000","journal-title":"Adv Dent Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1159\/000070868","article-title":"Non-mutans streptococci in patients receiving radiotherapy in the head and neck area","volume":"37","author":"HC Tong","year":"2003","journal-title":"Caries Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1136\/jcp.27.5.416","article-title":"Changes in the oral flora in Sj\u00f6gren\u2019s syndrome","volume":"27","author":"TW MacFarlane","year":"1974","journal-title":"J Clin Pathol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/1471-2180-9-259","article-title":"Defining the healthy \u201ccore microbiome\u201d of oral microbial communities","volume":"9","author":"E Zaura","year":"2009","journal-title":"BMC Microbiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1186\/1471-2164-11-523","article-title":"Study of inter- and intra-individual variations in the salivary microbiota","volume":"11","author":"V Lazarevic","year":"2010","journal-title":"BMC Genomics"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/nature06244","article-title":"The Human Microbiome Project","volume":"449","author":"PJ Turnbaugh","year":"2007","journal-title":"Nature"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1462-2920.2011.02585.x","article-title":"Beyond the Venn diagram: the hunt for a core microbiome","volume":"14","author":"A Shade","year":"2012","journal-title":"Environ Microbiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature03959","article-title":"Genome sequencing in open microfabricated high density picolitre reactors","volume":"437","author":"M Margulies","year":"2005","journal-title":"Nature"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e27310","DOI":"10.1371\/journal.pone.0027310","article-title":"Reducing the effects of PCR amplification and sequencing artifacts on 16S rRNA-based studies","volume":"6","author":"PD Schloss","year":"2011","journal-title":"PLoS One"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1177\/154405910808701104","article-title":"Pyrosequencing analysis of the oral microflora of healthy adults","volume":"87","author":"BJ Keijser","year":"2008","journal-title":"J Dent Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"10743","DOI":"10.3402\/jom.v4i0.10743","article-title":"Pyrosequencing as a tool for better understanding of human microbiomes","volume":"4","author":"JJ Siqueira","year":"2012","journal-title":"J Oral Microbiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s00248-010-9712-8","article-title":"Analysis of oral microbiota in children with dental caries by PCR-DGGE and barcoded pyrosequencing","volume":"60","author":"Z Ling","year":"2010","journal-title":"Microb Ecol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.radonc.2011.09.018","article-title":"Efficacy of routine pre-radiation dental screening and dental follow-up in head and neck oncology patients on intermediate and late radiation effects. A retrospective evaluation","volume":"101","author":"JM Schuurhuis","year":"2011","journal-title":"Radiother Oncol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1269\/jrr.11085","article-title":"Effects of intensity-modulated radiotherapy on human oral microflora","volume":"52","author":"ZY Shao","year":"2011","journal-title":"J Radiat Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1177\/00220345990780080601","article-title":"Oral microflora in subjects with reduced salivary secretion","volume":"78","author":"A Almst\u00e5hl","year":"1999","journal-title":"J Dent Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.envpol.2012.04.015","article-title":"Ionizing radiation-induced DNA damage response identified in marine mussels, Mytilus sp","volume":"168","author":"OD Alamri","year":"2012","journal-title":"Environ Pollut"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1097\/00002820-200306000-00008","article-title":"Mechanisms for radiation-induced oral mucositis and the consequences","volume":"26","author":"A Shih","year":"2003","journal-title":"Cancer Nurs"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nature07540","article-title":"A core gut microbiome in obese and lean twins","volume":"457","author":"PJ Turnbaugh","year":"2009","journal-title":"Nature"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1101\/gr.085464.108","article-title":"Microbial community profiling for human microbiome projects: Tools, techniques, and challenges","volume":"19","author":"M Hamady","year":"2009","journal-title":"Genome Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e34242","DOI":"10.1371\/journal.pone.0034242","article-title":"A core human microbiome as viewed through 16S rRNA sequence clusters","volume":"7","author":"SM Huse","year":"2012","journal-title":"PLoS One"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1126\/science.1177486","article-title":"Bacterial community variation in human body habitats across space and time","volume":"326","author":"EK Costello","year":"2009","journal-title":"Science"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0056343","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T00:48:32Z","timestamp":1562719712000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0056343"}},"subtitle":[],"editor":[{"given":"Ramy K.","family":"Aziz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,2,21]]},"references-count":24,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,2,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0056343","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,21]]}}}