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Krieger Publishing Company, Malabar, U.S.A. 197\u2013202."},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Dasgupta A, Dastidar SG, Shiratki Y, Motohashi N (2004) Antibacterial activity of artificial phenothiazines and isoflavones from plants, In: Bioactive Heterocycles VI; Vol. 15, 67\u2013132, Springer, Berlin\/Heidelberg.","DOI":"10.1007\/7081_2007_108"},{"key":"ref15","first-page":"869","article-title":"Antimicrobial property of methdilazine and its synergism with antibiotics and some chemotherapeutic agents, Arzneimittelforschung (FRG)","volume":"38","author":"D Chattopadhyay","year":"1988"},{"key":"ref16","first-page":"1116","article-title":"Evaluation of synergism between the aminoglycoside antibiotic streptomycin and the cardiovascular agent amlodipine, Biol. Pharm. Bull","volume":"27","author":"KK Asok","year":"2004"},{"key":"ref17","first-page":"239","article-title":"Experimental analyses of synergistic combinations of antibiotics with a recently recognized antibacterial agent, lacidipine. Eur. J. Clin. Microb. Infect. Dis","volume":"29","author":"A Dasgupta","year":"2010"},{"key":"ref18","first-page":"1243","article-title":"Evidences of Significant Synergism between Antibiotics and the Antipsychotic Antimicrobial Drug Flupenthixol. Eur. J. Clin. Microb. Infec. Dis","volume":"31","author":"L Jeyaseeli","year":"2012"},{"key":"ref19","unstructured":"Radhakrishnan V, Ganguly K, Ganguli M, Dastidar SG, Chakrabarty AN (1999) Potentiality of tricyclic compound thioridazine as an effective antibacterial and antiplasmid agent. Indian J. Exp. Biol. 671\u2013675."},{"key":"ref20","first-page":"165","article-title":"Thioridazine enantiomeres in human tissues. Forensic Sci. Int","volume":"64","author":"SA Jortani","year":"1994"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/0028-3908(88)90006-8","article-title":"Receptor affinity, neurochemistry and behavioral charactaristics of the enantiomeres of thioridazine: evidence for different stereoselectivities at D1 and D2 receptors in rat brain","volume":"27","author":"CN Svendsen","year":"1988","journal-title":"Neuropharmacology"},{"key":"ref22","first-page":"917","article-title":"Clinical concentration of thioridazine kill inracellular mltidrugresistant <italic>Mycobacterium tuberculosis<\/italic>. Antimicrob Agent Chemother","volume":"47","author":"D Ordway","year":"2003"},{"key":"ref23","unstructured":"Hendricks O (2007) Antimicrobial effects of selected Non-antibiotics on sensivity and invasion of Gram positive bacteria; PhD Thesis, University of Southern Denmark."},{"key":"ref24","unstructured":"Clinical and Laboratory Standards Institute. 2009. Methods for dilution antimicrobial susceptibility testing of bacteria that grow aerobically. 7<sup>th<\/sup> ed., approved standard M7-A7.2009. Clinical and Laboratory Standards Institute, Wayne, PA."},{"key":"ref25","first-page":"174","article-title":"Dasgupta A, Mukherjee S, Chaki S, Dastidar SG, Hendricks O, et al, 2010, Thioridazine protects the mouse from a virulent infection by <italic>Salmonella enterica<\/italic> serovar Typhimurium 74. Int. J. Antimicrob","volume":"35","journal-title":"Agents"},{"key":"ref26","first-page":"225","article-title":"Gunn JS, 2008, The Salmonella PmrAB regulon: Lippolysaccharide modifications, antimicrobial peptide resistance and more. 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