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(2009) News and Resources Centre Cancer Stats. Kidney Cancer. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.cancerresearchuk.org\/cancer-info\/cancerstats\/incidence\/commoncancers\/#Top\" xlink:type=\"simple\">http:\/\/www.cancerresearchuk.org\/cancer-info\/cancerstats\/incidence\/commoncancers\/#Top<\/ext-link>. Accessed 2012 Sep 25."},{"key":"ref9","unstructured":"American Cancer Society (2012) Cancer facts &amp; figures 2012. American Cancer Society. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.cancer.org\/acs\/groups\/content\/epidemiologysurveilance\/documents\/document\/acspc-031941.pdf\" xlink:type=\"simple\">http:\/\/www.cancer.org\/acs\/groups\/content\/epidemiologysurveilance\/documents\/document\/acspc-031941.pdf<\/ext-link>. Accessed: 2012 Aug 25."},{"key":"ref10","unstructured":"Taiwan Cancer Registry (2012) Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/tcr.cph.ntu.edu.tw\/main.php?Page=A1\" xlink:type=\"simple\">http:\/\/tcr.cph.ntu.edu.tw\/main.php?Page=A1<\/ext-link>. Accessed: 2012 Sep 20."},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1016\/j.juro.2006.07.130","article-title":"The epidemiology of renal cell carcinoma","volume":"176","author":"L Lipworth","year":"2006","journal-title":"J Urol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/j.1464-410X.1991.tb15158.x","article-title":"Acquired renal cystic disease: implications for the urologist","volume":"67","author":"JF Brennan","year":"1991","journal-title":"Br J Urol"},{"key":"ref13","unstructured":"McLaughlin JK (2006) Kidney Cancer. Oxford: Oxford University Press. 1087 p."},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00005792-198901000-00001","article-title":"von Hippel-Lindau disease affecting 43 members of a single kindred","volume":"68","author":"JM Lamiell","year":"1989","journal-title":"Medicine (Baltimore)"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nrc1364","article-title":"Searching for the hereditary causes of renal-cell carcinoma","volume":"4","author":"CP Pavlovich","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/0090-4295(91)80261-5","article-title":"Malignant renal tumors in tuberous sclerosis","volume":"37","author":"R Washecka","year":"1991","journal-title":"Urology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s00432-002-0336-3","article-title":"Estrogen receptor beta is expressed in human stomach adenocarcinoma","volume":"128","author":"S Matsuyama","year":"2002","journal-title":"J Cancer Res Clin Oncol"},{"key":"ref18","first-page":"2919","article-title":"Expression of estrogen receptor-beta isoforms in Barrett&apos;s metaplasia, dysplasia and esophageal adenocarcinoma","volume":"24","author":"L Liu","year":"2004","journal-title":"Anticancer Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1053\/hupa.2001.27117","article-title":"Estrogen receptor beta is expressed in human colorectal adenocarcinoma","volume":"32","author":"D Witte","year":"2001","journal-title":"Hum Pathol"},{"key":"ref20","first-page":"1459","article-title":"Estrogen receptor-beta is expressed in Barrett&apos;s metaplasia and associated adenocarcinoma of the esophagus","volume":"22","author":"H Akgun","year":"2002","journal-title":"Anticancer Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s10549-009-0413-2","article-title":"Estrogen receptor 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