{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:16:20Z","timestamp":1791407780969,"version":"4.3.3"},"reference-count":58,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2013,2,28]],"date-time":"2013-02-28T00:00:00Z","timestamp":1362009600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0058113","type":"journal-article","created":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T13:46:46Z","timestamp":1362145606000},"page":"e58113","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":38,"title":["A Direct Examination of the Effect of Intranasal Administration of Oxytocin on Approach-Avoidance Motor Responses to Emotional Stimuli"],"prefix":"10.1371","volume":"8","author":[{"given":"Angeliki","family":"Theodoridou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian S.","family":"Penton-Voak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela C.","family":"Rowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,2,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.yhbeh.2012.01.008","article-title":"Oxytocin and social affiliation in humans","volume":"61","author":"R Feldman","year":"2012","journal-title":"Horm Behav"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/nrn3044","article-title":"Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine","volume":"12","author":"A Meyer-Lindenberg","year":"2011","journal-title":"Nat Rev Neurosci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1098\/rstb.2006.1940","article-title":"Mother\u2013infant bonding and the evolution of mammalian social relationships","volume":"361","author":"KD Broad","year":"2006","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.peptides.2007.04.016","article-title":"Oxytocin during pregnancy and early postpartum: Individual patterns and maternal-fetal attachment","volume":"28","author":"A Levine","year":"2007","journal-title":"Peptides"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.yhbeh.2009.03.019","article-title":"Oxytocin and social perception: Oxytocin increases perceived facial trustworthiness and attractiveness","volume":"56","author":"A Theodoridou","year":"2009","journal-title":"Horm Behav"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.biopsych.2009.06.009","article-title":"Intranasal Administration of Oxytocin Increases Envy and Schadenfreude (Gloating)","volume":"66","author":"SG Shamay-Tsoory","year":"2009","journal-title":"Biol Psychiatry"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1073\/pnas.1015316108","article-title":"Oxytocin promotes human ethnocentrism","volume":"108","author":"CKW De Dreu","year":"2011","journal-title":"Proc Natl Acad Sci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1126\/science.1189047","article-title":"The Neuropeptide Oxytocin Regulates Parochial Altruism in Intergroup Conflict Among Humans","volume":"328","author":"CKW De Dreu","year":"2010","journal-title":"Science"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1001\/jama.2011.117","article-title":"Scientists probe oxytocin therapy for social deficits in autism, schizophrenia","volume":"305","author":"BM Kuehn","year":"2011","journal-title":"JAMA: The Journal of the American Medical Association"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.neuropsychologia.2009.09.003","article-title":"The effect of intranasal administration of oxytocin on fear recognition","volume":"48","author":"M Fischer-Shofty","year":"2010","journal-title":"Neuropsychologia"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s00213-010-1780-4","article-title":"Oxytocin improves specific recognition of positive facial expressions","volume":"209","author":"AA Marsh","year":"2010","journal-title":"Psychopharmacol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.psyneuen.2011.03.011","article-title":"Oxytocin increases recognition of masked emotional faces","volume":"36","author":"L Schulze","year":"2011","journal-title":"Psychoneuroendocrinology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1177\/0269881108095705","article-title":"Oxytocin enhances processing of positive versus negative emotional information in healthy male volunteers","volume":"23","author":"M Di Simplicio","year":"2009","journal-title":"J Psychopharmacol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.psyneuen.2011.07.015","article-title":"Intranasal oxytocin enhances emotion recognition from dynamic facial expressions and leaves eye-gaze unaffected","volume":"37","author":"A Lischke","year":"2012","journal-title":"Psychoneuroendocrinology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1038\/npp.2010.110","article-title":"Oxytocin decreases aversion to angry faces in an associative learning task","volume":"35","author":"S Evans","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"11489","DOI":"10.1523\/JNEUROSCI.3984-05.2005","article-title":"Oxytocin modulates neural circuitry for social cognition and fear in humans","volume":"25","author":"P Kirsch","year":"2005","journal-title":"J Neurosci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"6607","DOI":"10.1523\/JNEUROSCI.4572-07.2008","article-title":"Oxytocin attenuates affective evaluations of conditioned faces and amygdala activity","volume":"28","author":"P Petrovic","year":"2008","journal-title":"J Neurosci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.biopsych.2007.03.025","article-title":"Oxytocin attenuates amygdala responses to emotional faces regardless of valence","volume":"62","author":"G Domes","year":"2007","journal-title":"Biol Psychiatry"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.psyneuen.2009.06.016","article-title":"Effects of intranasal oxytocin on emotional face processing in women","volume":"35","author":"G Domes","year":"2010","journal-title":"Psychoneuroendocrinology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.biopsych.2008.10.011","article-title":"Intranasal oxytocin increases positive communication and reduces cortisol levels during couple conflict","volume":"65","author":"B Ditzen","year":"2009","journal-title":"Biol Psychiatry"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1177\/0963721411417547","article-title":"The Role of Oxytocin in Human Affect: A Novel Hypothesis","volume":"20","author":"AH Kemp","year":"2011","journal-title":"Curr Dir Psychol Sci"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.yhbeh.2006.06.028","article-title":"Neuropeptidergic regulation of affiliative behavior and social bonding in animals","volume":"50","author":"MM Lim","year":"2006","journal-title":"Horm Behav"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1037\/0033-295X.97.3.377","article-title":"Emotion, attention, and the startle reflex","volume":"97","author":"PJ Lang","year":"1990","journal-title":"Psychol Rev"},{"key":"ref24","unstructured":"Lewin K (1935) A dynamic theory of personality. McGraw Hill: New York."},{"key":"ref25","unstructured":"Osgood CE (1953) Method and theory in experimental psychology. Oxford University Press, New York."},{"key":"ref26","unstructured":"Schneirla TC (1959) An evolutionary and developmental theory of biphasic processes underlying approach and withdrawal. In: Jones MR (ed). Nebraska Symposium on Motivation. University of Nebraska Press: Oxford, England, 1\u201342."},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.jesp.2006.10.017","article-title":"The evaluation-behavior link: Direct and beyond valence","volume":"43","author":"T Alexopoulos","year":"2007","journal-title":"J Exp Soc Psychol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1037\/0022-3514.65.1.5","article-title":"Rudimentary determinants of attitudes: II. Arm flexion and extension have differential effects on attitudes","volume":"65","author":"JT Cacioppo","year":"1993","journal-title":"J Pers Soc Psychol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1177\/0146167299025002007","article-title":"Consequences of automatic evaluation: Immediate behavioral predispositions to approach or avoid the stimulus","volume":"25","author":"M Chen","year":"1999","journal-title":"Pers Soc Psychol Bull"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/1467-9280.00490","article-title":"The automatic evaluation of novel stimuli","volume":"13","author":"KL Duckworth","year":"2002","journal-title":"Psychol Sci"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1037\/1528-3542.5.1.119","article-title":"The effects of fear and anger facial expressions on approach- and avoidance-related behaviors","volume":"5","author":"AA Marsh","year":"2005","journal-title":"Emotion"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1037\/1528-3542.4.2.156","article-title":"Automatic affective evaluation does not automatically predispose for arm flexion and extension","volume":"4","author":"M Rotteveel","year":"2004","journal-title":"Emotion"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1037\/a0018169","article-title":"The impact of facial emotional expressions on behavioral tendencies in women and men","volume":"36","author":"EM Seidel","year":"2010","journal-title":"J Exp Psychol Hum Percept Perform"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1523\/JNEUROSCI.4260-08.2009","article-title":"Oxytocin makes a face in memory familiar","volume":"29","author":"U Rimmele","year":"2009","journal-title":"J Neurosci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S0924-9338(97)89104-3","article-title":"Quality of life instruments in depression","volume":"12","author":"P Bech","year":"1997","journal-title":"Eur Psychiatry"},{"key":"ref36","unstructured":"Spielberger CD, Gorsuch RL, Lushene R, Vagg PR, Jacobs GA (1983) Manual for the State-Trait Anxiety Inventory. Consulting Psychologists Press: Palo Alto, CA."},{"key":"ref37","unstructured":"Lundqvist D, Flykt A, \u0150hman A (1998) The Karolinska Directed Emotional Faces. Stockholm \u2013 KDEF, CD ROM from Department of Clinical Neuroscience, Psychology Section, Karolinska Institutet, ISBN 91-630-7164-9."},{"key":"ref38","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1109\/38.946630","article-title":"Prototyping and transforming facial textures for perception research","volume":"21","author":"B Tiddeman","year":"2001","journal-title":"IEEE Comput Graph Appl"},{"key":"ref39","unstructured":"Steyer R, Schwenkmezger P, Notz P, Eid M (1997) Der Mehrdimensionale Befindlichkeitsfragebogen (MDBF). G\u00f6ttingen: Hogrefe. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.metheval.uni-jena.de\/mdbf.php\" xlink:type=\"simple\">http:\/\/www.metheval.uni-jena.de\/mdbf.php<\/ext-link>."},{"key":"ref40","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1080\/026432900380526","article-title":"Early commitment of neural substrates for face recognition","volume":"17","author":"MJ Farah","year":"2000","journal-title":"Cogn Neuropsychol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1006\/nimg.2002.1179","article-title":"The amygdala response to emotional stimuli: A comparison of faces and scenes","volume":"17","author":"AR Hariri","year":"2002","journal-title":"Neuroimage"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s00426-003-0157-2","article-title":"Positive facial expressions are recognized faster than negative facial expressions, but why?","volume":"69","author":"JM Lepp\u00e4nen","year":"2004","journal-title":"Psychol Res"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1037\/0033-2909.115.3.401","article-title":"Relationship between attitudes and evaluative space: A critical review, with emphasis on the separability of positive and negative substrates","volume":"115","author":"JT Cacioppo","year":"1994","journal-title":"Psychol Bull"},{"key":"ref44","unstructured":"Lang PJ, Bradley MM, Cuthbert BN (1997) Motivated attention: Affect, activation, and action. In: Lang PJ, Simons RF, Balaban MT (eds). Attention and orienting: Sensory and motivational processes. Lawrence Erlbaum Associates Publishers: Mahwah, NJ. 97\u2013135."},{"key":"ref45","first-page":"582","article-title":"Effects of oxytocin on human social approach measured using intimacy equilibriums","volume":"62","author":"JC Liu","year":"2012","journal-title":"Horm Behav"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.yhbeh.2011.12.003","article-title":"Modulating social behavior with oxytocin: How does it work? What does it mean?","volume":"61","author":"PS Churchland","year":"2012","journal-title":"Horm Behav"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1080\/02699930701626582","article-title":"The Karolinska Directed Emotional Faces: A validation study","volume":"22","author":"E Goeleven","year":"2008","journal-title":"Cognition Emotion"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.biopsych.2008.02.008","article-title":"Oxytocin enhances the encoding of positive social memories in humans","volume":"64","author":"AJ Guastella","year":"2008","journal-title":"Biol Psychiatry"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/nn1057","article-title":"Distinct spatial frequency sensitivities for processing faces and emotional expressions","volume":"6","author":"P Vuilleumier","year":"2003","journal-title":"Nat Neurosci"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1177\/0956797611420576","article-title":"Sociality, pathogen avoidance, and the neuropeptides oxytocin and arginine vasopressin","volume":"22","author":"M Kavaliers","year":"2011","journal-title":"Psychol Sci"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"166.172","DOI":"10.1016\/j.conb.2008.06.006","article-title":"Fear, faces, and the human amygdala","volume":"18","author":"R Adolphs","year":"2008","journal-title":"Curr Opin Neurobiol"},{"key":"ref52","first-page":"301","article-title":"Social effects of oxytocin in humans: context and person matter","volume":"15","author":"JA Bartz","year":"2011","journal-title":"Trends Cogn Sci"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1467-8721.2006.00451.x","article-title":"Tend and befriend","volume":"15","author":"SE Taylor","year":"2006","journal-title":"Curr Dir Psychol Sci"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10673229.2011.549771","article-title":"The role of oxytocin in mother-infant relations: A systematic review of human studies","volume":"19","author":"M Galbally","year":"2011","journal-title":"Harv Rev Psychiatry"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1038\/nn1327","article-title":"The neurobiology of pair bonding","volume":"7","author":"LJ Young","year":"2004","journal-title":"Nat Neurosci"},{"key":"ref56","doi-asserted-by":"crossref","unstructured":"Fischer-Shofty M, Levkovitz Y, Shamay-Tsoory SG (2012) Oxytocin facilitates accurate perception of competition in men and kinship in women. Soc Cog Affect Neurosci. doi:10.1093\/scan\/nsr100.","DOI":"10.1093\/scan\/nsr100"},{"key":"ref57","doi-asserted-by":"crossref","unstructured":"Ditzen B, Nater UM, Schaer M, La Marca R, Bodenmann G, <etal>et al<\/etal>.. (2012) Sex-Specific Effects of Intranasal Oxytocin on Autonomic Nervous System and Emotional Responses to Couple Conflict. Soc Cogn Affect Neurosci. doi:10.1093\/scan\/nss083.","DOI":"10.1093\/scan\/nss083"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1177\/0269881110367452","article-title":"Selective influences of oxytocin on the evaluative processing of social stimuli","volume":"25","author":"GJ Norman","year":"2011","journal-title":"J Psychopharmacol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0058113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T08:31:39Z","timestamp":1589013099000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0058113"}},"subtitle":[],"editor":[{"given":"Angela","family":"Sirigu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,2,28]]},"references-count":58,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,2,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0058113","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,28]]}}}