{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T20:14:07Z","timestamp":1780344847401,"version":"3.54.1"},"reference-count":105,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2013,2,21]],"date-time":"2013-02-21T00:00:00Z","timestamp":1361404800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0056463","type":"journal-article","created":{"date-parts":[[2013,2,21]],"date-time":"2013-02-21T23:47:15Z","timestamp":1361490435000},"page":"e56463","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":55,"title":["Safety of Benzathine Penicillin for Preventing Congenital Syphilis: A Systematic Review"],"prefix":"10.1371","volume":"8","author":[{"given":"Tais F.","family":"Galvao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus T.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne J.","family":"Serruya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori M.","family":"Newman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D.","family":"Klausner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio G.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Fescina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,2,21]]},"reference":[{"key":"ref1","unstructured":"WHO (2012) Investment case for eliminating mother-to-child transmission of syphilis: promoting better maternal and child health and stronger health systems. Geneva: World Health Organization."},{"key":"ref2","first-page":"1","article-title":"Sexually transmitted diseases treatment guidelines, 2010","volume":"59","author":"KA Workowski","year":"2010","journal-title":"MMWR Recomm Rep"},{"key":"ref3","unstructured":"WHO (2003) Guidelines for the management of sexually transmitted infections. Geneva: World Health Organization."},{"key":"ref4","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1001\/jama.2009.143","article-title":"Penicillin treatment of syphilis: clearing away the shadow on the land","volume":"301","author":"JM Douglas","year":"2009","journal-title":"JAMA"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"S200","DOI":"10.1086\/342108","article-title":"Treatment of syphilis in pregnancy and prevention of congenital syphilis","volume":"35","author":"GD Wendel","year":"2002","journal-title":"Clin Infect Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/1471-2393-9-S1-S4","article-title":"Reducing stillbirths: prevention and management of medical disorders and infections during pregnancy","volume":"9","author":"EV Menezes","year":"2009","journal-title":"BMC Pregnancy Childbirth"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1186\/1471-2393-10-S1-S3","article-title":"Global report on preterm birth and stillbirth (3 of 7): evidence for effectiveness of interventions","volume":"10","author":"FC Barros","year":"2010","journal-title":"BMC Pregnancy Childbirth"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/S1473-3099(11)70104-9","article-title":"Effectiveness of interventions to improve screening for syphilis in pregnancy: a systematic review and meta-analysis","volume":"11","author":"S Hawkes","year":"2011","journal-title":"Lancet Infect Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1186\/1471-2458-11-S3-S9","article-title":"Lives Saved Tool supplement detection and treatment of syphilis in pregnancy to reduce syphilis related stillbirths and neonatal mortality","volume":"11","author":"H Blencowe","year":"2011","journal-title":"BMC Public Health"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Kamb ML, Newman LM, Riley PL, Mark J, Hawkes SJ, <etal>et al<\/etal>.. (2010) A road map for the global elimination of congenital syphilis. Obstet Gynecol Int 2010.","DOI":"10.1155\/2010\/312798"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0140-6736(07)60074-9","article-title":"Syphilis in China: results of a national surveillance programme","volume":"369","author":"ZQ Chen","year":"2007","journal-title":"Lancet"},{"key":"ref12","first-page":"413","article-title":"Congenital syphilis - United States, 2003\u20132008","volume":"59","year":"2010","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1097\/OLQ.0b013e31821898ca","article-title":"Congenital syphilis, a reemergent disease in Mexico: its epidemiology during the last 2 decades","volume":"38","author":"J Reyna-Figueroa","year":"2011","journal-title":"Sex Transm Dis"},{"key":"ref14","first-page":"w13325","article-title":"Congenital syphilis in Switzerland: gone, forgotten, on the return","volume":"141","author":"PM Meyer Sauteur","year":"2012","journal-title":"Swiss Med Wkly"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"F211","DOI":"10.1136\/adc.2010.183863","article-title":"Congenital syphilis in Italy: a multicentre study","volume":"97","author":"E Tridapalli","year":"2012","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"ref16","first-page":"787","article-title":"Diagnosis of penicillin allergy by skin testing: the Manitoba experience","volume":"118","author":"RJ Warrington","year":"1978","journal-title":"Can Med Assoc J"},{"key":"ref17","first-page":"1353","article-title":"Penicillin allergy: a practical approach to management","volume":"134","author":"GL Sussman","year":"1986","journal-title":"CMAJ"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1517\/14740338.2012.643866","article-title":"Adverse reactions to \u03b2-lactam antimicrobials","volume":"11","author":"P Lagac\u00e9-Wiens","year":"2012","journal-title":"Expert Opin Drug Saf"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/j.jaci.2012.08.021","article-title":"Allergy to \u03b2-lactam antibiotics","volume":"130","author":"R Solensky","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/S0140-6736(00)02799-9","article-title":"Adverse drug reactions: definitions, diagnosis, and management","volume":"356","author":"IR Edwards","year":"2000","journal-title":"Lancet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.jaci.2003.12.591","article-title":"Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003","volume":"113","author":"SG Johansson","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1365-2710.2005.00631.x","article-title":"Proposed mechanisms and preventative options of Jarisch-Herxheimer reactions","volume":"30","author":"MW Pound","year":"2005","journal-title":"J Clin Pharm Ther"},{"key":"ref23","unstructured":"Higgins J, Green S (2011) Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 ed: The Cochrane Collaboration."},{"key":"ref24","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jclinepi.2010.07.017","article-title":"GRADE guidelines: 4. Rating the quality of evidence\u2013study limitations (risk of bias)","volume":"64","author":"GH Guyatt","year":"2011","journal-title":"J Clin Epidemiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jclinepi.2010.07.015","article-title":"GRADE guidelines: 3. Rating the quality of evidence","volume":"64","author":"H Balshem","year":"2011","journal-title":"J Clin Epidemiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"417","DOI":"10.2307\/2348891","article-title":"Mid-P confidence intervals: a brief review","volume":"44","author":"G Berry","year":"1995","journal-title":"The Statistician"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Deeks JJ, Altman DG, Bradburn MJ (2001) Statistical methods for examining heterogeneity and combining results from several studies in meta-analysis. In: Egger M SG, Altman DG, editor. Systematic Reviews in Health Care: Meta-analysis in context. 2nd ed. London: BMJ Publishing Group.","DOI":"10.1002\/9780470693926.ch15"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Borenstein M, Hedges LV, Higgins JPT, Rothstein HR (2009) Introduction to meta-analysis. Chichester: Wiley.","DOI":"10.1002\/9780470743386"},{"key":"ref29","first-page":"457","article-title":"Penicillin reactions: analysis of a WHO questionnaire","volume":"18","author":"RR Willcox","year":"1958","journal-title":"Bull World Health Organ"},{"key":"ref30","first-page":"200","article-title":"Influence of penicillin allergic reactions on veneral disease control programmes","volume":"40","author":"RR Willcox","year":"1964","journal-title":"Br J Vener Dis"},{"key":"ref31","first-page":"176","article-title":"Side-effects of penicillin treatment","volume":"33","author":"RS Morton","year":"1957","journal-title":"Br J Vener Dis"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1056\/NEJM195911262612207","article-title":"Incidence of penicillin reactions after an antihistaminic simultaneously administered parenterally","volume":"261","author":"GW Sciple","year":"1959","journal-title":"N Engl J Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1136\/jcp.42.12.1281","article-title":"Serological screening tests for syphilis in pregnancy: results of a five year study (1983\u201387) in the Oxford region","volume":"42","author":"P Bowell","year":"1989","journal-title":"J Clin Pathol"},{"key":"ref34","unstructured":"Ricci JM, Fojaco RM, O\u2019Sullivan MJ (1989) Congenital syphilis: the University of Miami\/Jackson Memorial Medical Center experience, 1986\u20131988. Obstet Gynecol. United States. 687\u2013693."},{"key":"ref35","first-page":"257","article-title":"Sexually transmitted diseases amongst pregnant Vietnamese refugees in Hong Kong","volume":"66","author":"PA King","year":"1990","journal-title":"Genitourin Med"},{"key":"ref36","first-page":"98","article-title":"The association of gonorrhoea and syphilis with premature birth and low birthweight","volume":"69","author":"GG Donders","year":"1993","journal-title":"Genitourin Med"},{"key":"ref37","first-page":"248","article-title":"Syphilis in pregnancy: a medical audit in a rural district","volume":"39","author":"S Rutgers","year":"1993","journal-title":"Cent Afr J Med"},{"key":"ref38","unstructured":"McFarlin BL, Bottoms SF (1995) Maternal syphilis in Michigan: the challenge to prevent congenital syphilis. Midwifery. Scotland. 55\u201360."},{"key":"ref39","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/00007435-199704000-00006","article-title":"New approaches to syphilis control. Finding opportunities for syphilis treatment and congenital syphilis prevention in a women\u2019s correctional setting","volume":"24","author":"S Blank","year":"1997","journal-title":"Sex Transm Dis"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1111\/j.1471-0528.1997.tb11987.x","article-title":"Routine antenatal screening for syphilis in Lothian: a study of the results 1988 to 1994","volume":"104","author":"ST Cameron","year":"1997","journal-title":"Br J Obstet Gynaecol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/(SICI)1097-0223(199702)17:2<119::AID-PD39>3.0.CO;2-T","article-title":"In utero infection with Treponema pallidum in early pregnancy","volume":"17","author":"L Nathan","year":"1997","journal-title":"Prenat Diagn"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0020-7292(98)00165-9","article-title":"Maternal syphilis and vertical perinatal transmission of human immunodeficiency virus type-1 infection","volume":"63","author":"MJ Lee","year":"1998","journal-title":"Int J Gynaecol Obstet"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1136\/bmj.317.7173.1617","article-title":"Syphilis in pregnant women and their children in the United Kingdom: results from national clinician reporting surveys 1994\u20137","volume":"317","author":"AK Hurtig","year":"1998","journal-title":"BMJ"},{"key":"ref44","first-page":"1101","article-title":"Reducing the incidence of congenital syphilis in Milwaukee: a public\/private partnership","volume":"88","author":"GR Swain","year":"1998","journal-title":"Am J Public Health"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1201-9712(98)90113-8","article-title":"Prevalence, burden, and control of syphilis in Haiti\u2019s rural artibonite region","volume":"2","author":"DW Fitzgerald","year":"1998","journal-title":"International Journal of Infectious Diseases"},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"Blank S, Sternberg M, Neylans LL, Rubin SR, Weisfuse IB, <etal>et al<\/etal>.. (1999) Incident syphilis among women with multiple admissions to jail in New York City. J Infect Dis. United States. 1159\u20131163.","DOI":"10.1086\/315038"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/00126334-199912010-00009","article-title":"Placental membrane inflammation and risks of maternal-to-child transmission of HIV-1 in Uganda","volume":"22","author":"F Wabwire-Mangen","year":"1999","journal-title":"J Acquir Immune Defic Syndr"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1111\/j.1471-0528.2000.tb13339.x","article-title":"The transplacental transfer of the macrolide antibiotics erythromycin, roxithromycin and azithromycin","volume":"107","author":"T Heikkinen","year":"2000","journal-title":"BJOG"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1136\/sti.76.3.203","article-title":"An intervention study to reduce adverse pregnancy outcomes as a result of syphilis in Mozambique","volume":"76","author":"N Bique Osman","year":"2000","journal-title":"Sex Transm Infect"},{"key":"ref50","first-page":"203","article-title":"Pharmacokinetics of azithromycin in the term gravida","volume":"8","author":"PS Ramsey","year":"2000","journal-title":"Infect Dis Obstet Gynecol"},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"Sheffield JS, Sanchez PJ, Morris G, Maberry M, Zeray F, <etal>et al<\/etal>.. (2002) Congenital syphilis after maternal treatment for syphilis during pregnancy. Am J Obstet Gynecol. United States. 569\u2013573.","DOI":"10.1067\/mob.2002.121541"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1067\/mob.2003.141","article-title":"Maternal and transplacental pharmacokinetics of azithromycin","volume":"188","author":"PS Ramsey","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"ref53","first-page":"589","article-title":"Congenital syphilis in a Nairobi maternity hospital","volume":"81","author":"P Gichangi","year":"2004","journal-title":"East Afr Med J"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/01.OLQ.0000109516.47951.B8","article-title":"Congenital syphilis in Russia: the value of counting epidemiologic cases and clinical cases","volume":"31","author":"E Salakhov","year":"2004","journal-title":"Sex Transm Dis"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1097\/01.olq.0000204916.91780.d9","article-title":"Syphilis management in St. Petersburg, Russia: 1995\u20132001","volume":"33","author":"A Yakubovsky","year":"2006","journal-title":"Sexually Transmitted Diseases"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1016\/j.jmwh.2008.02.008","article-title":"Syphilis in pregnancy","volume":"53","author":"M O\u2019Connor","year":"2008","journal-title":"J Midwifery Womens Health"},{"key":"ref57","first-page":"71","article-title":"Epidemiology of congenital syphilis in a South Bronx population: a follow-up study","volume":"39","author":"VM Sia","year":"2011","journal-title":"J Perinat Med"},{"key":"ref58","first-page":"60","article-title":"The value of penicillin alone in the prevention and treatment of congenital syphilis","volume":"31","author":"NR Ingraham","year":"1950","journal-title":"Acta Derm Venereol Suppl (Stockh)"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/0002-9378(50)90111-6","article-title":"Penicillin therapy of the syphilitic pregnant woman: its practical application to a large urban obstetrical service","volume":"59","author":"V Wammock","year":"1950","journal-title":"American Journal of Obstetrics & Gynecology"},{"key":"ref60","first-page":"294","article-title":"Influence of antenatal screening on perinatal mortality caused by syphilis in Swaziland","volume":"64","author":"LF Guinness","year":"1988","journal-title":"Genitourin Med"},{"key":"ref61","first-page":"159","article-title":"Syphilis intervention in pregnancy: Zambian demonstration project","volume":"66","author":"SK Hira","year":"1990","journal-title":"Genitourinary Medicine"},{"key":"ref62","first-page":"619","article-title":"Treatment of early infectious syphilis with N,N\u2019-dibenzylethylenediamine dipenicillin G; a second report","volume":"10","author":"JK Shafer","year":"1954","journal-title":"Bull World Health Organ"},{"key":"ref63","doi-asserted-by":"crossref","unstructured":"Willcox RR (1955) The treatment of primary and Secondary syphilis. Postgrad Med J 31: 548\u2013551, 557.","DOI":"10.1136\/pgmj.31.361.548"},{"key":"ref64","first-page":"579","article-title":"A WHO study of treatment schedules for early syphilis in use throughout the world","volume":"10","author":"RR Willcox","year":"1954","journal-title":"Bull World Health Organ"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1046\/j.1365-3156.2000.00636.x","article-title":"Impact on perinatal mortality of missed opportunities to treat maternal syphilis in rural South Africa: Baseline results from a clinic randomized controlled trial","volume":"5","author":"K Rotchford","year":"2000","journal-title":"Tropical Medicine and International Health"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1258\/09564620260079653","article-title":"The epidemiology of syphilis in pregnancy","volume":"13","author":"P Lumbiganon","year":"2002","journal-title":"Int J STD AIDS"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1097\/00007435-199702000-00007","article-title":"Apparent failure of one injection of benzathine penicillin G for syphilis during pregnancy in human immunodeficiency virus-seronegative African women","volume":"24","author":"GG Donders","year":"1997","journal-title":"Sex Transm Dis"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1046\/j.1365-3156.1997.d01-127.x","article-title":"Epidemiology of syphilis in pregnancy in rural South Africa: opportunities for control","volume":"2","author":"D Wilkinson","year":"1997","journal-title":"Trop Med Int Health"},{"key":"ref69","unstructured":"Alexander JM, Sheffield JS, Sanchez PJ, Mayfield J, Wendel GD Jr (1999) Efficacy of treatment for syphilis in pregnancy. Obstet Gynecol. United States. 5\u20138."},{"key":"ref70","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1136\/sti.76.2.117","article-title":"Effect of a syphilis control programme on pregnancy outcome in Nairobi, Kenya","volume":"76","author":"M Temmerman","year":"2000","journal-title":"Sex Transm Infect"},{"key":"ref71","unstructured":"Watson-Jones D, Gumodoka B, Weiss H, Changalucha J, Todd J, <etal>et al<\/etal>.. (2002) Syphilis in pregnancy in Tanzania. II. The effectiveness of antenatal syphilis screening and single-dose benzathine penicillin treatment for the prevention of adverse pregnancy outcomes. J Infect Dis. United States. 948\u2013957."},{"key":"ref72","doi-asserted-by":"crossref","unstructured":"Myer L, Abdool Karim SS, Lombard C, Wilkinson D (2004) Treatment of maternal syphilis in rural South Africa: effect of multiple doses of benzathine penicillin on pregnancy loss. Trop Med Int Health. England. 1216\u20131221.","DOI":"10.1111\/j.1365-3156.2004.01330.x"},{"key":"ref73","doi-asserted-by":"crossref","unstructured":"Mullick S, Beksinksa M, Msomi S (2005) Treatment for syphilis in antenatal care: compliance with the three dose standard treatment regimen. Sex Transm Infect. England. 220\u2013222.","DOI":"10.1136\/sti.2004.011999"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1136\/sti.2006.023655","article-title":"Syphilis screening and intervention in 500 000 pregnant women in Shenzhen, the People\u2019s Republic of China","volume":"83","author":"JQ Cheng","year":"2007","journal-title":"Sexually Transmitted Infections"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1136\/sti.79.5.375","article-title":"Is antenatal syphilis screening still cost effective in sub-Saharan Africa","volume":"79","author":"F Terris-Prestholt","year":"2003","journal-title":"Sex Transm Infect"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1136\/sti.79.2.106","article-title":"Congenital syphilis in the Russian Federation: magnitude, determinants, and consequences","volume":"79","author":"L Tikhonova","year":"2003","journal-title":"Sex Transm Infect"},{"key":"ref77","first-page":"1519","article-title":"Outcome of maternal syphilis at Rajavithi Hospital on offsprings","volume":"88","author":"V Sangtawesin","year":"2005","journal-title":"J Med Assoc Thai"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1258\/095646206776790150","article-title":"UK National Audit of Early Syphilis Management. Case notes audit: diagnosis and treatment","volume":"17","author":"H McClean","year":"2006","journal-title":"Int J STD AIDS"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1097\/01.olq.0000251236.48770.35","article-title":"Demonstrating public health at work: a demonstration project of congenital syphilis prevention efforts in Bolivia","volume":"34","author":"SG Garcia","year":"2007","journal-title":"Sex Transm Dis"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/QAI.0b013e31815d2f71","article-title":"Do targeted HIV programs improve overall care for pregnant women?: Antenatal syphilis management in Zambia before and after implementation of prevention of mother-to-child HIV transmission programs","volume":"47","author":"D Potter","year":"2008","journal-title":"J Acquir Immune Defic Syndr"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1097\/OLQ.0b013e3181bc0960","article-title":"One-stop service for antenatal syphilis screening and prevention of congenital syphilis in Ulaanbaatar, Mongolia: a cluster randomized trial","volume":"36","author":"B Munkhuu","year":"2009","journal-title":"Sex Transm Dis"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/OLQ.0b013e3181b3915b","article-title":"Congenital syphilis: an economic evaluation of a prevention program in China","volume":"37","author":"FC Hong","year":"2010","journal-title":"Sex Transm Dis"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1016\/j.ijid.2009.09.009","article-title":"Maternal and congenital syphilis in Shanghai, China, 2002 to 2006","volume":"14","author":"L Zhu","year":"2010","journal-title":"International Journal of Infectious Diseases"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S1701-2163(16)34878-2","article-title":"Pregnancy and neonatal outcomes of women with reactive syphilis serology in Alberta, 2002 to 2006","volume":"33","author":"SC Caddy","year":"2011","journal-title":"J Obstet Gynaecol Can"},{"key":"ref85","first-page":"30","article-title":"An evaluation of the incidence of reactions to penicillin","volume":"36","author":"WJ Brown","year":"1960","journal-title":"Br J Vener Dis"},{"key":"ref86","first-page":"977","article-title":"[Penicillin consumption in Norway. Venereal disease-penicillin consumption-complications]","volume":"80","author":"HC Gjessing","year":"1960","journal-title":"Tidsskr Nor Laegeforen"},{"key":"ref87","first-page":"69","article-title":"Are people allergic to penicillin?","volume":"40","author":"J Shafer","year":"1954","journal-title":"The Journal of Social Hygiene"},{"key":"ref88","first-page":"1087","article-title":"Benzathine penicillin G in the: treatment of syphilis","volume":"15","author":"CA Smith","year":"1956","journal-title":"Bull World Health Organ"},{"key":"ref89","first-page":"209","article-title":"Sensitivity to repository penicillins","volume":"33","author":"RR Willcox","year":"1957","journal-title":"Br J Vener Dis"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1056\/NEJM195809182591206","article-title":"Untoward reactions to benzathine penicillin G in a study of rheumatic-fever prophylaxis in adults","volume":"259","author":"I Hsu","year":"1958","journal-title":"N Engl J Med"},{"key":"ref91","first-page":"101","article-title":"Effectiveness of benzathine penicillin regimen in the treatment of syphilis in pregnancy","volume":"72","author":"S Phaosavasdi","year":"1989","journal-title":"J Med Assoc Thai"},{"key":"ref92","first-page":"1308","article-title":"Allergic reactions to long-term benzathine penicillin prophylaxis for rheumatic fever","volume":"337","year":"1991","journal-title":"The Lancet"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.1016\/0020-7292(95)02326-8","article-title":"Syphilis control in pregnancy: decentralization of screening facilities to primary care level, a demonstration project in Nairobi, Kenya","volume":"48","author":"F Jenniskens","year":"1995","journal-title":"Int J Gynaecol Obstet"},{"key":"ref94","first-page":"329","article-title":"Anaphylaxis to Benzathine Penicillin G. Pediatric Asthma, Allergy &amp; Immunology","volume":"14","author":"D Napoli","year":"2000"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.jaci.2003.11.032","article-title":"Represcription of penicillin after allergic-like events","volume":"113","author":"AJ Apter","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1111\/j.1365-3156.2005.01473.x","article-title":"Antenatal syphilis screening in sub-Saharan Africa: Lessons learned from Tanzania","volume":"10","author":"D Watson-Jones","year":"2005","journal-title":"Tropical Medicine and International Health"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1097\/01.olq.0000245987.78067.0c","article-title":"Onsite rapid antenatal syphilis screening with an immunochromatographic strip improves case detection and treatment in rural South African clinics","volume":"34","author":"RN Bronzan","year":"2007","journal-title":"Sexually Transmitted Diseases"},{"key":"ref98","doi-asserted-by":"crossref","unstructured":"Carles G, Lochet S, Youssef M, El Guindi W, Helou G, <etal>et al<\/etal>.. (2008) [Syphilis and pregnancy]. J Gynecol Obstet Biol Reprod (Paris). France. 353\u2013357.","DOI":"10.1016\/j.jgyn.2007.08.006"},{"key":"ref99","doi-asserted-by":"crossref","unstructured":"Li J, Wang LN, Zheng HY (2012) Jarisch-Herxheimer reaction among syphilis patients in China. J Eur Acad Dermatol Venereol.","DOI":"10.1111\/j.1468-3083.2012.04544.x"},{"key":"ref100","doi-asserted-by":"crossref","unstructured":"Liu XS (2011) Implications of statistical power for confidence intervals. Br J Math Stat Psychol.","DOI":"10.1111\/j.2044-8317.2011.02035.x"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.anai.2011.11.006","article-title":"Multiple drug intolerance syndrome: prevalence, clinical characteristics, and management","volume":"108","author":"E Macy","year":"2012","journal-title":"Ann Allergy Asthma Immunol"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1471-2288-7-5","article-title":"Inclusion of zero total event trials in meta-analyses maintains analytic consistency and incorporates all available data","volume":"7","author":"JO Friedrich","year":"2007","journal-title":"BMC Med Res Methodol"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1017\/S0033291711000997","article-title":"Using electronic medical records to enable large-scale studies in psychiatry: treatment resistant depression as a model","volume":"42","author":"RH Perlis","year":"2012","journal-title":"Psychol Med"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"89","DOI":"10.7812\/TPP\/11-138","article-title":"Patient-centered research from electronic medical records","volume":"15","author":"M Aickin","year":"2011","journal-title":"Perm J"},{"key":"ref105","doi-asserted-by":"crossref","unstructured":"Miguel A, Azevedo LF, Lopes F, Freitas A, Pereira AC (2012) Methodologies for the detection of adverse drug reactions: comparison of hospital databases, chart review and spontaneous reporting. Pharmacoepidemiol Drug Saf.","DOI":"10.1002\/pds.3348"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0056463","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T05:43:36Z","timestamp":1644385416000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0056463"}},"subtitle":[],"editor":[{"given":"Roger C.","family":"Young","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,2,21]]},"references-count":105,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,2,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0056463","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,21]]}}}