{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T19:57:44Z","timestamp":1648843064460},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2013,2,19]],"date-time":"2013-02-19T00:00:00Z","timestamp":1361232000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0057137","type":"journal-article","created":{"date-parts":[[2013,2,19]],"date-time":"2013-02-19T18:15:14Z","timestamp":1361297714000},"page":"e57137","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Kinase Suppressor of Ras 1 Is Not Required for the Generation of Regulatory and Memory T Cells"],"prefix":"10.1371","volume":"8","author":[{"given":"Marie","family":"Le Borgne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin L.","family":"Filbert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey S.","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,2,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.4049\/jimmunol.178.4.2163","article-title":"A role for mammalian target of rapamycin in regulating T cell activation versus anergy","volume":"178","author":"Y Zheng","year":"2007","journal-title":"Journal of Immunology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"4743","DOI":"10.1182\/blood-2004-10-3932","article-title":"Rapamycin selectively expands CD4(+)CD25(+)FoxP3(+) regulatory T cells","volume":"105","author":"M Battaglia","year":"2005","journal-title":"Blood"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/ni.2005","article-title":"The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2","volume":"12","author":"GM Delgoffe","year":"2011","journal-title":"Nat Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1189\/jlb.1207851","article-title":"De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR","volume":"83","author":"J Kang","year":"2008","journal-title":"J Leukoc Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.immuni.2009.04.014","article-title":"The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment","volume":"30","author":"GM Delgoffe","year":"2009","journal-title":"Immunity"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.immuni.2010.06.002","article-title":"Mammalian Target of Rapamycin Protein Complex 2 Regulates Differentiation of Th1 and Th2 Cell Subsets via Distinct Signaling Pathways","volume":"32","author":"K Lee","year":"2010","journal-title":"Immunity"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature08155","article-title":"mTOR regulates memory CD8 T-cell differentiation","volume":"460","author":"K Araki","year":"2009","journal-title":"Nature"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nature08097","article-title":"Enhancing CD8 T-cell memory by modulating fatty acid metabolism","volume":"460","author":"EL Pearce","year":"2009","journal-title":"Nature"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.immuni.2009.10.010","article-title":"The mTOR Kinase Determines Effector versus Memory CD8(+) T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin","volume":"32","author":"RR Rao","year":"2010","journal-title":"Immunity"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nri3198","article-title":"Regulation and function of mTOR signalling in T cell fate decisions","volume":"12","author":"H Chi","year":"2012","journal-title":"Nature Reviews Immunology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"6095","DOI":"10.4049\/jimmunol.0803510","article-title":"Anergic T Cells Are Metabolically Anergic","volume":"183","author":"Y Zheng","year":"2009","journal-title":"Journal of Immunology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrm3025","article-title":"mTOR: from growth signal integration to cancer, diabetes and ageing","volume":"12","author":"R Zoncu","year":"2011","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.cell.2005.02.031","article-title":"Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis","volume":"121","author":"L Ma","year":"2005","journal-title":"Cell"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"13489","DOI":"10.1073\/pnas.0405659101","article-title":"Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase","volume":"101","author":"PP Roux","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"37288","DOI":"10.1074\/jbc.M303257200","article-title":"Inactivation of the tuberous sclerosis complex-1 and-2 gene products occurs by phosphoinositide 3-kinase\/Akt-dependent and -independent phosphorylation of tuberin","volume":"278","author":"AR Tee","year":"2003","journal-title":"Journal of Biological Chemistry"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1128\/MCB.01421-08","article-title":"The Mitogen-Activated Protein Kinase Scaffold KSR1 Is Required for Recruitment of Extracellular Signal-Regulated Kinase to the Immunological Synapse","volume":"29","author":"E Giurisato","year":"2009","journal-title":"Molecular and Cellular Biology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1128\/MCB.22.9.3035-3045.2002","article-title":"Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo","volume":"22","author":"A Nguyen","year":"2002","journal-title":"Molecular and Cellular Biology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nri2473","article-title":"Scaffold proteins and immune-cell signalling","volume":"9","author":"AS Shaw","year":"2009","journal-title":"Nature Reviews Immunology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1128\/MCB.01634-08","article-title":"KSR1 Modulates the Sensitivity of Mitogen-Activated Protein Kinase Pathway Activation in T Cells without Altering Fundamental System Outputs","volume":"29","author":"J Lin","year":"2009","journal-title":"Molecular and Cellular Biology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.molcel.2009.06.001","article-title":"KSR2 Is a Calcineurin Substrate that Promotes ERK Cascade Activation in Response to Calcium Signals","volume":"34","author":"MK Dougherty","year":"2009","journal-title":"Molecular Cell"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"7388","DOI":"10.4049\/jimmunol.0902294","article-title":"MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells","volume":"183","author":"RJ Salmond","year":"2009","journal-title":"J Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1073\/pnas.95.4.1432","article-title":"RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1","volume":"95","author":"PE Burnett","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"28130","DOI":"10.1074\/jbc.M300376200","article-title":"Mechanism of ribosomal p70S6 kinase activation by granulocyte macrophage colony-stimulating factor in neutrophils: cooperation of a MEK-related, THR421\/SER424 kinase and a rapamycin-sensitive, m-TOR-related THR389 kinase","volume":"278","author":"JA Lehman","year":"2003","journal-title":"J Biol Chem"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/80868","article-title":"Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo","volume":"1","author":"KS Schluns","year":"2000","journal-title":"Nat Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1038\/ni.1939","article-title":"The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells","volume":"11","author":"G Liu","year":"2010","journal-title":"Nat Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/ni889","article-title":"Lineage relationship and protective immunity of memory CD8 T cell subsets","volume":"4","author":"EJ Wherry","year":"2003","journal-title":"Nat Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1006\/smim.2000.0219","article-title":"Extracellular signals and scores of phosphatases: All roads lead to MAP kinase","volume":"12","author":"M Saxena","year":"2000","journal-title":"Seminars in Immunology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.4049\/jimmunol.1003613","article-title":"Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4(+) T Cell Subsets","volume":"186","author":"RD Michalek","year":"2011","journal-title":"Journal of Immunology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.cmet.2009.09.010","article-title":"KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity","volume":"10","author":"DL Costanzo-Garvey","year":"2009","journal-title":"Cell Metabolism"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"3718","DOI":"10.1128\/MCB.06754-11","article-title":"Kinase Suppressor of Ras 2 (KSR2) Regulates Tumor Cell Transformation via AMPK","volume":"32","author":"MR Fernandez","year":"2012","journal-title":"Mol Cell Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"4895","DOI":"10.4049\/jimmunol.0901459","article-title":"Dominant Role of Antigen Dose in CD4(+)Foxp3(+) Regulatory T Cell Induction and Expansion","volume":"183","author":"MS Turner","year":"2009","journal-title":"Journal of Immunology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.chembiol.2007.07.010","article-title":"Structural engineering of pMHC reagents for T cell Vaccines and diagnostics","volume":"14","author":"V Mitaksov","year":"2007","journal-title":"Chemistry & Biology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/ni.1603","article-title":"Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking","volume":"9","author":"LV Sinclair","year":"2008","journal-title":"Nature Immunology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.4049\/jimmunol.166.5.3402","article-title":"Organ-specific regulation of the CD8 T cell response to Listeria monocytogenes infection","volume":"166","author":"C Pope","year":"2001","journal-title":"J Immunol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0057137","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T18:46:38Z","timestamp":1562697998000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0057137"}},"subtitle":[],"editor":[{"given":"Vassiliki A.","family":"Boussiotis","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,2,19]]},"references-count":34,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,2,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0057137","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,19]]}}}