{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:59:20Z","timestamp":1791359960573,"version":"4.3.1"},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T00:00:00Z","timestamp":1361750400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0057662","type":"journal-article","created":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T22:11:42Z","timestamp":1361830302000},"page":"e57662","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["Aberrant Gene Expression in Dogs with Portosystemic Shunts"],"prefix":"10.1371","volume":"8","author":[{"given":"Frank G.","family":"van Steenbeek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Van den Bossche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy C. M.","family":"Grinwis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Kummeling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid H. M.","family":"van Gils","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian J. A. Groot.","family":"Koerkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dik","family":"van Leenen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank C. P.","family":"Holstege","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis C.","family":"Penning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Rothuizen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A. J.","family":"Leegwater","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Spee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,2,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.5326\/0390169","article-title":"Portosystemic shunts: Diagnosis, prognosis, and treatment of 64 cases (1993\u20132001)","volume":"39","author":"JT Winkler","year":"2003","journal-title":"Journal of the American Animal Hospital Association"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0195-5616(85)50013-3","article-title":"Portosystemic shunts","volume":"15","author":"JC Vulgamott","year":"1985","journal-title":"The Veterinary Clinics of North America.Small Animal Practice"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S0022-3476(99)70031-4","article-title":"The long-term prognosis of congenital portosystemic venous shunt","volume":"135","author":"T Uchino","year":"1999","journal-title":"The Journal of Pediatrics"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0034-5288(18)32353-1","article-title":"Rectal ammonia tolerance test in the evaluation of portal circulation in dogs with liver disease","volume":"33","author":"J Rothuizen","year":"1982","journal-title":"Res Vet Sci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1136\/vr.142.3.55","article-title":"Morphology of congenital intrahepatic portacaval shunts in dogs and cats","volume":"142","author":"CR Lamb","year":"1998","journal-title":"Vet Rec"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0195-5616(93)50309-1","article-title":"Congenital portosystemic shunts in the dog and cat","volume":"23","author":"RA Martin","year":"1993","journal-title":"The Veterinary Clinics of North America.Small Animal Practice"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s00335-011-9364-0","article-title":"Inherited liver shunts in dogs elucidate pathways regulating embryonic development and clinical disorders of the portal vein","volume":"23","author":"FG van Steenbeek","year":"2012","journal-title":"Mammalian Genome: Official Journal of the International Mammalian Genome Society"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1111\/j.1939-1676.2009.0319.x","article-title":"Evidence of inheritance of intrahepatic portosystemic shunts in irish wolfhounds","volume":"23","author":"FG van Steenbeek","year":"2009","journal-title":"J Vet Intern Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1892\/0891-6640(2005)19[321:ICEPSI]2.0.CO;2","article-title":"Inherited congenital extrahepatic portosystemic shunts in cairn terriers","volume":"19","author":"G van Straten","year":"2005","journal-title":"J Vet Intern Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/ca.20574","article-title":"The clinical anatomy of congenital portosystemic venous shunts","volume":"21","author":"MD Stringer","year":"2008","journal-title":"Clinical Anatomy (New York, N.Y.)"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Grall A, Guaguere E, Planchais S, Grond S, Bourrat E, <etal>et al<\/etal>. (2012) PNPLA1 mutations cause autosomal recessive congenital ichthyosis in golden retriever dogs and humans. Nature Genetics 44: 140-147. 10.1038\/ng.1056; 10.1038\/ng.1056.","DOI":"10.1038\/ng.1056"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/ng.726","article-title":"CCDC39 is required for assembly of inner dynein arms and the dynein regulatory complex and for normal ciliary motility in humans and dogs","volume":"43","author":"AC Merveille","year":"2011","journal-title":"Nature Genetics 43"},{"key":"ref13","first-page":"76","article-title":"The anatomy and embryology of portosystemic shunts in dogs and cats","volume":"5","author":"JT Payne","year":"1990","journal-title":"Seminars in Veterinary Medicine and Surgery (Small Animal)"},{"key":"ref14","first-page":"80S","article-title":"Congenital portosystemic shunts (PSS) in dogs are a genetic disorder","volume":"116","author":"HP Meyer","year":"1991","journal-title":"Tijdschr Diergeneeskd"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"385","DOI":"10.5326\/0390385","article-title":"Determination of inheritance of single congenital portosystemic shunts in yorkshire terriers","volume":"39","author":"KM Tobias","year":"2003","journal-title":"J Am Anim Hosp Assoc"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1136\/vr.136.1.13","article-title":"Increasing incidence of hereditary intrahepatic portosystemic shunts in irish wolfhounds in the netherlands (1984 to 1992)","volume":"136","author":"HP Meyer","year":"1995","journal-title":"Vet Rec"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.2460\/javma.2003.223.1636","article-title":"Association of breed with the diagnosis of congenital portosystemic shunts in dogs: 2,400 cases (1980\u20132002)","volume":"223","author":"KM Tobias","year":"2003","journal-title":"J Am Vet Med Assoc"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1080\/01652176.1995.9694536","article-title":"Circulatory disorders of the liver in dogs and cats","volume":"17","author":"TS van den Ingh","year":"1995","journal-title":"Vet Q"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1751-0813.1994.tb03382.x","article-title":"Congenital portosystemic shunts in maltese and australian cattle dogs","volume":"71","author":"PL Tisdall","year":"1994","journal-title":"Aust Vet J"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/j.1751-0813.2004.tb13233.x","article-title":"Effect of breed on anatomy of portosystemic shunts resulting from congenital diseases in dogs and cats: A review of 242 cases","volume":"82","author":"GB Hunt","year":"2004","journal-title":"Aust Vet J"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.2460\/ajvr.1998.59.12.1553","article-title":"Prediction of inherited portosystemic shunts in irish wolfhounds on the basis of pedigree analysis","volume":"59","author":"GJ Ubbink","year":"1998","journal-title":"Am J Vet Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1476-5926-6-8","article-title":"Major HGF-mediated regenerative pathways are similarly affected in human and canine cirrhosis","volume":"6","author":"B Spee","year":"2007","journal-title":"Comparative Hepatology"},{"key":"ref23","first-page":"1241","article-title":"Cross-species immunohistochemical investigation of the activation of the liver progenitor cell niche in different types of liver disease. Liver International: Official Journal of the International Association for the Study of the Liver","volume":"29","author":"BA Schotanus","year":"2009"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.tvjl.2009.02.016","article-title":"Characterisation of the hepatic progenitor cell compartment in normal liver and in hepatitis: An immunohistochemical comparison between dog and man","volume":"184","author":"J Ijzer","year":"2010","journal-title":"Veterinary Journal (London, England: 1997)"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.jhep.2008.12.011","article-title":"Angiogenesis in liver disease","volume":"50","author":"M Fernandez","year":"2009","journal-title":"Journal of Hepatology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00534-006-1125-1","article-title":"Mechanism of impaired hepatic regeneration in cholestatic liver","volume":"14","author":"Y Yokoyama","year":"2007","journal-title":"Journal of Hepato-Biliary-Pancreatic Surgery"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1159\/000084720","article-title":"The pathophysiology of portal hypertension","volume":"23","author":"G Treiber","year":"2005","journal-title":"Digestive Diseases (Basel, Switzerland)"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/ng1502","article-title":"An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas","volume":"37","author":"P Roepman","year":"2005","journal-title":"Nature Genetics"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/sj.embor.embor798","article-title":"Monitoring global messenger RNA changes in externally controlled microarray experiments","volume":"4","author":"J van de Peppel","year":"2003","journal-title":"EMBO Reports"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1093\/nar\/30.4.e15","article-title":"Normalization for cDNA microarray data: A robust composite method addressing single and multiple slide systematic variation","volume":"30","author":"YH Yang","year":"2002","journal-title":"Nucleic Acids Research"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/msb.2009.21","article-title":"Adaptable gene-specific dye bias correction for two-channel DNA microarrays","volume":"5","author":"T Margaritis","year":"2009","journal-title":"Molecular Systems Biology"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Wu H, Kerr MK, Cui X, Churchill GA (2003) MAANOVA: A software package for the analysis of spotted cDNA microarray experiments. In: Parmigiani GG, Garrett ES, Irizarri RA, Zeger SL, editors. The analysis of gene expression data: methods and software. New York: Springer. 313\u2013339.","DOI":"10.1007\/0-387-21679-0_14"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1002\/jcb.21426","article-title":"Comparison of RNA amplification methods and chip platforms for microarray analysis of samples processed by laser capture microdissection","volume":"103","author":"E Caretti","year":"2008","journal-title":"Journal of Cellular Biochemistry"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"3406","DOI":"10.1093\/nar\/gkg595","article-title":"Mfold web server for nucleic acid folding and hybridization prediction","volume":"31","author":"M Zuker","year":"2003","journal-title":"Nucleic Acids Research"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ab.2006.06.001","article-title":"Development and evaluation of canine reference genes for accurate quantification of gene expression","volume":"356","author":"B Brinkhof","year":"2006","journal-title":"Analytical Biochemistry"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"RESEARCH0034","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"J Vandesompele","year":"2002","journal-title":"Genome Biology"},{"key":"ref37","unstructured":"R Development Core Team. (2011) R: A language and environment for statistical computing."},{"key":"ref38","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene expression omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"R Edgar","year":"2002","journal-title":"Nucleic Acids Research"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0014-5793(95)00123-Q","article-title":"Molecular cloning and expression of a cDNA for human kidney cysteine conjugate beta-lyase","volume":"360","author":"S Perry","year":"1995","journal-title":"FEBS Letters"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1172\/JCI23445","article-title":"Integrin alpha4beta1-VCAM-1-mediated adhesion between endothelial and mural cells is required for blood vessel maturation","volume":"115","author":"B Garmy-Susini","year":"2005","journal-title":"The Journal of Clinical Investigation"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/j.1460-2075.1993.tb05633.x","article-title":"Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15","volume":"12","author":"CH McGowan","year":"1993","journal-title":"The EMBO Journal"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"Hong KS, Kim HS, Kim SH, Lim DJ, Park JY, <etal>et al<\/etal>. (2011) Hypoxia induces wee1 expression and attenuates hydrogen peroxide-induced endothelial damage in MS1 cells. Experimental &amp; Molecular Medicine.","DOI":"10.3858\/emm.2011.43.12.074"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0090-6980(74)90042-2","article-title":"The effects of prostaglandins, prostaglandin inhibitors, and oxygen on the closure of the ductus arteriosus, pulmonary arteries and umbilical vessels in vitro","volume":"8","author":"MB Starling","year":"1974","journal-title":"Prostaglandins"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.jpeds.2006.12.015","article-title":"Pre-ductal and post-ductal O2 saturation in healthy term neonates after birth","volume":"150","author":"G Mariani","year":"2007","journal-title":"The Journal of Pediatrics"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.jpeds.2005.12.050","article-title":"Oxygen saturation in healthy infants immediately after birth","volume":"148","author":"CO Kamlin","year":"2006","journal-title":"The Journal of Pediatrics"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.jpeds.2005.12.047","article-title":"Oxygen saturation trends immediately after birth","volume":"148","author":"Y Rabi","year":"2006","journal-title":"The Journal of Pediatrics"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Coceani F, Baragatti B (2012) Mechanisms for ductus arteriosus closure. Seminars in Perinatology 36: 92\u201397. 10.1053\/j.semperi.2011.09.018; 10.1053\/j.semperi.2011.09.018.","DOI":"10.1053\/j.semperi.2011.09.018"}],"updated-by":[{"DOI":"10.1371\/annotation\/5cccaae3-f06c-413f-857e-46546e87fce1","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T00:00:00Z","timestamp":1381795200000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0057662","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T13:16:51Z","timestamp":1715001411000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0057662"}},"subtitle":[],"editor":[{"given":"Erica","family":"Villa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,2,25]]},"references-count":47,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,2,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0057662","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,25]]}}}