{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:28:33Z","timestamp":1792452513184,"version":"4.5.0"},"reference-count":71,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T00:00:00Z","timestamp":1361491200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0057181","type":"journal-article","created":{"date-parts":[[2013,2,23]],"date-time":"2013-02-23T09:33:14Z","timestamp":1361611994000},"page":"e57181","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Elevated Serum Levels of Macrophage Migration Inhibitory Factor Are Associated with Progressive Chronic Cardiomyopathy in Patients with Chagas Disease"],"prefix":"10.1371","volume":"8","author":[{"given":"Romina A.","family":"Cutrullis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia B.","family":"Petray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgardo","family":"Schapachnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rub\u00e9n","family":"S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Postan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariela N.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo S.","family":"Corral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,2,22]]},"reference":[{"key":"ref1","unstructured":"Pan American Health Organization (2009) Joint Meeting of Southern Cone, Central American, Andean, Amazon and Mexican Subregional Initiatives for the Prevention and Control of Chagas&apos; disease PAHO, dichlorodihydrofluorescein diacetate, Brazil."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1056\/NEJMoa053241","article-title":"Development and validation of a risk score for predicting death in Chagas&apos; heart disease","volume":"355","author":"A Rassi Jr","year":"2006","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.pcad.2009.11.008","article-title":"Chagas cardiomyopathy--where do we stand after a hundred years?","volume":"52","author":"A Biolo","year":"2010","journal-title":"Prog Cardiovasc Dis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1161\/CIRCULATIONAHA.106.624296","article-title":"Pathogenesis of chronic Chagas heart disease","volume":"115","author":"JA Marin-Neto","year":"2007","journal-title":"Circulation"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0008-6363(03)00361-4","article-title":"Pathophysiology of the heart in Chagas&apos; disease: current status and new developments","volume":"60","author":"ML Higuchi","year":"2003","journal-title":"Cardiovasc Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1590\/S0036-46652008000200001","article-title":"Chagas disease cardiomyopathy: current concepts of an old disease","volume":"50","author":"AMB Bilate","year":"2008","journal-title":"Rev Inst Med Trop S\u00e2o Paulo"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"485","DOI":"10.4269\/ajtmh.1997.56.485","article-title":"Association of an increase in CD8+ T cells with the presence of <italic>Trypanosoma cruzi<\/italic> antigens in chronic, human, chagasic myocarditis","volume":"56","author":"MD Higuchi","year":"1997","journal-title":"Am J Trop Med Hyg"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e29","DOI":"10.1017\/S1462399410001560","article-title":"The endless race between <italic>Trypanosoma cruzi<\/italic> and host immunity: lessons for and beyond Chagas disease","volume":"12","author":"C Junqueira","year":"2010","journal-title":"Exp Rev Mol Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/nri1200","article-title":"Macrophage migration inhibitory factor: a regulator of innate immunity","volume":"3","author":"T Calandra","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1084\/jem.20030286","article-title":"MIF signal transduction initiated by binding to CD74","volume":"197","author":"L Leng","year":"2003","journal-title":"J Exp Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/joe.0.1820001","article-title":"Macrophage migration inhibitory factor: molecular, cellular and genetic aspects of a key neuroendocrine molecule","volume":"182","author":"RP Donn","year":"2004","journal-title":"J Endocrinol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.immuni.2006.08.020","article-title":"CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex","volume":"25","author":"X Shi","year":"2006","journal-title":"Immunity"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nm1567","article-title":"MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment","volume":"13","author":"J Bernhagen","year":"2007","journal-title":"Nat Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s001090050204","article-title":"Regulation of the immune response by macrophage migration inhibitory factor: biological and structural features","volume":"76","author":"J Bernhagen","year":"1998","journal-title":"J Mol Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0014-5793(03)00900-1","article-title":"Regulated secretion of macrophage migration inhibitory factor is mediated by a non-classical pathway involving an ABC transporter","volume":"551","author":"O Flieger","year":"2003","journal-title":"FEBS Lett"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1002\/art.20470","article-title":"Reduced leukocyte-endothelial cell interactions in the inflamed microcirculation of macrophage migration inhibitory factor-deficient mice","volume":"50","author":"JL Gregory","year":"2004","journal-title":"Arthritis Rheum"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e37613","DOI":"10.1371\/journal.pone.0037613","article-title":"Macrophage migration inhibitory factor induces autophagy via reactive oxygen species generation","volume":"7","author":"YC Chuang","year":"2012","journal-title":"PloS One"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1093\/rheumatology\/41.5.558","article-title":"Macrophage migration inhibitory factor in rheumatoid arthritis: clinical correlations","volume":"41","author":"EF Morand","year":"2002","journal-title":"Rheumatology (Oxford)"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/01.shk.0000140305.01641.c8","article-title":"Macrophage migration inhibitory factor levels correlate with fatal outcome in sepsis","volume":"22","author":"FA Bozza","year":"2004","journal-title":"Shock"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1161\/CIRCULATIONAHA.107.729125","article-title":"Macrophage migration inhibitory factor in cardiovascular disease","volume":"117","author":"A Zernecke","year":"2008","journal-title":"Circulation"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1128\/CVI.13.3.415-419.2006","article-title":"Role of macrophage migration inhibitory factor in hepatitis B virus-specific cytotoxic-T-lymphocyte-induced liver injury","volume":"13","author":"K Kimura","year":"2006","journal-title":"Clin Vaccine Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.virol.2009.12.018","article-title":"Elevated levels of macrophage migration inhibitory factor (MIF) in the plasma of HIV-1-infected patients and in HIV-1-infected cell cultures: a relevant role on viral replication","volume":"399","author":"EG Regis","year":"2010","journal-title":"Virology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1084\/jem.20052398","article-title":"A critical role for the host mediator macrophage migration inhibitory factor in the pathogenesis of malarial anemia","volume":"203","author":"MA McDevitt","year":"2006","journal-title":"J Exp Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.yjmcc.2004.05.016","article-title":"Blockade of macrophage migration inhibitory factor ameliorates experimental autoimmune myocarditis","volume":"37","author":"Y Matsui","year":"2004","journal-title":"J Mol Cell Cardiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"400","DOI":"10.2119\/molmed.2009.00128","article-title":"ISO-1, a macrophage migration inhibitory factor antagonist, inhibits airway remodeling in a murine model of chronic asthma","volume":"16","author":"PF Chen","year":"2010","journal-title":"Mol Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jneuroim.2011.02.009","article-title":"Disease-associated inflammatory biomarker profiles in blood in different subtypes of multiple sclerosis: prospective clinical and MRI follow-up study","volume":"234","author":"S Hagman","year":"2011","journal-title":"J Neuroimmunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e38376","DOI":"10.1371\/journal.pone.0038376","article-title":"Macrophage migration inhibitory factor is enhanced in acute coronary syndromes and is associated with the inflammatory response","volume":"7","author":"II M\u00fcller","year":"2012","journal-title":"PLoS One"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/0035-9203(86)90193-8","article-title":"A histopathological analysis of the course of myocarditis in C3H\/He mice infected with <italic>Trypanosoma cruzi<\/italic> clone Sylvio-X10\/4","volume":"80","author":"M Postan","year":"1986","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0035-9203(88)90432-4","article-title":"Histopathology of the heart conducting system in experimental Chagas disease in mice","volume":"82","author":"HA Molina","year":"1988","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.micinf.2008.04.013","article-title":"Impaired <italic>Trypanosoma cruzi<\/italic>-specific IFN-gamma secretion by T cells bearing the BV9 T-cell receptor is associated with local IL-10 production in non-lymphoid tissues of chronically infected mice","volume":"10","author":"J Vogt","year":"2008","journal-title":"Microbes Infect"},{"key":"ref31","first-page":"249","article-title":"Evaluation of cardiac function by radioisotopic angiography, in patients with chronic Chagas cardiopathy","volume":"45","author":"E Kuschnir","year":"1985","journal-title":"Arq Bras Cardiol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1084\/jem.179.6.1895","article-title":"The macrophage is an important and previously unrecognized source of macrophage migration inhibitory factor","volume":"179","author":"T Calandra","year":"1994","journal-title":"J Exp Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1128\/IAI.62.5.1820-1829.1994","article-title":"Depletion of T-cell subpopulations results in exacerbation of myocarditis and parasitism in experimental Chagas&apos; disease","volume":"62","author":"RL Tarleton","year":"1994","journal-title":"Infect Immun"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1128\/IAI.74.1.135-143.2006","article-title":"The CC chemokine receptor 5 is important in control of parasite replication and acute cardiac inflammation following infection with <italic>Trypanosoma cruzi<\/italic>","volume":"74","author":"JL Hardison","year":"2006","journal-title":"Infect Immun"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"5890","DOI":"10.4049\/jimmunol.158.12.5890","article-title":"Glycosylphosphatidylinositol-anchored mucin-like glycoproteins isolated from <italic>Trypanosoma cruzi<\/italic> trypomastigotes initiate the synthesis of proinflammatory cytokines by macrophages","volume":"158","author":"MM Camargo","year":"1997","journal-title":"J Immunol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1365-3024.2008.01022.x","article-title":"Abnormal IFN-gamma-dependent immunoproteasome modulation by <italic>Trypanosoma cruzi<\/italic>-infected macrophages","volume":"30","author":"M Bergeron","year":"2008","journal-title":"Parasite Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"190354","DOI":"10.1155\/2009\/190354","article-title":"Oxidative stress in Chagas disease","volume":"2009","author":"S Gupta","year":"2009","journal-title":"Interdiscip Perspect Infect Dis"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.1365-3083.2010.02462.x","article-title":"Cytokine levels in serious cardiopathy of Chagas disease after in vitro stimulation with recombinant antigens from <italic>Trypanosoma cruzi<\/italic>","volume":"72","author":"VM Lorena","year":"2010","journal-title":"Scand J Immunol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.ejheart.2004.10.014","article-title":"The influence of aetiology on inflammatory and neurohumoral activation in patients with severe heart failure: a prospective study comparing Chagas&apos; heart disease and idiopathic dilated cardiomyopathy","volume":"7","author":"AO Mocelin","year":"2005","journal-title":"Eur J Heart Fail"},{"key":"ref40","first-page":"1096","article-title":"Determining the C-reactive protein level in patients with different clinical forms of Chagas Disease","volume":"63","author":"CA da Silva","year":"2010","journal-title":"Rev Esp Cardiol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.7150\/ijbs.7.1239","article-title":"Macrophage migration inhibitory factor (MIF): A key player in protozoan infections","volume":"7","author":"JD Rosado","year":"2011","journal-title":"Int J Biol Sci"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1146\/annurev.iy.10.040192.002125","article-title":"Regulation of immunity to parasites by T cells and T cell-derived cytokines","volume":"10","author":"A Sher","year":"1992","journal-title":"Annu Rev Immunol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1756-0500-2-36","article-title":"Macrophage migration inhibitory factor is associated with mortality in cerebral malaria patients in India","volume":"2","author":"V Jain","year":"2009","journal-title":"BMC Res Notes"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e25259","DOI":"10.1371\/journal.pone.0025259","article-title":"MIF participates in <italic>Toxoplasma gondii<\/italic>-induced pathology following oral infection","volume":"6","author":"MG Cavalcanti","year":"2011","journal-title":"PLoS One"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"e1198","DOI":"10.1371\/journal.pntd.0001198","article-title":"Evidence that lipopolisaccharide may contribute to the cytokine storm and cellular activation in patients with visceral leishmaniasis","volume":"5","author":"JR Santos-Oliveira","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1128\/IAI.01648-05","article-title":"Macrophage migration inhibitory factor contributes to host defense against acute <italic>Trypanosoma cruzi<\/italic> infection","volume":"74","author":"JL Reyes","year":"2006","journal-title":"Infect Immun"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1159\/000218333","article-title":"Timing of expression of inflammatory mediators in skeletal muscles from mice acutely infected with the RA strain of <italic>Trypanosoma cruzi<\/italic>","volume":"76","author":"RA Cutrullis","year":"2009","journal-title":"Pathobiol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.7150\/ijbs.7.1298","article-title":"MIF synergizes with <italic>Trypanosoma cruzi<\/italic> antigens to promote efficient dendritic cell maturation and IL-12 production via p38 MAPK","volume":"7","author":"CA Terrazas","year":"2011","journal-title":"Int J Biol Sci"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1002\/eji.200636705","article-title":"Unraveling the lethal synergism between <italic>Trypanosoma cruzi<\/italic> infection and LPS: a role for increased macrophage reactivity","volume":"37","author":"CN Paiva","year":"2007","journal-title":"Eur J Immunol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"3807","DOI":"10.1172\/JCI39738","article-title":"Cardiac macrophage migration inhibitory factor inhibits JNK pathway activation and injury during ischemia\/reperfusion","volume":"119","author":"D Qi","year":"2009","journal-title":"J Clin Invest"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1177\/002215540305100508","article-title":"Expression of macrophage migration inhibitory factor in acute ischemic myocardial injury","volume":"51","author":"CM Yu","year":"2003","journal-title":"J Histochem Cytochem"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"8072","DOI":"10.4049\/jimmunol.177.11.8072","article-title":"Macrophage migration inhibitory factor induces macrophage recruitment via CC chemokine ligand 2","volume":"177","author":"JL Gregory","year":"2006","journal-title":"J Immunol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S1286-4579(00)00388-9","article-title":"Kinetics of cytokine gene expression in experimental chagasic cardiomyopathy: tissue parasitism and endogenous IFN-gamma as important determinants of chemokine mRNA expression during infection with <italic>Trypanosoma cruzi<\/italic>","volume":"2","author":"A Talvani","year":"2000","journal-title":"Microbes Infect"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.4049\/jimmunol.1002928","article-title":"Myeloid-derived suppressor cells infiltrate the heart in acute <italic>Trypanosoma cruzi<\/italic> infection","volume":"187","author":"H Cuervo","year":"2011","journal-title":"J Immunol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"5533","DOI":"10.4049\/jimmunol.1201161","article-title":"Macrophage migration inhibitory factor promotes tumor growth and metastasis by inducing myeloid-derived suppressor cells in the tumor microenvironment","volume":"189","author":"KD Simpson","year":"2012","journal-title":"J Immunol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1128\/IAI.60.5.1984-1993.1992","article-title":"Interleukin-3 induces antimicrobial activity against <italic>Leishmania amazonensis<\/italic> and <italic>Trypanosoma cruzi<\/italic> and tumoricidal activity in human peripheral blood-derived macrophages","volume":"60","author":"JL Ho","year":"1992","journal-title":"Infect Immun"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0165-2478(92)90090-B","article-title":"Activation of human macrophages for the killing of intracellular <italic>Trypanosoma cruzi<\/italic> by TNF-alpha and IFN-gamma through a nitric oxide-dependent mechanism","volume":"33","author":"MA Mu\u00f1oz-Fern\u00e1ndez","year":"1992","journal-title":"Immunol Lett"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"637","DOI":"10.4269\/ajtmh.1993.48.637","article-title":"Characterization of inflammatory infiltrates in chronic chagasic myocardial lesions: presence of tumor necrosis factor-\u03b1+ cells and dominance of granzyme A+, CD8+ lymphocytes","volume":"48","author":"DD Reis","year":"1993","journal-title":"Am J Trop Med Hyg"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1128\/IAI.71.3.1185-1193.2003","article-title":"Evidence that development of severe cardiomyopathy in human Chagas&apos; disease is due to a Th1-specific immune response","volume":"71","author":"JA Gomes","year":"2003","journal-title":"Infect Immun"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.micinf.2005.08.009","article-title":"TNF gene polymorphisms are associated with reduced survival in severe Chagas&apos; disease cardiomyopathy patients","volume":"8","author":"SA Drigo","year":"2006","journal-title":"Microbes Infect"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"e28449","DOI":"10.1371\/journal.pone.0028449","article-title":"Cardiac-oxidized antigens are targets of immune recognition by antibodies and potential molecular determinants in Chagas disease pathogenesis","volume":"7","author":"M Dhiman","year":"2012","journal-title":"PLoS One"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2174\/138920112798868782","article-title":"Reactive oxygen species in myocardial reperfusion injury: from physiopathology to therapeutic approaches","volume":"13","author":"V Braunersreuther","year":"2012","journal-title":"Curr Pharm Biotechnol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1016\/j.freeradbiomed.2004.08.018","article-title":"Oxidative damage during chagasic cardiomyopathy development: role of mitochondrial oxidant release and inefficient antioxidant defense","volume":"37","author":"JJ Wen","year":"2004","journal-title":"Free Radic Biol Med"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.freeradbiomed.2006.04.009","article-title":"Increased oxidative stress is correlated with mitochondrial dysfunction in chagasic patients","volume":"41","author":"JJ Wen","year":"2006","journal-title":"Free Radic Biol Med"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/B978-0-12-385895-5.00007-4","article-title":"ROS signalling of inflammatory cytokines during <italic>Trypanosoma cruzi<\/italic> infection","volume":"76","author":"S Gupta","year":"2011","journal-title":"Adv Parasitol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/cvr\/cvp225","article-title":"Protein degradation systems in viral myocarditis leading to dilated cardiomyopathy","volume":"85","author":"H Luo","year":"2010","journal-title":"Cardiovasc Res"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/bjc.2012.392","article-title":"Macrophage migration inhibitory factor produced by the tumour stroma but not by tumour cells regulates angiogenesis in the B16-F10 melanoma model","volume":"107","author":"E Girard","year":"2012","journal-title":"Br J Cancer"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1006\/clim.2002.5255","article-title":"Elevated levels of serum macrophage migration inhibitory factor in patients with pulmonary tuberculosis","volume":"104","author":"G Yamada","year":"2002","journal-title":"Clin Immunol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"e16239","DOI":"10.1371\/journal.pone.0016239","article-title":"Hyperglycemic myocardial damage is mediated by proinflammatory cytokine: macrophage migration inhibitory factor","volume":"6","author":"XY Yu","year":"2011","journal-title":"PLoS One"},{"key":"ref70","first-page":"50","article-title":"Pathogenesis of coxsackievirus B3-induced myocarditis: role of macrophage migration inhibitory factor","volume":"125","author":"XH Yu","year":"2012","journal-title":"Chin Med J"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3109\/s10165-011-0466-z","article-title":"Elevated serum levels of macrophage migration inhibitory factor and their significant correlation with rheumatoid vasculitis disease activity","volume":"22","author":"K Wakabayashi","year":"2011","journal-title":"Mod Rheumatol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0057181","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T18:44:29Z","timestamp":1688064269000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0057181"}},"subtitle":[],"editor":[{"given":"Guillermo H.","family":"Giambartolomei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,2,22]]},"references-count":71,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,2,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0057181","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,22]]}}}