{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T05:38:11Z","timestamp":1775367491499,"version":"3.50.1"},"reference-count":26,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T00:00:00Z","timestamp":1360713600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0056741","type":"journal-article","created":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T21:59:19Z","timestamp":1360792759000},"page":"e56741","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":29,"title":["A20 (TNFAIP3) Deletion in Epstein-Barr Virus-Associated Lymphoproliferative Disorders\/Lymphomas"],"prefix":"10.1371","volume":"8","author":[{"given":"Midori","family":"Ando","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuharu","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuyoshi","family":"Takata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Nomoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Ohshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamotsu","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yorihisa","family":"Orita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Yoshino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,2,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1126\/science.1153629","article-title":"Oncogenic CARD11 mutations in human diffuse large B cell lymphoma","volume":"319","author":"G Lenz","year":"2008","journal-title":"Science"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature04870","article-title":"Nuclear factor-kappaB in cancer development and progression","volume":"441","author":"M Karin","year":"2006","journal-title":"Nature"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/nature07969","article-title":"Frequent inactivation of A20 in B-cell lymphomas","volume":"459","author":"M Kato","year":"2009","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1182\/blood-2008-12-194852","article-title":"TNFAIP3\/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas","volume":"114","author":"K Honma","year":"2009","journal-title":"Blood"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"4918","DOI":"10.1182\/blood-2008-08-174110","article-title":"The NF-{kappa}B negative regulator TNFAIP3 (A20) is inactivated by somatic mutations and genomic deletions in marginal zone lymphomas","volume":"113","author":"U Novak","year":"2009","journal-title":"Blood"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1002\/gcc.20463","article-title":"Genome-wide array-based comparative genomic hybridization of ocular marginal zone B cell lymphoma: comparison with pulmonary and nodal marginal zone B cell lymphoma","volume":"46","author":"WS Kim","year":"2007","journal-title":"Genes Chromosomes Cancer"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/path.2466","article-title":"A20 deletion is associated with copy number gain at the TNFA\/B\/C locus and occurs preferentially in translocation-negative MALT lymphoma of the ocular adnexa and salivary glands","volume":"217","author":"E Chanudet","year":"2009","journal-title":"J Pathol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"926","DOI":"10.3324\/haematol.2010.036798","article-title":"A20 inactivation in ocular adnexal MALT lymphoma","volume":"97","author":"Y Bi","year":"2011","journal-title":"Haematologica"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/nature07968","article-title":"Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma","volume":"459","author":"M Compagno","year":"2009","journal-title":"Nature"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1158\/1078-0432.CCR-10-1859","article-title":"A20, ABIN-1\/2, and CARD11 mutations and their prognostic value in gastrointestinal diffuse large B-cell lymphoma","volume":"17","author":"G Dong","year":"2011","journal-title":"Clin Cancer Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1084\/jem.20090528","article-title":"TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma","volume":"206","author":"R Schmitz","year":"2009","journal-title":"J Exp Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1186\/1471-2407-12-457","article-title":"Deletion of the TNFAIP3\/A20 gene detected by FICTION analysis in classical Hodgkin lymphoma","volume":"12","author":"J Nomoto","year":"2012","journal-title":"BMC Cancer"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"4930","DOI":"10.1182\/blood-2011-06-359166","article-title":"Alteration of BIRC3 and multiple other NF-kappaB pathway genes in splenic marginal zone lymphoma","volume":"118","author":"D Rossi","year":"2011","journal-title":"Blood"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4852","DOI":"10.1182\/blood-2010-10-310995","article-title":"A20 (TNFAIP3) genetic alterations in EBV-associated AIDS-related lymphoma","volume":"117","author":"L Giulino","year":"2011","journal-title":"Blood"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1038\/leu.2011.101","article-title":"Tumor suppressor TNFAIP3 (A20) is frequently deleted in Sezary syndrome","volume":"25","author":"FC Braun","year":"2011","journal-title":"Leukemia"},{"key":"ref16","unstructured":"Swerdlow SH, Campo E, Harris NL, Stein H, Jaffe ES, Pileri SA, <etal>et al<\/etal>.. (2008) WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon: World Health Organization."},{"key":"ref17","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0002-9440(10)63284-1","article-title":"BCL2 translocation defines a unique tumor subset within the germinal center B-cell-like diffuse large B-cell lymphoma","volume":"165","author":"J Iqbal","year":"2004","journal-title":"Am J Pathol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4702","DOI":"10.1158\/1078-0432.CCR-11-3169","article-title":"Epstein-Barr virus infection and expression of B-cell oncogenic markers in HIV-related diffuse large B-cell lymphoma","volume":"18","author":"C Chao","year":"2012","journal-title":"Clin Cancer Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/modpathol.2012.52","article-title":"EBV-positive diffuse large B-cell lymphoma of the elderly is an aggressive post-germinal center B-cell neoplasm characterized by prominent nuclear factor-kB activation","volume":"25","author":"S Montes-Moreno","year":"2012","journal-title":"Mod Pathol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3960\/jslrt.46.5","article-title":"Pyothorax-associated lymphoma","volume":"46","author":"K Aozasa","year":"2006","journal-title":"J Clin Exp Hematop"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1084\/jem.194.12.1861","article-title":"Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells","volume":"194","author":"RE Davis","year":"2001","journal-title":"J Exp Med"},{"key":"ref22","first-page":"1044","article-title":"Epstein-Barr virus in pyothorax-associated pleural lymphoma","volume":"143","author":"M Fukayama","year":"1993","journal-title":"Am J Pathol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1136\/jcp.49.1.72","article-title":"Expression of Epstein-Barr virus encoded latent genes in nasal T cell lymphomas","volume":"49","author":"J van Gorp","year":"1996","journal-title":"J Clin Pathol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/(SICI)1097-0215(19961104)68:3<285::AID-IJC3>3.0.CO;2-Y","article-title":"Nasal NK- and T-cell lymphomas share the same type of Epstein-Barr virus latency as nasopharyngeal carcinoma and Hodgkin&apos;s disease","volume":"68","author":"AK Chiang","year":"1996","journal-title":"Int J Cancer"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nrc1452","article-title":"Epstein-Barr virus: 40 years on","volume":"4","author":"LS Young","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1182\/blood-2011-04-346890","article-title":"Identification of FOXO3 and PRDM1 as tumor-suppressor gene candidates in NK-cell neoplasms by genomic and functional analyses","volume":"118","author":"K Karube","year":"2011","journal-title":"Blood"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0056741","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T02:16:12Z","timestamp":1588990572000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0056741"}},"subtitle":[],"editor":[{"given":"Joseph S.","family":"Pagano","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,2,13]]},"references-count":26,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,2,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0056741","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,13]]}}}