{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:11:17Z","timestamp":1761059477116},"reference-count":70,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2013,2,20]],"date-time":"2013-02-20T00:00:00Z","timestamp":1361318400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0056561","type":"journal-article","created":{"date-parts":[[2013,2,20]],"date-time":"2013-02-20T23:26:55Z","timestamp":1361402815000},"page":"e56561","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Dishevelled Proteins Are Associated with Olfactory Sensory Neuron Presynaptic Terminals"],"prefix":"10.1371","volume":"8","author":[{"given":"Diego J.","family":"Rodriguez-Gil","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilbur","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles A.","family":"Greer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,2,20]]},"reference":[{"key":"ref1","first-page":"25","article-title":"Genomics of olfactory receptors","volume":"47","author":"X Zhang","year":"2009","journal-title":"Results Probl Cell Differ"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"4025","DOI":"10.1523\/JNEUROSCI.22-10-04025.2002","article-title":"Aberrant sensory innervation of the olfactory bulb in neuropilin-2 mutant mice","volume":"22","author":"A Walz","year":"2002","journal-title":"J Neurosci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S0896-6273(02)00635-9","article-title":"Neuropilin-2 mediates axonal fasciculation, zonal segregation, but not axonal convergence, of primary accessory olfactory neurons","volume":"33","author":"JF Cloutier","year":"2002","journal-title":"Neuron"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0092-8674(03)00568-3","article-title":"Axonal ephrin-As and odorant receptors: coordinate determination of the olfactory sensory map","volume":"114","author":"T Cutforth","year":"2003","journal-title":"Cell"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"9094","DOI":"10.1523\/JNEUROSCI.2217-07.2007","article-title":"Requirement for Slit-1 and Robo-2 in zonal segregation of olfactory sensory neuron axons in the main olfactory bulb","volume":"27","author":"JH Cho","year":"2007","journal-title":"J Neurosci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/cne.21834","article-title":"Wnt\/Frizzled family members mediate olfactory sensory neuron axon extension","volume":"511","author":"DJ Rodriguez-Gil","year":"2008","journal-title":"J Comp Neurol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.cell.2006.10.031","article-title":"A neuronal identity code for the odorant receptor-specific and activity-dependent axon sorting","volume":"127","author":"S Serizawa","year":"2006","journal-title":"Cell"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.neuron.2008.01.023","article-title":"BIG-2 mediates olfactory axon convergence to target glomeruli","volume":"57","author":"T Kaneko-Goto","year":"2008","journal-title":"Neuron"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mcn.2006.01.013","article-title":"Disrupted compartmental organization of axons and dendrites within olfactory glomeruli of mice deficient in the olfactory cell adhesion molecule, OCAM","volume":"32","author":"A Walz","year":"2006","journal-title":"Mol Cell Neurosci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"9405","DOI":"10.1523\/JNEUROSCI.2356-09.2009","article-title":"Tenascin-C is an inhibitory boundary molecule in the developing olfactory bulb","volume":"29","author":"HB Treloar","year":"2009","journal-title":"J Neurosci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/(SICI)1097-4695(19980215)34:3<271::AID-NEU6>3.0.CO;2-#","article-title":"Differential expression of extracellular matrix and cell adhesion molecules in the olfactory nerve and glomerular layers of adult rats","volume":"34","author":"KW Kafitz","year":"1998","journal-title":"J Neurobiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.cell.2004.05.011","article-title":"A contextual model for axonal sorting into glomeruli in the mouse olfactory system","volume":"117","author":"P Feinstein","year":"2004","journal-title":"Cell"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0092-8674(00)81145-9","article-title":"Odorant receptors govern the formation of a precise topographic map","volume":"93","author":"F Wang","year":"1998","journal-title":"Cell"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1126\/science.1131794","article-title":"Odorant receptor-derived cAMP signals direct axonal targeting","volume":"314","author":"T Imai","year":"2006","journal-title":"Science"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"6675","DOI":"10.1523\/JNEUROSCI.0699-07.2007","article-title":"Absence of adenylyl cyclase 3 perturbs peripheral olfactory projections in mice","volume":"27","author":"DJ Zou","year":"2007","journal-title":"J Neurosci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"16498","DOI":"10.1523\/JNEUROSCI.4225-10.2010","article-title":"Hyperpolarization-activated cyclic nucleotide-gated channels in olfactory sensory neurons regulate axon extension and glomerular formation","volume":"30","author":"AS Mobley","year":"2010","journal-title":"J Neurosci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"9757","DOI":"10.1523\/JNEUROSCI.0763-07.2007","article-title":"Activation of the Wnt-beta catenin pathway in a cell population on the surface of the forebrain is essential for the establishment of olfactory axon connections","volume":"27","author":"AA Zaghetto","year":"2007","journal-title":"J Neurosci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1002\/dneu.20606","article-title":"A unique cell population in the mouse olfactory bulb displays nuclear beta-catenin signaling during development and olfactory sensory neuron regeneration","volume":"68","author":"T Booker-Dwyer","year":"2008","journal-title":"Dev Neurobiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.1002\/dvdy.21712","article-title":"Activation of the Wnt\/beta-catenin signaling reporter in developing mouse olfactory nerve layer marks a specialized subgroup of olfactory ensheathing cells","volume":"237","author":"YZ Wang","year":"2008","journal-title":"Dev Dyn"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1242\/dev.033910","article-title":"Towards an integrated view of Wnt signaling in development","volume":"136","author":"R van Amerongen","year":"2009","journal-title":"Development"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.cellsig.2009.11.021","article-title":"Dishevelled: The hub of Wnt signaling","volume":"22","author":"C Gao","year":"2010","journal-title":"Cell Signal"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e1000259","DOI":"10.1371\/journal.pgen.1000259","article-title":"Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development","volume":"4","author":"SL Etheridge","year":"2008","journal-title":"PLoS Genet"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e6729","DOI":"10.1371\/journal.pone.0006729","article-title":"Dendritic branching of olfactory bulb mitral and tufted cells: regulation by TrkB","volume":"4","author":"F Imamura","year":"2009","journal-title":"PLoS One"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"9713","DOI":"10.1523\/JNEUROSCI.21-24-09713.2001","article-title":"Structure and emergence of specific olfactory glomeruli in the mouse","volume":"21","author":"SM Potter","year":"2001","journal-title":"J Neurosci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1523\/JNEUROSCI.3937-08.2009","article-title":"The FXG: a presynaptic fragile X granule expressed in a subset of developing brain circuits","volume":"29","author":"SB Christie","year":"2009","journal-title":"J Neurosci"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"10067","DOI":"10.1523\/JNEUROSCI.1776-10.2010","article-title":"Chromosomal location-dependent nonstochastic onset of odor receptor expression","volume":"30","author":"DJ Rodriguez-Gil","year":"2010","journal-title":"J Neurosci"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s11068-005-3334-y","article-title":"Protocols for two- and three-color fluorescent RNA in situ hybridization of the main and accessory olfactory epithelia in mouse","volume":"33","author":"T Ishii","year":"2004","journal-title":"J Neurocytol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1242\/jcs.021964","article-title":"G alpha o mediates WNT-JNK signaling through dishevelled 1 and 3, RhoA family members, and MEKK 1 and 4 in mammalian cells","volume":"121","author":"RK Bikkavilli","year":"2008","journal-title":"J Cell Sci"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.1091\/mbc.E06-03-0193","article-title":"PAR1b promotes cell-cell adhesion and inhibits dishevelled-mediated transformation of Madin-Darby canine kidney cells","volume":"17","author":"M Elbert","year":"2006","journal-title":"Mol Biol Cell"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"4757","DOI":"10.1128\/MCB.24.11.4757-4768.2004","article-title":"Wnt proteins induce dishevelled phosphorylation via an LRP5\/6- independent mechanism, irrespective of their ability to stabilize beta-catenin","volume":"24","author":"JM Gonzalez-Sancho","year":"2004","journal-title":"Mol Cell Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1101\/gad.1022203","article-title":"Coactivation of Rac and Rho by Wnt\/Frizzled signaling is required for vertebrate gastrulation","volume":"17","author":"R Habas","year":"2003","journal-title":"Genes Dev"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"52703","DOI":"10.1074\/jbc.M408675200","article-title":"Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family","volume":"279","author":"E Torban","year":"2004","journal-title":"J Biol Chem"},{"key":"ref33","first-page":"4547","article-title":"Wnt pathway activation in mesothelioma: evidence of Dishevelled overexpression and transcriptional activity of beta-catenin","volume":"63","author":"K Uematsu","year":"2003","journal-title":"Cancer Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"7218","DOI":"10.1038\/sj.onc.1206817","article-title":"Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression","volume":"22","author":"K Uematsu","year":"2003","journal-title":"Oncogene"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/j.1349-7006.2003.tb01475.x","article-title":"Amplification, up-regulation and over-expression of DVL-1, the human counterpart of the Drosophila disheveled gene, in primary breast cancers","volume":"94","author":"T Nagahata","year":"2003","journal-title":"Cancer Sci"},{"key":"ref36","first-page":"743","article-title":"Dishevelled promotes axon differentiation by regulating atypical protein kinase C. Nat Cell Biol","volume":"9","author":"X Zhang","year":"2007"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1083\/jcb.151.1.83","article-title":"Dishevelled-1 regulates microtubule stability: a new function mediated by glycogen synthase kinase-3beta","volume":"151","author":"O Krylova","year":"2000","journal-title":"J Cell Biol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/j.1460-9568.2006.04596.x","article-title":"Expression of planar cell polarity genes during development of the mouse CNS","volume":"23","author":"F Tissir","year":"2006","journal-title":"Eur J Neurosci"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1002\/dvdy.21595","article-title":"Dynamic expression patterns of ECM molecules in the developing mouse olfactory pathway","volume":"237","author":"EL Shay","year":"2008","journal-title":"Dev Dyn"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/cne.901690104","article-title":"Synapse formation in the mouse olfactory bulb. II. Morphogenesis","volume":"169","author":"JW Hinds","year":"1976","journal-title":"J Comp Neurol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1073\/pnas.93.2.884","article-title":"The chromosomal distribution of mouse odorant receptor genes","volume":"93","author":"SL Sullivan","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1111\/j.0953-816X.2004.03331.x","article-title":"NQO1 activity in the main and the accessory olfactory systems correlates with the zonal topography of projection maps","volume":"19","author":"F Gussing","year":"2004","journal-title":"Eur J Neurosci"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1046\/j.1432-1033.2003.03571.x","article-title":"O-MACS, a novel member of the medium-chain acyl-CoA synthetase family, specifically expressed in the olfactory epithelium in a zone-specific manner","volume":"270","author":"Y Oka","year":"2003","journal-title":"Eur J Biochem"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.neuron.2008.11.010","article-title":"Mapping of class I and class II odorant receptors to glomerular domains by two distinct types of olfactory sensory neurons in the mouse","volume":"61","author":"T Bozza","year":"2009","journal-title":"Neuron"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/nature05066","article-title":"A second class of chemosensory receptors in the olfactory epithelium","volume":"442","author":"SD Liberles","year":"2006","journal-title":"Nature"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"5830","DOI":"10.1523\/JNEUROSCI.17-15-05830.1997","article-title":"OCAM: A new member of the neural cell adhesion molecule family related to zone-to-zone projection of olfactory and vomeronasal axons","volume":"17","author":"Y Yoshihara","year":"1997","journal-title":"J Neurosci"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1083\/jcb.200511054","article-title":"Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter release","volume":"174","author":"A Ahmad-Annuar","year":"2006","journal-title":"J Cell Biol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/(SICI)1096-9861(19990503)407:2<261::AID-CNE7>3.0.CO;2-G","article-title":"Compartmental organization of the olfactory bulb glomerulus","volume":"407","author":"HJ Kasowski","year":"1999","journal-title":"J Comp Neurol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0896-6273(00)00084-2","article-title":"Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP","volume":"28","author":"G Feng","year":"2000","journal-title":"Neuron"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1002\/dneu.20389","article-title":"Adult-generated neurons exhibit diverse developmental fates","volume":"67","author":"MC Whitman","year":"2007","journal-title":"Dev Neurobiol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1002\/cne.20135","article-title":"Members of the Wnt, Fz, and Frp gene families expressed in postnatal mouse cerebral cortex","volume":"473","author":"T Shimogori","year":"2004","journal-title":"J Comp Neurol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1101\/gad.9.9.1087","article-title":"The dishevelled protein is modified by wingless signaling in Drosophila","volume":"9","author":"S Yanagawa","year":"1995","journal-title":"Genes Dev"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1083\/jcb.200309096","article-title":"A divergent canonical WNT-signaling pathway regulates microtubule dynamics: dishevelled signals locally to stabilize microtubules","volume":"164","author":"L Ciani","year":"2004","journal-title":"J Cell Biol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1146\/annurev.neuro.27.070203.144336","article-title":"Mechanisms of vertebrate synaptogenesis","volume":"28","author":"CL Waites","year":"2005","journal-title":"Annu Rev Neurosci"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/ncb2404","article-title":"Wnt7a-Fzd7 signalling directly activates the Akt\/mTOR anabolic growth pathway in skeletal muscle","volume":"14","author":"J von Maltzahn","year":"2012","journal-title":"Nat Cell Biol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1242\/dev.046722","article-title":"Frizzled-5, a receptor for the synaptic organizer Wnt7a, regulates activity-mediated synaptogenesis","volume":"137","author":"M Sahores","year":"2010","journal-title":"Development"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"5022","DOI":"10.1128\/MCB.25.12.5022-5030.2005","article-title":"Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5","volume":"25","author":"Z Wang","year":"2005","journal-title":"Mol Cell Biol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/ng1552","article-title":"Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways","volume":"37","author":"M Simons","year":"2005","journal-title":"Nat Genet"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/ncb1670","article-title":"Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms","volume":"10","author":"KC Corbit","year":"2008","journal-title":"Nat Cell Biol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0070-2153(08)00807-7","article-title":"Ciliary function and Wnt signal modulation","volume":"85","author":"JM Gerdes","year":"2008","journal-title":"Curr Top Dev Biol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/ng.2007.12","article-title":"Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response","volume":"39","author":"JM Gerdes","year":"2007","journal-title":"Nat Genet"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"15917","DOI":"10.1073\/pnas.0704140104","article-title":"Hypomorphic CEP290\/NPHP6 mutations result in anosmia caused by the selective loss of G proteins in cilia of olfactory sensory neurons","volume":"104","author":"DP McEwen","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref63","first-page":"e19694","article-title":"Renal cystic disease proteins play critical roles in the organization of the olfactory epithelium","volume":"6(5)","year":"2011","journal-title":"PLoS One"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1038\/ng1418","article-title":"Loss of BBS proteins causes anosmia in humans and defects in olfactory cilia structure and function in the mouse","volume":"36","author":"HM Kulaga","year":"2004","journal-title":"Nat Genet"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0092-8674(93)90422-M","article-title":"Spatial segregation of odorant receptor expression in the mammalian olfactory epithelium","volume":"74","author":"R Vassar","year":"1993","journal-title":"Cell"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/0092-8674(93)90145-G","article-title":"A zonal organization of odorant receptor gene expression in the olfactory epithelium","volume":"73","author":"KJ Ressler","year":"1993","journal-title":"Cell"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/nn800","article-title":"The olfactory receptor gene superfamily of the mouse","volume":"5","author":"X Zhang","year":"2002","journal-title":"Nat Neurosci"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"3586","DOI":"10.1523\/JNEUROSCI.0324-05.2005","article-title":"Continuous and overlapping expression domains of odorant receptor genes in the olfactory epithelium determine the dorsal\/ventral positioning of glomeruli in the olfactory bulb","volume":"25","author":"K Miyamichi","year":"2005","journal-title":"J Neurosci"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.celrep.2012.06.006","article-title":"An Olfactory Subsystem that Mediates High-Sensitivity Detection of Volatile Amines","volume":"2","author":"R Pacifico","year":"2012","journal-title":"Cell Reports"},{"key":"ref70","doi-asserted-by":"crossref","unstructured":"Johnson MA, Tsai L, Roy DS, Valenzuela DH, Mosley C, <etal>et al<\/etal>.. (2012) Neurons expressing trace amine-associated receptors project to discrete glomeruli and constitute an olfactory subsystem. Proc Natl Acad Sci U S A.","DOI":"10.1073\/pnas.1206724109"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0056561","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T07:02:02Z","timestamp":1589007722000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0056561"}},"subtitle":[],"editor":[{"given":"John I.","family":"Glendinning","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,2,20]]},"references-count":70,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,2,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0056561","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,20]]}}}