{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T15:23:35Z","timestamp":1778081015014,"version":"3.51.4"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2013,2,21]],"date-time":"2013-02-21T00:00:00Z","timestamp":1361404800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0057091","type":"journal-article","created":{"date-parts":[[2013,2,21]],"date-time":"2013-02-21T18:41:45Z","timestamp":1361472105000},"page":"e57091","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":39,"title":["Genotypic Analysis of Klebsiella pneumoniae Isolates in a Beijing Hospital Reveals High Genetic Diversity and Clonal Population Structure of Drug-Resistant Isolates"],"prefix":"10.1371","volume":"8","author":[{"given":"Qi","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan K. L.","family":"Tsang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick C. Y.","family":"Woo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cui Hua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,2,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1017\/S0950268811000781","article-title":"Wide dissemination of extended-spectrum beta-lactamase (ESBL)-producing <italic>Escherichia coli<\/italic> and <italic>Klebsiella spp<\/italic>. in acute care and rehabilitation hospitals","volume":"140","author":"A Kohlenberg","year":"2012","journal-title":"Epidemiol Infect"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1128\/AAC.05036-11","article-title":"Nosocomial Outbreak of VIM-1-producing <italic>Klebsiella pneumoniae<\/italic> of multilocus sequence type 15: Molecular basis, clinical risk factors, and outcome","volume":"56","author":"I S\u00e1nchez-Romero","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1099\/jmm.0.015826-0","article-title":"Outbreak of <italic>Klebsiella pneumoniae<\/italic> carbapenemase 2-producing <italic>K. pneumoniae<\/italic> with high qnr prevalence in a Chinese hospital","volume":"60","author":"R Zhang","year":"2011","journal-title":"J Med Microbiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1469-0691.2011.03478.x","article-title":"Outcome of carbapenem resistant <italic>Klebsiella pneumoniae<\/italic> bloodstream infections","volume":"18","author":"D Ben-David","year":"2012","journal-title":"Clin Microbiol Infect"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1128\/AAC.00782-08","article-title":"Prospective observational study of the impact of VIM-1 metallo-beta-lactamase on the outcome of patients with <italic>Klebsiella pneumoniae<\/italic> bloodstream infections","volume":"53","author":"GL Daikos","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1086\/319757","article-title":"Extended-spectrum\u03b2-lactamase-producing <italic>Escherichia coli<\/italic> and <italic>Klebsiella pneumoniae<\/italic>: risk factors for infection and impact of resistance on outcomes","volume":"32","author":"E Lautenbach","year":"2001","journal-title":"Clin Infect Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1469-0691.2011.03570.x","article-title":"Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance","volume":"18","author":"AP Magiorakos","year":"2012","journal-title":"Clin Microbiol Infect"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1128\/AAC.49.3.1150-1156.2005","article-title":"Extended-spectrum beta-lactamases among <italic>Enterobacter<\/italic> isolates obtained in Tel Aviv, Israel","volume":"49","author":"J Schlesinger","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"ref9","first-page":"62","article-title":"Carbapenem-nonsusceptible strains of <italic>Klebsiella pneumoniae<\/italic> producing SHV-5 and\/or DHA-1 beta-lactamases in a Czech hospital","volume":"309","author":"E Chud\u00e1ckov\u00e1","year":"2010","journal-title":"FEMS Microbiol Lett"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1128\/AAC.01452-10","article-title":"Outbreak of OXA-48-positive carbapenem-resistant <italic>Klebsiella pneumoniae<\/italic> isolates in France","volume":"55","author":"G Cuzon","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S1473-3099(10)70276-0","article-title":"Global spread of New Delhi metallo-beta-lactamase 1","volume":"10","author":"AM Hammerum","year":"2010","journal-title":"Lancet Infect Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.3201\/eid1710.110655","article-title":"Global Spread of Carbapenemase-producing <italic>Enterobacteriaceae<\/italic>","volume":"17","author":"P Nordmann","year":"2011","journal-title":"Emerg Infect Dis"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1128\/JCM.01773-10","article-title":"How To Detect NDM-1 Producers","volume":"49","author":"P Nordmann","year":"2010","journal-title":"J Clin Microbiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1128\/JCM.00219-10","article-title":"Extended-Spectrum-\u03b2-Lactamase, AmpC, and Carbapenemase issues","volume":"48","author":"KS Thomson","year":"2010","journal-title":"J Clin Microbiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1093\/jac\/dkr546","article-title":"Nosocomial spread of multidrug-resistant group B streptococci with reduced penicillin susceptibility belonging to clonal complex 1","volume":"67","author":"N Nagano","year":"2012","journal-title":"J Antimicrob Chemother"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1017\/S0950268810001457","article-title":"Putative household outbreaks of campylobacteriosis typically comprise single MLST genotypes","volume":"138","author":"O Rotariu","year":"2010","journal-title":"Epidemiol Infect"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"W728","DOI":"10.1093\/nar\/gki415","article-title":"The multilocus sequence typing network: mlst.net","volume":"33","author":"DM Aanensen","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4178","DOI":"10.1128\/JCM.43.8.4178-4182.2005","article-title":"Multilocus Sequence Typing of <italic>Klebsiella pneumoniae<\/italic> Nosocomial Isolates","volume":"43","author":"D Laure","year":"2005","journal-title":"J Clin Microbiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e42280","DOI":"10.1371\/journal.pone.0042280","article-title":"Analysis of drug resistance determinants in <italic>Klebsiella pneumoniae<\/italic> isolates from a tertiary-care hospital in Beijing, China","volume":"7","author":"B Li","year":"2012","journal-title":"PLoS One"},{"key":"ref20","unstructured":"Performance Standards for antimicrobial Susceptibility Testing; Twenty-first Informational Supplement. Clinical and Laboratory Standards Institute (CLSI); 2011."},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1128\/JB.186.5.1518-1530.2004","article-title":"eBURST: inferring patterns of evolutionary descent among clusters of related bacterial genotypes from multilocus sequence typing data","volume":"186","author":"EJ Feil","year":"2004","journal-title":"J Bacteriol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1093\/bioinformatics\/17.12.1230","article-title":"Sequence type analysis and recombinational tests (START)","volume":"17","author":"KA Jolley","year":"2001","journal-title":"Bioinformatics"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1534\/genetics.106.063305","article-title":"Inference of bacterial microevolution using multilocus sequence data","volume":"175","author":"X Didelot","year":"2006","journal-title":"Genetics"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"W557","DOI":"10.1093\/nar\/gki352","article-title":"PHYML Online\u2013a web server for fast maximum likelihood-based phylogenetic inference","volume":"33","author":"S Guindon","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jhin.2006.02.022","article-title":"Hospital-acquired infection surveillance in a neurosurgical intensive care unit","volume":"64","author":"GB Orsi","year":"2006","journal-title":"J Hospital Infect"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1093\/jac\/dkn287","article-title":"Expansion and countrywide dissemination of ST11, ST15 and ST147 ciprofloxacin-resistant CTX-M-15-type beta-lactamase-producing <italic>Klebsiella pneumoniae<\/italic> epidemic clones in Hungary in 2005\u2013the new \u2018MRSAs\u2019?","volume":"62","author":"I Damjanova","year":"2008","journal-title":"J Antimicrob Chemother"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ijantimicag.2011.03.020","article-title":"High prevalence of CTX-M-15-producing <italic>Klebsiella pneumoniae<\/italic> isolates in Asian countries: diverse clones and clonal dissemination","volume":"38","author":"MY Lee","year":"2011","journal-title":"Int J Antimicrob Agents"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s10096-011-1153-x","article-title":"Identification of CTX-M15-, SHV-28-producing <italic>Klebsiella pneumoniae<\/italic> ST15 as an epidemic clone in the Copenhagen area using a semi-automated Rep-PCR typing assay. Eur","volume":"30","author":"JB Nielsen","year":"2011","journal-title":"J Clin Microbiol Infect Dis"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1128\/AAC.01672-07","article-title":"Spread of OXA-48-Positive Carbapenem-Resistant <italic>Klebsiella pneumoniae<\/italic> Isolates in Istanbul, Turkey","volume":"52","author":"A Carr\u00ebr","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s10096-011-1334-7","article-title":"Fecal carriage of serotype K1 <italic>Klebsiella pneumoniae<\/italic> ST23 strains closely related to liver abscess isolates in Koreans living in Korea. Eur","volume":"31","author":"DR Chung","year":"2012","journal-title":"J Clin Microbiol Infect Dis"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"3761","DOI":"10.1128\/JCM.00977-11","article-title":"Molecular typing and virulence analysis of serotype K1 <italic>Klebsiella pneumoniae<\/italic> strains isolated from liver abscess patients and stool samples from noninfectious subjects in Hong Kong, Singapore, and Taiwan","volume":"49","author":"LK Siu","year":"2011","journal-title":"J Clin Microbiol"},{"key":"ref32","article-title":"<italic>Klebsiella pneumoniae<\/italic> resistant to third-generation cephalosporins in five African and two Vietnamese major towns: multiclonal population structure with two major international clonal groups, CG15 and CG258","author":"S Breurec","year":"2012","journal-title":"Clin Microbiol Infect"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/jac\/dkq431","article-title":"ST11, the dominant clone of KPC-producing <italic>Klebsiella pneumoniae<\/italic> in China","volume":"66","author":"Y Qi","year":"2011","journal-title":"J Antimicrob Chemother"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1128\/AAC.05753-11","article-title":"Bacteremia caused by extended-spectrum-\u03b2-lactamase-producing <italic>Escherichia coli<\/italic> sequence type ST131 and non-ST131 clones: comparison of demographic data, clinical features, and mortality","volume":"56","author":"HC Chung","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1093\/jac\/dkp272","article-title":"Detection of <italic>aac(6\u2032)-Ib-cr<\/italic> in KPC-producing <italic>Klebsiella pneumoniae<\/italic> isolates from Tel Aviv, Israel","volume":"64","author":"I Chmelnitsky","year":"2009","journal-title":"J Antimicro Chemother"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"4114","DOI":"10.1128\/AAC.00778-06","article-title":"Analysis of antibiotic resistance genes in multidrug-resistant <italic>Acinetobacter<\/italic> sp. isolates from military and civilian patients treated at the Walter Reed Army Medical Center","volume":"50","author":"KM Hujer","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"365","DOI":"10.4103\/0255-0857.43581","article-title":"Molecular characterization of nosocomial CTX-M type \u03b2-lactamase producing <italic>Enterobacteriaceae<\/italic> from a tertiary care hospital in south India","volume":"26","author":"SA Jemima","year":"2008","journal-title":"Indian J Med Microbiol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"3396","DOI":"10.1128\/AAC.00285-06","article-title":"High-Level Carbapenem Resistance in a <italic>Klebsiella pneumoniae<\/italic> Clinical Isolate Is Due to the Combination of bla ACT-1 \u03b2-Lactamase Production, Porin OmpK35\/36 Insertional Inactivation, and Down-Regulation of the Phosphate Transport Porin PhoE","volume":"50","author":"FM Kaczmarek","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.drup.2010.08.003","article-title":"Aminoglycoside modifying enzymes","volume":"13","author":"MS Ramirez","year":"2010","journal-title":"Drug Resist Update"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1128\/AAC.00339-07","article-title":"New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an <italic>Escherichia coli<\/italic> clinical isolate","volume":"51","author":"K Yamane","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1128\/AAC.00218-06","article-title":"Endocarditis caused by extended-spectrum-\u03b2-lactamase-producing <italic>Klebsiella pneumoniae<\/italic>: emergence of resistance to ciprofloxacin and piperacillin-tazobactam during treatment despite initial susceptibility","volume":"50","author":"O Zimhony","year":"2006","journal-title":"Antimicrob Agents Chemother"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0057091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T01:23:05Z","timestamp":1539998585000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0057091"}},"subtitle":[],"editor":[{"given":"Riccardo","family":"Manganelli","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,2,21]]},"references-count":41,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,2,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0057091","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718490112.793497301","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,21]]}}}