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In: Heptinstall&apos;s Pathology of the Kidney. 6th edition. Chapter 2. Eds Jennette JC, Olson JL, Schwartz MM, Silva FG. Lippincott-Raven, Philadelphia-New York, USA. pp. 71\u201395."},{"key":"ref58","doi-asserted-by":"crossref","unstructured":"Woolf AS, Pitera JE (2009) Embryology. In: Pediatric Nephrology. 6th Edition. Chapter 1. Eds Avner ED, Harmon WE, Niaudet P, Yoshikawa N. 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