{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:36:19Z","timestamp":1791153379438,"version":"4.1.0"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T00:00:00Z","timestamp":1361750400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0056971","type":"journal-article","created":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T22:09:10Z","timestamp":1361830150000},"page":"e56971","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":37,"title":["Metabolic Profiling for Detection of Staphylococcus aureus Infection and Antibiotic Resistance"],"prefix":"10.1371","volume":"8","author":[{"given":"Henrik","family":"Antti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Fahlgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elin","family":"N\u00e4sstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Kouremenos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Sund\u00e9n-Cullberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YongZhi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Moritz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Wolf-Watz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Fallman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,2,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"e1001104","DOI":"10.1371\/journal.pmed.1001104","article-title":"Mortality and hospital stay associated with resistant <italic>Staphylococcus aureus<\/italic> and <italic>Escherichia coli<\/italic> bacteremia: estimating the burden of antibiotic resistance in Europe","volume":"8","author":"ME de Kraker","year":"2011","journal-title":"PLoS Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/S0140-6736(09)61999-1","article-title":"Community-associated meticillin-resistant <italic>Staphylococcus aureus<\/italic>","volume":"375","author":"FR Deleo","year":"2010","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1126\/science.1175325","article-title":"Environment. Looming global-scale failures and missing institutions","volume":"325","author":"B Walker","year":"2009","journal-title":"Science"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"S114","DOI":"10.1086\/320184","article-title":"Survey of infections due to <italic>Staphylococcus<\/italic> species: frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, Latin America, Europe, and the Western Pacific region for the SENTRY Antimicrobial Surveillance Program, 1997\u20131999","volume":"32","author":"DJ Diekema","year":"2001","journal-title":"Clin Infect Dis"},{"key":"ref5","unstructured":"Mandell GL, Bennett JE, Dolin R (2010) Mandell, Douglas, and Bennett\u2019s principles and practice of infectious diseases. Philadelphia, PA: Churchill Livingstone\/Elsevier."},{"key":"ref6","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1001\/archinte.162.1.25","article-title":"Treatment and outcome of <italic>Staphylococcus aureus<\/italic> bacteremia: a prospective study of 278 cases","volume":"162","author":"AG Jensen","year":"2002","journal-title":"Arch Intern Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1136\/bmj.38834.421713.2F","article-title":"Mortality after <italic>Staphylococcus aureus<\/italic> bacteraemia in two hospitals in Oxfordshire, 1997\u20132003: cohort study","volume":"333","author":"DH Wyllie","year":"2006","journal-title":"BMJ"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ijantimicag.2011.05.013","article-title":"Increased mortality associated with methicillin-resistant <italic>Staphylococcus aureus<\/italic> (MRSA) infection in the intensive care unit: results from the EPIC II study","volume":"38","author":"H Hanberger","year":"2011","journal-title":"Int J Antimicrob Agents"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.aca.2009.11.042","article-title":"Chemometrics in metabolomics\u2013a review in human disease diagnosis","volume":"659","author":"R Madsen","year":"2010","journal-title":"Anal Chim Acta"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1164\/rccm.201103-0474CI","article-title":"The emerging field of quantitative blood metabolomics for biomarker discovery in critical illnesses","volume":"184","author":"NJ Serkova","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1097\/01.CCM.0000155991.88802.4D","article-title":"Persistent elevation of high mobility group box-1 protein (HMGB1) in patients with severe sepsis and septic shock","volume":"33","author":"J Sund\u00e9n-Cullberg","year":"2005","journal-title":"Crit Care Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1097\/01.CCM.0000266536.14736.03","article-title":"Pronounced elevation of resistin correlates with severity of disease in severe sepsis and septic shock","volume":"35","author":"J Sund\u00e9n-Cullberg","year":"2007","journal-title":"Crit Care Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1378\/chest.101.6.1644","article-title":"Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP\/SCCM Consensus Conference Committee. American College of Chest Physicians\/Society of Critical Care Medicine","volume":"101","author":"RC Bone","year":"1992","journal-title":"Chest"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"8086","DOI":"10.1021\/ac051211v","article-title":"Extraction and GC\/MS analysis of the human blood plasma metabolome","volume":"77","author":"A Jiye","year":"2005","journal-title":"Anal Chem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"5635","DOI":"10.1021\/ac050601e","article-title":"High-throughput data analysis for detecting and identifying differences between samples in GC\/MS-based metabolomic analyses","volume":"77","author":"P Jonsson","year":"2005","journal-title":"Anal Chem"},{"key":"ref16","unstructured":"Chan M (2012) Antimicrobial resistance in the European Union and the world. World Health Organization."},{"key":"ref17","doi-asserted-by":"crossref","first-page":"10795","DOI":"10.1158\/0008-5472.CAN-06-0755","article-title":"Mass spectrometry-based metabolic profiling reveals different metabolite patterns in invasive ovarian carcinomas and ovarian borderline tumors","volume":"66","author":"C Denkert","year":"2006","journal-title":"Cancer Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1172\/JCI35111","article-title":"Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury","volume":"118","author":"GD Lewis","year":"2008","journal-title":"J Clin Invest"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.cmet.2012.01.024","article-title":"Interplay between Lipids and Branched-Chain Amino Acids in Development of Insulin Resistance","volume":"15","author":"CB Newgard","year":"2012","journal-title":"Cell Metab"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1038\/nature07762","article-title":"Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression","volume":"457","author":"A Sreekumar","year":"2009","journal-title":"Nature"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"4719","DOI":"10.1128\/JB.05132-11","article-title":"Metabolomics reveals phospholipids as important nutrient sources during Salmonella growth in bile in vitro and in vivo","volume":"193","author":"LC Antunes","year":"2011","journal-title":"J Bacteriol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e1000305","DOI":"10.1371\/journal.ppat.1000305","article-title":"Quantitative metabolomics reveals an epigenetic blueprint for iron acquisition in uropathogenic Escherichia coli","volume":"5","author":"JP Henderson","year":"2009","journal-title":"PLoS Pathog"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1007\/s11745-006-5048-z","article-title":"Fatty acids and monoacylglycerols inhibit growth of <italic>Staphylococcus aureus<\/italic>","volume":"41","author":"JA Kelsey","year":"2006","journal-title":"Lipids"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"4482","DOI":"10.1128\/JB.00221-09","article-title":"Wall teichoic acid protects <italic>Staphylococcus aureus<\/italic> against antimicrobial fatty acids from human skin","volume":"191","author":"T Kohler","year":"2009","journal-title":"J Bacteriol"},{"key":"ref25","first-page":"tr3","article-title":"The inositol trisphosphate (IP3) signal transduction pathway","volume":"3","author":"JD Thatcher","year":"2010","journal-title":"Sci Signal"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e10146","DOI":"10.1371\/journal.pone.0010146","article-title":"Identification of genes involved in polysaccharide-independent <italic>Staphylococcus aureus<\/italic> biofilm formation","volume":"5","author":"BR Boles","year":"2010","journal-title":"PLoS One"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/nrm2334","article-title":"Inositol derivatives: evolution and functions","volume":"9","author":"RH Michell","year":"2008","journal-title":"Nat Rev Mol Cell Biol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0056971","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T05:17:32Z","timestamp":1540012652000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0056971"}},"subtitle":[],"editor":[{"given":"Martin","family":"Rottman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,2,25]]},"references-count":27,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,2,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0056971","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,25]]}}}