{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:51:59Z","timestamp":1787061119047,"version":"build-2736575974"},"reference-count":23,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2013,3,22]],"date-time":"2013-03-22T00:00:00Z","timestamp":1363910400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0058215","type":"journal-article","created":{"date-parts":[[2013,3,22]],"date-time":"2013-03-22T18:38:50Z","timestamp":1363977530000},"page":"e58215","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":62,"title":["Effects of C-phycocyanin and Spirulina on Salicylate-Induced Tinnitus, Expression of NMDA Receptor and Inflammatory Genes"],"prefix":"10.1371","volume":"8","author":[{"given":"Juen-Haur","family":"Hwang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Cherng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin-Ching","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,3,22]]},"reference":[{"key":"ref1","first-page":"37","article-title":"Health and Nutrition Examination Survey of 1971\u201375: Part II. Tinnitus, subjective hearing loss, and well-being. J Am Acad Audiol","volume":"5(1)","author":"JC Cooper Jr","year":"1994"},{"key":"ref2","first-page":"35","article-title":"Tinnitus in noise-exposed workers. Occup Med (Lond)","volume":"43(1)","author":"WH Phoon","year":"1993"},{"key":"ref3","first-page":"811","article-title":"Phantom auditory sensation in rats: an animal model for tinnitus. Behav. Neurosci","volume":"102","author":"PJ Jastreboff","year":"1988"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"3944","DOI":"10.1523\/JNEUROSCI.23-09-03944.2003","article-title":"Salicylate induces tinnitus through activation of cochlear NMDA receptors","volume":"23","author":"MJ Guitton","year":"2003","journal-title":"J Neurosci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1742-2094-8-30","article-title":"Expression of TNF-alpha and IL-1beta genes in the cochlea and midbrain in salicylate-induced tinnitus","volume":"8","author":"JH Hwang","year":"2011","journal-title":"J Neuroinflammation"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/lary.21283","article-title":"Expression of COX-2 and NMDA receptor genes at the cochlea and midbrain in salicylate-induced tinnitus","volume":"121","author":"JH Hwang","year":"2011","journal-title":"Laryngoscope"},{"key":"ref7","first-page":"210","article-title":"The effects of melatonin on tinnitus and sleep. Otolaryngol Head Neck Surg","volume":"134(2)","author":"UC Megwalu","year":"2006"},{"key":"ref8","first-page":"712","article-title":"Drug treatments for subjective tinnitus: serendipitous discovery versus rational drug design. Curr Opin Investig Drugs","volume":"6(7)","author":"PF Smith","year":"2005"},{"key":"ref9","first-page":"1487","article-title":"Scopolamine attenuates tinnitus-related plasticity in the auditory cortex. Neuroreport","volume":"17(14)","author":"E Wallh\u00e4usser-Franke","year":"2006"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2174\/1876142911002030187","article-title":"Present and potential industrial applications of macro- and microalgae","volume":"2","author":"AM Sanghvi","year":"2010","journal-title":"Recent Pat Food Nutr Agric"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1211\/0022357991772646","article-title":"Phycocyanin extract reduces leukoltriene B4 levels in arachidonic acid-induced mouse ear inflammation test","volume":"51","author":"C Romay","year":"1999","journal-title":"Journal of Pharmacy & Pharmacology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.mehy.2008.09.061","article-title":"Oral phycocyanobilin may diminish the pathogenicity of activated brain microglia in neurodegenerative disorders","volume":"74","author":"MF McCarty","year":"2010","journal-title":"Medical Hypotheses"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/0166-2236(96)10049-7","article-title":"Microglia: a sensor for pathological events in the CNS","volume":"19","author":"GW Kreutzberg","year":"1996","journal-title":"Trends Neurosci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1006\/exnr.2001.7688","article-title":"Tumor necrosis factor alpha is toxic to embryonic mesencephalic dopamine neurons","volume":"169","author":"SO McGuire","year":"2001","journal-title":"Experimental Neurology"},{"key":"ref15","first-page":"345","article-title":"Blockade of interleukin-6 signaling suppressed cochlear inflammatory response and improved hearing impairment in noise-damaged mice cochlea. Neurosci Res","volume":"66","author":"K Wakabayashi","year":"2010"},{"key":"ref16","first-page":"53","article-title":"Selective GSK-3beta inhibitors attenuate the cisplatin-induced cytotoxicity of auditory cells. Hear Res","volume":"257","author":"HJ Park","year":"2009"},{"key":"ref17","first-page":"1237","article-title":"Tumor necrosis factor-alpha-induced neutral sphingomyelinase-2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors. J Neurochem","volume":"109","author":"D Wheeler","year":"2009"},{"key":"ref18","first-page":"232","article-title":"IL-1ra alleviates inflammatory hyperalgesia through preventing phosphorylation of NMDA receptor NR-1 subunit in rats. Pain","volume":"135","author":"RX Zhang","year":"2008"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1089\/neu.2009.1016","article-title":"Tumor necrosis factor alpha enhances glutamatergic transmission onto spinal motoneurons","volume":"27","author":"P Han","year":"2010","journal-title":"J Neurotrauma"},{"key":"ref20","first-page":"29","article-title":"Impact of a relaxation training on psychometric and immunologic parameters in tinnitus sufferers. J Psychosom Res","volume":"52","author":"C Weber","year":"2002"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.expneurol.2004.12.014","article-title":"Dietary supplementation with blueberries, spinach, or Spirulina reduces ischemic brain damage","volume":"193","author":"Y Wang","year":"2005","journal-title":"Exp Neurol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.expneurol.2005.08.013","article-title":"Blueberry- and Spirulina-enriched diets enhance striatal dopamine recovery and induce a rapid, transient microglia activation after injury of the rat nigrostriatal dopamine system","volume":"196","author":"I Str\u00f6mberg","year":"2005","journal-title":"Exp Neurol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"186","DOI":"10.3177\/jnsv.57.186","article-title":"Spirulina prevents memory dysfunction, reduces oxidative stress damage and augments antioxidant activity in senescence-accelerated mice","volume":"57","author":"JH Hwang","year":"2011","journal-title":"J Nutri Sci Vitaminol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0058215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T04:07:40Z","timestamp":1562818060000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0058215"}},"subtitle":[],"editor":[{"given":"Alfred","family":"Lewin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,3,22]]},"references-count":23,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,3,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0058215","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,22]]}}}