{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:58:09Z","timestamp":1789181889537,"version":"build-2803163510"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T00:00:00Z","timestamp":1361750400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0056374","type":"journal-article","created":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T22:13:22Z","timestamp":1361830402000},"page":"e56374","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":61,"title":["Prevention of Canine Leishmaniosis in a Hyper-Endemic Area Using a Combination of 10% Imidacloprid\/4.5% Flumethrin"],"prefix":"10.1371","volume":"8","author":[{"given":"Domenico","family":"Otranto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipe","family":"Dantas-Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donato","family":"de Caprariis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Di Paola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana D.","family":"Tarallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria S.","family":"Latrofa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo P.","family":"Lia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giada","family":"Annoscia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward B.","family":"Breitshwerdt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Cantacessi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gioia","family":"Capelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothee","family":"Stanneck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,2,25]]},"reference":[{"key":"ref1","first-page":"417","article-title":"Leishmaniasis. Public health aspects and control","volume":"14","author":"P Desjeux","year":"1996","journal-title":"Clin Dermatol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/nrmicro1748","article-title":"Visceral leishmaniasis: what are the needs for diagnosis, treatment and control?","volume":"5","author":"F Chappuis","year":"2007","journal-title":"Nat Rev Microbiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.3201\/eid1407.071589","article-title":"Spread of vector-borne diseases and neglect of Leishmaniasis, Europe","volume":"14","author":"JC Dujardin","year":"2008","journal-title":"Emerg Infect Dis"},{"issue":"12","key":"ref4","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.pt.2012.08.007","article-title":"Canine leishmaniosis in the Old and New Worlds: unveiled similarities and differences","volume":"28","author":"F Dantas-Torres","year":"2012","journal-title":"Trends Parasitol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.pt.2008.04.001","article-title":"Canine leishmaniosis - new concepts and insights on an expanding zoonosis: part one","volume":"24","author":"G Baneth","year":"2008","journal-title":"Trends Parasitol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/nrmicro981","article-title":"Leishmaniasis","volume":"2","author":"P Desjeux","year":"2004","journal-title":"Nat Rev Microbiol"},{"key":"ref7","article-title":"Phlebotomine sand flies and the spreading of leishmaniases and other diseases of public health concern","author":"M Maroli","year":"2012","journal-title":"Med Vet Entomol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1093\/tropej\/fmi102","article-title":"Sero-epidemiological survey on canine visceral leishmaniasis and the distribution of sandfly vectors in the Northwestern Turkey: prevention strategies for childhood visceral leishmaniasis","volume":"52","author":"N Dogan","year":"2005","journal-title":"J Trop Pediatr"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.actatropica.2012.02.003","article-title":"A cross-sectional sero-epidemiological study of canine leishmaniasis in Greek mainland","volume":"122","author":"LV Athanasiou","year":"2012","journal-title":"Acta Tropica"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.cvsm.2009.06.008","article-title":"Canine leishmaniasis in North America: emerging or newly recognized?","volume":"39","author":"CA Petersen","year":"2009","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1365-3156.2007.01998.x","article-title":"The northward spread of leishmaniasis in Italy: evidence from retrospective and ongoing studies on the canine reservoir and phlebotomine vectors","volume":"13","author":"M Maroli","year":"2008","journal-title":"Trop Med Int Health"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1186\/1756-3305-2-S1-S2","article-title":"Changing distribution patterns of canine vector borne diseases in Italy: leishmaniosis vs. dirofilariosis","volume":"2","author":"D Otranto","year":"2009","journal-title":"Parasit Vectors"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.vetpar.2006.03.008","article-title":"Seroepidemiological survey on canine leishmaniasis among dogs from an urban area of Brazil","volume":"310","author":"F Dantas-Torres","year":"2006","journal-title":"Vet Parasitol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1128\/CVI.00268-08","article-title":"Toward diagnosing <italic>Leishmania infantum<\/italic> infection in asymptomatic dogs in an area where leishmaniasis is endemic","volume":"16","author":"D Otranto","year":"2009","journal-title":"Clin Vaccine Immunol"},{"key":"ref15","first-page":"127","article-title":"Aplica\u00e7\u00e3o domicilada de DDT como base da profilaxia das leishmanioses \u2013 Estudo de um foco de leishmaniose mucocutanea cinco anos depois da aspers\u00e3o periodica com aquele inseticida","volume":"6","author":"F Nery-Guimaraes","year":"1954","journal-title":"Rev Bras Malariol Doencas Trop"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1590\/S0074-02762005000800001","article-title":"<italic>Lutzomyia longipalpis<\/italic> and the eco-epidemiology of American visceral leishmaniasis, with particular reference to Brazil: a review","volume":"100","author":"R Lainson","year":"2005","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2915.2003.00420.x","article-title":"Control of phlebotomine sandflies","volume":"17","author":"B Alexander","year":"2003","journal-title":"Med Vet Entomol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0140-6736(05)67182-6","article-title":"Health risks and benefits of bis (4- chlorophenyl)-1,1,1-trichloroethane (DDT)","volume":"366","author":"W Rogan","year":"2005","journal-title":"Lancet"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.vetpar.2010.05.017","article-title":"Prevention of endemic canine vector-borne diseases using imidacloprid 10% and permethrin 50% in young dogs: a longitudinal field study","volume":"172","author":"D Otranto","year":"2010","journal-title":"Vet Parasitol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ijpara.2003.09.006","article-title":"Are insecticide-impregnated dog collars a feasible alternative to dog culling as a strategy for controlling canine visceral leishmaniasis in Brazil?","volume":"34","author":"R Reithinger","year":"2004","journal-title":"Int J Parasitol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1365-2915.1997.tb00298.x","article-title":"Protection of dogs from the bites of phlebotomine sandflies by deltamethrin collars for the control of canine leishmaniasis","volume":"11","author":"R Killick-Kendrick","year":"1997","journal-title":"Med Vet Entomol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1046\/j.0269-283x.2001.00321.x","article-title":"Evidence for an impact on the incidence of canine leishmaniasis by the mass use of deltamethrin-impregnated dog collars in Southern Italy","volume":"15","author":"M Maroli","year":"2001","journal-title":"Med Vet Entomol 2001"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.vetpar.2006.09.012","article-title":"Efficacy of a combination of 10% imidacloprid\/50% permethrin for the prevention of leishmaniasis in kennelled dogs in an endemic area","volume":"144","author":"D Otranto","year":"2007","journal-title":"Vet Parasitol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1128\/JCM.00379-10","article-title":"Diagnosis of canine vector-borne diseases in young dogs: a longitudinal study","volume":"48","author":"D Otranto","year":"2010","journal-title":"J Clin Microbiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1756-3305-5-73","article-title":"The synergistic action of imidacloprid and flumethrin and their release kinetics from collars applied for ectoparasite control in dogs and cats","volume":"5","author":"D Stanneck","year":"2012","journal-title":"Parasit Vectors"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1756-3305-5-66","article-title":"Evaluation of the long-term efficacy and safety of an imidacloprid 10%\/flumethrin 4.5% polymer matrix collar (Seresto\u00ae) in dogs and cats naturally infested with fleas and\/or ticks in multicentre clinical field studies in Europe","volume":"5","author":"D Stanneck","year":"2012","journal-title":"Parasit Vectors"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.actatropica.2010.08.013","article-title":"Phlebotomine sand fly population dynamics in a leishmaniasis endemic peri-urban area in southern Italy","volume":"116","author":"VD Tarallo","year":"2010","journal-title":"Acta Trop"},{"key":"ref28","first-page":"251","article-title":"Sandflies in Italy: observations on their distribution and methods of control","volume":"36","author":"M Maroli","year":"1994","journal-title":"Parassitologia"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.vetpar.2004.05.019","article-title":"Assessment of an optimized dog-culling program in the dynamics of canine <italic>Leishmania<\/italic> transmission","volume":"6","author":"ED Moreira Jr","year":"2004","journal-title":"Vet Parasitol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.vetpar.2006.06.029","article-title":"Deltamethrin-impregnated collars for the control of canine leishmaniasis: evaluation of the protective effect and influence on the clinical outcome of <italic>Leishmania<\/italic> infection in kennelled stray dogs","volume":"142","author":"V Foglia Manzillo","year":"2006","journal-title":"Vet Parasitol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1439-0450.2006.00964.x","article-title":"Incidence of canine leishmaniasis in an endemic area of Southern Italy","volume":"53","author":"P Paradies","year":"2006","journal-title":"J Vet Med B"},{"issue":"10","key":"ref32","doi-asserted-by":"crossref","first-page":"e1344","DOI":"10.1371\/journal.pntd.0001344","article-title":"Canine antibody response to <italic>Phlebotomus perniciosus<\/italic> bites negatively correlates with the risk of <italic>Leishmania infantum<\/italic> transmission","volume":"5","author":"M Vlkova","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1046\/j.0269-283x.2001.00321.x","article-title":"Evidence for an impact on the incidence of canine leishmaniasis by the use of deltamethrin-impregnated dog collars in southern Italy","volume":"15","author":"M Maroli","year":"2001","journal-title":"Med Vet Entomol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1128\/JCM.44.4.1318-1322.2006","article-title":"Incidence and time course of <italic>Leishmania infantum<\/italic> infections examined by parasitological, serologic, and nested-PCR techniques in a cohort of na\u00efve dogs exposed to three consecutive transmission seasons","volume":"44","author":"G Oliva","year":"2006","journal-title":"J Clin Microbiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1128\/CVI.13.2.271-276.2006","article-title":"Kinetics and diagnostic and prognostic potential of quantitative Western blot analysis and antigen-specific enzyme-linked immunosorbent assay in experimental canine leishmaniasis","volume":"13","author":"D Talmi-Frank","year":"2006","journal-title":"Clin Vaccine Immunol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1756-3305-3-34","article-title":"Imported and travelling dogs as carriers of canine vector-borne pathogens in Germany","volume":"3","author":"B Menn","year":"2010","journal-title":"Parasit Vectors"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0056374","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T03:26:13Z","timestamp":1562729173000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0056374"}},"subtitle":[],"editor":[{"given":"Stuart Alexander","family":"Ralph","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,2,25]]},"references-count":36,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,2,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0056374","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,25]]}}}